2021
Spatial and Simultaneous Seroprevalence of Anti-Leptospira Antibodies in Owners and Their Domiciled Dogs in a Major City of Southern Brazil
do Nascimento Benitez A, Monica T, Miura A, Romanelli M, Giordano L, Freire R, Mitsuka-Breganó R, Martins C, Biondo A, Serrano I, Lopes T, Reis R, Gomes J, Costa F, Wunder E, Ko A, Navarro I. Spatial and Simultaneous Seroprevalence of Anti-Leptospira Antibodies in Owners and Their Domiciled Dogs in a Major City of Southern Brazil. Frontiers In Veterinary Science 2021, 7: 580400. PMID: 33490126, PMCID: PMC7820180, DOI: 10.3389/fvets.2020.580400.Peer-Reviewed Original ResearchRisk factorsAnti-Leptospira antibodiesLogistic regression analysisRisk of infectionDog casesPositive dogsHigh titersSerogroup CanicolaInfectionSeropositivityHuman casesDogsFrequent serogroupsSame titerCanicolaTitersGreater likelihoodRegression analysisSeroprevalenceCase distributionSame householdDog ownersAntibodiesPresent studySerogroups
2020
Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study
Mahajan S, Srinivasan R, Redlich CA, Huston SK, Anastasio KM, Cashman L, Massey DS, Dugan A, Witters D, Marlar J, Li SX, Lin Z, Hodge D, Chattopadhyay M, Adams MD, Lee C, Rao LV, Stewart C, Kuppusamy K, Ko AI, Krumholz HM. Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study. The American Journal Of Medicine 2020, 134: 526-534.e11. PMID: 33130124, PMCID: PMC7598362, DOI: 10.1016/j.amjmed.2020.09.024.Peer-Reviewed Original ResearchConceptsSARS-CoV-2-specific IgG antibodiesWeighted seroprevalenceIgG antibodiesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodiesSARS-CoV-2-specific antibodiesConnecticut residentsSelf-reported adherenceImmunoglobulin G antibodiesSARS-CoV-2Symptomatic illnessSerology testingSeroprevalence studyG antibodiesPrevalence studyGeneral populationPercentage of peopleSeroprevalenceLack antibodiesMajority of respondentsAntibodiesHispanic subpopulationsConvenience sampleHispanic populationCOVID-19Risk mitigation behaviors
2019
Risk of Zika microcephaly correlates with features of maternal antibodies
Robbiani DF, Olsen PC, Costa F, Wang Q, Oliveira TY, Nery N, Aromolaran A, do Rosário MS, Sacramento GA, Cruz JS, Khouri R, Wunder EA, Mattos A, de Paula Freitas B, Sarno M, Archanjo G, Daltro D, Carvalho GBS, Pimentel K, de Siqueira IC, de Almeida JRM, Henriques DF, Lima JA, Vasconcelos PFC, Schaefer-Babajew D, Azzopardi SA, Bozzacco L, Gazumyan A, Belfort R, Alcântara AP, Carvalho G, Moreira L, Araujo K, Reis MG, Keesler RI, Coffey LL, Tisoncik-Go J, Gale M, Rajagopal L, Waldorf K, Dudley DM, Simmons HA, Mejia A, O’Connor D, Steinbach RJ, Haese N, Smith J, Lewis A, Colgin L, Roberts V, Frias A, Kelleher M, Hirsch A, Streblow DN, Rice CM, MacDonald MR, de Almeida ARP, Van Rompay KKA, Ko AI, Nussenzweig MC. Risk of Zika microcephaly correlates with features of maternal antibodies. Journal Of Experimental Medicine 2019, 216: 2302-2315. PMID: 31413072, PMCID: PMC6781003, DOI: 10.1084/jem.20191061.Peer-Reviewed Original ResearchConceptsMaternal antibodiesFetal brain damageSerum antibody responseZika virus infectionInfected pregnanciesMicrocephalic infantsAntibody responsePregnant macaquesRisk factorsBrain damageVirus infectionCongenital abnormalitiesLow titersBrazilian womenMicrocephalyTitersPregnancyZIKVAntibodiesBirthRiskInfantsInfectionAbnormalitiesFlavivirusesSeroprevalence, Risk Factors, and Rodent Reservoirs of Leptospirosis in an Urban Community of Puerto Rico, 2015
