Combining anti-gene γPNA with small molecules and RNA inhibitors: A strategy to enhance anti-tumor efficacy
Pradeep S, DiVasto B, Glazer P, Bahal R. Combining anti-gene γPNA with small molecules and RNA inhibitors: A strategy to enhance anti-tumor efficacy. Molecular Therapy - Nucleic Acids 2026, 37: 102804. DOI: 10.1016/j.omtn.2025.102804.Peer-Reviewed Original Research
Anti-tumor efficacyC-MycSmall interfering RNAGenomic DNAC-myc mRNA expressionAnti-tumor effectsCell viability in vitroHistone deacetylase inhibitorsC-Myc inhibitorEfficacy in vitroC-myc mRNAViability in vitroGamma-peptide nucleic acidPeptide nucleic acidPreclinical modelsDeacetylase inhibitorsCancer therapyCo-deliverySmall moleculesCombined treatmentSilence oncogenesMRNA expressionCancer treatmentProtein expressionTherapeutic avenues