Publications

2025

Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statementBorate U, Pugh K, Waller A, Welkie R, Huang Y, Bewersdorf J, Stahl M, DeZern A, Platzbecker U, Sekeres M, Wei A, Buckstein R, Roboz G, Savona M, Loghavi S, Hasserjian R, Fenaux P, Sallman D, Hourigan C, Della Porta M, Nimer S, Little R, Santini V, Efficace F, Taylor J, Garcia-Manero G, Odenike O, Kim T, Halene S, Komrokji R, Griffiths E, Greenberg P, Xu M, Xie Z, Bejar R, Sanz G, Patnaik M, Figueroa M, Carraway H, Abdel-Wahab O, Starczynowski D, Padron E, Boultwood J, Gore S, Daver N, Churpek J, Majeti R, Bennett J, List A, Brunner A, Zeidan A. Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement. Blood 2025, 145: 1369-1381. PMID: 40146152, DOI: 10.1182/blood.2023023717.
In the time of COVID-19: challenges, successes and lessons learned from studies in cancer patientsMack P, Crawford J, Chang A, Yin A, Klein S, Shea P, Hirsch F, Zidar D, Simon V, Gleason C, McBride R, Cordon-Cardo C, VanOudenhove J, Halene S, Lee F, Mantis N, Kushi L, Weiskopf D, Merchant A, Reckamp K, Skarbinski J, Figueiredo J. In the time of COVID-19: challenges, successes and lessons learned from studies in cancer patients. Journal Of The National Cancer Institute 2025, djaf073. PMID: 40127178, DOI: 10.1093/jnci/djaf073.
Igniting Language Intelligence: The Hitchhiker's Guide from Chain-of-Thought Reasoning to Language AgentsZhang Z, Yao Y, Zhang A, Tang X, Ma X, He Z, Wang Y, Gerstein M, Wang R, Liu G, Zhao H. Igniting Language Intelligence: The Hitchhiker's Guide from Chain-of-Thought Reasoning to Language Agents. ACM Computing Surveys 2025, 57: 1-39. DOI: 10.1145/3719341.
Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s diseaseCai Y, Kanyo J, Wilson R, Bathla S, Cardozo P, Tong L, Qin S, Fuentes L, Pinheiro-de-Sousa I, Huynh T, Sun L, Mansuri M, Tian Z, Gan H, Braker A, Trinh H, Huttner A, Lam T, Petsalaki E, Brennand K, Nairn A, Grutzendler J. Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease. Nature Aging 2025, 5: 504-527. PMID: 40065072, PMCID: PMC11922768, DOI: 10.1038/s43587-025-00823-3.
Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic deliveryLynn A, Shin K, Eaton D, Rose M, Zhang X, Ene M, Grundler J, Deschenes E, Rivero R, Bracaglia L, Glazer P, Stitelman D, Saltzman W. Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery. Biomaterials 2025, 320: 123238. PMID: 40064138, DOI: 10.1016/j.biomaterials.2025.123238.
Synthetic Genetic Elements Enable Rapid Characterization of Inorganic Carbon Uptake Systems in Cupriavidus necator H16Nakamura A, Fulk E, Johnson C, Isaacs F. Synthetic Genetic Elements Enable Rapid Characterization of Inorganic Carbon Uptake Systems in Cupriavidus necator H16. ACS Synthetic Biology 2025, 14: 943-953. PMID: 40048245, DOI: 10.1021/acssynbio.4c00869.
Hypercholesterolemia-induced LXR signaling in smooth muscle cells contributes to vascular lesion remodeling and visceral functionZhang H, de Urturi D, Fernández-Tussy P, Huang Y, Jovin D, Zhang X, Huang S, Lek M, da Silva Catarino J, Sternak M, Citrin K, Swirski F, Gustafsson J, Greif D, Esplugues E, Biwer L, Suárez Y, Fernández-Hernando C. Hypercholesterolemia-induced LXR signaling in smooth muscle cells contributes to vascular lesion remodeling and visceral function. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2417512122. PMID: 40035761, PMCID: PMC11912459, DOI: 10.1073/pnas.2417512122.
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)Loughran G, Andreev D, Terenin I, Namy O, Mikl M, Yordanova M, McManus C, Firth A, Atkins J, Fraser C, Ignatova Z, Iwasaki S, Kufel J, Larsson O, Leidel S, Mankin A, Mariotti M, Tanenbaum M, Topisirovic I, Vázquez-Laslop N, Viero G, Caliskan N, Chen Y, Clark P, Dinman J, Farabaugh P, Gilbert W, Ivanov P, Kieft J, Mühlemann O, Sachs M, Shatsky I, Sonenberg N, Steckelberg A, Willis A, Woodside M, Valasek L, Dmitriev S, Baranov P. Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR). Nature Structural & Molecular Biology 2025, 32: 418-430. PMID: 40033152, DOI: 10.1038/s41594-025-01492-x.
Corrigendum to ‘Prospective solutions to ovarian reserve damage during the ovarian tissue cryopreservation and transplantation procedure’ [Fertility and Sterility 122 (2024) 565-573]Mercier A, Johnson J, Kallen A. Corrigendum to ‘Prospective solutions to ovarian reserve damage during the ovarian tissue cryopreservation and transplantation procedure’ [Fertility and Sterility 122 (2024) 565-573]. Fertility And Sterility 2025 PMID: 40047740, DOI: 10.1016/j.fertnstert.2024.12.021.
Implications of gene × environment interactions in post-traumatic stress disorder risk and treatmentSeah C, Sidamon-Eristoff A, Huckins L, Brennand K. Implications of gene × environment interactions in post-traumatic stress disorder risk and treatment. Journal Of Clinical Investigation 2025, 135: e185102. PMID: 40026250, PMCID: PMC11870735, DOI: 10.1172/jci185102.
Beyond the Marrow–Moving Toward a Systemic Perspective of Radiation-Induced CytopeniasBrowning S, Lourdes M, Neparidze N, Robinson T. Beyond the Marrow–Moving Toward a Systemic Perspective of Radiation-Induced Cytopenias. International Journal Of Radiation Oncology • Biology • Physics 2025, 121: 1039-1041. PMID: 39988417, DOI: 10.1016/j.ijrobp.2024.11.100.
Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairsDong C, Zhang F, He E, Ren P, Verma N, Zhu X, Feng D, Cai J, Zhao H, Chen S. Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairs. Patterns 2025, 6: 101184. DOI: 10.1016/j.patter.2025.101184.
Real-world outcomes with T-VEC in patients with anti-PD-1 resistant in-transit disease from melanoma and Merkel cell carcinomaSu D, McNamara M, Kaszycki M, Frey A, Ishizuka J, Costa P, Tran T, Kluger H, Clune J, Weiss S, Olino K. Real-world outcomes with T-VEC in patients with anti-PD-1 resistant in-transit disease from melanoma and Merkel cell carcinoma. Surgical Oncology Insight 2025, 2: 100120. DOI: 10.1016/j.soi.2024.100120.
Engineering Mice to Study Human Immunity.Sefik E, Xiao T, Chiorazzi M, Odell I, Zhang F, Agrawal K, Micevic G, Flavell R. Engineering Mice to Study Human Immunity. Annual Review Of Immunology 2025 PMID: 40020225, DOI: 10.1146/annurev-immunol-082523-124415.
Norovirus co-opts NINJ1 for selective protein secretionSong J, Zhang L, Moon S, Fang A, Wang G, Gheshm N, Loeb S, Cao P, Wallace J, Alfajaro M, Strine M, Beatty W, Jamieson A, Orchard R, Robinson B, Nice T, Wilen C, Orvedahl A, Reese T, Lee S. Norovirus co-opts NINJ1 for selective protein secretion. Science Advances 2025, 11: eadu7985. PMID: 40020060, PMCID: PMC11870086, DOI: 10.1126/sciadv.adu7985.
Deep multimodal representations and classification of first-episode psychosis via live face processingSingh R, Zhang Y, Bhaskar D, Srihari V, Tek C, Zhang X, Noah J, Krishnaswamy S, Hirsch J. Deep multimodal representations and classification of first-episode psychosis via live face processing. Frontiers In Psychiatry 2025, 16: 1518762. PMID: 40134976, PMCID: PMC11934110, DOI: 10.3389/fpsyt.2025.1518762.
Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signalingIsraelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro M, Wei J, Dong H, Homer R, Ring A, Wilen C, Iwasaki A. Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. Journal Of Experimental Medicine 2025, 222: e2020124102192025c. PMID: 40009071, PMCID: PMC11864074, DOI: 10.1084/jem.2020124102192025c.
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombinationWu L, Yadavalli A, Senigl F, Matos-Rodrigues G, Xu D, Pintado-Urbanc A, Simon M, Wu W, Nussenzweig A, Schatz D. Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination. Molecular Cell 2025 PMID: 40049160, DOI: 10.1016/j.molcel.2025.02.007.
Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocksKurbanov D, Ahangari F, Adams T, De Man R, Tang J, Carlon M, Abu Hussein N, Cortesi E, Zapata M, De Sadelaar L, Wuyts W, Vanaudenaerde B, Kaminski N, McDonough J. Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2025, 328: l456-l462. PMID: 39970931, DOI: 10.1152/ajplung.00171.2024.
Modeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity?Prendergast A, Sheppard M, Famulski J, Nicoli S, Mukherjee S, Sips P, Elefteriades J. Modeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity? Frontiers In Cardiovascular Medicine 2025, 12: 1480407. PMID: 40066353, PMCID: PMC11892108, DOI: 10.3389/fcvm.2025.1480407.
CD103+ dendritic cell — fibroblast crosstalk via TLR9, TDO2, and AHR signaling drives lung fibrogenesisCarter H, Costa R, Adams T, Gilchrist T, Emch C, Bame M, Oldham J, Huang S, Linderholm A, Noth I, Kaminski N, Moore B, Gurczynski S. CD103+ dendritic cell — fibroblast crosstalk via TLR9, TDO2, and AHR signaling drives lung fibrogenesis. JCI Insight 2025, 10 PMID: 39964756, PMCID: PMC11949071, DOI: 10.1172/jci.insight.177072.
γ-secretase facilitates retromer-mediated retrograde transportTakeo Y, Crite M, Mehmood K, DiMaio D. γ-secretase facilitates retromer-mediated retrograde transport. Journal Of Cell Science 2025, 138: jcs263538. PMID: 39865938, PMCID: PMC11883284, DOI: 10.1242/jcs.263538.
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infectionFagerberg E, Attanasio J, Dien C, Singh J, Kessler E, Abdullah L, Shen J, Hunt B, Connolly K, De Brouwer E, He J, Iyer N, Buck J, Borr E, Damo M, Foster G, Giles J, Huang Y, Tsang J, Krishnaswamy S, Cui W, Joshi N. KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection. Science 2025, 387: eadn2337. PMID: 39946463, DOI: 10.1126/science.adn2337.
Targeting the SARS-CoV-2 reservoir in long COVIDProal A, Aleman S, Bomsel M, Brodin P, Buggert M, Cherry S, Chertow D, Davies H, Dupont C, Deeks S, Ely E, Fasano A, Freire M, Geng L, Griffin D, Henrich T, Hewitt S, Iwasaki A, Krumholz H, Locci M, Marconi V, Mehandru S, Muller-Trutwin M, Painter M, Pretorius E, Price D, Putrino D, Qian Y, Roan N, Salmon D, Tan G, VanElzakker M, Wherry E, Van Weyenbergh J, Yonker L, Peluso M. Targeting the SARS-CoV-2 reservoir in long COVID. The Lancet Infectious Diseases 2025 PMID: 39947217, DOI: 10.1016/s1473-3099(24)00769-2.
Engineering a genomically recoded organism with one stop codonGrome M, Nguyen M, Moonan D, Mohler K, Gurara K, Wang S, Hemez C, Stenton B, Cao Y, Radford F, Kornaj M, Patel J, Prome M, Rogulina S, Sozanski D, Tordoff J, Rinehart J, Isaacs F. Engineering a genomically recoded organism with one stop codon. Nature 2025, 639: 512-521. PMID: 39910296, PMCID: PMC11903333, DOI: 10.1038/s41586-024-08501-x.
