Rajita Sinha, PhD
Foundations Fund Professor of Psychiatry and Professor in the Child Study Center and of NeuroscienceCards
Appointments
Additional Titles
Deputy Chair of Psychiatry for Psychology, Psychiatry
Director, Yale Interdisciplinary Stress Center
Chief, Psychology Section in Psychiatry
Contact Info
Appointments
Additional Titles
Deputy Chair of Psychiatry for Psychology, Psychiatry
Director, Yale Interdisciplinary Stress Center
Chief, Psychology Section in Psychiatry
Contact Info
Appointments
Additional Titles
Deputy Chair of Psychiatry for Psychology, Psychiatry
Director, Yale Interdisciplinary Stress Center
Chief, Psychology Section in Psychiatry
Contact Info
About
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Titles
Foundations Fund Professor of Psychiatry and Professor in the Child Study Center and of Neuroscience
Deputy Chair of Psychiatry for Psychology, Psychiatry; Director, Yale Interdisciplinary Stress Center; Chief, Psychology Section in Psychiatry
Biography
Rajita Sinha, Ph.D. is the Foundations Fund Endowed Professor in Psychiatry, and Professor in Neuroscience and in Child Study at the Yale University School of Medicine. She is a licensed Clinical Psychologist and Clinical Neuroscientist, Deputy Chair of Psychiatry for Psychology and Chief of the Psychology Section in Psychiatry. She is the founding director of the Yale Interdisciplinary Stress Center that focuses on understanding the neurobiology and psychology of stress, trauma and resilient versus vulnerable biobehavioral coping mechanisms that promote neuropsychiatric diseases such as alcohol use disorders, substance use disorders, chronic pain, PTSD and other chronic diseases. She has developed novel stress, pain and craving provocation paradigms to understand mechanisms that drive these states and related pathologies and their impact on clinical addiction outcomes in alcohol use disorder, substance use disorders and related conditions. Her lab also develops and tests novel pharmacologic and integrative behavioral approaches to address chronic stress and addiction relapse risk to improve addiction treatment outcomes. These objectives are being accomplished through a series of NIH funded research projects and she has published widely on these topics. She is the 2020 recipient of the Research Society on Alcoholism's Distinguished Researcher Award, and the 2020 recipient of the James Tharpe Award for outstanding contributions to Addiction Research. She has served on many NIH special emphasis panels, review committees and workshops, presented at numerous national and international conferences, and her work is widely cited.
Appointments
Psychiatry
ProfessorPrimaryNeuroscience
ProfessorSecondary
Other Departments & Organizations
- All Institutions
- Center for Brain & Mind Health
- Connecticut Mental Health Center
- Diabetes Research Center
- Division of Addictions
- Division of Substance Abuse
- MR Core
- Neuroscience
- Neuroscience Research Training Program (NRTP)
- Psychiatry
- Psychology Section
- Psychotherapy Development Center
- South Asian Studies
- Stress & Addiction Clinical Research Program
- Yale Center for the Science of Cannabis and Cannabinoids
- Yale Obesity Research Center (Y-Weight)
- Yale Stress Center
- Yale Ventures
- Yale-Drug use, Addiction, and HIV prevention Research Scholars (DAHRS)
Education & Training
- PhD
- Yale University, Psychology/Clinical Respecialization (1992)
- PhD
- Oklahoma University Health Sciences Center (1990)
Research
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Overview
Medical Research Interests
ORCID
0000-0003-3012-4349
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Dongju Seo, PhD
Verica Milivojevic, PhD
Nia Fogelman, PhD
Stephanie Wemm, PhD
Todd Constable, PhD
Zachary Harvanek, MD, PhD
Stress, Psychological
Substance-Related Disorders
Chronic Disease
Neurobiology
Publications
2026
Mindfulness Intervention for Parent Stress and Childhood Obesity Risk: A Randomized Trial.
Fogelman N, Bernstein H, Bautista T, Savoye M, Chaplin T, Silverman W, Jastreboff A, Sinha R. Mindfulness Intervention for Parent Stress and Childhood Obesity Risk: A Randomized Trial. 2026 PMID: 41786283, DOI: 10.1542/peds.2025-072230.Peer-Reviewed Original ResearchAltmetricSex-specific neural activation to stress and alcohol cues in high-risk drinkers: links between orbitofrontal circuits, alcohol craving, and future drinking
Freeman C, Radoman M, Martins J, Lacadie C, Seo D, Sinha R. Sex-specific neural activation to stress and alcohol cues in high-risk drinkers: links between orbitofrontal circuits, alcohol craving, and future drinking. Neuropsychopharmacology 2026, 1-9. PMID: 41792252, DOI: 10.1038/s41386-026-02379-1.Peer-Reviewed Original ResearchAltmetricSafety, tolerability, and drug-drug interactions of NYX-783 and oxycodone in persons using opioids recreationally: Preliminary results from a randomized, double-blind, placebo-controlled phase 1 study.
