2024
Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings
Gao H, Magin Z, Fogelman N, Sinha R, Angarita G, Milivojevic V. Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings. Life 2024, 14: 1483. PMID: 39598281, PMCID: PMC11595496, DOI: 10.3390/life14111483.Peer-Reviewed Original ResearchCocaine use disorderSubstance use disordersUse disorderPregnenolone levelsTreatment of cocaine use disorderReduce alcohol cravingTreatment-seeking individualsAssociated across timeAdministration of pregnenoloneEight-week trialSignificant main effectAlcohol cravingPregnenolone administrationNegative health risksDouble-blind clinical trialMain effectPilot findingsLevels of pregnenoloneChronic dosingStudy medication doseMedication dosesDisordersCocainePilot studyStress biologyStress and substance use disorders: risk, relapse, and treatment outcomes
Sinha R. Stress and substance use disorders: risk, relapse, and treatment outcomes. Journal Of Clinical Investigation 2024, 134: e172883. PMID: 39145454, PMCID: PMC11324296, DOI: 10.1172/jci172883.Peer-Reviewed Original ResearchConceptsSubstance use disordersDrug-related environmentPathophysiology of addictionAdaptive stress responseSUD treatment outcomesAssociated with substance misuseTreatment outcomesStress-related alterationsDrug motivationIncreased cravingNeurobiological disruptionsMaladaptive copingRepeated stressorsTreatment implicationsSubstance misuseStress pathophysiologyStress responseDrug intakeDrug withdrawalRelapse riskDrug misuseIntervention developmentDisordersCravingRelapse
2023
Sex differences in neural responses to stress and drug cues predicts future drug use in individuals with substance use disorder
Smith K, Lacadie C, Milivojevic V, Fogelman N, Sinha R. Sex differences in neural responses to stress and drug cues predicts future drug use in individuals with substance use disorder. Drug And Alcohol Dependence 2023, 244: 109794. PMID: 36758371, PMCID: PMC10024802, DOI: 10.1016/j.drugalcdep.2023.109794.Peer-Reviewed Original ResearchConceptsSubstance use disordersDrug cuesFuture drug useDrug use daysCue exposureNeural responsesUse daysSex differencesVentromedial prefrontal cortexScript-driven imageryDrug cue exposureNeutral cue exposureWhole-brain analysisWhole-brain correlationUse disordersDrug use outcomesCue-induced anxietyBrain responsesHeart rateFMRI scansPrefrontal cortexDrug cravingDrug useBrain analysisBrain correlations
2018
98. Effects of Childhood Maltreatment on Neural and Biobehavioral Biomarkers of Relapse and Recovery in Substance Use Disorders
Sinha R, Seo D, Lacadie C, Constable T, Hermes G. 98. Effects of Childhood Maltreatment on Neural and Biobehavioral Biomarkers of Relapse and Recovery in Substance Use Disorders. Biological Psychiatry 2018, 83: s40. DOI: 10.1016/j.biopsych.2018.02.116.Peer-Reviewed Original ResearchCentral and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability
Milivojevic V, Sinha R. Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability. Trends In Molecular Medicine 2018, 24: 173-186. PMID: 29396148, PMCID: PMC6511993, DOI: 10.1016/j.molmed.2017.12.010.Peer-Reviewed Original ResearchConceptsSubstance use disordersTreatment of SUDsDevelopment of SUDHigh relapse rateFunctional brain alterationsCentral stress responseAdrenal axis markersStress response measuresRelapse ratePeripheral biomarkersClinical symptomatologyBrain alterationsUse disordersCandidate biomarkersAutonomic responsesRelapse vulnerabilityPutative biomarkersAddiction riskStress responseBiomarkersTreatmentResponsePathophysiologySymptomatologyPrevention
2007
Co-Occurring Mental and Substance Use Disorders: The Neurobiological Effects of Chronic Stress
Brady K, Sinha R. Co-Occurring Mental and Substance Use Disorders: The Neurobiological Effects of Chronic Stress. FOCUS The Journal Of Lifelong Learning In Psychiatry 2007, 5: 229-239. DOI: 10.1176/foc.5.2.foc229.Peer-Reviewed Original ResearchSubstance use disordersUse disordersPsychiatric disordersCo-Occurring MentalCo-occurring disordersAttention deficit hyperactivity disorderArea of comorbidityPosttraumatic stress disorderPopulation of peopleDeficit hyperactivity disorderNeurotransmitter systemsMood disordersNeurobiological effectsMental illnessDiagnostic groupsChronic stressNeurobiological interfaceNeural circuitryStress disorderHyperactivity disorderDisordersHigh rateComorbiditiesTechnical advancesIllness