Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsGreg Rhee, PhD, FACE
Associate Professor Adjunct in PsychiatryDownloadHi-Res Photo
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Associate Professor Adjunct in Psychiatry
Biography
Greg Rhee, PhD, FACE, is Associate Professor of Medicine (Psychiatry) and Public Health (Epidemiology and Biostatistics). He is a pharmaco-epidemiologist and mental health services researcher studying access to care, quality of care, and clinical and patient-reported outcomes in patients with psychiatric and/or substance use disorders. His current research focuses on mood disorders, dementias, and suicide/suicidal behaviors as well as cannabis and opioids.
As an accredited professional statistician (PStat®) certified by the American Statistical Association, his expertise is grounded in (1) population-based observational studies using large databases; (2) systematic reviews and meta-analyses of existing studies; and (3) analyses of clinical trial data. In particular, he has extensive knowledge and experience with administrative claims data (e.g., Medicare and Medicaid), national health and healthcare survey data, and other data sources including electronic health records (e.g., Epic® database from Yale-New Haven Health), RCT data, and mortality data. He also investigates long-term comparative effectiveness and cost-effectiveness of pharmacological and non-pharmacological interventions for psychiatric and/or substance use disorders.
He has 250+ peer-reviewed research articles published in highly respected medical, psychiatric, and healthcare policy journals, such as Lancet, Lancet Neurology, JAMA, JAMA Psychiatry, and American Journal of Psychiatry. He has also been a successful Principal Investigator or Co-Investigator on multiple research projects funded by federal agencies, including Agency for Healthcare Research and Quality (AHRQ), Food and Drug Administration (FDA), and National Institutes of Health (NIH).
Outside Yale Psychiatry, he also serves as an Investigator at the VA Connecticut Healthcare System VISN 1 MIRECC and as a Senior Investigator at the Institute for Health Metrics and Evaluation (IHME).
Last Updated on March 22, 2025.
Departments & Organizations
Education & Training
- NIH Postdoctoral Fellowship
- Yale University School of Medicine (2019)
- PhD
- University of Minnesota, Twin Cities (2017)
- MA
- The University of Chicago (2011)
- AB
- Emory University (2008)
Research
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Overview
Medical Research Interests
Delivery of Health Care; Epidemiologic Methods; Geriatric Psychiatry; Health Services Research; Mental Disorders; Meta-Analysis; Network Meta-Analysis; Population Surveillance; Psychotropic Drugs; Substance-Related Disorders; United States Food and Drug Administration
Public Health Interests
Health Equity, Disparities, Social Determinants and Justice; Mental Health; Aging; Pharmaceuticals and Medical Devices; Health Policy
ORCID
0000-0003-4961-3361
Research at a Glance
Yale Co-Authors
Frequent collaborators of Greg Rhee's published research.
Publications Timeline
A big-picture view of Greg Rhee's research output by year.
Research Interests
Research topics Greg Rhee is interested in exploring.
Samuel Wilkinson, MD
Joseph Ross, MD, MHS
Robert Rosenheck, MD
Sina Nikayin, MD
Gerard Sanacora, PhD, MD
John Havlik, MD, MBA
149Publications
3,501Citations
Substance-Related Disorders
Mental Disorders
Psychotropic Drugs
Delivery of Health Care
Publications
2025
Longitudinal associations of electroconvulsive therapy with all-cause mortality and suicide deaths in severe unipolar or bipolar depression: a systematic review and meta-analysis
Rhee T, Shim S, Nasir M, McIntyre R, Kaster T, Wilkinson S. Longitudinal associations of electroconvulsive therapy with all-cause mortality and suicide deaths in severe unipolar or bipolar depression: a systematic review and meta-analysis. BMJ Mental Health 2025, 28: e302083. PMID: 41407487, PMCID: PMC12716550, DOI: 10.1136/bmjment-2025-302083.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsBipolar depressionElectroconvulsive therapyAll-Cause MortalityMonths of follow-upTreatment-resistant mood disordersLongitudinal associationsSuicide deathsEffects of electroconvulsive therapyAssociation of electroconvulsive therapyDiagnosis of mental disordersLongitudinal cohort study designOutcome measuresRisk of all-cause mortalityElectroconvulsive therapy useFollow-upCohort study designSchizoaffective disorderMood disordersSuicide riskMental disordersModeration analysisRandom-effects modelUsual careAdjusted HRDepressionEffects of Intravenous Ketamine on Posttraumatic Stress Disorder (PTSD): A Systematic Review
