Regina Hooley, MD
Professor of Radiology and Biomedical ImagingCards
Additional Titles
Executive Vice Chair for Clinical Affairs, Radiology & Biomedical Imaging
Administrative Support
Clinical Specialties
Additional Titles
Executive Vice Chair for Clinical Affairs, Radiology & Biomedical Imaging
Administrative Support
Clinical Specialties
Additional Titles
Executive Vice Chair for Clinical Affairs, Radiology & Biomedical Imaging
Administrative Support
Clinical Specialties
About
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Titles
Professor of Radiology and Biomedical Imaging
Executive Vice Chair for Clinical Affairs, Radiology & Biomedical Imaging
Biography
Regina Hooley MD is Professor & Executive Vice Chair for Clinical Affairs in the Department of Radiology & Biomedical Imaging at the Yale School of Medicine. Dr. Hooley’s area of medical expertise includes all aspects of breast imaging and direct patient care, including screening and breast interventional procedures.
When Connecticut passed the nation’s first breast density inform law, she published early research regarding breast density and supplemental screening ultrasound. Her current research interests include novel screening techniques. Dr. Hooley is a fellow of the Society of Breast Imaging and has many publications, including scientific manuscripts, review articles, and book chapters. She contributes to the popular radiology educational series, StatDx and is an associate editor for Radiology. Her activities includes serving as is an advisory board member of National Accreditation Program for Breast Centers and the popular educational website DenseBreasts-info. She has been a featured guest for the NYTimes, CBS News, and WNPR. In her free time, she and her husband enjoy spending time being active outdoors, while keeping up with their four sons and two dogs. Watch a video with Dr. Regina Hooley >>
Appointments
Radiology & Biomedical Imaging
ProfessorPrimary
Other Departments & Organizations
- Breast Imaging
- Center for Breast Cancer
- Clinical Radiology
- Radiology & Biomedical Imaging
- WHRY Pilot Project Program Investigators
- Women's Health Research at Yale
- Yale Cancer Center
- Yale Medicine
- Yale New Haven Health System
- Yale Ventures
Education & Training
- Resident
- Beth Israel Mt Sinai
- MD
- University of Pittsburgh School of Medicine
- BS
- Duke University
Research
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Overview
- Screening breast ultrasound outcomes and diagnostic performance.
ORCID
0000-0002-3093-1338
Research at a Glance
Yale Co-Authors
Publications Timeline
Reni Butler, MD
Alexey Bersenev, MD, PhD
Anees Chagpar, MD, MBA, MPH, FACS, FRCS(C)
Diane Krause, MD, PhD
Donald Lannin, MD
Lajos Pusztai, MD, DPhil
Publications
Featured Publications
Screening Breast Ultrasound: Update After 10 Years of Breast Density Notification Laws.
Butler RS, Hooley RJ. Screening Breast Ultrasound: Update After 10 Years of Breast Density Notification Laws. American Journal Of Roentgenology 2020, 214: 1424-1435. PMID: 32182096, DOI: 10.2214/ajr.19.22275.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2026
Breast US: State of the Art.
Chang J, Leung J, Heacock L, Lee S, Moon W, Hooley R. Breast US: State of the Art. Radiology 2026, 318: e233101. PMID: 41528223, DOI: 10.1148/radiol.233101.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBreast USPercutaneous biopsyLymph nodesBreast massesBreast cancer risk assessmentPalpable breast massesAxillary lymph nodesBiopsy of breast massesPrimary imaging modalityContrast-enhanced USWhole-breast USArtificial intelligenceClinical breast examinationBreast imaging toolUS technologyCancer risk assessmentBackground echotexturePreoperative stagingUS examinationDense breastsBreast cancerDiagnostic accuracyBreast examinationScreening mammographyAccurate diagnosis
2025
The Real and Reliable Finding of Nonmass Lesions at Breast US.
Hooley R. The Real and Reliable Finding of Nonmass Lesions at Breast US. Radiology 2025, 317: e253599. PMID: 41363977, DOI: 10.1148/radiol.253599.Peer-Reviewed Original ResearchAltmetric
2024
Cancer Metrics on Subsequent Screening Rounds: Another Piece in the Complicated Puzzle.
