Lei Shen
Associate Research ScientistAbout
Research
Publications
2026
Gut microbiota-derived cholic acid ameliorates lung inflammation in bronchopulmonary dysplasia through modulation of macrophage function
Zhao D, Gao C, Zhu D, Zheng X, Sun J, Liu C, Chen L, Shen L, Wang X, Zhang Y. Gut microbiota-derived cholic acid ameliorates lung inflammation in bronchopulmonary dysplasia through modulation of macrophage function. IScience 2026, 29: 115398. PMID: 41971995, PMCID: PMC13068612, DOI: 10.1016/j.isci.2026.115398.Peer-Reviewed Original ResearchTCR-NF-κB signaling activates the SENP1-NR4A1 axis to fine-tune effector activation of CD8+ T cells
Jiang C, Yang Y, Tian J, Liang Z, Fan Q, Wang Q, Shen L, Wang S, He J, Cheng J. TCR-NF-κB signaling activates the SENP1-NR4A1 axis to fine-tune effector activation of CD8+ T cells. Cell Reports 2026, 45: 117102. PMID: 41831233, DOI: 10.1016/j.celrep.2026.117102.Peer-Reviewed Original ResearchObesity disrupts ILC2 metabolic and functional homeostasis by inhibiting mTORC1 signaling
Hu L, Wang D, Chen Y, Qiu J, Wang H, Zhang Y, Zhang M, Su X, Qiu J, Sun J, Shen L. Obesity disrupts ILC2 metabolic and functional homeostasis by inhibiting mTORC1 signaling. Cellular & Molecular Immunology 2026, 23: 301-314. PMID: 41593294, PMCID: PMC12948970, DOI: 10.1038/s41423-026-01389-9.Peer-Reviewed Original Research
2025
mTORC1 signaling in group 2 innate lymphoid cells coordinates neuro-immune crosstalk in allergic lung inflammation
Wang D, Hu L, Chen J, Qiu J, Chen Y, Zhang M, Zhao L, Su X, Sun J, Qiu J, Tang W, Zhou W, Shen L. mTORC1 signaling in group 2 innate lymphoid cells coordinates neuro-immune crosstalk in allergic lung inflammation. Nature Communications 2025, 17: 62. PMID: 41318705, PMCID: PMC12769748, DOI: 10.1038/s41467-025-66683-y.Peer-Reviewed Original ResearchMetabolic heterogeneity in adipose resident immunocytes and its link to type 2 diabetes via response to catabolism defects
Huang S, Chen X, Yuan Y, Yuan Y, Shen L, Wang H, Tang W, Bi Y, Wu T. Metabolic heterogeneity in adipose resident immunocytes and its link to type 2 diabetes via response to catabolism defects. Genomics 2025, 117: 111152. PMID: 41207448, DOI: 10.1016/j.ygeno.2025.111152.Peer-Reviewed Original ResearchJawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement
Wang X, Chen Q, Sun J, Huang Z, Zhang Z, Lu T, Huang X, Sun S, Liu Y, Pan H, Mei L, Cooper P, Dai Q, Shen L, Jiang L. Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement. Frontiers In Bioengineering And Biotechnology 2025, 13: 1596143. PMID: 40861852, PMCID: PMC12375904, DOI: 10.3389/fbioe.2025.1596143.Peer-Reviewed Original ResearchLKB1 regulates ILC3 postnatal development and effector function through metabolic programming
Zhang H, Zhao L, Zhang Q, Hu L, Su X, Sun J, Shen L. LKB1 regulates ILC3 postnatal development and effector function through metabolic programming. Frontiers In Immunology 2025, 16: 1587256. PMID: 40539052, PMCID: PMC12176730, DOI: 10.3389/fimmu.2025.1587256.Peer-Reviewed Original ResearchT-bet+ILC3 in peripheral blood is increased in the ankylosing spondylitis with high disease activity
Liu Y, Shen Y, Ding H, He D, Cheng P, Wu X, Xiang Z, Shen L, Bian Y, Zhu Q. T-bet+ILC3 in peripheral blood is increased in the ankylosing spondylitis with high disease activity. Heliyon 2025, 11: e41678. PMID: 39866450, PMCID: PMC11757778, DOI: 10.1016/j.heliyon.2025.e41678.Peer-Reviewed Original Research
2024
Osteopetrosis-like disorders induced by osteoblast-specific retinoic acid signaling inhibition in mice
Sun S, Liu Y, Sun J, Zan B, Cui Y, Jin A, Xu H, Huang X, Zhu Y, Yang Y, Gao X, Lu T, Wang X, Liu J, Mei L, Shen L, Dai Q, Jiang L. Osteopetrosis-like disorders induced by osteoblast-specific retinoic acid signaling inhibition in mice. Bone Research 2024, 12: 61. PMID: 39419968, PMCID: PMC11487257, DOI: 10.1038/s41413-024-00353-5.Peer-Reviewed Original ResearchSirtuin 6 inhibits group 3 innate lymphoid cell function and gut immunity by suppressing IL-22 production
Su X, Zhao L, Zhang H, Wang D, Sun J, Shen L. Sirtuin 6 inhibits group 3 innate lymphoid cell function and gut immunity by suppressing IL-22 production. Frontiers In Immunology 2024, 15: 1402834. PMID: 39253083, PMCID: PMC11381250, DOI: 10.3389/fimmu.2024.1402834.Peer-Reviewed Original Research
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