Yin L, Lu A, Le G, Dri C, Wong S, Teopiz K, Xu H, Ho R, Rhee T, Lo H, Sioufi M, Zheng Y, Au H, Guillen‐Burgos H, Cao B, McIntyre R. Effects of Intravenous Ketamine on Posttraumatic Stress Disorder (PTSD): A Systematic Review. Acta Psychiatrica Scandinavica 2025 PMID: 41326978, DOI: 10.1111/acps.70053.Peer-Reviewed Original ResearchAltmetricConceptsPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Effects of intravenous ketamineStress disorderTreatment of posttraumatic stress disorderIntravenous ketaminePosttraumatic stress disorder symptomsExposure to traumatic eventsKetamine's therapeutic effectsVentromedial prefrontal cortexKetamine's mechanismPrefrontal cortexDSM-5Neurobiological mechanismsPsychotherapeutic interventionsKetamine treatmentMental disordersTraumatic eventsKetamine administrationIES-RSymptom improvementPreliminary evidenceKetamineDisordersClinical outcomesEffects of MAO-B and COMT inhibitors on sleep disturbances in Parkinson’s disease: A network meta-analysis
Lee S, Shim S, Kwon K, Rhee T, Jung Y. Effects of MAO-B and COMT inhibitors on sleep disturbances in Parkinson’s disease: A network meta-analysis. Journal Of Movement Disorders 2025 PMID: 41199509, DOI: 10.14802/jmd.25253.Peer-Reviewed Original ResearchConceptsCatechol-O-methyltransferase inhibitorCatechol-O-methyltransferaseNetwork Meta-AnalysisNon-motor symptomsDaytime sleepinessSleep disturbanceMAO-BMeta-analysisParkinson's diseaseREM sleep durationObjective polysomnographySleep qualityPolysomnography dataDebilitating non-motor symptomSleep outcomesPolysomnographyQuality of lifeInclusion criteriaSleep onsetSleep disruptionMotor benefitMonoamine oxidase BSleep durationSleepWake timeThe effects of ketamine and esketamine on functional outcomes in major depressive disorder and treatment-resistant depression: A systematic review
Ji I, Cheng M, Teopiz K, Dri C, Wong S, Le G, Rhee T, Guillen-Burgos H, Lo H, Zheng Y, McIntyre R. The effects of ketamine and esketamine on functional outcomes in major depressive disorder and treatment-resistant depression: A systematic review. Journal Of Psychiatric Research 2025, 192: 280-288. PMID: 41176897, DOI: 10.1016/j.jpsychires.2025.10.056.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsTreatment-resistant depressionN-methyl-D-aspartateDepressive disorderFunctional impairmentEffects of ketamineIntranasal esketamineGoal of recoveryMood symptomsGlutamatergic modulationSymptom reductionDepressive symptomsFunctional outcomesPsychosocial functioningRandomized Controlled TrialsEsketamineExtant evidenceFamily difficultiesNo controlled studiesMDDImpairmentKetamineRCT analysisWorkplace domainsDepressionWorkplace performanceEffects of glutamatergic modulators on striatal activation, functional connectivity and reward in persons with major depressive disorder and healthy controls: A systematic review of fMRI studies
Teopiz K, Wong S, Le G, Badulescu S, Lo H, Guillen-Burgos H, Ho R, Rhee T, Dri C, Cao B, Ly-Uson J, Lee S, McIntyre R. Effects of glutamatergic modulators on striatal activation, functional connectivity and reward in persons with major depressive disorder and healthy controls: A systematic review of fMRI studies. Journal Of Affective Disorders 2025, 394: 120476. PMID: 41106639, DOI: 10.1016/j.jad.2025.120476.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsFunctional magnetic resonance imagingFrontostriatal activityGlutamatergic modulationDepressive disorderFunctional connectivityHealthy controlsFunctional magnetic resonance imaging studyEffects of ketamineManual search of reference listsAntidepressant responseGlutamatergic agentsReward processingAntidepressant effectsFrontostriatal connectivityStriatal activityStriatal regionsFMRI studyConverging evidenceBrain structuresMDDOnset of actionReward functionReplication evidenceRewardPreliminary evidenceEfficacy and safety profiles of FDA-approved dual orexin receptor antagonists in depression: A systematic review of pre-clinical and clinical studies
Vasudeva S, Wong S, Le G, Dri C, Teopiz K, Ho R, Rhee T, McIntyre R. Efficacy and safety profiles of FDA-approved dual orexin receptor antagonists in depression: A systematic review of pre-clinical and clinical studies. Journal Of Psychiatric Research 2025, 191: 752-769. PMID: 41109037, DOI: 10.1016/j.jpsychires.2025.10.001.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDual orexin receptor antagonistsMajor depressive disorderOrexin receptor antagonistsDepressive symptomsInsomnia disorderSymptoms of major depressive disorderContext of Major Depressive DisorderComorbid major depressive disorderMDD populationComorbid psychiatric conditionsReview of pre-clinicalReceptor antagonistSafety profileSleep onset latencyDepressive disorderPsychiatric conditionsTotal sleep timeDebilitating symptomsSystematic reviewLong-term clinical trialsInsomniaSleep onsetOnset latencySleep architectureSleep disturbanceQuestionable Data and Design in Esketamine Study
Wilkinson S, Rhee T. Questionable Data and Design in Esketamine Study. JAMA Psychiatry 2025, 82: 1054-1054. PMID: 40833767, DOI: 10.1001/jamapsychiatry.2025.2059.Peer-Reviewed Original ResearchAltmetricAssociations of oseltamivir with neuropsychiatric and behavioral adverse events: A systematic review and meta-analysis.