Hooley R, Philpotts L. Cancer Metrics on Subsequent Screening Rounds: Another Piece in the Complicated Puzzle. Radiology 2024, 312: e241540. PMID: 39078301, DOI: 10.1148/radiol.241540.Peer-Reviewed Original ResearchAltmetricSIFT-DBT: Self-Supervised Initialization and Fine-Tuning for Imbalanced Digital Breast Tomosynthesis Image Classification
Du Y, Hooley R, Lewin J, Dvornek N. SIFT-DBT: Self-Supervised Initialization and Fine-Tuning for Imbalanced Digital Breast Tomosynthesis Image Classification. 2011 IEEE International Symposium On Biomedical Imaging: From Nano To Macro 2024, 00: 1-5. PMID: 39263046, PMCID: PMC11386909, DOI: 10.1109/isbi56570.2024.10635723.Peer-Reviewed Original ResearchCitations
2023
Core Needle Biopsies as an Alternative Source for Ex Vivo Expanded TIL for Adoptive Cell Therapy in Triple-Negative Breast Cancer
Coman M, Pusztai L, Hooley R, Andreveja L, Kim L, Joshi N, Bersenev A, Krause D, Park T. Core Needle Biopsies as an Alternative Source for Ex Vivo Expanded TIL for Adoptive Cell Therapy in Triple-Negative Breast Cancer. Journal Of Immunotherapy 2023, 47: 49-53. PMID: 37991241, DOI: 10.1097/cji.0000000000000495.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTumor-infiltrating lymphocytesCore needle biopsyTriple-negative breast cancerNeedle biopsyBreast cancerEx vivoT-cell receptor clonalityUltrasound-guided core needle biopsyTriple negative breast cancer tumorsMorbidity of surgeryAdoptive cell therapyBreast cancer tumorsTIL generationAdoptive transferTIL culturesMultiple lesionsCytokine secretionMetastatic cancerSame patientTumor tissueCell therapyPatientsCancer tumorsCancerSurgeryModern Challenges in Assessing Breast Cancer Screening Strategies: A Call for Added Resources.
Hooley R, Butler R. Modern Challenges in Assessing Breast Cancer Screening Strategies: A Call for Added Resources. Radiology 2023, 306: e230145. PMID: 36749216, DOI: 10.1148/radiol.230145.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Equalizing the Performance of Radiologists and Physician Extenders in Screening Mammography.
Hooley R, Durand M. Equalizing the Performance of Radiologists and Physician Extenders in Screening Mammography. Radiology 2022, 306: 110-111. PMID: 36098645, DOI: 10.1148/radiol.221960.Peer-Reviewed Original ResearchCitationsAltmetricThe Benefits of Early Detection: Evidence From Modern International Mammography Service Screening Programs
Eby P, Ghate S, Hooley R. The Benefits of Early Detection: Evidence From Modern International Mammography Service Screening Programs. Journal Of Breast Imaging 2022, 4: 346-356. PMID: 38416986, DOI: 10.1093/jbi/wbac041.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRandomized Controlled TrialsEquitable careScreening researchStudy designPopulation-based observational studyService screening programsBenefits of early detectionBreast cancer mortalityHealth service programsEfficacy of screeningOptimal screening techniqueDiverse patient populationsPatient-specific outcomesCohort/case-controlVariable study designsLong-term randomized controlled trialsCancer mortalityScreening mammographyHealth careScreening programRegular screeningControlled TrialsObservational studyService programsPatient population
2021
Transitioning From Training to Breast Imaging Practice: Building an Academic Career
Butler R, Lee J, Hooley R. Transitioning From Training to Breast Imaging Practice: Building an Academic Career. Journal Of Breast Imaging 2021, 4: 70-77. PMID: 38422416, DOI: 10.1093/jbi/wbab092.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAcademic careerCareer successClinician-educator trackEducational scholarshipFaculty goalsMedical educationAcademic departmentsProgram developmentProfessional satisfactionEducationPersonal strengthsCareerBreast imaging practicesStrategic planSuch resourcesLeadershipClinical program developmentOriginal researchWork-life integrationOpportunitiesPracticeBroad fieldTraditional areasMentorshipSuccess
Clinical Care
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Overview
“You’re going to be okay.” Those are the reassuring first words Regina Hooley, MD, a Yale Medicine breast imager, tells patients who have abnormal mammogram, breast ultrasound or breast MRI results. She is a professor at Yale School of Medicine and Vice Chair for Clinical Affairs in the Department of Radiology & Biomedical Imaging.
“Every woman is unique, which is what makes breast imaging challenging because every normal breast looks different,” says Dr. Hooley, explaining that the composition of fatty and glandular breast tissue varies from person to person, like a fingerprint.
“If I recommend a biopsy, I know that more than half of the time what we biopsy turns out to be a non-cancerous finding,” says Dr. Hooley, who performs image-guided breast biopsies at the Breast Center at Smilow Cancer Hospital. “And if it does turn out to be a cancer, I also feel that patients are going to be well taken care of here.”
To ensure the best outcomes for her patients, Dr. Hooley is part of a multidisciplinary team of doctors who gather weekly at tumor board meetings to make decisions about treatment plans for patients who are diagnosed with breast cancer.
In addition to her work as a breast imager at Smilow and its Care Centers, Dr. Hooley has conducted extensive research on breast density and supplemental screening ultrasound. She is also part of Women’s Health Research at Yale School of Medicine and is the co-author of Breast Tomosynthesis (Elsevier 2018).
Clinical Specialties
Fact Sheets
Digital Breast Tomosynthesis (3D Mammography)
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Board Certifications
Diagnostic Radiology
- Certification Organization
- AB of Radiology
- Original Certification Date
- 1994
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