2024
Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness
Sieu L, Singla S, Liu J, Zheng X, Sharafeldin A, Chandrasekaran G, Valcarce-Aspegren M, Niknahad A, Fu I, Doilicho N, Gummadavelli A, McCafferty C, Crouse R, Perrenoud Q, Picciotto M, Cardin J, Blumenfeld H. Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness. Cell Reports 2024, 43: 115012. PMID: 39643969, DOI: 10.1016/j.celrep.2024.115012.Peer-Reviewed Original ResearchCortical slow wavesFocal seizuresBehavioral responsesAuditory stimuliImpaired behavioral responsesFocal temporal lobe seizuresImpaired consciousnessMouse modelAwake mouse modelResponses to auditory stimuliBehavioral responses to auditory stimuliDecreased cortical arousalImpaired behaviorSlow wavesTemporal lobe seizuresCholinergic releaseModel of focal seizuresHigh-frequency activityCortical functionCortical arousalDepressed cortical functionSubcortical arousalArousalAcetylcholine releaseRat model
2014
Neuromodulation by acetylcholine: examples from schizophrenia and depression
Higley MJ, Picciotto MR. Neuromodulation by acetylcholine: examples from schizophrenia and depression. Current Opinion In Neurobiology 2014, 29: 88-95. PMID: 24983212, PMCID: PMC4268065, DOI: 10.1016/j.conb.2014.06.004.Peer-Reviewed Original Research