Harvanek ZM, Mignosa MM, Kitaneh R, Oliva HNP, Borelli A, Dauginikas E, Fogelman N, Sakmar E, Taylor J, DiLeone R, Sinha R, Angarita GA. Safety, tolerability, and drug-drug interactions of NYX-783 and oxycodone in persons using opioids recreationally: Preliminary results from a randomized, double-blind, placebo-controlled phase 1 study. Drug Alcohol Depend 2026, 279: 113041. PMID: 41604752, DOI: 10.1016/j.drugalcdep.2026.113041.Peer-Reviewed Original Research
2025
Assessing Autonomic Regulation Under Stress with the Yale Pain Stress Test in Social Drinking and Alcohol Use Disorder
Barreto S, McGowan C, Fogelman N, Sinha R, Wemm S. Assessing Autonomic Regulation Under Stress with the Yale Pain Stress Test in Social Drinking and Alcohol Use Disorder. Behavioral Sciences 2025, 15: 1732. PMCID: PMC12729474, DOI: 10.3390/bs15121732.Peer-Reviewed Original ResearchAltmetricConceptsAlcohol use disorderUse disorderSocial drinkingSocial drinking controlsHeart rate variability recoveryPredictor of chronic illnessPre-stress baselineCold pressor testDSM-5 criteriaHeart rate variabilitySubstance use disordersEffects of stressAcute stress responseDSM-5New Haven areaAutonomic reactivityDrinking controlsAutonomic flexibilityStress exposureLevels of stressStress-related chronic diseasesChronic illnessTime-period effectsClinical careRepeated trialsDynamic brain mechanisms supporting salient memories under cortisol
Huang Y, O’Connor D, Harris B, Sinha R, Constable R, Goldfarb E. Dynamic brain mechanisms supporting salient memories under cortisol. Science Advances 2025, 11: eadz4143. PMID: 41370392, PMCID: PMC12693973, DOI: 10.1126/sciadv.adz4143.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEmotional memoryWhole-brain functional connectivity networksConnectome-based predictive modelingFormation of emotional memoriesEmotionally arousing experiencesBrain network processFunctional connectivity networksPharmacological fMRIBrain mechanismsArousing experiencesBrain networksWhole-brainSalient informationArousalMemoryConnectivity networksCortisolFMRINeural networkEmotionsFunctional overlapBrainMemorandaNetwork processDevelopment of the Yale pain stress test to elicit a multi-level stress response and assess stress adaptability
Fogelman N, Barreto S, McGowan C, Wemm S, Sinha R. Development of the Yale pain stress test to elicit a multi-level stress response and assess stress adaptability. Psychopharmacology 2025, 1-14. PMID: 41361589, DOI: 10.1007/s00213-025-06972-y.Peer-Reviewed Original ResearchCitationsConceptsCold pressor taskPredictor of chronic illnessPain tolerancePre-stress baselineAcute physiological stress responseStress-related illnessesAcute stress responseLevels of stressPain stressStress responseResilient copingWithin-subject experimentPhysiological stress responseHealthy copingBasal anxietyChronic illnessSubjective distressHigher DBPHigher SBPSubjective stressGreater reactivityLower painStress testPain ratingsComponents of resilienceEarly alcohol abstinence symptoms and the role of cumulative adversity
Fox H, Alcina J, Hyman S, Milivojevic V, Sinha R. Early alcohol abstinence symptoms and the role of cumulative adversity. Alcohol Clinical And Experimental Research 2025, 49: 2225-2238. PMID: 41021116, PMCID: PMC12519049, DOI: 10.1111/acer.70137.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAlcohol-dependent individualsCumulative lifetime adversityAbstinence symptomsLifetime adversitySymptom patternsCumulative adversityWeeks of inpatient treatmentAlcohol treatment outcomesAlcohol-dependent participantsInpatient alcoholism treatmentAlcohol use disorderAlcohol cravingAbstinence severityWithdrawal symptomsUse disorderMood statesInpatient participantsControl participantsAlcohol treatmentSymptom presentationTreatment admissionsInpatient treatmentAdverse experiencesModerating factorsAdversityIntegrating breathing‐based stress reduction to address stress and alcohol misuse: A novel digital intervention delivered via telehealth and smartphone application