Author Correction: Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapyZhang F, Chow R, He E, Dong C, Xin S, Mirza D, Feng Y, Tian X, Verma N, Majety M, Zhang Y, Wang G, Chen S. Author Correction: Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy. Nature Biotechnology 2025, 1-1. PMID: 39901026, DOI: 10.1038/s41587-025-02576-1.
G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migrationBoraas L, Hu M, Martino P, Thornton L, Vejnar C, Zhen G, Zeng L, Parker D, Cox A, Giraldez A, Su X, Mayr C, Wang S, Nicoli S. G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration. Cell Reports 2025, 44: 115237. PMID: 39883578, PMCID: PMC11923778, DOI: 10.1016/j.celrep.2025.115237.
BPS2025 - Multispectral vibrational imaging for high-resolution tracking of live-cell metabolic processesShuster S, Curtis A, Davis C. BPS2025 - Multispectral vibrational imaging for high-resolution tracking of live-cell metabolic processes. Biophysical Journal 2025, 124: 377a-378a. DOI: 10.1016/j.bpj.2024.11.2042.
The sex differences in diseases progression and prognosis among persons with HIV and HBV coinfectionYang R, Chen Q, Jiao F, Yu X, Xiong Y. The sex differences in diseases progression and prognosis among persons with HIV and HBV coinfection. Scientific Reports 2025, 15: 4018. PMID: 39893294, PMCID: PMC11787304, DOI: 10.1038/s41598-025-88530-2.
Deep mutational scanning of the Trypanosoma brucei developmental regulator RBP6 reveals an essential disordered region influenced by positive residuesRojas-Sánchez S, Kolev N, Tschudi C. Deep mutational scanning of the Trypanosoma brucei developmental regulator RBP6 reveals an essential disordered region influenced by positive residues. Nature Communications 2025, 16: 1168. PMID: 39885181, PMCID: PMC11782513, DOI: 10.1038/s41467-025-56553-y.
Drosophila Modulo is essential for transposon silencing and developmental robustnessParikh R, Nayak D, Lin H, Gangaraju V. Drosophila Modulo is essential for transposon silencing and developmental robustness. Journal Of Biological Chemistry 2025, 301: 108210. PMID: 39848495, PMCID: PMC11879677, DOI: 10.1016/j.jbc.2025.108210.
Intelligence at the Edge of ChaosZhang, Shiyang, et al. "Intelligence at the Edge of Chaos." arXiv preprint arXiv:2410.02536 (2024).
Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II IntronsFedorova O, Luo M, Jagdmann G, Van Zandt M, Sisto L, Pyle A. Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns. ACS Chemical Biology 2025, 20: 378-385. PMID: 39824511, PMCID: PMC11851433, DOI: 10.1021/acschembio.4c00631.
Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapyZhang F, Chow R, He E, Dong C, Xin S, Mirza D, Feng Y, Tian X, Verma N, Majety M, Zhang Y, Wang G, Chen S. Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy. Nature Biotechnology 2025, 1-14. PMID: 39820813, DOI: 10.1038/s41587-024-02535-2.
Specification of claustro-amygdalar and palaeocortical neurons and circuitsKaur N, Kovner R, Gulden F, Pletikos M, Andrijevic D, Zhu T, Silbereis J, Shibata M, Shibata A, Liu Y, Ma S, Salla N, de Martin X, Klarić T, Burke M, Franjic D, Cho H, Yuen M, Chatterjee I, Soric P, Esakkimuthu D, Moser M, Santpere G, Mineur Y, Pattabiraman K, Picciotto M, Huang H, Sestan N. Specification of claustro-amygdalar and palaeocortical neurons and circuits. Nature 2025, 638: 469-478. PMID: 39814878, PMCID: PMC11821539, DOI: 10.1038/s41586-024-08361-5.
The human and non-human primate developmental GTEx projectsBell T, Blanchard T, Hernandez R, Linn R, Taylor D, VonDran M, Ahooyi T, Beitra D, Bernieh A, Delaney M, Faith M, Fattahi E, Footer D, Gilbert M, Guambaña S, Gulino S, Hanson J, Hattrell E, Heinemann C, Kreeb J, Leino D, Mcdevitt L, Palmieri A, Pfeiffer M, Pryhuber G, Rossi C, Rasool I, Roberts R, Salehi A, Savannah E, Stachowicz K, Stokes D, Suplee L, Van Hoose P, Wilkins B, Williams-Taylor S, Zhang S, Ardlie K, Getz G, Lappalainen T, Montgomery S, Aguet F, Anderson L, Bernstein B, Choudhary A, Domenech L, Gaskell E, Johnson M, Liu Q, Marderstein A, Nedzel J, Okonda J, Padhi E, Rosano M, Russell A, Walker B, Sestan N, Gerstein M, Milosavljevic A, Borsari B, Cho H, Clarke D, Deveau A, Galeev T, Gobeske K, Hameed I, Huttner A, Jensen M, Jiang Y, Li J, Liu J, Liu Y, Ma J, Mane S, Meng R, Nadkarni A, Ni P, Park S, Petrosyan V, Pochareddy S, Salamon I, Xia Y, Yates C, Zhang M, Zhao H, Conrad D, Feng G, Brady F, Boucher M, Carbone L, Castro J, del Rosario R, Held M, Hennebold J, Lacey A, Lewis A, Lima A, Mahyari E, Moore S, Okhovat M, Roberts V, de Castro S, Wessel B, Zaniewski H, Zhang Q, Arguello A, Baroch J, Dayal J, Felsenfeld A, Ilekis J, Jose S, Lockhart N, Miller D, Minear M, Parisi M, Price A, Ramos E, Zou S. The human and non-human primate developmental GTEx projects. Nature 2025, 637: 557-564. PMID: 39815096, DOI: 10.1038/s41586-024-08244-9.
