Xin Li
Associate Research ScientistCards
About
Research
Publications
2026
DISCERN: inferring drug sensitivity from single-cell transcriptomes using cell-type-specific genetic interaction networks
Liu M, Tian Y, Jia Y, Zhang J, Yi X, Sang S, Zhang N, Liu K, Peng Y, Wang Y, Li X, Chen B, Liang H, Gu Y. DISCERN: inferring drug sensitivity from single-cell transcriptomes using cell-type-specific genetic interaction networks. Genome Medicine 2026 PMID: 42304445, DOI: 10.1186/s13073-026-01688-w.Peer-Reviewed Original ResearchClu+ transitional alveolar epithelial cells promote lung injury repair and fibrosis progression
Wang Y, Guo J, Wang Y, Liu Q, Cui Y, Ning Z, Chen Y, Liu Y, Luo Z, Gao H, Jin T, Wang X, Guo E, Zhang Y, Bian Y, Pan T, Wang S, Li X, Liang H, Gu Y. Clu+ transitional alveolar epithelial cells promote lung injury repair and fibrosis progression. British Journal Of Pharmacology 2026, 183: 3252-3271. PMID: 41797553, DOI: 10.1111/bph.70389.Peer-Reviewed Original ResearchTRPM7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn2+ Homeostasis
Li X, Li X, Li C, Feng J, Yue Z, Yan J, Matsushita M, Qyang Y, Runnels L, Ai X, Yue L. TRPM7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn2+ Homeostasis. Circulation 2026, 153: 1210-1229. PMID: 41645903, PMCID: PMC13019533, DOI: 10.1161/circulationaha.125.074791.Peer-Reviewed Original Research
2025
Myofibroblast specific knockdown of NSUN2 suppresses cardiac fibrosis post-myocardial infarction
Sun Z, Li N, Huang M, Li Y, Wang C, Qu Z, Yu S, Mei Z, Wu B, Dou S, Jiang J, Zhang Y, Huang C, Han J, Yue Y, Li X, Dong Y, Du W. Myofibroblast specific knockdown of NSUN2 suppresses cardiac fibrosis post-myocardial infarction. Journal Of Molecular And Cellular Cardiology 2025, 209: 27-36. PMID: 41045987, DOI: 10.1016/j.yjmcc.2025.09.009.Peer-Reviewed Original ResearchAmbient temperature and coronary plaque rupture risk in STEMI: Insights from OCT analysis
Xu Q, Jin C, Qin Z, Zhao P, Wang Y, Zhang Y, Tian Y, Li X, Li X, Yu B, Tian J. Ambient temperature and coronary plaque rupture risk in STEMI: Insights from OCT analysis. Atherosclerosis 2025, 409: 120510. PMID: 40930906, DOI: 10.1016/j.atherosclerosis.2025.120510.Peer-Reviewed Original ResearchAdvanced tissue-engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes
Luo H, Anderson C, Li X, Lu Y, Hoareau M, Xing Q, Fooladi S, Liu Y, Xu Z, Park J, Fallon M, Thomas J, Gruber P, Elder R, Mak M, Riaz M, Campbell S, Qyang Y. Advanced tissue-engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes. Acta Biomaterialia 2025, 211: 92-103. PMID: 40582540, PMCID: PMC12338880, DOI: 10.1016/j.actbio.2025.06.055.Peer-Reviewed Original ResearchNew Schinortriterpenoids Including an Unprecedented 7/5/5/5 Carbon Skeleton with Antineuroinflammatory Activity from Leaves of Schisandra chinensis
Zhang Y, Li X, Liu X, Zhang Q, Jiang P, Xu W, Lu D, Luo Y, Pan J, Guan W, Li M, Chen Q, Zhang L, Kuang H, Yang B, Liu Y. New Schinortriterpenoids Including an Unprecedented 7/5/5/5 Carbon Skeleton with Antineuroinflammatory Activity from Leaves of Schisandra chinensis. Journal Of Agricultural And Food Chemistry 2025, 73: 18939-18952. PMID: 40561195, DOI: 10.1021/acs.jafc.5c02110.Peer-Reviewed Original ResearchZLY032 mediated activation of Notch1/Hes1 signaling inhibits cardiomyocyte ferroptosis to protect against myocardial Ischemia-Reperfusion injury in mice
Li H, Liu D, Gong M, Zhang Y, Liu J, Ren J, Cheng M, Zhang Y, Wang H, Wang S, Huang J, Feng X, Jiang S, Li X, Liu T, Yang M, Liu W, Jiao L, Li M, Zhang Y. ZLY032 mediated activation of Notch1/Hes1 signaling inhibits cardiomyocyte ferroptosis to protect against myocardial Ischemia-Reperfusion injury in mice. Biochemical Pharmacology 2025, 239: 117039. PMID: 40499841, DOI: 10.1016/j.bcp.2025.117039.Peer-Reviewed Original ResearchDiscovery of schinortriterpenoids schisaterpenes O–R from the fruits of Schisandra chinensis via molecular networking
Jiang P, Luo Y, Li X, Liu X, Zhang S, Guan W, Zhang Y, Hao Z, Chen Q, Zhang L, Yao H, He X, Kuang H, Yang B, Liu Y. Discovery of schinortriterpenoids schisaterpenes O–R from the fruits of Schisandra chinensis via molecular networking. Journal Of Molecular Structure 2025, 1333: 141765. DOI: 10.1016/j.molstruc.2025.141765.Peer-Reviewed Original ResearchDiscovery of undescribed schinortriterpenoids from Schisandra chinensis by molecular networking and their neuroprotective effects
Jiang P, Luo Y, Li X, Zhang S, Guan W, Anam-Naseem, Fan Y, Chen Q, Zhang L, Yao H, He X, Kuang H, Yang B, Liu Y. Discovery of undescribed schinortriterpenoids from Schisandra chinensis by molecular networking and their neuroprotective effects. Phytochemistry 2025, 237: 114524. PMID: 40306533, DOI: 10.1016/j.phytochem.2025.114524.Peer-Reviewed Original Research