Briskin EA, Casanovas-Massana A, Ryff KR, Morales-Estrada S, Hamond C, Perez-Rodriguez NM, Benavidez KM, Weinberger DM, Castro-Arellano I, Wunder EA, Sharp TM, Rivera-Garcia B, Ko AI. Seroprevalence, Risk Factors, and Rodent Reservoirs of Leptospirosis in an Urban Community of Puerto Rico, 2015. The Journal Of Infectious Diseases 2019, 220: 1489-1497. PMID: 31342075, PMCID: PMC6761939, DOI: 10.1093/infdis/jiz339.Peer-Reviewed Original ResearchConceptsRisk factorsAnti-Leptospira antibodiesBurden of leptospirosisRisk of infectionMicroscopic agglutination testCross-sectional surveyQuantitative polymerase chain reactionSeropositive individualsPrevious infectionPolymerase chain reactionLeptospira infectionLeptospira carriageSerogroup IcterohaemorrhagiaeHigh titersStudy participantsAgglutination testLeptospira exposurePathogenic LeptospiraInfectionRodent reservoirsChain reactionAntibodiesRodent trappingSeroprevalenceCommunity sites
2008
Impact of Environment and Social Gradient on Leptospira Infection in Urban Slums
Reis RB, Ribeiro GS, Felzemburgh RD, Santana FS, Mohr S, Melendez AX, Queiroz A, Santos AC, Ravines RR, Tassinari WS, Carvalho MS, Reis MG, Ko AI. Impact of Environment and Social Gradient on Leptospira Infection in Urban Slums. PLOS Neglected Tropical Diseases 2008, 2: e228. PMID: 18431445, PMCID: PMC2292260, DOI: 10.1371/journal.pntd.0000228.Peer-Reviewed Original ResearchConceptsLeptospira antibodiesLeptospira infectionRisk factorsIndependent risk factorSocioeconomic statusUrban slumsCommunity-based surveyPopulation-based informationHousehold environmental factorsPoisson regression modelsBlack raceOverall prevalencePrior infectionHealth outcomesHealth problemsUrban leptospirosisInfection riskInfectionSocial gradientUnequal health outcomesEffective preventionLeptospira transmissionTransmission determinantsAntibodiesSystem survey
2003
Monoclonal antibodies against an outer membrane protein from pathogenic Leptospira
Lüdtke C, Coutinho M, Jouglard S, Moreira C, Fernandes C, Brod C, Haake D, Ko A, Dellagostin O, Aleixo J. Monoclonal antibodies against an outer membrane protein from pathogenic Leptospira. Brazilian Journal Of Microbiology 2003, 34: 1-4. DOI: 10.1590/s1517-83822003000500001.Peer-Reviewed Original ResearchBALB/c miceMonoclonal antibodiesPathogenic LeptospiraSP2/OWhole-cell antigen preparationsIndirect ELISANon-pathogenic serovarsIgG2b isotypesC miceSpleen cellsAntigen preparationsMAb specificityDiagnostic testsPathogenic serovarsRecombinant LipL32Non-pathogenic LeptospiraMAbsLeptospiraELISAHybridoma productionAntibodiesLipL32SerovarsOuter membrane proteinsCells
1987
Characterization of protective and non-protective surface membrane carbohydrate epitopes of Schistosoma mansoni
Ko A, Harn D. Characterization of protective and non-protective surface membrane carbohydrate epitopes of Schistosoma mansoni. Memórias Do Instituto Oswaldo Cruz 1987, 82: 115-119. PMID: 2474123, DOI: 10.1590/s0074-02761987000800019.Peer-Reviewed Original ResearchConceptsKeyhole limpet hemocyaninNon-protective antibodiesMonoclonal antibodiesCarbohydrate epitopesProtective monoclonal antibodyEpitope mapping studiesDifferent carbohydrate epitopesLimpet hemocyaninSchistosomula antigensDifferent epitopesSchistosoma mansoniAntibodiesAntigenEpitopesImmunoprecipitation studiesBinding assaysInhibition studiesVaccineMansoni