Francesc Lopez-Giraldez, PhD
Research Scientist in GeneticsCards
About
Titles
Research Scientist in Genetics
YCGA Associate Director of Bioinformatics, Genetics
Appointments
Genetics
Research ScientistPrimary
Other Departments & Organizations
- Genetics
- Genomics, Genetics, and Epigenetics
- Yale Cancer Center
- Yale Center for Genome Analysis (YCGA)
- Yale-BI Biomedical Data Science Fellowship
Education & Training
- Post-Doctoral fellowship Beatriu de Pinós
- Generalitat de Catalunya (2009)
- PhD
- Autonomous University of Barcelona, Evolutionary Genetics (2006)
- Graduate student fellowship
- Generalitat de Catalunya (2004)
- MSc
- Pompeu Fabra University, Health and Life Sciences (2004)
- BS
- University of Girona, Biology (2000)
- Undergraduate student fellowship to develop a project on the Phylogeny of the genus Merluccius
- Gobierno de España (2000)
Research
Publications
2026
DMEM and EMEM as alternate growth media for pathogenic Leptospira
Garcia L, Lin Z, Culos S, Muenker M, Johnson E, Wang Z, Lopez-Giraldez F, Giraud-Gatineau A, Jackson A, Picardeau M, Goodlett D, Townsend J, Pětrošová H, Wunder E. DMEM and EMEM as alternate growth media for pathogenic Leptospira. PLOS Neglected Tropical Diseases 2026, 20: e0014136. PMID: 41843624, PMCID: PMC13008252, DOI: 10.1371/journal.pntd.0014136.Peer-Reviewed Original ResearchTargeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes
Heer C, Elia J, Menon V, Johnson S, Arbelaez S, Friedman S, Lopez-Giraldez F, Sundaram R, Herzon S, Bindra R, Gueble S. Targeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes. NAR Cancer 2026, 8: zcaf052. PMID: 41522810, PMCID: PMC12783042, DOI: 10.1093/narcan/zcaf052.Peer-Reviewed Original Research
2025
Correction to: mTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis
Min W, Qin L, Zhang H, López-Giráldez F, Jiang N, Kim Y, Mohan V, Su M, Murray K, Grutzendler J, Zhou J. Correction to: mTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis. Circulation Research 2025, 137: e16-e17. PMID: 40536942, DOI: 10.1161/res.0000000000000718.Commentaries, Editorials and LettersSystemic in utero gene editing as a treatment for cystic fibrosis
Ricciardi A, Barone C, Putman R, Quijano E, Gupta A, Nguyen R, Mandl H, Piotrowski-Daspit A, Lopez-Giraldez F, Luks V, Freedman-Weiss M, Farrelly J, Ahle S, Lynn A, Glazer P, Saltzman W, Stitelman D, Egan M. Systemic in utero gene editing as a treatment for cystic fibrosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2418731122. PMID: 40493185, PMCID: PMC12184489, DOI: 10.1073/pnas.2418731122.Peer-Reviewed Original ResearchRates of Evolution of Developmental Changes in Gene Expression in Sordariomycetes
Wang Y, Wang F, Meng G, Lopez-Giraldez F, Dong C, Wang Z, Townsend J. Rates of Evolution of Developmental Changes in Gene Expression in Sordariomycetes. Molecular Biology And Evolution 2025, 42: msaf131. PMID: 40452442, PMCID: PMC12203517, DOI: 10.1093/molbev/msaf131.Peer-Reviewed Original ResearchGenomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes
Sierant M, Jin S, Bilguvar K, Morton S, Dong W, Jiang W, Lu Z, Li B, López-Giráldez F, Tikhonova I, Zeng X, Lu Q, Choi J, Zhang J, Nelson-Williams C, Knight J, Zhao H, Cao J, Mane S, Sedore S, Gruber P, Lek M, Goldmuntz E, Deanfield J, Giardini A, Mital S, Russell M, Gaynor J, King E, Wagner M, Srivastava D, Shen Y, Bernstein D, Porter G, Newburger J, Seidman J, Roberts A, Yandell M, Yost H, Tristani-Firouzi M, Kim R, Chung W, Gelb B, Seidman C, Brueckner M, Lifton R. Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2420343122. PMID: 40127276, PMCID: PMC12002227, DOI: 10.1073/pnas.2420343122.Peer-Reviewed Original ResearchSpatial Transcriptomics Reveals Differential Inflammatory Pathways in Discoid Lupus Erythematosus and Lichen Planus
Kidacki M, Cho C, Lopez-Giraldez F, Breidbart R, Jaiswal A, Lee M, Chowdhury S, Damsky W, Chen L, Vesely M. Spatial Transcriptomics Reveals Differential Inflammatory Pathways in Discoid Lupus Erythematosus and Lichen Planus. Journal Of Investigative Dermatology 2025, 145: 2344-2348.e7. PMID: 40113031, PMCID: PMC12353771, DOI: 10.1016/j.jid.2025.02.148.Peer-Reviewed Original ResearchThis study investigates immune pathway differences in discoid lupus and lichen planus, showing stronger type 2 inflammation in lichen planus, potentially explaining symptomatic itch.Recessive genetic contribution to congenital heart disease in 5,424 probands
Dong W, Jin S, Sierant M, Lu Z, Li B, Lu Q, Morton S, Zhang J, López-Giráldez F, Nelson-Williams C, Knight J, Zhao H, Cao J, Mane S, Gruber P, Lek M, Goldmuntz E, Deanfield J, Giardini A, Mital S, Russell M, Gaynor J, Cnota J, Wagner M, Srivastava D, Bernstein D, Porter G, Newburger J, Roberts A, Yandell M, Yost H, Tristani-Firouzi M, Kim R, Seidman J, Chung W, Gelb B, Seidman C, Lifton R, Brueckner M. Recessive genetic contribution to congenital heart disease in 5,424 probands. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2419992122. PMID: 40030011, PMCID: PMC11912448, DOI: 10.1073/pnas.2419992122.Peer-Reviewed Original ResearchPD-1H (VISTA) Expression in Cutaneous Squamous Cell Carcinoma Is Correlated with T-Cell Infiltration and Activation
Kidacki M, Cho C, Lopez-Giraldez F, Huang B, He J, Gaule P, Chen L, Vesely M. PD-1H (VISTA) Expression in Cutaneous Squamous Cell Carcinoma Is Correlated with T-Cell Infiltration and Activation. Journal Of Investigative Dermatology 2025, 145: 2313-2324.e6. PMID: 39983979, PMCID: PMC12353361, DOI: 10.1016/j.jid.2025.01.030.Peer-Reviewed Original ResearchDMEM and EMEM are suitable surrogate media to mimic host environment and expand leptospiral pathogenesis studies using in vitro tools.
Garcia LE, Lin Z, Culos S, Catherine Muenker M, Johnson EE, Wang Z, Lopez-Giraldez F, Giraud-Gatineau A, Jackson A, Picardeau M, Goodlett DR, Townsend JP, Pětrošová H, Wunder EA Jr. DMEM and EMEM are suitable surrogate media to mimic host environment and expand leptospiral pathogenesis studies using in vitro tools. BioRxiv 2025 PMID: 39896660, DOI: 10.1101/2025.01.22.634353.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Teaching & Mentoring
Links
Media
Yale Center for Genome Analysis Shared Resource
Located on West Campus, the Yale Center for Genome Analysis offers RNA expression profiling, DNA genotyping, and high-throughput sequencing services.
Contact
Francesc Lopez-Giraldez
Get In Touch
Contacts
Locations
The Anlyan Center
Academic Office
300 Cedar Street, Wing North, Fl 2, Rm 212
New Haven, CT 06519
General Information
203.737.6864