Phase 1 trial of hypofractionated stereotactic re-irradiation in combination with nivolumab, ipilimumab, and bevacizumab for recurrent high-grade gliomasSahebjam S, Raval R, Forsyth P, Enderling H, Tran N, Arrington J, Macaulay R, Perlow H, Palmer J, Ghose J, Rajappa P, Giglio P, Li Z, Etame A, Mokhtari S, Cruz-Chamorro R, Bhandari M, Thapa R, Robinson T, Chen D, Yu H. Phase 1 trial of hypofractionated stereotactic re-irradiation in combination with nivolumab, ipilimumab, and bevacizumab for recurrent high-grade gliomas. Neuro-Oncology Advances 2025, 7: vdaf033. PMID: 40134851, PMCID: PMC11934552, DOI: 10.1093/noajnl/vdaf033.
Hidden human costs of AIGreenbaum D, Gerstein M. Hidden human costs of AI. Science 2025, 387: 32-32. DOI: 10.1126/science.adu1541.
Chapter 14 Impact of androgens on cardiovascular risk in women with polycystic ovary syndrome and transgender menStachenfeld N, Alexander L, Bender J, Weinzimer S, Pal L, Reckelhoff J. Chapter 14 Impact of androgens on cardiovascular risk in women with polycystic ovary syndrome and transgender men. 2025, 279-293. DOI: 10.1016/b978-0-443-22266-5.00014-8.
Dysregulation of mTOR signalling is a converging mechanism in lissencephalyZhang C, Liang D, Ercan-Sencicek A, Bulut A, Cortes J, Cheng I, Henegariu O, Nishimura S, Wang X, Peksen A, Takeo Y, Caglar C, Lam T, Koroglu M, Narayanan A, Lopez-Giraldez F, Miyagishima D, Mishra-Gorur K, Barak T, Yasuno K, Erson-Omay E, Yalcinkaya C, Wang G, Mane S, Kaymakcalan H, Guzel A, Caglayan A, Tuysuz B, Sestan N, Gunel M, Louvi A, Bilguvar K. Dysregulation of mTOR signalling is a converging mechanism in lissencephaly. Nature 2025, 638: 172-181. PMID: 39743596, PMCID: PMC11798849, DOI: 10.1038/s41586-024-08341-9.
Application of Stem Cells to Understanding Psychiatric DisordersBirtele M, Quadrato G, Brennand K. Application of Stem Cells to Understanding Psychiatric Disorders. 2025, 53-64. DOI: 10.1093/med/9780197640654.003.0005.

2024

SINGLE-CELL ANALYSIS OF SOMATIC MUTATIONS IN HUMAN LUNG REVEALS ASSOCIATION WITH TRANSCRIPTIONAL CHANGES IN AGINGDe Man R, Adams T, McDonough J, Cala-Garcia J, Moss B, Yan X, Rosas I, Kaminski N. SINGLE-CELL ANALYSIS OF SOMATIC MUTATIONS IN HUMAN LUNG REVEALS ASSOCIATION WITH TRANSCRIPTIONAL CHANGES IN AGING. Innovation In Aging 2024, 8: 571-572. PMCID: PMC11690935, DOI: 10.1093/geroni/igae098.1872.
Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregationBlack E, Ramírez Parrado C, Trier I, Li W, Joo Y, Pichurin J, Liu Y, Kabeche L. Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation. Nature Communications 2024, 15: 10782. PMID: 39737931, PMCID: PMC11685634, DOI: 10.1038/s41467-024-54922-7.
NaP-TRAP reveals the regulatory grammar in 5’UTR-mediated translation regulation during zebrafish developmentStrayer E, Krishna S, Lee H, Vejnar C, Neuenkirchen N, Gupta A, Beaudoin J, Giraldez A. NaP-TRAP reveals the regulatory grammar in 5’UTR-mediated translation regulation during zebrafish development. Nature Communications 2024, 15: 10898. PMID: 39738051, PMCID: PMC11685710, DOI: 10.1038/s41467-024-55274-y.
Mapping the gene space at single-cell resolution with gene signal pattern analysisVenkat A, Leone S, Youlten S, Fagerberg E, Attanasio J, Joshi N, Perlmutter M, Krishnaswamy S. Mapping the gene space at single-cell resolution with gene signal pattern analysis. Nature Computational Science 2024, 4: 955-977. PMID: 39706866, DOI: 10.1038/s43588-024-00734-0.
A role for the kinetochore protein, NUF2, in ribosome biogenesis.Brown T, Pichurin J, Parrado C, Kabeche L, Baserga S. A role for the kinetochore protein, NUF2, in ribosome biogenesis. Molecular Biology Of The Cell 2024, 36: ar16. PMID: 39705402, PMCID: PMC11809303, DOI: 10.1091/mbc.e24-08-0337.
Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associationsLiu J, Borsari B, Li Y, Liu S, Gao Y, Xin X, Lou S, Jensen M, Garrido-Martín D, Verplaetse T, Ash G, Zhang J, Girgenti M, Roberts W, Gerstein M. Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations. Cell 2024, 188: 515-529.e15. PMID: 39706190, DOI: 10.1016/j.cell.2024.11.012.
Predicting lung aging using scRNA-Seq dataSong Q, Singh A, McDonough J, Adams T, Vos R, De Man R, Myers G, Ceulemans L, Vanaudenaerde B, Wuyts W, Yan X, Schupp J, Hagood J, Kaminski N, Bar-Joseph Z. Predicting lung aging using scRNA-Seq data. PLOS Computational Biology 2024, 20: e1012632. PMID: 39700255, PMCID: PMC11741621, DOI: 10.1371/journal.pcbi.1012632.
Quantitative profiling of human translation initiation reveals elements that potently regulate endogenous and therapeutically modified mRNAsLewis C, Xie L, Bhandarkar S, Jin D, Abdallah K, Draycott A, Chen Y, Thoreen C, Gilbert W. Quantitative profiling of human translation initiation reveals elements that potently regulate endogenous and therapeutically modified mRNAs. Molecular Cell 2024, 85: 445-459.e5. PMID: 39706187, PMCID: PMC11780321, DOI: 10.1016/j.molcel.2024.11.030.
Microscopic phage adsorption assay: High-throughput quantification of virus particle attachment to host bacterial cellsAntani J, Ward T, Emonet T, Turner P. Microscopic phage adsorption assay: High-throughput quantification of virus particle attachment to host bacterial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2410905121. PMID: 39700139, PMCID: PMC11670125, DOI: 10.1073/pnas.2410905121.
Biodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman PrimateEaton D, Lynn A, Surprenant J, Deschenes E, Guerra M, Rivero R, Yung N, O'Connor M, Glazer P, Bahtiyar M, Saltzman W, Stitelman D. Biodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate. Biomedicine Hub 2024, 10: 543138. PMID: 39845408, PMCID: PMC11753793, DOI: 10.1159/000543138.
Intracellular endothelial cell metabolism in vascular function and dysfunctionCitrin K, Chaube B, Fernández-Hernando C, Suárez Y. Intracellular endothelial cell metabolism in vascular function and dysfunction. Trends In Endocrinology And Metabolism 2024 PMID: 39672762, DOI: 10.1016/j.tem.2024.11.004.
Confronting risks of mirror lifeAdamala K, Agashe D, Belkaid Y, Bittencourt D, Cai Y, Chang M, Chen I, Church G, Cooper V, Davis M, Devaraj N, Endy D, Esvelt K, Glass J, Hand T, Inglesby T, Isaacs F, James W, Jones J, Kay M, Lenski R, Liu C, Medzhitov R, Nicotra M, Oehm S, Pannu J, Relman D, Schwille P, Smith J, Suga H, Szostak J, Talbot N, Tiedje J, Venter J, Winter G, Zhang W, Zhu X, Zuber M. Confronting risks of mirror life. Science 2024, 386: 1351-1353. PMID: 39666824, DOI: 10.1126/science.ads9158.
Diverse phage communities are maintained stably on a clonal bacterial hostPyenson N, Leeks A, Nweke O, Goldford J, Schluter J, Turner P, Foster K, Sanchez A. Diverse phage communities are maintained stably on a clonal bacterial host. Science 2024, 386: 1294-1300. PMID: 39666794, PMCID: PMC7617280, DOI: 10.1126/science.adk1183.
Piwi regulates the usage of alternative transcription start sites in the Drosophila ovaryChen J, Liu N, Qi H, Neuenkirchen N, Huang Y, Lin H. Piwi regulates the usage of alternative transcription start sites in the Drosophila ovary. Nucleic Acids Research 2024, 53: gkae1160. PMID: 39657757, PMCID: PMC11724274, DOI: 10.1093/nar/gkae1160.
Evidence-based guideline: Premature Ovarian Insufficiency † ‡ESHRE A, Yeganeh L, Giri R, Flanagan M, Panay N, Anderson R, Bennie A, Cedars M, Davies M, Ee C, Gravholt C, Kalantaridou S, Kallen A, Kim K, Misrahi M, Mousa A, Nappi R, Rocca W, Ruan X, Teede H, Vermeulen N, Vogt E, Vincent A. Evidence-based guideline: Premature Ovarian Insufficiency † ‡. Fertility And Sterility 2024, 123: 221-236. PMID: 39652037, DOI: 10.1016/j.fertnstert.2024.11.007.
Integrative spatial protein profiling with multi-omicsFan R. Integrative spatial protein profiling with multi-omics. Nature Methods 2024, 21: 2223-2225. PMID: 39643677, DOI: 10.1038/s41592-024-02533-x.
A meta-analysis highlights the idiosyncratic nature of tradeoffs in laboratory models of virus evolutionKabengele K, Turner W, Turner P, Ogbunugafor C. A meta-analysis highlights the idiosyncratic nature of tradeoffs in laboratory models of virus evolution. Virus Evolution 2024, 10: veae105. PMID: 39717708, PMCID: PMC11665823, DOI: 10.1093/ve/veae105.
X-linked deletion of Crossfirre, Firre, and Dxz4 in vivo uncovers diverse phenotypes and combinatorial effects on autosomesHasenbein T, Hoelzl S, Smith Z, Gerhardinger C, Gonner M, Aguilar-Pimentel A, Amarie O, Becker L, Calzada-Wack J, Dragano N, da Silva-Buttkus P, Garrett L, Hölter S, Kraiger M, Östereicher M, Rathkolb B, Sanz-Moreno A, Spielmann N, Wurst W, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Meissner A, Engelhardt S, Rinn J, Andergassen D. X-linked deletion of Crossfirre, Firre, and Dxz4 in vivo uncovers diverse phenotypes and combinatorial effects on autosomes. Nature Communications 2024, 15: 10631. PMID: 39638999, PMCID: PMC11621363, DOI: 10.1038/s41467-024-54673-5.
An integrative TAD catalog in lymphoblastoid cell lines discloses the functional impact of deletions and insertions in human genomes.Li C, Bonder M, Syed S, Jensen M, Gerstein M, Zody M, Chaisson M, Talkowski M, Marschall T, Korbel J, Eichler E, Lee C, Shi X. An integrative TAD catalog in lymphoblastoid cell lines discloses the functional impact of deletions and insertions in human genomes. Genome Research 2024, 34: 2304-2318. PMID: 39638559, PMCID: PMC11694747, DOI: 10.1101/gr.279419.124.
Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney diseaseSrivastava S, Zhou H, Shenoi R, Morris M, Lainez-Mas B, Goedeke L, Rajendran B, Setia O, Aryal B, Kanasaki K, Koya D, Inoki K, Dardik A, Bell T, Fernández-Hernando C, Shulman G, Goodwin J. Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease. Science Advances 2024, 10: eadn6068. PMID: 39630889, PMCID: PMC11616692, DOI: 10.1126/sciadv.adn6068.
Author Correction: Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expressionSeah C, Breen M, Rusielewicz T, Bader H, Xu C, Hunter C, McCarthy B, Deans P, Chattopadhyay M, Goldberg J, Dobariya S, Desarnaud F, Makotkine I, Flory J, Bierer L, Staniskyte M, Noggle S, Huckins L, Paull D, Brennand K, Yehuda R. Author Correction: Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression. Nature Neuroscience 2024, 28: 214-214. PMID: 39633181, PMCID: PMC11706769, DOI: 10.1038/s41593-024-01854-6.
Deep learning analysis of fMRI data for predicting Alzheimer’s Disease: A focus on convolutional neural networks and model interpretabilityZhou X, Kedia S, Meng R, Gerstein M. Deep learning analysis of fMRI data for predicting Alzheimer’s Disease: A focus on convolutional neural networks and model interpretability. PLOS ONE 2024, 19: e0312848. PMID: 39630834, PMCID: PMC11616848, DOI: 10.1371/journal.pone.0312848.
