Tommaso Volpi

2025

• Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT

  Volpi T, Toyonaga T, Khattar N, Gallezot J, Naganawa M, Vanderlinden G, Honhar P, Zeng T, Fontaine K, Mulnix T, Hu L, Sun X, Henry S, Matuskey D, Radhakrishnan R, Guo L, Hu Y, Zhang J, Zheng X, Nabulsi N, Huang Y, Badawi R, Cherry S, Hillmer A, Jones T, Liu C, Morris E, Qi J, Li H, Carson R. Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT. European Journal Of Nuclear Medicine And Molecular Imaging 2025, 1-12. PMID: 41177836, DOI: 10.1007/s00259-025-07605-4.

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• Measuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual‐Tracer Positron Emission Tomography Imaging Study

  Sadabad F, Volpi T, Honhar P, Tinaz S, Dias M, Toyonaga T, Naganawa M, Gallezot J, Yang Y, Ibrahim W, Pittman B, Cayir S, Radhakrishnan R, Angarita G, Holmes S, Comley R, Carson R, Finnema S, Matuskey D. Measuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual‐Tracer Positron Emission Tomography Imaging Study. Movement Disorders 2025, 40: 2678-2687. PMID: 41040062, DOI: 10.1002/mds.70041.

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• Carotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling.

  Volpi T, Gallezot J, Henry S, Dias M, Khattar N, Toyonaga T, Fontaine K, Mulnix T, Zhang J, Guo L, Gravel P, Radhakrishnan R, Hillmer A, Matuskey D, Carson R. Carotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling. Journal Of Nuclear Medicine 2025, 66: 1993-2001. PMID: 41043999, PMCID: PMC12676648, DOI: 10.2967/jnumed.125.270414.

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• Toward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates

  Gravel P, Gu J, Wang C, Volpi T, Gallezot J, Holden D, Fowles K, Zheng M, Zhang L, Borroni E, Honer M, Gobbi L, Tamagnan G, Huang Y, Carson R. Toward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates. Journal Of Nuclear Medicine 2025, 66: 1652-1658. PMID: 40908122, PMCID: PMC12487869, DOI: 10.2967/jnumed.125.270332.

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• Condensates of synaptic vesicles and synapsin-1 mediate actin sequestering and polymerization.

  Chhabra A, Hoffmann C, Aguilar Pérez G, Korobeinikov AA, Rentsch J, Hümpfer N, Kokwaro L, Gnidovec L, Petrović A, Wallace JN, Tromm JV, Román-Vendrell C, Johnson EC, Ranković B, Perego E, Volpi T, Fernández-Busnadiego R, Köster S, Rizzoli SO, Ewers H, Morgan JR, Milovanović D. Condensates of synaptic vesicles and synapsin-1 mediate actin sequestering and polymerization. EMBO J 2025 PMID: 40813925, DOI: 10.1038/s44318-025-00516-y.

  Peer-Reviewed Original Research

• Connecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography

  Reed M, Cocchi L, Sander C, Chen J, Matheson G, Fisher P, Volpi T, Khattar N, DeLorenzo C, Gryglewski G, Silberbauer L, Murgaš M, Godbersen G, Nics L, Walter M, Hacker M, Bertoldo A, Lubberink M, Silfstein M, Ogden R, Mann J, Suhara T, Varrone A, Boellaard R, Gunn R, Hammers A, Biswal B, Rosen B, Knudsen G, Carson R, Price J, Lanzenberger R, Hahn A. Connecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography. European Journal Of Nuclear Medicine And Molecular Imaging 2025, 53: 48-58. PMID: 40455254, PMCID: PMC12660352, DOI: 10.1007/s00259-025-07357-1.

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• The brain's "dark energy" puzzle upgraded: [(18)F]FDG uptake, delivery and phosphorylation, and their coupling with resting-state brain activity.

  Volpi T, Lee JJ, Vlassenko AG, Goyal MS, Corbetta M, Bertoldo A. The brain's "dark energy" puzzle upgraded: [(18)F]FDG uptake, delivery and phosphorylation, and their coupling with resting-state brain activity. J Cereb Blood Flow Metab 2025, 271678X251329707. PMID: 40370305, DOI: 10.1177/0271678X251329707.

  Peer-Reviewed Original Research

• A novel approach for modeling in vivo enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase

  Volpi T, Holden D, Gallezot J, Nabulsi N, Lim K, Labaree D, Gao H, Kapinos M, Keliher E, Fonseca K, Trapa P, Varrone A, Halldin C, Maresca K, Huang Y, Carson R. A novel approach for modeling in vivo enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2025, 45: 1947-1960. PMID: 40370302, PMCID: PMC12081407, DOI: 10.1177/0271678x251329254.

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• Molecular connectivity studies in neurotransmission: a scoping review.

  Severino M, Peretti DE, Bardiau M, Cavaliere C, Doyen M, Gonzalez-Escamilla G, Horowitz T, Nørgaard M, Perez JAM, Perovnik M, Rullmann M, Steenken D, Talmasov D, Tang C, Volpi T, Xu Z, Bertoldo A, Calhoun VD, Caminiti SP, Di X, Habeck C, Jamadar S, Perani D, Sala A, Sossi V, Yakushev I, Pereira JB, Veronese M. Molecular connectivity studies in neurotransmission: a scoping review. Imaging Neurosci (Camb) 2025, 3 PMID: 40800788, DOI: 10.1162/imag_a_00530.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

• Current Advances in PARP1‐Targeted Theranostics

  Tong J, Chen B, Volpi T, Li Y, Ellison P, Cai Z. Current Advances in PARP1‐Targeted Theranostics. Journal Of Labelled Compounds And Radiopharmaceuticals 2025, 68: e4135. PMID: 39995212, DOI: 10.1002/jlcr.4135.

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