Henrique Oliva, MD, PhD
Associate Research Scientist of PsychiatryAbout
Research
Publications
Featured Publications
Effects of exercise intervention on psychotic symptoms: A meta-analysis and hypothetical model of neurobiological mechanisms
Oliva H, Monteiro-Junior R, Oliva I, Powers A. Effects of exercise intervention on psychotic symptoms: A meta-analysis and hypothetical model of neurobiological mechanisms. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2023, 125: 110771. PMID: 37075881, DOI: 10.1016/j.pnpbp.2023.110771.Peer-Reviewed Original ResearchConceptsExercise interventionGeneral symptomsPsychotic symptomsEfficacy of exerciseEffects of exerciseSpecific brain areasWeb of ScienceCochrane CENTRALSymptom improvementTemporal lobeBrain areasLarge effect sizesPsychotic patientsPositive symptomsNegative symptomsSymptomsNeurobiological mechanismsNeurophysiology studiesInterventionExerciseEffect sizeDatabase searchSignificant improvementNeurobiological modelsPatientsMiddle cerebral artery blood velocity and cognitive function after high- and moderate-intensity aerobic exercise sessions
Oliva H, Oliveira G, Oliva I, Cassilhas R, de Paula A, Monteiro-Junior R. Middle cerebral artery blood velocity and cognitive function after high- and moderate-intensity aerobic exercise sessions. Neuroscience Letters 2023, 817: 137511. PMID: 37820993, DOI: 10.1016/j.neulet.2023.137511.Peer-Reviewed Original ResearchConceptsModerate-intensity continuous trainingHigh-intensity interval trainingCognitive functionExercise sessionsSessions of high-intensity interval trainingHealthy young adultsRandomized exercise sessionsCognitive improvementAerobic exercise sessionYoung adultsAcute effectsInterval trainingFluencyHealthy adultsSessionsContinuous trainingClinically healthy adultsCrossover studyMiddle cerebral artery blood velocityCerebral artery blood velocityLactate increaseAdultsArtery blood velocityCognitionCerebrovascular circulationSubstance use and spine density: a systematic review and meta-analysis of preclinical studies
Oliva H, Prudente T, Nunes E, Cosgrove K, Radhakrishnan R, Potenza M, Angarita G. Substance use and spine density: a systematic review and meta-analysis of preclinical studies. Molecular Psychiatry 2024, 29: 2873-2885. PMID: 38561468, PMCID: PMC11894807, DOI: 10.1038/s41380-024-02519-3.Peer-Reviewed Original ResearchSpine densityPrefrontal cortexSubstance useDrug Self-AdministrationHippocampal spine densityEffects of cocaineSubstance use disordersConvergence of findingsSpine density changesSubstances of abuseMeta-analysis of preclinical studiesNucleus accumbensBehavioral sensitizationSelf-AdministrationBrain mechanismsPreclinical studiesBrain regionsMorphine effectsSynaptic density changesMeta-analysisAmphetamineSynaptic densityCocaineModerate-to-highCortexSafety of Stimulants Across Patient Populations
Oliva H, Prudente T, Mayerson T, Mignosa M, Oliva I, Potenza M, Jegede O, Angarita G. Safety of Stimulants Across Patient Populations. JAMA Network Open 2025, 8: e259492. PMID: 40343695, PMCID: PMC12065045, DOI: 10.1001/jamanetworkopen.2025.9492.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderRandomized clinical trialsAdverse eventsStimulant medicationData extractionSafety of stimulationRisk ratioIncreased riskMethodological quality assessmentPreferred Reporting ItemsPatient populationClinical conditionsDiverse patient populationsRisk of biasSafety of stimulant medicationsUnclear risk of biasTreatment of attention-deficit/hyperactivity disorderOverall AEsRandom-effects modelWeb of ScienceBinge Eating DisorderStimulant use disorderComprehensive literature searchMain OutcomesReporting ItemsSleep alterations in substance use disorders: a systematic review and meta-analysis
Oliva H, Prudente T, Naveda A, Monteiro-Junior R, Potenza M, Morgan P, Angarita G. Sleep alterations in substance use disorders: a systematic review and meta-analysis. EClinicalMedicine 2026, 91: 103723. PMID: 41552000, PMCID: PMC12805338, DOI: 10.1016/j.eclinm.2025.103723.Peer-Reviewed Original ResearchSubstance use disordersUse disorderSlow-wave sleepTotal sleep timeMeta-analytical levelSystematic reviewNational Institute on Drug AbuseMeta-analysisPre-registered protocolAddictive substancesSleep abnormalitiesSleep alterationsDrug abuseSleep disturbanceWeb of ScienceSleep qualitySleep timeEligible publicationsDisordersAUDSleepCAUDNo studyAlterationsOUD
2026
Effect of Dual-task Exercise on Cognition and Dual-task Cost in the Elderly with Mild Cognitive Impairment: A Randomized Pilot Study