Dysregulation in keratinocytes drives systemic lupus erythematosus onsetTian J, Shi L, Zhang D, Yao X, Zhao M, Kumari S, Lu J, Yu D, Lu Q. Dysregulation in keratinocytes drives systemic lupus erythematosus onset. Cellular & Molecular Immunology 2024, 22: 83-96. PMID: 39627610, PMCID: PMC11686216, DOI: 10.1038/s41423-024-01240-z.
Rhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and MortalityZhang Z, Hu X, Du Q, Liu J, Chen X, Mo P, Luo M, Jiang Q, Deng L, Xiong Y. Rhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and Mortality. Journal Of Medical Virology 2024, 96: e70095. PMID: 39624019, DOI: 10.1002/jmv.70095.
Cellular translational enhancer elements that recruit eukaryotic initiation factor 3.Koubek J, Kaur J, Bhandarkar S, Lewis C, Niederer R, Stanciu A, Aitken C, Gilbert W. Cellular translational enhancer elements that recruit eukaryotic initiation factor 3. RNA 2024, 31: 193-207. PMID: 39626887, PMCID: PMC11789482, DOI: 10.1261/rna.080310.124.
4.1 – 00057 Tissue resident memory programs of intestinal CD4+ and CD8+ T cells facilitate HIV-1 persistenceWei Y, Ma H, Wong M, Konnikova L, Tebas P, Morgenstern R, Papasavvas E, Montaner L, Ho Y. 4.1 – 00057 Tissue resident memory programs of intestinal CD4+ and CD8+ T cells facilitate HIV-1 persistence. Journal Of Virus Eradication 2024, 10: 13. DOI: 10.1016/j.jve.2024.100412.
Ezrin drives adaptation of monocytes to the inflamed lung microenvironmentGudneppanavar R, Di Pietro C, H Öz H, Zhang P, Cheng E, Huang P, Tebaldi T, Biancon G, Halene S, Hoppe A, Kim C, Gonzalez A, Krause D, Egan M, Gupta N, Murray T, Bruscia E. Ezrin drives adaptation of monocytes to the inflamed lung microenvironment. Cell Death & Disease 2024, 15: 864. PMID: 39613751, PMCID: PMC11607083, DOI: 10.1038/s41419-024-07255-8.
Identification of coilin interactors reveals coordinated control of Cajal body number and structureEscayola D, Zhang C, Nischwitz E, Schärfen L, Dörner K, Straube K, Kutay U, Butter F, Neugebauer K. Identification of coilin interactors reveals coordinated control of Cajal body number and structure. Journal Of Cell Biology 2024, 224: e202305081. PMID: 39602297, PMCID: PMC11602656, DOI: 10.1083/jcb.202305081.
Clonal hematopoiesis of indeterminate potential is associated with increased risk of immune checkpoint inhibitor myocarditis in a prospective study of a cardio-oncology cohortJaber Chehayeb R, Singh J, Matute-Martinez C, Chen N, Guajardo A, Lin D, Jayakrishnan R, Christofides A, Leveille E, Im Y, Biancon G, VanOudenhove J, Ibrahim E, Ardasheva A, Jha A, Hwa J, Halene S, Kwan J. Clonal hematopoiesis of indeterminate potential is associated with increased risk of immune checkpoint inhibitor myocarditis in a prospective study of a cardio-oncology cohort. Cardio-Oncology 2024, 10: 84. PMID: 39587635, PMCID: PMC11590368, DOI: 10.1186/s40959-024-00289-z.
Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma.McGeary M, Damsky W, Daniels A, Lang S, Xu Q, Song E, Huet-Calderwood C, Lou H, Paradkar S, Micevic G, Kaech S, Calderwood D, Turk B, Yan Q, Iwasaki A, Bosenberg M. Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma. Cancer Immunology Research 2024, 13: 245-257. PMID: 39589394, DOI: 10.1158/2326-6066.cir-23-0514.
Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responsesZapatero M, Tong A, Opzoomer J, O'Sullivan R, Rodriguez F, Sufi J, Vlckova P, Nattress C, Qin X, Claus J, Hochhauser D, Krishnaswamy S, Tape C. Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses. Cell 2024, 187: 7335-7349. PMID: 39603238, DOI: 10.1016/j.cell.2024.11.023.
The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleusKojima M, Hoppe C, Giraldez A. The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus. Nature Reviews Genetics 2024, 26: 245-267. PMID: 39587307, PMCID: PMC11928286, DOI: 10.1038/s41576-024-00792-0.
Improved Prediction of Ligand–Protein Binding Affinities by Meta-modelingLee H, Emani P, Gerstein M. Improved Prediction of Ligand–Protein Binding Affinities by Meta-modeling. Journal Of Chemical Information And Modeling 2024, 64: 8684-8704. PMID: 39576762, PMCID: PMC11632770, DOI: 10.1021/acs.jcim.4c01116.
SARS-CoV-2 reprograms murine alveolar macrophages to dampen fluTabachnikova A, Iwasaki A. SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu. Trends In Immunology 2024, 45: 925-927. PMID: 39580310, DOI: 10.1016/j.it.2024.11.002.
The cell-type underpinnings of the human functional cortical connectomeAnderson K, Chopra S, Dhamala E, Emani P, Gerstein M, Margulies D, Holmes A. The cell-type underpinnings of the human functional cortical connectome. Nature Neuroscience 2024, 28: 150-160. PMID: 39572742, DOI: 10.1038/s41593-024-01812-2.
GENCODE 2025: reference gene annotation for human and mouseMudge J, Carbonell-Sala S, Diekhans M, Martinez J, Hunt T, Jungreis I, Loveland J, Arnan C, Barnes I, Bennett R, Berry A, Bignell A, Cerdán-Vélez D, Cochran K, Cortés L, Davidson C, Donaldson S, Dursun C, Fatima R, Hardy M, Hebbar P, Hollis Z, James B, Jiang Y, Johnson R, Kaur G, Kay M, Mangan R, Maquedano M, Gómez L, Mathlouthi N, Merritt R, Ni P, Palumbo E, Perteghella T, Pozo F, Raj S, Sisu C, Steed E, Sumathipala D, Suner M, Uszczynska-Ratajczak B, Wass E, Yang Y, Zhang D, Finn R, Gerstein M, Guigó R, Hubbard T, Kellis M, Kundaje A, Paten B, Tress M, Birney E, Martin F, Frankish A. GENCODE 2025: reference gene annotation for human and mouse. Nucleic Acids Research 2024, 53: d966-d975. PMID: 39565199, PMCID: PMC11701607, DOI: 10.1093/nar/gkae1078.
Identifying the minimal sets of distance restraints for FRET‐assisted protein structural modelingLiu Z, Grigas A, Sumner J, Knab E, Davis C, O'Hern C. Identifying the minimal sets of distance restraints for FRET‐assisted protein structural modeling. Protein Science 2024, 33: e5219. PMID: 39548730, PMCID: PMC11568256, DOI: 10.1002/pro.5219.
Cotranslational molecular condensation of cochaperones and assembly factors facilitates axonemal dynein biogenesisLi Y, Xu W, Cheng Y, Djenoune L, Zhuang C, Cox A, Britto C, Yuan S, Wang S, Sun Z. Cotranslational molecular condensation of cochaperones and assembly factors facilitates axonemal dynein biogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2402818121. PMID: 39541357, PMCID: PMC11588059, DOI: 10.1073/pnas.2402818121.
Abstract I001: Long noncoding RNAs at the intersection of cancer pathwaysDimitrova N. Abstract I001: Long noncoding RNAs at the intersection of cancer pathways. Molecular Cancer Therapeutics 2024, 23: i001-i001. DOI: 10.1158/1538-8514.rnadrivers24-i001.
Sex differences in postacute infection syndromesSilva J, Iwasaki A. Sex differences in postacute infection syndromes. Science Translational Medicine 2024, 16: eado2102. PMID: 39536120, DOI: 10.1126/scitranslmed.ado2102.
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studiesOberdoerffer S, Gilbert W. Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies. Nature Reviews Molecular Cell Biology 2024, 26: 249-249. PMID: 39533117, DOI: 10.1038/s41580-024-00810-3.
Abstract 4141772: “SETDB2 regulates the Innate Immune Memory response and influences Inflammatory Immune landscape in Atherosclerosis”JAISWAL A, Halasz L, Suarez Y, Fernandez-Hernando C, Osborne T. Abstract 4141772: “SETDB2 regulates the Innate Immune Memory response and influences Inflammatory Immune landscape in Atherosclerosis”. Circulation 2024, 150: a4141772-a4141772. DOI: 10.1161/circ.150.suppl_1.4141772.
Abstract 4144255: Treatment of Human Engineered Heart Tissue with Serum from Cancer Patients with Clonal Hematopoiesis of Indeterminate Potential Cytokine Leads to Impaired FunctionKaur H, Halder S, Espinoza J, Chen N, VanOudenhove J, Biancon G, Gu S, Chakraborty R, Jain K, Park J, Qyang Y, Ibrahim E, Halene S, Hwa J, Campbell S, Jha A, Kwan J. Abstract 4144255: Treatment of Human Engineered Heart Tissue with Serum from Cancer Patients with Clonal Hematopoiesis of Indeterminate Potential Cytokine Leads to Impaired Function. Circulation 2024, 150: a4144255-a4144255. DOI: 10.1161/circ.150.suppl_1.4144255.
Modeling Endothelial Cell-Targeted Polymeric Nanoparticle Delivery in Renal GlomeruliRichfield O, Tolbert-Schwartz E, Saltzman W. Modeling Endothelial Cell-Targeted Polymeric Nanoparticle Delivery in Renal Glomeruli. 2024 DOI: 10.70534/zjdh1719.
GPR68 supports AML cells through the calcium/calcineurin pro-survival pathway and confers chemoresistance by mediating glucose metabolic symbiosisHe X, Hawkins C, Lawley L, Phan T, Park I, Joven N, Zhang J, Wunderlich M, Mizukawa B, Pei S, Patel A, VanOudenhove J, Halene S, Fang J. GPR68 supports AML cells through the calcium/calcineurin pro-survival pathway and confers chemoresistance by mediating glucose metabolic symbiosis. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2024, 1871: 167565. PMID: 39522891, DOI: 10.1016/j.bbadis.2024.167565.
A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped virusesYang Y, Treger R, Hernandez-Bird J, Lu P, Mao T, Iwasaki A. A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses. Science Immunology 2024, 9: eadd6608. PMID: 39514636, DOI: 10.1126/sciimmunol.add6608.
Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese populationDing J, Liu H, Zhang X, Zhao N, Peng Y, Shi J, Chen J, Chi X, Li L, Zhang M, Liu W, Zhang L, Ouyang J, Yuan Q, Liao M, Tan Y, Li M, Xu Z, Tang W, Xie C, Li Y, Pan Q, Xu Y, Cai S, Byrne C, Targher G, Ouyang X, Zhang L, Jiang Z, Zheng M, Sun F, Chai J. Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population. Science Translational Medicine 2024, 16: eadh9940. PMID: 39504356, DOI: 10.1126/scitranslmed.adh9940.
65 High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogeneticsTang K, Zhou X, Fang S, Vandenbulcke E, Du A, Shen J, Cao H, Zhou J, Chen K, Xin S, Zhou L, Lin S, Majety M, Lin X, Lam S, Chow R, Bai S, Nottoli T, Booth C, Liu C, Dong M, Chen S. 65 High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics. 2024, a72-a72. DOI: 10.1136/jitc-2024-sitc2024.0065.
MISTRG6kitW41: Enhanced Engraftment in a Cytokine Humanized Patient-Derived Xenotransplantation Mouse ModelBaassiri A, Maziarz J, Blackburn H, Maul-Newby H, VanOudenhove J, Zhang X, Matthews M, Paul S, Liu W, Sefik E, Salomonis N, Grimes H, Flavell R, Halene S. MISTRG6kitW41: Enhanced Engraftment in a Cytokine Humanized Patient-Derived Xenotransplantation Mouse Model. Blood 2024, 144: 1815-1815. DOI: 10.1182/blood-2024-211908.
