Vijay Menon
Associate Research ScientistCards
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Research
Publications
2026
Targeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes
Heer C, Elia J, Menon V, Johnson S, Arbelaez S, Friedman S, Lopez-Giraldez F, Sundaram R, Herzon S, Bindra R, Gueble S. Targeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes. NAR Cancer 2026, 8: zcaf052. PMID: 41522810, PMCID: PMC12783042, DOI: 10.1093/narcan/zcaf052.Peer-Reviewed Original Research
2025
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
Arif T, Qiu J, Khademian H, Lohithakshan A, Menon A, Menon V, Slavinsky M, Batignes M, Lin M, Sebra R, Beaumont K, Benson D, Tzavaras N, Ménager M, Ghaffari S. Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells. Cell Stem Cell 2025, 32: 1904-1922.e7. PMID: 41289991, DOI: 10.1016/j.stem.2025.10.012.Peer-Reviewed Original ResearchDNA repair helicases: from mechanistic understanding to therapeutic implications
Menon V, Gueble S. DNA repair helicases: from mechanistic understanding to therapeutic implications. NAR Cancer 2025, 7: zcaf034. PMID: 41064806, PMCID: PMC12501782, DOI: 10.1093/narcan/zcaf034.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2024
Mitochondrial regulation of erythropoiesis in homeostasis and disease
Menon V, Slavinsky M, Hermine O, Ghaffari S. Mitochondrial regulation of erythropoiesis in homeostasis and disease. British Journal Of Haematology 2024, 205: 429-439. PMID: 38946206, PMCID: PMC11619715, DOI: 10.1111/bjh.19600.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2023
Antitumor active trans‑platinum complexes through metabolic stability and enhanced cellular accumulation
Menon V, Katner S, Lee D, Peterson E, Koblinski J, Farrell N. Antitumor active trans‑platinum complexes through metabolic stability and enhanced cellular accumulation. Journal Of Inorganic Biochemistry 2023, 252: 112475. PMID: 38199050, DOI: 10.1016/j.jinorgbio.2023.112475.Peer-Reviewed Original ResearchElevated CDKN1a (p21) mediates β-thalassemia erythroid apoptosis but its loss does not improve β-thalassemic erythropoiesis
Liang R, Lin M, Menon V, Qiu J, Menon A, Breda L, Arif T, Rivella S, Ghaffari S. Elevated CDKN1a (p21) mediates β-thalassemia erythroid apoptosis but its loss does not improve β-thalassemic erythropoiesis. Blood Advances 2023, 7: 6873-6885. PMID: 37672319, PMCID: PMC10685172, DOI: 10.1182/bloodadvances.2022007655.Peer-Reviewed Original ResearchNext-generation sequencing methodologies to detect low-frequency mutations: “Catch me if you can”
Menon V, Brash D. Next-generation sequencing methodologies to detect low-frequency mutations: “Catch me if you can”. Mutation Research/Reviews In Mutation Research 2023, 792: 108471. PMID: 37716438, PMCID: PMC10843083, DOI: 10.1016/j.mrrev.2023.108471.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
Protocol to identify and analyze mouse and human quiescent hematopoietic stem cells using flow cytometry combined with confocal imaging
Qiu J, Menon V, Tzavaras N, Liang R, Ghaffari S. Protocol to identify and analyze mouse and human quiescent hematopoietic stem cells using flow cytometry combined with confocal imaging. STAR Protocols 2022, 3: 101828. PMID: 36595934, PMCID: PMC9676629, DOI: 10.1016/j.xpro.2022.101828.Peer-Reviewed Original Research
2021
Mitochondrial localization and moderated activity are key to murine erythroid enucleation
Liang R, Menon V, Qiu J, Arif T, Renuse S, Lin M, Nowak R, Hartmann B, Tzavaras N, Benson DL, Chipuk JE, Fribourg M, Pandey A, Fowler V, Ghaffari S. Mitochondrial localization and moderated activity are key to murine erythroid enucleation. Blood Advances 2021, 5: 2490-2504. PMID: 34032849, PMCID: PMC8152511, DOI: 10.1182/bloodadvances.2021004259.Peer-Reviewed Original ResearchErythroid enucleation: a gateway into a “bloody” world
Menon V, Ghaffari S. Erythroid enucleation: a gateway into a “bloody” world. Experimental Hematology 2021, 95: 13-22. PMID: 33440185, PMCID: PMC8147720, DOI: 10.1016/j.exphem.2021.01.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAnimalsBirdsCalciumCell NucleusChromatinColony-Forming Units AssayComputational BiologyCytokinesCytoskeletal ProteinsDNA-Binding ProteinsErythroblastsErythrocytesErythropoiesisIntercellular Signaling Peptides and ProteinsMammalsMiceMicroRNAsProto-Oncogene ProteinsReceptors, Thyroid HormoneRepressor ProteinsReticulocytesrho GTP-Binding ProteinsTranscription FactorsTransport VesiclesYolk Sac
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