2021
Anticoagulation Is Associated with Increased Mortality in Splenic Injuries
Bhattacharya B, Becher RD, Schuster KM, Davis KA, Maung AA. Anticoagulation Is Associated with Increased Mortality in Splenic Injuries. Journal Of Surgical Research 2021, 266: 1-5. PMID: 33975026, DOI: 10.1016/j.jss.2021.04.002.Peer-Reviewed Original ResearchConceptsNon-ACS patientsSplenic injuryAC patientsMultivariable binary logistic regressionIndependent risk factorEffect of anticoagulationInjury Severity ScoreUnits of RBCsBinary logistic regressionHospital courseMedian LOSIncreased MortalitySeverity scoreRisk factorsWorse outcomesAnticoagulationSplenic surgeryAC groupPatientsHigh mortalityInjuryLogistic regressionMortalitySerious injuriesAngiography
2006
Increased CD4+ CD25+ T Regulatory Cell Activity in Trauma Patients Depresses Protective Th1 Immunity
MacConmara MP, Maung AA, Fujimi S, McKenna AM, Delisle A, Lapchak PH, Rogers S, Lederer JA, Mannick JA. Increased CD4+ CD25+ T Regulatory Cell Activity in Trauma Patients Depresses Protective Th1 Immunity. Annals Of Surgery 2006, 124: 179-188. PMID: 16998360, PMCID: PMC1856576, DOI: 10.1097/01.sla.0000239031.06906.1f.Peer-Reviewed Original ResearchConceptsCD4 T cellsT cell proliferationT cellsDay 1IL-10IFNgamma productionDay 7Inhibitory cytokine IL-10Patient CD4 T cellsCD4 T cell proliferationCD3/CD28 antibodiesTh1-type immunityCytokine IL-10Regulatory cell activityTh1 cytokine productionCytometric bead arrayT Regulatory Cell ActivityTh2-type cytokinesProtective Th1 immunityCell proliferationT cell activationActivation of cellsIncreased CD4Treg activityTreg suppression