2024
Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses
Cervantes Rincón T, Kapoor T, Keeffe J, Simonelli L, Hoffmann H, Agudelo M, Jurado A, Peace A, Lee Y, Gazumyan A, Guidetti F, Cantergiani J, Cena B, Bianchini F, Tamagnini E, Moro S, Svoboda P, Costa F, Reis M, Ko A, Fallon B, Avila-Rios S, Reyes-Téran G, Rice C, Nussenzweig M, Bjorkman P, Ruzek D, Varani L, MacDonald M, Robbiani D. Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses. Cell Reports 2024, 43: 114298. PMID: 38819991, DOI: 10.1016/j.celrep.2024.114298.Peer-Reviewed Original ResearchPowassan virusEnvelope domain IIIYellow fever virusZika virusFever virusSerological neutralizing activityTemperate regionsDengue virusTicksTropical areasInfect humansLineage IMosquito-borne flavivirusNeutralizing activityHuman antibodiesVirusNeurological illnessBrazilFlavivirusesP002P003Human diseases
2021
Social determinants associated with Zika virus infection in pregnant women
Nery N, Ticona J, Gambrah C, Doss-Gollin S, Aromolaran A, Rastely-Júnior V, Lessa M, Sacramento GA, Cruz JS, de Oliveira D, dos Santos LL, da Silva CG, Botosso VF, Soares CP, Araujo DB, Oliveira DB, dos Santos Alves RP, Andreata-Santos R, Durigon EL, de Souza Ferreira LC, Wunder EA, Khouri R, Oliveira-Filho J, de Siqueira IC, Almeida ARP, Reis MG, Ko AI, Costa F. Social determinants associated with Zika virus infection in pregnant women. PLOS Neglected Tropical Diseases 2021, 15: e0009612. PMID: 34329305, PMCID: PMC8323902, DOI: 10.1371/journal.pntd.0009612.Peer-Reviewed Original ResearchConceptsPregnant womenSocial determinantsZIKV exposureZIKV infectionZika virusPlaque reduction neutralization testReferral maternity hospitalZika virus infectionReduction neutralization testCross-sectional studyKey social determinantsZIKV resultsClinical characteristicsMaternity hospitalRisk factorsVirus infectionExposure statusSociodemographic determinantsNeutralization testMultivariate analysisInfection riskLogistic regressionLower educationFuture interventionsInfectionDevelopmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
Ticona J, Nery N, Ladines-Lim JB, Gambrah C, Sacramento G, de Paula Freitas B, Bouzon J, Oliveira-Filho J, Borja A, Adhikarla H, Montoya M, Chin A, Wunder EA, Ballalai V, Vieira C, Belfort R, Almeida A, Reis MG, Harris E, Ko AI, Costa F. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study. PLOS Neglected Tropical Diseases 2021, 15: e0009162. PMID: 33544730, PMCID: PMC7891708, DOI: 10.1371/journal.pntd.0009162.Peer-Reviewed Original ResearchConceptsPopulation attributable fractionZIKV exposureMonths of ageMild cognitive delayZika virus exposureZIKV-exposed childrenPopulation-based cohortCognitive delayDevelopmental alterationsMonoclonal antibody blockadeMonths of lifeGross birth defectsAppropriate control groupsProspective serosurveyCohort studyNeurodevelopmental outcomesAntibody blockadeNeurodevelopmental evaluationVirus exposureAttributable fractionBehavioral abnormalitiesControl groupRest of womenZika virusCohortRisk of Sexually Transmitted Zika Virus in a Cohort of Economically Disadvantaged Urban Residents
Ticona J, Baig H, Nery N, Doss-Gollin S, Sacramento GA, Adhikarla H, Muenker MC, Wunder EA, Nascimento EJM, Marques ETA, Reis MG, Ko AI, Costa F. Risk of Sexually Transmitted Zika Virus in a Cohort of Economically Disadvantaged Urban Residents. The Journal Of Infectious Diseases 2021, 224: 860-864. PMID: 33395487, PMCID: PMC8522079, DOI: 10.1093/infdis/jiab001.Peer-Reviewed Original Research
2019
Zika Virus Infection — After the Pandemic
Musso D, Ko AI, Baud D. Zika Virus Infection — After the Pandemic. New England Journal Of Medicine 2019, 381: 1444-1457. PMID: 31597021, DOI: 10.1056/nejmra1808246.Peer-Reviewed Original ResearchImpact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region
Rodriguez-Barraquer I, Costa F, Nascimento EJM, Nery N, Castanha PMS, Sacramento GA, Cruz J, Carvalho M, De Olivera D, Hagan JE, Adhikarla H, Wunder EA, Coêlho DF, Azar SR, Rossi SL, Vasilakis N, Weaver SC, Ribeiro GS, Balmaseda A, Harris E, Nogueira ML, Reis MG, Marques ETA, Cummings DAT, Ko AI. Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. Science 2019, 363: 607-610. PMID: 30733412, PMCID: PMC8221194, DOI: 10.1126/science.aav6618.Peer-Reviewed Original ResearchConceptsZika virusZIKV NS1 antigenAttack rateZika virus emergenceHigh antibody titersDengue-endemic regionsZIKV immunityClinical outcomesDengue immunityZIKV infectionAntibody titersNS1 antigenRisk factorsEndemic regionsDengue virusImmunityVirusRiskVirus emergenceFuture transmissionCohortSymptomsInfectionAntigenTiters
2017
Adverse birth outcomes associated with Zika virus exposure during pregnancy in São José do Rio Preto, Brazil
Nogueira ML, Júnior N, Estofolete CF, Terzian A, Guimarães GF, Zini N, da Silva R, Silva G, Franco L, Rahal P, Bittar C, Carneiro B, Vasconcelos PFC, Henriques D, Barbosa DMU, Rombola P, de Grande L, Reis A, Palomares SA, Catelan M, Cruz LEAA, Necchi SH, Mendonça RCV, dos Santos I, Caron S, Costa F, Bozza FA, de Souza A, de Mattos C, de Mattos LC, Vasilakis N, Oliani AH, Oliani D, Ko A. Adverse birth outcomes associated with Zika virus exposure during pregnancy in São José do Rio Preto, Brazil. Clinical Microbiology And Infection 2017, 24: 646-652. PMID: 29133154, DOI: 10.1016/j.cmi.2017.11.004.Peer-Reviewed Original ResearchConceptsAdverse outcomesZIKV infectionPregnant womenZika virusNewborn outcomesCongenital Zika infectionSame adverse outcomesZika virus exposureAdverse birth outcomesBroad clinical spectrumEmergence of ZIKVCases of microcephalyDengue-endemic areasPublic health authoritiesBirth outcomesClinical outcomesClinical presentationThird trimesterSubependymal cystsClinical spectrumZIKV RNAReverse transcription-PCRVirus exposureZika infectionEpidemiologic data