2023
Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis
Hagler M, Ferrara M, Yoviene Sykes L, Li F, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Perkins D, Mathalon D, Seidman L, Tsuang M, Walker E, Powers A, Allen A, Srihari V, Woods S. Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis. Schizophrenia Research 2023, 255: 239-245. PMID: 37028205, PMCID: PMC10207144, DOI: 10.1016/j.schres.2023.03.047.Peer-Reviewed Original ResearchMeSH KeywordsHumansLongitudinal StudiesNorth AmericaProdromal SymptomsProtective FactorsPsychotic DisordersConceptsFirst-episode psychosis servicesClinical high riskClinical high-risk individualsEarly detectionFirst-episode psychosis individualsRecent psychiatric hospitalizationCourse of illnessHigh-risk individualsAttenuated positive symptomsCHR researchGeographic catchmentSyndromal psychosisPsychosis individualsPsychiatric hospitalizationEarly intervention effortsHigh riskPsychosis servicesPositive symptomsGlobal functioningClinical resourcesProtective factorsDifferent populationsFE participantsGeneralizability of findingsFES programSelf-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis
Karp E, Williams T, Ellman L, Strauss G, Walker E, Corlett P, Woods S, Powers A, Gold J, Schiffman J, Waltz J, Silverstein S, Mittal V. Self-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis. Schizophrenia Bulletin 2023, 49: 746-755. PMID: 36939086, PMCID: PMC10154698, DOI: 10.1093/schbul/sbac197.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesGesturesHumansNeuropsychological TestsProdromal SymptomsPsychotic DisordersSelf ReportConceptsClinical high riskGesture deficitsInternalizing disordersCHR groupGesture interpretationLower verbal learningViable assessment toolVerbal learningNeurocognitive tasksGeneral intelligencePerformance deficitsNonverbal behaviorProcessing speedCHR participantsSimilar deficitsGreater deficitsHigh riskClinical InterviewFull psychotic disorderDeficitsSpecific subdomainsSRGPPsychotic disordersPsychosisGestures
2022
Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk
Collins M, Ji J, Chung Y, Lympus C, Afriyie-Agyemang Y, Addington J, Goodyear B, Bearden C, Cadenhead K, Mirzakhanian H, Tsuang M, Cornblatt B, Carrión R, Keshavan M, Stone W, Mathalon D, Perkins D, Walker E, Woods S, Powers A, Anticevic A, Cannon T. Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk. Molecular Psychiatry 2022, 28: 1182-1189. PMID: 36434057, PMCID: PMC10005940, DOI: 10.1038/s41380-022-01870-7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCerebral Cortical ThinningEthnicityFemaleHumansLongitudinal StudiesMaleMinority GroupsProdromal SymptomsPsychotic DisordersConceptsCHR-NCPercent thickness changeCortical thinningPsychosis onsetHealth controlsProgressive grey matter lossNorth American Prodrome Longitudinal StudyClinical high-risk individualsGray matter lossHigh-risk individualsLongitudinal studyGreater percent decreaseNovel treatment targetsParietal cortical regionsTargeted early interventionsCortical thicknessCortical areasMRI scansCHR individualsTreatment targetsEarly interventionCortical regionsLeft hemisphere regionsROC analysisHC participants
2020
Enhancing Psychosis Risk Prediction Through Computational Cognitive Neuroscience
Gold JM, Corlett PR, Strauss GP, Schiffman J, Ellman LM, Walker EF, Powers AR, Woods SW, Waltz JA, Silverstein SM, Mittal VA. Enhancing Psychosis Risk Prediction Through Computational Cognitive Neuroscience. Schizophrenia Bulletin 2020, 46: 1346-1352. PMID: 32648913, PMCID: PMC7707066, DOI: 10.1093/schbul/sbaa091.Peer-Reviewed Original ResearchMeSH KeywordsCognitive NeuroscienceDisease ProgressionHumansProdromal SymptomsPrognosisPsychotic DisordersRisk AssessmentSchizophreniaConceptsClinical high riskComputational cognitive neuroscienceNew behavioral measureCognitive neuroscienceBehavioral measuresPsychosis risk predictionCognitive mechanismsTrait vulnerabilityDisorganization symptomsNeural systemsPsychosis symptomsPsychosis riskSpecialized interviewsPhenotype measuresNeuroscienceCHR assessmentTreatment targetsPsychotic disordersCourse of illnessInterview methodPsychosisNew treatment targetsIllness progressionPositive predictive valueMeasures
