2024
Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness
Sieu L, Singla S, Liu J, Zheng X, Sharafeldin A, Chandrasekaran G, Valcarce-Aspegren M, Niknahad A, Fu I, Doilicho N, Gummadavelli A, McCafferty C, Crouse R, Perrenoud Q, Picciotto M, Cardin J, Blumenfeld H. Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness. Cell Reports 2024, 43: 115012. PMID: 39643969, DOI: 10.1016/j.celrep.2024.115012.Peer-Reviewed Original ResearchCortical slow wavesFocal seizuresBehavioral responsesAuditory stimuliImpaired behavioral responsesFocal temporal lobe seizuresImpaired consciousnessMouse modelAwake mouse modelResponses to auditory stimuliBehavioral responses to auditory stimuliDecreased cortical arousalImpaired behaviorSlow wavesTemporal lobe seizuresCholinergic releaseModel of focal seizuresHigh-frequency activityCortical functionCortical arousalDepressed cortical functionSubcortical arousalArousalAcetylcholine releaseRat model
2015
Reduction of aggressive behavior in mouse models by the selective α7 nicotinic partial agonist GTS-21
Lewis A, Garvey K, Mineur Y, Picciotto M. Reduction of aggressive behavior in mouse models by the selective α7 nicotinic partial agonist GTS-21. Biochemical Pharmacology 2015, 97: 632-633. DOI: 10.1016/j.bcp.2015.08.034.Peer-Reviewed Original Research
2014
Expression of the 5-HT1A Serotonin Receptor in the Hippocampus Is Required for Social Stress Resilience and the Antidepressant-Like Effects Induced by the Nicotinic Partial Agonist Cytisine
Mineur YS, Einstein EB, Bentham MP, Wigestrand MB, Blakeman S, Newbold SA, Picciotto MR. Expression of the 5-HT1A Serotonin Receptor in the Hippocampus Is Required for Social Stress Resilience and the Antidepressant-Like Effects Induced by the Nicotinic Partial Agonist Cytisine. Neuropsychopharmacology 2014, 40: 938-946. PMID: 25288485, PMCID: PMC4330507, DOI: 10.1038/npp.2014.269.Peer-Reviewed Original ResearchMeSH Keywords8-Hydroxy-2-(di-n-propylamino)tetralinAlkaloidsAnimalsAntidepressive AgentsAzocinesDisease Models, AnimalDrug SynergismFluoxetineGene Expression RegulationHEK293 CellsHindlimb SuspensionHippocampusHumansInterpersonal RelationsMaleMiceMice, Inbred C57BLMotor ActivityQuinolizinesReceptor, Serotonin, 5-HT1ASelective Serotonin Reuptake InhibitorsSerotonin Receptor AgonistsStress, PsychologicalConceptsAntidepressant-like effectsSelective serotonin reuptake inhibitorsDorsal rapheCholinergic systemAgonist cytisineNicotinic acetylcholine receptor blockersEffects of cytisineTreatment-resistant patientsSerotonin reuptake inhibitorsAcetylcholine receptor blockerSSRI fluoxetineReceptor blockersAntidepressant efficacyReuptake inhibitorsSerotonin depletionCholinergic drugsMood disordersSerotonin receptorsMouse modelPharmacological approachesHippocampusReceptorsCytisineRapheMolecular mechanisms
2010
Cortico-Thalamic Connectivity is Vulnerable to Nicotine Exposure During Early Postnatal Development through α4/β2/α5 Nicotinic Acetylcholine Receptors
Heath CJ, King SL, Gotti C, Marks MJ, Picciotto MR. Cortico-Thalamic Connectivity is Vulnerable to Nicotine Exposure During Early Postnatal Development through α4/β2/α5 Nicotinic Acetylcholine Receptors. Neuropsychopharmacology 2010, 35: 2324-2338. PMID: 20736992, PMCID: PMC2955839, DOI: 10.1038/npp.2010.130.Peer-Reviewed Original ResearchConceptsDevelopmental nicotine exposureNicotine exposureNicotinic acetylcholine receptorsAcetylcholine receptorsΑ5 nicotinic acetylcholine receptorConstituents of smokeEarly post-natal periodPrimary addictive componentΑ5 nAChR subunitTobacco smoke exposureCortico-thalamic connectivityPost-natal periodEarly postnatal developmentPassive avoidance behaviorCorticothalamic neuronsAddictive componentCorticothalamic projectionsSmoke exposureReceptor subtypesNAChR subtypesDevelopmental exposureMouse modelNeurodevelopmental periodAnimal modelsBehavioral alterations
2009
Cytisine-Based Nicotinic Partial Agonists as Novel Antidepressant Compounds
Mineur YS, Eibl C, Young G, Kochevar C, Papke RL, Gündisch D, Picciotto MR. Cytisine-Based Nicotinic Partial Agonists as Novel Antidepressant Compounds. Journal Of Pharmacology And Experimental Therapeutics 2009, 329: 377-386. PMID: 19164465, PMCID: PMC2670591, DOI: 10.1124/jpet.108.149609.Peer-Reviewed Original ResearchMeSH KeywordsAlkaloidsAnimalsAntidepressive AgentsAzocinesCloning, MolecularData Interpretation, StatisticalElectrophysiologyEnvironmentFeeding BehaviorHindlimb SuspensionLaburnumMaleMiceMice, Inbred C57BLMotor ActivityNicotinic AgonistsOocytesPatch-Clamp TechniquesQuinolizinesReceptors, CholinergicSwimmingXenopus laevisConceptsAntidepressant-like effectsAntidepressant-like propertiesNicotinic partial agonistPartial agonistAntidepressant efficacyDose-dependent antidepressant-like effectNovelty-suppressed feeding testC57/BL6 miceBeta2 nAChRsAntidepressant-like activityTail suspension testBlood-brain barrierSelective partial agonistNicotinic acetylcholine receptorsNovel antidepressantsDevelopment of drugsBL6 miceAlpha3/beta4Alpha7 nAChRsAgonist effectsMood disordersRodent modelsSuspension testTail suspensionMouse model
2006
Antidepressant-Like Effects of Ceftriaxone in Male C57BL/6J Mice
Mineur YS, Picciotto MR, Sanacora G. Antidepressant-Like Effects of Ceftriaxone in Male C57BL/6J Mice. Biological Psychiatry 2006, 61: 250-252. PMID: 16860779, DOI: 10.1016/j.biopsych.2006.04.037.Peer-Reviewed Original ResearchConceptsAntidepressant-like effectsMajor depressive disorderUptake of glutamateBeta-lactam antibiotic agentsNovelty-suppressed feeding testExcessive glutamatergic neurotransmissionDepressive-like behaviorAntidepressant-like activityMale C57BL/6J miceTail suspension testNovelty-suppressed feedingCeftriaxone treatmentC57BL/6J miceGlutamatergic neurotransmissionDepressive disorderAntidepressant compoundsSuspension testMouse modelThree monthsCeftriaxoneAntibiotic agentsRecent evidenceMiceSimilar effectsFeeding tests