2023
Using micro-cognition biomarkers of neurosystem dysfunction to redefine ADHD subtypes: A scalable digital path to diagnosis based on brain function
Wexler B, Kish R. Using micro-cognition biomarkers of neurosystem dysfunction to redefine ADHD subtypes: A scalable digital path to diagnosis based on brain function. Psychiatry Research 2023, 326: 115348. PMID: 37494880, PMCID: PMC10517859, DOI: 10.1016/j.psychres.2023.115348.Peer-Reviewed Original ResearchMeSH KeywordsAttentionAttention Deficit Disorder with HyperactivityBiomarkersBrainChildCognitionHumansConceptsPoor response inhibitionResponse inhibitionSymptom-based diagnosisGO/NOGO testMarked performance decrementsNew treatment developmentTD childrenADHD childrenADHD subtypesPerformance decrementsInconsistent attentionAbstract categoriesTreatment developmentNatural categoriesBrain functionADHDDifferent neuropathologiesChildren 6Individual patientsTreatment selection
2019
Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD
Smith SD, Crowley MJ, Ferrey A, Ramsey K, Wexler BE, Leckman JF, Sukhodolsky DG. Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD. Psychiatry Research 2019, 278: 248-257. PMID: 31233935, PMCID: PMC6637759, DOI: 10.1016/j.psychres.2019.06.021.Peer-Reviewed Original ResearchConceptsBehavioral measuresAttentional controlIntegrated brainGo/No-Go taskGo-P3 latencySlower reaction timesSocial interventionsRobust treatment effectAttentional systemADHD groupERP measuresDifference waveP3 latencyBrain activityADHDTAU groupEEG proceduresHealthy controlsHC groupReaction timeReplication purposesERPTreatment effectsChildrenSecondary goal
2015
Social skills training and computer-assisted cognitive remediation in schizophrenia
Kurtz MM, Mueser KT, Thime WR, Corbera S, Wexler BE. Social skills training and computer-assisted cognitive remediation in schizophrenia. Schizophrenia Research 2015, 162: 35-41. PMID: 25640526, PMCID: PMC5146951, DOI: 10.1016/j.schres.2015.01.020.Peer-Reviewed Original ResearchConceptsActive control conditionCognitive remediationComputer-assisted cognitive remediationComputer skills training programEvidence-based psychosocial interventionsCognitive remediation interventionsSocial skills trainingControl conditionSkills training programPerformance-based measuresRehabilitation interventionsStrategy trainingBody of researchNeurocognitive measuresRemediation interventionsSocial skillsSST programPsychosocial functioningPsychosocial interventionsSkills trainingImproved empathySkill groupsNeurocognitive functionPsychosocial functionTraining program
2013
Emotion self-regulation and empathy depend upon longer stimulus exposure
Ikezawa S, Corbera S, Wexler BE. Emotion self-regulation and empathy depend upon longer stimulus exposure. Social Cognitive And Affective Neuroscience 2013, 9: 1561-1568. PMID: 24064924, PMCID: PMC4187273, DOI: 10.1093/scan/nst148.Peer-Reviewed Original ResearchConceptsLate positive potentialSelf-regulatory processesEvent-related potentialsEmpathic responsesLate event-related potentialsThreat-related stimuliPain-related stimuliLonger stimulus exposuresLate ERP componentsPictures of handsStimulus exposure durationAttentional modulationERP responsesERP componentsNeural basisBrain processingStimulus exposureTask conditionsStimulus presentationNeutral situationsProcessing existClinical populationsStimulus durationExposure durationJudgment conditionAnatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia
Colibazzi T, Wexler BE, Bansal R, Hao X, Liu J, Sanchez-Peña J, Corcoran C, Lieberman JA, Peterson BS. Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia. PLOS ONE 2013, 8: e55783. PMID: 23418459, PMCID: PMC3572102, DOI: 10.1371/journal.pone.0055783.Peer-Reviewed Original ResearchConceptsCortical thicknessWhite matterCortical surface areaGray matterAnatomical abnormalitiesGM volumeWM abnormalitiesContribution of abnormalitiesRegional GM volumeHealthy controlsHigh burdenCingulate gyrusTotal cortical surface areaThinner cortexSuperior frontalAbnormalitiesLocation of abnormalitiesPerisylvian cortexSchizophreniaWM surfaceBrainCortical surfaceBrain anatomyPatientsSerial position task
2011
Heterogeneity of Auditory Verbal Working Memory in Schizophrenia
Bruder GE, Alschuler DM, Kroppmann CJ, Fekri S, Gil RB, Jarskog LF, Harkavy-Friedman JM, Goetz R, Kayser J, Wexler BE. Heterogeneity of Auditory Verbal Working Memory in Schizophrenia. Journal Of Psychopathology And Clinical Science 2011, 120: 88-97. PMID: 21319926, PMCID: PMC3061570, DOI: 10.1037/a0021661.Peer-Reviewed Original ResearchConceptsVerbal WM deficitsVerbal WMSustained attentionWM deficitsLanguage-related cortical regionsWechsler Memory Scale-RevisedAuditory hallucinationsAuditory-verbal WMVerbal Working MemoryVerbal memory deficitsGeneralized cognitive deficitHeterogeneity of schizophreniaExplicit memoryWorking memoryNonverbal memoryVisual memoryTone discriminationNonverbal testsAttentional dysfunctionAuditory perceptionSpecific deficitsCognitive deficitsMemory deficitsDiscrimination performanceMarked deficit
