Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsRichard Young, MD
Associate Clinical ProfessorAbout
Research
Publications
2026
Active RNA synthesis patterns nuclear condensates
Goychuk A, Banani S, Natarajan P, Zheng M, Wang H, Dall'Agnese G, Young R, Kardar M, Henninger J, Chakraborty A. Active RNA synthesis patterns nuclear condensates. Cell Systems 2026, 101613. PMID: 42190656, PMCID: PMC13293446, DOI: 10.1016/j.cels.2026.101613.Peer-Reviewed Original Research
2025
Protein codes and mobility together shape cellular function and disease
Kilgore H, Moreno S, Young R. Protein codes and mobility together shape cellular function and disease. Trends In Biochemical Sciences 2025, 51: 8-26. PMID: 41318327, PMCID: PMC12703758, DOI: 10.1016/j.tibs.2025.10.009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCell signaling meets gene transcription
Young R. Cell signaling meets gene transcription. Science 2025, 390: 568-569. PMID: 41196973, DOI: 10.1126/science.aec1434.Peer-Reviewed Original ResearchTransient gene melting governs the timing of oligodendrocyte maturation
Allan K, Zhan J, Morton A, Cohn E, Scavuzzo M, Nikhil A, Elitt M, Clayton B, Hu L, Shick H, Vrabic J, Olsen H, Factor D, Henninger J, Bachmann G, Powers B, Young R, Lin C, Scacheri P, Miller T, Tesar P. Transient gene melting governs the timing of oligodendrocyte maturation. Cell 2025, 188: 6205-6219.e23. PMID: 40858115, PMCID: PMC12926747, DOI: 10.1016/j.cell.2025.07.039.Peer-Reviewed Original ResearchCRISPR-Cas13d functional transcriptomics reveals widespread isoform-selective cancer dependencies on lncRNAs
Morelli E, Aktas-Samur A, Maisano D, Gao C, Favasuli V, Papaioannou D, De Nola G, Henninger J, Liu N, Turi M, Folino P, Vreux L, Cumerlato M, Chen L, Aifantis I, Fulciniti M, Anderson K, Lytton-Jean A, Gulla A, Young R, Samur M, Munshi N. CRISPR-Cas13d functional transcriptomics reveals widespread isoform-selective cancer dependencies on lncRNAs. Blood 2025, 146: 847-860. PMID: 40403231, PMCID: PMC12783513, DOI: 10.1182/blood.2025028746.Peer-Reviewed Original ResearchExploring the complexity of MECP2 function in Rett syndrome
Liu Y, Whitfield T, Bell G, Guo R, Flamier A, Young R, Jaenisch R. Exploring the complexity of MECP2 function in Rett syndrome. Nature Reviews Neuroscience 2025, 26: 379-398. PMID: 40360671, DOI: 10.1038/s41583-025-00926-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsProtein codes promote selective subcellular compartmentalization
Kilgore H, Chinn I, Mikhael P, Mitnikov I, Van Dongen C, Zylberberg G, Afeyan L, Banani S, Wilson-Hawken S, Lee T, Barzilay R, Young R. Protein codes promote selective subcellular compartmentalization. Science 2025, 387: 1095-1101. PMID: 39913643, PMCID: PMC12034300, DOI: 10.1126/science.adq2634.Peer-Reviewed Original Research
2024
Proteolethargy is a pathogenic mechanism in chronic disease
Dall'Agnese A, Zheng M, Moreno S, Platt J, Hoang A, Kannan D, Dall'Agnese G, Overholt K, Sagi I, Hannett N, Erb H, Corradin O, Chakraborty A, Lee T, Young R. Proteolethargy is a pathogenic mechanism in chronic disease. Cell 2024, 188: 207-221.e30. PMID: 39610243, PMCID: PMC11724756, DOI: 10.1016/j.cell.2024.10.051.Peer-Reviewed Original ResearchAn RNA-centric view of transcription and genome organization
Henninger J, Young R. An RNA-centric view of transcription and genome organization. Molecular Cell 2024, 84: 3627-3643. PMID: 39366351, PMCID: PMC11495847, DOI: 10.1016/j.molcel.2024.08.021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRNA and condensates: Disease implications and therapeutic opportunities
Han T, Portz B, Young R, Boija A, Klein I. RNA and condensates: Disease implications and therapeutic opportunities. Cell Chemical Biology 2024, 31: 1593-1609. PMID: 39303698, DOI: 10.1016/j.chembiol.2024.08.009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements