Elizabeth Woo
MD, PhD Student, NeuroscienceAbout
Research
Publications
2025
Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness
Yang S, Datta D, Krienen F, Woo E, May A, Anderson G, Galvin V, Gonzalez-Burgos G, Lewis D, Ling E, McCarroll S, Arnsten A, Wang M. Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness. Molecular Psychiatry 2025, 1-11. PMID: 41413200, DOI: 10.1038/s41380-025-03425-y.Peer-Reviewed Original ResearchHigher cognitive deficitsCognitive deficitsPrimate dlPFCKAT IIKynurenic acidNeuronal firingDorsolateral prefrontal cortexAged macaquesPlasma kynurenine/tryptophan ratioSystemic administration of agentsSystemic administrationHuman dlPFCPrefrontal cortexWorking memoryDlPFC neuronsAged monkeysKynurenic acid productionCognitive performanceDLPFCCognitive functionMental illnessKynurenine/tryptophan ratioNonhuman primatesDeficitsApplication of kynurenic acidAdvancements in Cellular Therapeutics in Corneal Diseases
Woo E, Henick D, Tahvildari M. Advancements in Cellular Therapeutics in Corneal Diseases. Cells 2025, 14: 1838. PMID: 41369327, PMCID: PMC12691177, DOI: 10.3390/cells14231838.Peer-Reviewed Original ResearchConceptsCorneal diseaseLimbal stem cell functionLimbal stem cell deficiencyTreatment of corneal diseasesCorneal transplant proceduresEndothelial cell disorderStem cell deficiencyEndothelial cell dysfunctionCell-based therapiesStem cell functionCell-based therapeuticsCell deficiencyCell disordersAdjunctive therapyPrevent blindnessTransplant proceduresCellular therapeuticsImmune rejectionRegenerative therapyCell dysfunctionCornealTherapyCell functionIn vivoCorneaRyanodine receptor 2-mediated calcium leak is associated with increased glyoxalase I in the aging brain
Woo E, Datta D, Bathla S, Beatty H, Caglayan P, Albizu A, Lam T, Kanyo J, Joyce M, Leslie S, Uchendu S, DeLong J, Guan Q, Li J, Abramson E, Herman A, Cooper D, Licznerski P, Horvath T, Jonas E, Nairn A, Arnsten A, Sansing L. Ryanodine receptor 2-mediated calcium leak is associated with increased glyoxalase I in the aging brain. JCI Insight 2025, 10: e184041. PMID: 41100182, PMCID: PMC12643534, DOI: 10.1172/jci.insight.184041.Peer-Reviewed Original ResearchConceptsPrefrontal cortexCalcium leakImpaired working memoryGlo1 expressionCalcium dysregulationAlzheimer's diseaseRyanodine receptor 2Working memoryAge-related increaseStage of diseaseDownstream consequencesAging BrainAD mouse modelMonths of ageAged macaquesMutant miceReceptor 2Mouse modelRyR2RyanodineBrainMiceLeakDysregulationMacaquesDysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation
Bathla S, Datta D, Bolat D, Woo E, Duque A, Arellano J, Arnsten A, Nairn A. Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation. Frontiers In Aging Neuroscience 2025, 17: 1549770. PMID: 40365352, PMCID: PMC12069431, DOI: 10.3389/fnagi.2025.1549770.Peer-Reviewed Original ResearchTau pathologyTau hyperphosphorylationAlzheimer's diseaseAssociated with tau hyperphosphorylationSoluble phosphorylated tauSporadic Alzheimer's diseaseCalcium signalingDysregulated calcium signalingTau etiologyEarly stages of ADHyperphosphorylationSignaling pathwayHuman ADInflammatory signaling pathwaysCalpain-2Stages of ADMolecular processesHydrolyze cAMPTauEntorhinal cortexCarboxypeptidase IIGlutamate carboxypeptidase IIDephosphorylationSUSCEPTIBLE PYRAMIDAL NEURONS IN PRIMATE DORSOLATERAL PREFRONTAL CORTEX EXPRESS AN ENRICHED CALCIUM INTERACTOME: CRITICAL ROLE OF CALBINDIN AND CAV1.2 IN HIGHER-ORDER COGNITION
Datta *, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman R, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O'dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. SUSCEPTIBLE PYRAMIDAL NEURONS IN PRIMATE DORSOLATERAL PREFRONTAL CORTEX EXPRESS AN ENRICHED CALCIUM INTERACTOME: CRITICAL ROLE OF CALBINDIN AND CAV1.2 IN HIGHER-ORDER COGNITION. The International Journal Of Neuropsychopharmacology 2025, 28: i57-i58. PMCID: PMC11814899, DOI: 10.1093/ijnp/pyae059.100.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexMacaque dlPFCPrefrontal cortexWorking memoryLayer 3 pyramidal cellsAlzheimer s diseasePrefrontal cortex dysfunctionExpression of Grin2bPyramidal cellsHigher-order cognitionIncreased risk of mental disordersRisk of neuropsychiatric disordersDendritic spine pathologyRisk of mental disordersIncreased risk of neuropsychiatric disordersL-type calcium channel Cav1.2Primate dlPFCDLPFC functionCognitive deficitsLayer III pyramidal cellsMemory impairmentPsychiatric disordersBrain circuitryNeuropsychiatric disordersMental representations
2024
Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders
Datta D, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman M, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O’Dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA Psychiatry 2024, 81: 870-881. PMID: 38776078, PMCID: PMC11112502, DOI: 10.1001/jamapsychiatry.2024.1112.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexLayer III pyramidal cellsWorking memoryCognitive disordersNeuronal firingPrimate dorsolateral prefrontal cortexPyramidal cellsSpatial working memoryWorking memory performanceRisk of mental disordersCalcium-related proteinsReduced neuronal firingL-type calcium channel Cav1.2GluN2B-NMDA receptorsL-type calcium channel activityPrefrontal neuronsL-type calcium channel blockerMemory performanceL-type calcium channelsMental disordersRisk of cognitive disordersCognitive behaviorProtein expressionAssociated with increased risk
2022
Inhibition of glutamate-carboxypeptidase-II in dorsolateral prefrontal cortex: potential therapeutic target for neuroinflammatory cognitive disorders
Yang S, Datta D, Elizabeth Woo, Duque A, Morozov YM, Arellano J, Slusher BS, Wang M, Arnsten AFT. Inhibition of glutamate-carboxypeptidase-II in dorsolateral prefrontal cortex: potential therapeutic target for neuroinflammatory cognitive disorders. Molecular Psychiatry 2022, 27: 4252-4263. PMID: 35732693, PMCID: PMC9718677, DOI: 10.1038/s41380-022-01656-x.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexDendritic spinesNeuronal firingGCPII inhibitionCognitive disordersPrefrontal cortexApparent side effectsPotential therapeutic targetBrain-penetrant inhibitorMacaque dorsolateral prefrontal cortexReceptor type 3GCPII expressionPrimate dlPFCInflammatory disordersSystemic administrationCOVID19 infectionSide effectsTherapeutic targetNeuronal physiologyImpaired cognitionOld monkeysAged monkeysBeneficial effectsPotassium channelsExtensive expressionGlutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex
Woo E, Datta D, Arnsten AFT. Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex. Frontiers In Neuroanatomy 2022, 16: 849937. PMID: 35444520, PMCID: PMC9013768, DOI: 10.3389/fnana.2022.849937.Peer-Reviewed Original ResearchPrelimbic medial prefrontal cortexRat prelimbic medial prefrontal cortexMedial prefrontal cortexLayer IIIPrefrontal cortexDendritic spinesReceptor type 3Dorsolateral prefrontal cortexPrimate dlPFCReceptor subtypesAxon terminalsNeuronal firingPL-mPFCIntervaricose segmentsMGlu3Glial membranesRhesus monkeysPredominant locationType 3GliaCognitive functioningDLPFCCortexSpineCurrent studyUnusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia
Arnsten AFT, Woo E, Yang S, Wang M, Datta D. Unusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia. Biological Psychiatry 2022, 92: 480-490. PMID: 35305820, PMCID: PMC9372235, DOI: 10.1016/j.biopsych.2022.02.003.Peer-Reviewed Original ResearchConceptsEnvironmental insultsMore superficial layersDorsolateral prefrontal cortexPrimate dlPFCInflammatory mechanismsInflammatory insultKynurenic acidNMDA receptorsReceptor neurotransmissionDendritic spinesLayer IIICAMP/PKAGlutamatergic synapsePrefrontal cortexInsultPotassium channelsNeurotransmissionCalcium signalingSynapsesGenetic insultsSuperficial layersSchizophreniaSpineCortexNeuromodulation
2021
Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance
Datta D, Leslie SN, Woo E, Amancharla N, Elmansy A, Lepe M, Mecca AP, Slusher BS, Nairn AC, Arnsten AFT. Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance. Frontiers In Aging Neuroscience 2021, 13: 760270. PMID: 34867287, PMCID: PMC8634091, DOI: 10.3389/fnagi.2021.760270.Peer-Reviewed Original ResearchCognitive disordersRat medial PFCMedial PFCGCPII inhibitorsPFC cognitive deficitsPrefrontal cortical activationGlutamate carboxypeptidase IIGCPII proteinMGluR3 expressionLocal infusionSystemic administrationAged ratsGCPII inhibitionMemory performancePrefrontal cortex impairsCortical activationCognitive impairmentCognitive deficitsInflammationGenetic insultsCarboxypeptidase IIDisordersGCPIICurrent studyInhibitors
News
News
- December 01, 2025
How the Brain Protects Itself from Alzheimer’s Disease
- December 15, 2023
Yuen Directs Film Production for Novel Intervention Program
- April 11, 2023
#TraineeTuesday: Elizabeth Woo
- March 09, 2023
Anna Lynn and Elizabeth Woo are 3-Minute Thesis Divisional Winners