Alves M, Rodrigues A, Tinini R, Rodrigues V, Leão L, Machado F, Santos S, Oliva H, Monteiro-Junior R. Effect of Dual-task Exercise on Cognition and Dual-task Cost in the Elderly with Mild Cognitive Impairment: A Randomized Pilot Study. CNS & Neurological Disorders - Drug Targets 2026, 25 DOI: 10.2174/0118715273412249251201232228.Peer-Reviewed Original ResearchDual-task costsMild cognitive impairmentDT trainingDual-taskDT exerciseTraining modalitiesOlder adultsWorking memoryDual-task exercisesMild cognitive impairment statusDual-task interventionsVR groupPost-intervention analysisCognitive impairmentDaily task performanceStrength exercisesDigit span backward testDual-task performanceExercise groupRandomized pilot studyWorking memory performancePost-interventionFunctional gainsCognitive statusNon-MCISafety, tolerability, and drug-drug interactions of NYX-783 and oxycodone in persons using opioids recreationally: Preliminary results from a randomized, double-blind, placebo-controlled phase 1 study
Harvanek Z, Mignosa M, Kitaneh R, Oliva H, Borelli A, Dauginikas E, Fogelman N, Sakmar E, Taylor J, DiLeone R, Sinha R, Angarita G. Safety, tolerability, and drug-drug interactions of NYX-783 and oxycodone in persons using opioids recreationally: Preliminary results from a randomized, double-blind, placebo-controlled phase 1 study. Drug And Alcohol Dependence 2026, 279: 113041. PMID: 41604752, PMCID: PMC12924154, DOI: 10.1016/j.drugalcdep.2026.113041.Peer-Reviewed Original ResearchConceptsDrug-drug interactionsOpioid use disorderDouble-blindAdverse eventsDrug effectsSubjective drug effectsPlacebo-controlled phase 1 studyPositive allosteric modulatorsPhase 1 studyDiastolic blood pressureUse disorderOxycodone dosePrimary endpointInpatient studyOpioid useSynaptic plasticityPlasma levelsContext of opioid useOxycodoneAllosteric modulatorsPupillary dilationBlood pressureNovel treatmentRespiratory safetyHealthy humansRemote Exercise Effects on Physical/Cognitive Abilities in Active Older Adults: Preliminary Report
da Costa M, Alves M, de Paula A, Santos S, Oliva H, Soares W, Monteiro-Junior R. Remote Exercise Effects on Physical/Cognitive Abilities in Active Older Adults: Preliminary Report. Translational Journal Of The American College Of Sports Medicine 2026, 11: e000340. DOI: 10.1249/tjx.0000000000000340.Peer-Reviewed Original ResearchActive older adultsOlder adultsAerobic capacityPhysical exerciseGlobal cognitionPhysically active older adultsOnline exercise programExercise training programWeb-based interventionExercise programExercise engagementPhysical functionExercise effectsHealth interventionsTraining programFunctional capacityPhysical capabilitiesDynamic balanceHealthy agingExerciseAdultsInterventionParticipantsCognitive abilitiesProgramActigraphy-based sleep outcomes in substance use disorders: A protocol for a systematic review and meta-analysis
Paredes Naveda A, Oliva H, Ghadimi D, Angarita G. Actigraphy-based sleep outcomes in substance use disorders: A protocol for a systematic review and meta-analysis. PLOS ONE 2026, 21: e0340595. PMID: 41499544, PMCID: PMC12779124, DOI: 10.1371/journal.pone.0340595.Peer-Reviewed Original ResearchConceptsNon-randomized studiesSubstance use disordersRisk of biasUse disorderSystematic reviewProspective Register for Systematic ReviewsMeta-analysisDiagnosis of substance useRelapse riskSubstance use disorder populationsSleep outcomesSleep-wake characteristicsWeb of ScienceMatched ControlsGold standardEligibility criteriaRest-activity patternsInternational Prospective Register for Systematic ReviewsIndependent reviewersFull-text screeningNon-randomized studies of exposureStudy sleepIntervention studiesSleepSleep disturbance
2025
Readability, linguistic complexity, and stigma in ChatGPT responses to opioid use disorder FAQs: A comparative analysis
Campos V, Heringer D, Costa G, Oliva H, Anand A. Readability, linguistic complexity, and stigma in ChatGPT responses to opioid use disorder FAQs: A comparative analysis. American Journal On Addictions 2025 PMID: 41189042, DOI: 10.1111/ajad.70101.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News & Links
News
- March 03, 2026
Oliva Chosen to Receive ASCP Annual Meeting New Investigator Award
- January 29, 2026Source: eClinical Medicine
Sleep Alterations in Substance Use Disorders: A Systematic Review and Meta-Analysis
- May 09, 2025Source: JAMA Network Open
Safety of Stimulants Across Patient Populations
- March 07, 2025
Oliva Receives Travel Scholarship to Attend ASAM Annual Meeting