2019
Predictive validity of conversion from the clinical high risk syndrome to frank psychosis
Yoviene Sykes LA, Ferrara M, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Perkins DO, Mathalon DH, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH, Woodberry KA, Powers AR, Ponce AN, Cahill JD, Pollard JM, Srihari VH, Woods SW. Predictive validity of conversion from the clinical high risk syndrome to frank psychosis. Schizophrenia Research 2019, 216: 184-191. PMID: 31864837, PMCID: PMC7239715, DOI: 10.1016/j.schres.2019.12.002.Peer-Reviewed Original ResearchConceptsFrank psychosisFirst-episode psychosis patientsOne-yearNorth American Prodromal Longitudinal StudySeverity of illnessClinical high-risk syndromeCurrent antipsychotic medicationsHigh-risk syndromePsychosis risk syndromeClinical high riskPredictive validityFEP casesPrescription ratesAntipsychotic medicationPsychosis patientsRisk syndromePsychosis onsetHigh riskLittle investigative attentionDiagnostic stabilityCHR individualsPsychosis paradigmPsychosisLongitudinal studySyndromeDuration of the psychosis prodrome
Powers AR, Addington J, Perkins DO, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Mathalon DH, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH, Woods SW. Duration of the psychosis prodrome. Schizophrenia Research 2019, 216: 443-449. PMID: 31806523, PMCID: PMC7539292, DOI: 10.1016/j.schres.2019.10.051.Peer-Reviewed Original ResearchConceptsSyndrome onsetPsychosis prodromeNorth American Prodrome Longitudinal StudyCHR-P patientsClinical high-risk syndromeHigh-risk syndromePsychosis risk syndromeMedication exposureProdromal periodFrank psychosisRisk syndromeProdromePsychosisLongitudinal studySyndromeOnsetStructured interviewsDurationFirst descriptionThirdYearsFinal thirdPatientsMonthsDoes hallucination perceptual modality impact psychosis risk?
Niles H, Walsh B, Woods S, Powers A. Does hallucination perceptual modality impact psychosis risk? Acta Psychiatrica Scandinavica 2019, 140: 360-370. PMID: 31355420, PMCID: PMC6752971, DOI: 10.1111/acps.13078.Peer-Reviewed Original ResearchConceptsClinical high riskPerceptual abnormalitiesPsychosis riskNon-verbal contentAuditory perceptual abnormalitiesIndividuals ages 12Verbal experienceAuditory experienceCHR individualsThought contentCHR sampleUnusual thought contentPredictive validityAuditory scoresGustatory componentsAge 12Meeting criteriaPsychotic disordersPhenomenological aspectsInterview notesPsychosisConversion riskScoresIndividualsExperience
2017
Lack of Diagnostic Pluripotentiality in Patients at Clinical High Risk for Psychosis: Specificity of Comorbidity Persistence and Search for Pluripotential Subgroups
Woods SW, Powers AR, Taylor JH, Davidson CA, Johannesen JK, Addington J, Perkins DO, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH. Lack of Diagnostic Pluripotentiality in Patients at Clinical High Risk for Psychosis: Specificity of Comorbidity Persistence and Search for Pluripotential Subgroups. Schizophrenia Bulletin 2017, 44: 254-263. PMID: 29036402, PMCID: PMC5814797, DOI: 10.1093/schbul/sbx138.Peer-Reviewed Original ResearchConceptsCHR syndromeDiagnostic outcomesCHR subgroupsClinical high-risk syndromeHigh-risk syndromeOnset of psychosisClinical high riskPersistence of anxietyEmergent psychosisCHR patientsRisk syndromeObservational studyCHR casesHigh riskNonpsychotic disordersComorbid disordersComparison subjectsBipolar disorderDiagnostic InterviewSyndromeDSM-IVPatientsPsychosisDiagnostic specificityComparison group