Lei Shen
Associate Research ScientistAbout
Research
Publications
2026
Corrigendum to “Gut microbiota-derived cholic acid ameliorates lung inflammation in bronchopulmonary dysplasia through modulation of macrophage function” [iScience 29 (2026) 115398]
Zhao D, Gao C, Zhu D, Zheng X, Sun J, Liu C, Chen L, Shen L, Wang X, Zhang Y. Corrigendum to “Gut microbiota-derived cholic acid ameliorates lung inflammation in bronchopulmonary dysplasia through modulation of macrophage function” [iScience 29 (2026) 115398]. IScience 2026, 29: 116713. PMID: 42540661, PMCID: PMC13426209, DOI: 10.1016/j.isci.2026.116713.Commentaries, Editorials and LettersMaraviroc ameliorates doxorubicin-induced atrioventricular block through blocking CCL5-CCR5 interaction in macrophage-cardiomyocyte axis
Wang H, Zhang Y, Shen L, Wu G, Yu H, Zhang L, Sun Y, Xue S. Maraviroc ameliorates doxorubicin-induced atrioventricular block through blocking CCL5-CCR5 interaction in macrophage-cardiomyocyte axis. European Journal Of Pharmacology 2026, 1028: 178985. PMID: 42155834, DOI: 10.1016/j.ejphar.2026.178985.Peer-Reviewed Original ResearchGut microbiota-derived cholic acid ameliorates lung inflammation in bronchopulmonary dysplasia through modulation of macrophage function
Zhao D, Gao C, Zhu D, Zheng X, Sun J, Liu C, Chen L, Shen L, Wang X, Zhang Y. Gut microbiota-derived cholic acid ameliorates lung inflammation in bronchopulmonary dysplasia through modulation of macrophage function. IScience 2026, 29: 115398. PMID: 41971995, PMCID: PMC13068612, DOI: 10.1016/j.isci.2026.115398.Peer-Reviewed Original ResearchTCR-NF-κB signaling activates the SENP1-NR4A1 axis to fine-tune effector activation of CD8+ T cells
Jiang C, Yang Y, Tian J, Liang Z, Fan Q, Wang Q, Shen L, Wang S, He J, Cheng J. TCR-NF-κB signaling activates the SENP1-NR4A1 axis to fine-tune effector activation of CD8+ T cells. Cell Reports 2026, 45: 117102. PMID: 41831233, DOI: 10.1016/j.celrep.2026.117102.Peer-Reviewed Original ResearchObesity disrupts ILC2 metabolic and functional homeostasis by inhibiting mTORC1 signaling
Hu L, Wang D, Chen Y, Qiu J, Wang H, Zhang Y, Zhang M, Su X, Qiu J, Sun J, Shen L. Obesity disrupts ILC2 metabolic and functional homeostasis by inhibiting mTORC1 signaling. Cellular & Molecular Immunology 2026, 23: 301-314. PMID: 41593294, PMCID: PMC12948970, DOI: 10.1038/s41423-026-01389-9.Peer-Reviewed Original ResearchPD-1 engagement and circulating Th17 effector activity during secukinumab treatment in plaque psoriasis
Zhang M, Feng X, Yan K, Zhou J, Shen L, Zhang Z. PD-1 engagement and circulating Th17 effector activity during secukinumab treatment in plaque psoriasis. Clinical & Experimental Immunology 2026, 220: uxag037. PMID: 42376866, PMCID: PMC13344862, DOI: 10.1093/cei/uxag037.Peer-Reviewed Original Research
2025
mTORC1 signaling in group 2 innate lymphoid cells coordinates neuro-immune crosstalk in allergic lung inflammation
Wang D, Hu L, Chen J, Qiu J, Chen Y, Zhang M, Zhao L, Su X, Sun J, Qiu J, Tang W, Zhou W, Shen L. mTORC1 signaling in group 2 innate lymphoid cells coordinates neuro-immune crosstalk in allergic lung inflammation. Nature Communications 2025, 17: 62. PMID: 41318705, PMCID: PMC12769748, DOI: 10.1038/s41467-025-66683-y.Peer-Reviewed Original ResearchMetabolic heterogeneity in adipose resident immunocytes and its link to type 2 diabetes via response to catabolism defects
Huang S, Chen X, Yuan Y, Yuan Y, Shen L, Wang H, Tang W, Bi Y, Wu T. Metabolic heterogeneity in adipose resident immunocytes and its link to type 2 diabetes via response to catabolism defects. Genomics 2025, 117: 111152. PMID: 41207448, DOI: 10.1016/j.ygeno.2025.111152.Peer-Reviewed Original ResearchJawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement
Wang X, Chen Q, Sun J, Huang Z, Zhang Z, Lu T, Huang X, Sun S, Liu Y, Pan H, Mei L, Cooper P, Dai Q, Shen L, Jiang L. Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement. Frontiers In Bioengineering And Biotechnology 2025, 13: 1596143. PMID: 40861852, PMCID: PMC12375904, DOI: 10.3389/fbioe.2025.1596143.Peer-Reviewed Original ResearchLKB1 regulates ILC3 postnatal development and effector function through metabolic programming
Zhang H, Zhao L, Zhang Q, Hu L, Su X, Sun J, Shen L. LKB1 regulates ILC3 postnatal development and effector function through metabolic programming. Frontiers In Immunology 2025, 16: 1587256. PMID: 40539052, PMCID: PMC12176730, DOI: 10.3389/fimmu.2025.1587256.Peer-Reviewed Original Research
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