Jeong H, Lee Y, Rhee T, Shim S. Associations of oseltamivir with neuropsychiatric and behavioral adverse events: A systematic review and meta-analysis. Journal Of Managed Care & Specialty Pharmacy 2025, 31: 1051-1061. PMID: 41004206, PMCID: PMC12467762, DOI: 10.18553/jmcp.2025.31.10.1051.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsNeuropsychiatric eventsBehavioral adverse eventsAdverse eventsMeta-analysisSystematic reviewSuicide-related behaviorsFirst-line pharmacotherapyCochrane Library databasesAnxiety disordersSchizophrenia/psychotic disordersAffective disordersOseltamivir useSuicide attemptsMeta-analyses guidelinesComprehensive Meta-AnalysisSubgroup analysisNeuropsychiatric symptomsOseltamivirLibrary databasesSevere casesBehavioral eventsPatientsControl groupDisordersMeta-analysesKetamine and Esketamine: Is There a Meaningful Clinical Difference?
Wilkinson S, Rhee T. Ketamine and Esketamine: Is There a Meaningful Clinical Difference? The Journal Of Clinical Psychiatry 2025, 86 PMID: 41004166, DOI: 10.4088/jcp.25com16003.Peer-Reviewed Original ResearchBeyond symptom improvement: transdiagnostic and disorder‐specific ways to assess functional and quality of life outcomes across mental disorders in adults
Correll C, Cortese S, Solmi M, Boldrini T, Demyttenaere K, Domschke K, Fusar-Poli P, Gorwood P, Harvey P, Keefe R, Knaevelsrud C, Kotov R, Nohr L, Rhee T, Roe D, Rose M, Schneider L, Slade M, Stein D, Sunkel C, McIntyre R. Beyond symptom improvement: transdiagnostic and disorder‐specific ways to assess functional and quality of life outcomes across mental disorders in adults. World Psychiatry 2025, 24: 296-318. PMID: 40948079, PMCID: PMC12434368, DOI: 10.1002/wps.21338.Peer-Reviewed Original ResearchCitationsAltmetricConceptsOutcome domainsMental disordersPersonal recoveryClinical careDomains of self-careGoal of clinical carePersonal recovery outcomesMental health conditionsQuality of life outcomesLeisure time activitiesPost-traumatic stress disorderQuality of lifeClinician-rated measuresDisorder-specific measuresWell-being/life satisfactionSubstance use disordersService useSelf-CareRecovery outcomesHealth conditionsPatient assessmentPersonality disorderAnxiety disordersObsessive-CompulsiveCategorical diagnosis
Academic Achievements & Community Involvement
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Activities
activity Journal of Clinical Psychiatry
06/01/2022 - PresentJournal ServiceEditorial Board Memberactivity Depression and Anxiety
10/01/2022 - PresentJournal ServiceAssociate Editoractivity American Journal of Geriatric Psychiatry
2023 - PresentJournal ServiceEditorial Board Memberactivity National Institutes of Health Center for Scientific Review (CSR) - Study Section
2023 - PresentPeer Review Groups and Grant Study SectionsCommittee Member
Honors
honor Delta Omega Honorary Society in Public Health
05/05/2023International AwardDelta Omega (Faculty Mentor)honor Fellow
10/29/2022International AwardAmerican College of EpidemiologyDetailsUnited Stateshonor NIMH Advanced Research Institute (ARI) in Aging and Mental Health
02/01/2021National AwardNational Institute of Mental HealthDetailsUnited Stateshonor Research Career Institute in Mental Health of Aging (CIMA) Award
06/25/2019National AwardNational Institute of Mental HealthDetailsUnited Stateshonor Travel Fellowship
06/25/2019National AwardAssociation for Multidisciplinary Education and Research in Substance Use and Addiction (AMERSA)DetailsUnited States
News
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News
- December 18, 2025Source: BMJ Mental Health
Longitudinal Associations of Electroconvulsive Therapy with All-Cause Mortality and Suicide Deaths in Severe Unipolar or Bipolar Depression: A Systematic Review and Meta-Analysis
- October 30, 2025Source: eClinical Medicine
Analysis: Efficacy of Intranasal Esketamine Versus rTMS for Treatment-Resistant Depression
- September 16, 2025Source: World Psychiatry
Beyond Symptom Improvement: Transdiagnostic and Disorder-Specific Ways to Assess Functional and Quality of Life Outcomes Across Mental Disorders in Adults
- May 29, 2025Source: American Journal of Psychiatry
National Trends in Suicidal Thoughts and Suicide Attempts Among High School Students in the United States
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