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Erol Fikrig, MD, is honored for his work leading to a Lyme disease vaccine, and Haifan Lin, PhD, is recognized for two "hallmark" stem cell theories.

Yale Cancer Center and Smilow Cancer Hospital people who have been honored

Two Yale Cancer Center members are among six Yale researchers to receive High-Risk, High-Reward NIH grants.

Two distinguished Yale professors, Dr. Hongyu Zhao, PhD, and Dr. Mark Gerstein, PhD, have been awarded a $1.9 million grant from the National Human Genome Research Institute (NHGRI) to advance the Developmental Genotype-Tissue Expression (dGTEx) project. This landmark initiative aims to unravel the complexities of gene expression patterns across developmental stages, providing critical insights into genetic influences on health and disease.

Patho-DBiT uses DNA barcoding to map the spatial relationships of RNA and proteins, allowing for a full examination of RNA (some types have regulatory roles in cancer). The technology, created in the lab of Yale’s Rong Fan, is now licensed to Yale spin-out AtlasXomics. Dr. Fan is a member of Yale Cancer Center.

Yale researchers and scientists in 14 other countries have established a new system of dengue lineages which, they say, will allow better tracking and improve vaccine development. They recently described the new system in a study published in the journal PLOS Biology.

A new Yale Neuroscience study sheds light on how the use of alternative translation initiation sites produces multiple synaptic protein isoforms with diverse localization and functions.

Yale Principal Investigators Rong Fan, PhD, Mina L. Xu, MD, Stephanie Halene, MD, and Zongming Ma, PhD, have received an NIH U01 award to establish the Center for Human Lymphoma Spatiotemporal Atlas (HuLymSTA) to construct an atlas of human lymphomas in transformation from indolent to aggressive cancer. In addition, Gisela Gabernet, PhD, Associate Research Scientist in Pathology in the Lab of Steven Kleinstein, PhD, Anthony N. Brady Professor of Pathology, received a NIH U01 grant for her project titled, “Large-scale integrated data analysis of lymphocyte receptor repertoires with workflows.” It is a three-year, $1.5M project.

Valerie Reinke, PhD, whose research explores gene regulation in germ cells, is also chair of Yale School of Medicine's Department of Genetics.