Seo D, Choi J, Goldberg L, Sinha R. Integrating breathing‐based stress reduction to address stress and alcohol misuse: A novel digital intervention delivered via telehealth and smartphone application. Alcohol Clinical And Experimental Research 2025, 49: 2076-2091. PMID: 40781881, DOI: 10.1111/acer.70131.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAlcohol use disorderAlcohol-related behaviorsAlcohol misuse severityAlcohol misuseUse disorderProgression of alcohol use disorderSelf-ControlStress-induced drinkingAssociated with negative treatment outcomesCognitive-behavioral strategiesStress-related pathologiesNegative treatment outcomesSample of individualsEmotion regulationDepressed moodStudy 1Study 2Effective treatment approachDigital interventionsBehavioral interventionsHazardous drinkingPostintervention reductionsFollow-upStress reductionTreatment outcomes1771-P: Influence of Stressful and Traumatic Life Events and Chronic Stress on Ad-lib Sweet Food Intake and Its Relationship to Obesity
DOYLE E, FOGELMAN N, JOSEPH K, HU P, JASTREBOFF A, SINHA R. 1771-P: Influence of Stressful and Traumatic Life Events and Chronic Stress on Ad-lib Sweet Food Intake and Its Relationship to Obesity. Diabetes 2025, 74 DOI: 10.2337/db25-1771-p.Peer-Reviewed Original ResearchConceptsTraumatic life eventsCumulative Adversity InterviewLife eventsChronic stressSweet food intakeCue contextLife traumaAcute stressCumulative stressful life eventsScript-driven imageryFood ad libitumRecent life eventsStressful life eventsTotal life eventsSnack foods ad libitumSweet food consumptionFood intakeEffects of stressChronic stress scoresStress scoresFood cuesCommunity adultsNeutral contextsCue conditionTraumatic eventsPregnenolone reduces provoked craving and cocaine use in men and women with cocaine use disorder: A pilot trial
Sakmar E, Wemm S, Fogelman N, Hermes G, Sinha R, Milivojevic V. Pregnenolone reduces provoked craving and cocaine use in men and women with cocaine use disorder: A pilot trial. Drug And Alcohol Dependence 2025, 274: 112765. PMID: 40570771, PMCID: PMC12264926, DOI: 10.1016/j.drugalcdep.2025.112765.Peer-Reviewed Original ResearchConceptsCocaine use disorderCocaine useNeuroactive steroidsUse disorderTreatment of cocaine use disorderCocaine use outcomePregnenolone levelsTreatment-seeking individualsDays of cocaineChronic cocaine useExposure to stressPreg groupCocaine cuesCocaine cravingCraving responsesNeutral cuesInduce cravingCravingWeek 2CocaineChronic treatmentPilot findingsCocaine amountPrecursor pregnenoloneLinear mixed effects models
Clinical Trials
Current Trials
Prazosin for Alcohol Use Disorder
HIC ID2000029805RolePrincipal InvestigatorPrimary Completion Date01/15/2026Recruiting ParticipantsGenderBothAge18 years - 70 yearsCharacterizing Subjective and Physiological Responses to Stress and Pain and Cognitive Learning and Executive Function
HIC ID2000026626RolePrincipal InvestigatorPrimary Completion Date06/30/2023Recruiting ParticipantsGenderBothAge18 years - 50 years
Academic Achievements & Community Involvement
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Media
- Higher the cumulative stress exposure, greater the reduction in brain volume in specific regions of the medial, anterior and lateral prefrontal cortex, and in the insula and striatum (shown in yellow blobs). These are regions involved in emotion, reward and motivation processing. Ansel et al., Biological Psychiatry 2011.
News
- March 11, 2026Source: U.S. News & World Report (with Rajita Sinha)
Lowering Parents' Stress Can Reduce Risk Of Childhood Obesity
- March 08, 2026Source: Science Daily
Parents’ Stress May Be Quietly Driving Childhood Obesity, Yale Study Finds
- March 06, 2026Source: Yale News
The Weight of Stress: Helping Parents May Protect Children from Obesity
- December 10, 2025Source: Yale News
Stress Hormones can Alter Brain Networks—and Strengthen Emotional Memories
Related Links
- AARP Bulletin Today on how stress can impact your health - Published 5/1/2009
- Even in the healthy, stress causes brain to shrink, Yale study shows
- Gender in the mix: Under stress, men crave alcohol more than women do - The Los Angeles Times, Health section (5/19/08)
- Link between stress and alcohol craving in alcoholics struggling to achieve recovery - Neuropsychopharmacology, 6/18/08
- Yale Stress Center
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