2023
Natural cubic splines for the analysis of Alzheimer’s trials
Donohue M, Langford O, Insel P, van Dyck C, Petersen R, Craft S, Raman R, Sims J, Sperling R, Aisen P. Natural cubic splines for the analysis of Alzheimer’s trials. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.070862.Peer-Reviewed Original ResearchVersion effectsType I error controlNatural cubic splinesDegrees of freedomPreclinical AlzheimerTreatment effect estimatesType I errorMild dementiaProportional treatment effectLongitudinal data analysisSimulation studyModel selection techniquesMild Alzheimer's dementiaEffect assumptionSpline modelMMRMCubic splinesSplinesA4 studyTrial of donepezilOff-scheduleADAS-CogAlzheimer's dementiaEffect estimatesTreat principle
2019
Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease
van Dyck CH, Nygaard HB, Chen K, Donohue MC, Raman R, Rissman RA, Brewer JB, Koeppe RA, Chow TW, Rafii MS, Gessert D, Choi J, Turner RS, Kaye JA, Gale SA, Reiman EM, Aisen PS, Strittmatter SM. Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease. JAMA Neurology 2019, 76: 1219-1229. PMID: 31329216, PMCID: PMC6646979, DOI: 10.1001/jamaneurol.2019.2050.Peer-Reviewed Original ResearchAZD0530 treatmentAdverse eventsPrimary outcomeTreatment groupsAlzheimer's Disease Cooperative Study-ActivitiesAlzheimer's diseasePositron emission tomography evidenceMini-Mental State Examination scoreAlzheimer's Disease Assessment Scale-cognitive subscaleCerebral metabolic declineFrequent adverse eventsSecondary end pointsCerebral metabolic rateMild Alzheimer's dementiaState Examination scorePlasma drug levelsClinical Dementia RatingVolumetric magnetic resonanceEffect of AZD0530Neuronal cell surfaceModified intentionTreat populationSecondary outcomesNeuropsychiatric InventoryEfficacy analysis