Immune Landscape and Outcomes of Patients with RNA Splicing Factor-Mutant Acute Myeloid Leukemia and Myelodysplastic Syndromes Treated with Azacitidine +/- the Anti-PD-L1 Antibody DurvalumabBewersdorf J, Hasle V, Shallis R, Thompson E, De Menezes D, Rose S, Boss I, Mendez L, Podoltsev N, Stahl M, Kewan T, Halene S, Haferlach T, Fox B, Zeidan A. Immune Landscape and Outcomes of Patients with RNA Splicing Factor-Mutant Acute Myeloid Leukemia and Myelodysplastic Syndromes Treated with Azacitidine +/- the Anti-PD-L1 Antibody Durvalumab. Blood 2024, 144: 4585. DOI: 10.1182/blood-2024-194929.
Clinically Driven Algorithms Identify Patients with Large Granular Lymphocytic Leukemia at Risk of Significant Cytopenia Requiring TreatmentKiwan A, Kewan T, Bravo-Perez C, Visconte V, Gurnari C, Durmaz A, Siddon A, Halene S, Sethi T, Maciejewski J, Foss F. Clinically Driven Algorithms Identify Patients with Large Granular Lymphocytic Leukemia at Risk of Significant Cytopenia Requiring Treatment. Blood 2024, 144: 4436. DOI: 10.1182/blood-2024-209344.
Impact of Sepsis and Stress Hematopoiesis on the Acquisition and Persistence of Clonal HematopoiesisOgbue O, Kewan T, Unlu S, Lakhotiya K, Mehkri O, Ellison R, Fadell F, Reynolds M, Cheema A, Durmaz A, Brady Z, VanOudenhove J, Singh A, Visconte V, Mendez L, Bosler D, Duggal A, Halene S, Al-Jaghbeer M, Maciejewski J, Gurnari C. Impact of Sepsis and Stress Hematopoiesis on the Acquisition and Persistence of Clonal Hematopoiesis. Blood 2024, 144: 5634-5634. DOI: 10.1182/blood-2024-209240.
O6-Guanine Targeting Novel DNA Cross-Linker and ATR Inhibitor Combination for MGMT-Silenced IDH1/2 Mutant Acute Myeloid LeukemiaBhardwaj P, Sundaram R, Friedman S, Baassiri A, Matthews M, VanOudenhove J, Gueble S, Halene S, Bindra R. O6-Guanine Targeting Novel DNA Cross-Linker and ATR Inhibitor Combination for MGMT-Silenced IDH1/2 Mutant Acute Myeloid Leukemia. Blood 2024, 144: 6130. DOI: 10.1182/blood-2024-210621.
Clonal Dissection of MDS and Secondary AML Resolves Shared Splicing Neoantigens and Mechanistic Underpinnings of Hypomethylating Agent Therapeutic ResponseZhang X, Li G, Oliverio A, VanOudenhove J, DeZern A, Ghiaur G, Halene S, Grimes H, Salomonis N. Clonal Dissection of MDS and Secondary AML Resolves Shared Splicing Neoantigens and Mechanistic Underpinnings of Hypomethylating Agent Therapeutic Response. Blood 2024, 144: 1810-1810. DOI: 10.1182/blood-2024-211099.
Unraveling the Drivers of the Stress Granule Signature in Splicing Factor-Mutant Myeloid MalignanciesBiancon G, Busarello E, Cheng M, Sidoli S, VanOudenhove J, Bucciarelli G, Tebaldi T, Halene S. Unraveling the Drivers of the Stress Granule Signature in Splicing Factor-Mutant Myeloid Malignancies. Blood 2024, 144: 4117. DOI: 10.1182/blood-2024-211265.
Precision-Cut Lung Slices: Emerging Tools for Preclinical and Translational Lung Research: An Official American Thoracic Society Workshop ReportLehmann M, Krishnan R, Sucre J, Kulkarni H, Pineda R, Anderson C, Banovich N, Behrsing H, Dean C, Haak A, Gosens R, Kaminski N, Zagorska A, Koziol-White C, Metcalf J, Kim Y, Loebel C, Neptune E, Noel A, Raghu G, Sewald K, Sharma A, Suki B, Sperling A, Tatler A, Turner S, Rosas I, van Ry P, Wille T, Randell S, Pryhuber G, Rojas M, Bourke J, Königshoff M. Precision-Cut Lung Slices: Emerging Tools for Preclinical and Translational Lung Research: An Official American Thoracic Society Workshop Report. American Journal Of Respiratory Cell And Molecular Biology 2024, 72: 16-31. PMID: 39499861, PMCID: PMC11707673, DOI: 10.1165/rcmb.2024-0479st.
A variational graph-partitioning approach to modeling protein liquid-liquid phase separationWang G, Warrell J, Zheng S, Gerstein M. A variational graph-partitioning approach to modeling protein liquid-liquid phase separation. Cell Reports Physical Science 2024, 5: 102292. PMID: 39866853, PMCID: PMC11760192, DOI: 10.1016/j.xcrp.2024.102292.
Evidence-based guideline: premature ovarian insufficiency†‡ASRM C, Panay N, Anderson R, Bennie A, Cedars M, Davies M, Ee C, Gravholt C, Kalantaridou S, Kallen A, Kim K, Misrahi M, Mousa A, Nappi R, Rocca W, Ruan X, Teede H, Vermeulen N, Vogt E, Vincent A. Evidence-based guideline: premature ovarian insufficiency†‡. Climacteric 2024, 27: 510-520. PMID: 39647506, DOI: 10.1080/13697137.2024.2423213.
REliable PIcking by Consensus (REPIC): a consensus methodology for harnessing multiple cryo-EM particle pickersCameron C, Seager S, Sigworth F, Tagare H, Gerstein M. REliable PIcking by Consensus (REPIC): a consensus methodology for harnessing multiple cryo-EM particle pickers. Communications Biology 2024, 7: 1421. PMID: 39482410, PMCID: PMC11528043, DOI: 10.1038/s42003-024-07045-0.

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