Collin Heer, PhD
Associate Research Scientist in Therapeutic RadiologyAbout
Research
Publications
2026
NAPRT expression and epigenetic regulation in pediatric rhabdomyosarcoma as a potential biomarker for NAMPT inhibition
Kim A, Bhardwaj P, Rehman S, Zhao S, Lucas K, Noronha K, Bhatt D, Friedman S, Morotti R, Sundaram R, Dela Cruz F, Feinberg T, Ramakrishnan S, Xue W, Barkauskas D, Hall D, Shern J, Sun W, Barr F, Yi J, Spurrier J, Yu A, Brenner C, Heer C, Heske C, Vasquez J. NAPRT expression and epigenetic regulation in pediatric rhabdomyosarcoma as a potential biomarker for NAMPT inhibition. Molecular Cancer Therapeutics 2026, 10.1158/1535-7163.mct-25-0619. PMID: 42017774, PMCID: PMC13184901, DOI: 10.1158/1535-7163.mct-25-0619.Peer-Reviewed Original ResearchTargeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes
Heer C, Elia J, Menon V, Johnson S, Arbelaez S, Friedman S, Lopez-Giraldez F, Sundaram R, Herzon S, Bindra R, Gueble S. Targeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes. NAR Cancer 2026, 8: zcaf052. PMID: 41522810, PMCID: PMC12783042, DOI: 10.1093/narcan/zcaf052.Peer-Reviewed Original Research
2025
Synthesis and Biological Evaluation of Colibactin Derivatives
Airan Y, Fedorova O, Heer C, Rees M, Ronan M, Roth J, Bindra R, Herzon S. Synthesis and Biological Evaluation of Colibactin Derivatives. ACS Chemical Biology 2025, 21: 26-36. PMID: 41419211, PMCID: PMC12856499, DOI: 10.1021/acschembio.5c00639.Peer-Reviewed Original ResearchSomatic CRISPR tumorigenesis and multiomic analysis reveal a pentose phosphate pathway disruption vulnerability in MPNSTs
McGivney G, Brockman Q, Borcherding N, Scherer A, Rauckhorst A, Gutierrez W, Solst S, Heer C, Warrier A, Floyd W, Kirsch D, Knepper-Adrian V, Laverty E, Roughton G, Spitz D, Taylor E, Dodd R. Somatic CRISPR tumorigenesis and multiomic analysis reveal a pentose phosphate pathway disruption vulnerability in MPNSTs. Science Advances 2025, 11: eadu2906. PMID: 40802750, PMCID: PMC12346278, DOI: 10.1126/sciadv.adu2906.Peer-Reviewed Original ResearchMitoregulin Promotes Cell Cycle Progression in Non-Small Cell Lung Cancer Cells
Stein C, Linzer C, Heer C, Witmer N, Cochran J, Spitz D, Boudreau R. Mitoregulin Promotes Cell Cycle Progression in Non-Small Cell Lung Cancer Cells. International Journal Of Molecular Sciences 2025, 26: 1939. PMID: 40076565, PMCID: PMC11899852, DOI: 10.3390/ijms26051939.Peer-Reviewed Original Research
2021
Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide
Sishc B, Ding L, Nam T, Heer C, Rodman S, Schoenfeld J, Fath M, Saha D, Pulliam C, Langen B, Beardsley R, Riley D, Keene J, Spitz D, Story M. Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide. Science Translational Medicine 2021, 13: eabb3768. PMID: 33980575, PMCID: PMC8314936, DOI: 10.1126/scitranslmed.abb3768.Peer-Reviewed Original ResearchInhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide‐induced microglial and astrocytic neuroinflammation by increasing NAD+
Roboon J, Hattori T, Ishii H, Takarada‐Iemata M, Nguyen D, Heer C, O'Meally D, Brenner C, Yamamoto Y, Okamoto H, Higashida H, Hori O. Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide‐induced microglial and astrocytic neuroinflammation by increasing NAD+. Journal Of Neurochemistry 2021, 158: 311-327. PMID: 33871064, PMCID: PMC8282715, DOI: 10.1111/jnc.15367.Peer-Reviewed Original ResearchADP-ribosyl Cyclase 1AnimalsApigeninAstrocytesChemokinesCytokinesGene DeletionHippocampusInflammationInjections, IntraventricularLipopolysaccharidesMacrophage ActivationMaleMembrane GlycoproteinsMiceMice, Inbred ICRMice, KnockoutMicrogliaNADNerve DegenerationNF-kappa BNiacinamidePyridinium Compounds
2020
Succinate Accumulation Links Mitochondrial MnSOD Depletion to Aberrant Nuclear DNA Methylation and Altered Cell Fate.
Cramer-Morales K, Heer C, Mapuskar K, Domann F. Succinate Accumulation Links Mitochondrial MnSOD Depletion to Aberrant Nuclear DNA Methylation and Altered Cell Fate. Journal Of Experimental Pathology 2020, 1: 60-70. PMID: 33585836, PMCID: PMC7876477.Peer-Reviewed Original ResearchCoronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity
Heer C, Sanderson D, Voth L, Alhammad Y, Schmidt M, Trammell S, Perlman S, Cohen M, Fehr A, Brenner C. Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity. Journal Of Biological Chemistry 2020, 295: 17986-17996. PMID: 33051211, PMCID: PMC7834058, DOI: 10.1074/jbc.ra120.015138.Peer-Reviewed Original ResearchLetting off electrons to cope with metabolic stress
Heer C, Brenner C. Letting off electrons to cope with metabolic stress. Nature Metabolism 2020, 2: 485-486. PMID: 32694728, DOI: 10.1038/s42255-020-0207-8.Peer-Reviewed Original Research
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