2008
Predictors of change in life skills in schizophrenia after cognitive remediation
Kurtz MM, Seltzer JC, Fujimoto M, Shagan DS, Wexler BE. Predictors of change in life skills in schizophrenia after cognitive remediation. Schizophrenia Research 2008, 107: 267-274. PMID: 19006657, PMCID: PMC3399665, DOI: 10.1016/j.schres.2008.10.014.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAttentionCognition DisordersComprehensionComputer-Assisted InstructionFemaleHumansInhibition, PsychologicalMemory, Short-TermMiddle AgedNeuropsychological TestsProblem SolvingPrognosisPsychiatric Status Rating ScalesPsychometricsPsychomotor PerformanceRemedial TeachingSchizophreniaSchizophrenic PsychologySocializationSoftwareVerbal LearningYoung AdultConceptsCognitive remediationAuditory attentionPerformance-based measuresRemediation interventionsComputer-assisted cognitive remediationLife skillsCognitive remediation interventionsSustained auditory attentionEveryday life skillsTreatment-related improvementTreatment process variablesOutpatient rehabilitation treatmentPredictors of changeMeasures of symptomsVerbal abilityVerbal learningTreatment outcome measuresNeurocognitive variablesNeurocognitive functionMemoryNegative symptomsSchizoaffective disorderPredictor studiesCurrent studySchizophrenia
2007
Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance
Bell M, Fiszdon J, Greig T, Wexler B, Bryson G. Neurocognitive enhancement therapy with work therapy in schizophrenia: 6-month follow-up of neuropsychological performance. The Journal Of Rehabilitation Research And Development 2007, 44: 761. PMID: 17943687, DOI: 10.1682/jrrd.2007.02.0032.Peer-Reviewed Original ResearchConceptsNeurocognitive enhancement therapyWork therapyEnhancement therapyExecutive function tasksComputer-based trainingNonverbal memoryFunction tasksExecutive functionNeuropsychological performanceNeuropsychological testsNeuropsychological assessmentCognitive deficitsCompletion of trainingNeuropsychological improvementOccupational dysfunctionMemorySchizoaffective disorderCurrent studySchizophreniaTrainingJob placementWork activitiesActive interventionTaskAnalysis of variance
2006
Computer-assisted cognitive remediation in schizophrenia: What is the active ingredient?
Kurtz MM, Seltzer JC, Shagan DS, Thime WR, Wexler BE. Computer-assisted cognitive remediation in schizophrenia: What is the active ingredient? Schizophrenia Research 2006, 89: 251-260. PMID: 17070671, PMCID: PMC2095777, DOI: 10.1016/j.schres.2006.09.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCognition DisordersComputer User TrainingComputer-Assisted InstructionFemaleHumansMaleMemory, Short-TermMental RecallMiddle AgedNeuropsychological TestsPattern Recognition, VisualProblem SolvingReaction TimeRemedial TeachingSchizophreniaSchizophrenic LanguageSchizophrenic PsychologySpeech PerceptionConceptsComputer-assisted cognitive remediationTraining control conditionCognitive remediationNeurocognitive functionComprehensive neuropsychological test batteryCognitive remediation interventionsCognitive remediation trainingSpatial episodic memoryControl conditionNeuropsychological test batteryEpisodic memoryComplex behavioral treatmentsBody of researchCognitive stimulationRemediation interventionsCognitive challengesNeurocognitive testsProcessing speedBehavioral treatmentTest batteryMemoryExperimental interventionSchizophreniaNon-specific stimulationIntervention
2005
Differences in performance and learning proficiency on the Wisconsin Card Sorting Test in schizophrenia: Do they reflect distinct neurocognitive subtypes with distinct functional profiles?
Kurtz MM, Wexler BE. Differences in performance and learning proficiency on the Wisconsin Card Sorting Test in schizophrenia: Do they reflect distinct neurocognitive subtypes with distinct functional profiles? Schizophrenia Research 2005, 81: 167-171. PMID: 16243489, DOI: 10.1016/j.schres.2005.09.003.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAttentionCognition DisordersCuesDiscrimination LearningFemaleHumansLearning DisabilitiesMaleMemory, Short-TermMiddle AgedNeuropsychological TestsPractice, PsychologicalProblem SolvingPsychometricsPsychomotor PerformanceReaction TimeSchizophreniaSchizophrenic PsychologyConceptsWisconsin Card Sorting TestUCSD Performance-based Skills AssessmentCard Sorting TestSorting TestComprehensive neurocognitive test batteryPerformance-Based Skills AssessmentDifferent neurocognitive profilesNeurocognitive test batteryPerformance-based measuresBehavioral treatment interventionsSecond measureNeurocognitive subtypesNeurocognitive profileMotor sequencingWCST performancePoor learnersTest batteryGood learnersDistinct functional profilesSubtyping of patientsTreatment interventionsIndependent measuresLearnersSkills assessmentGreater functional capacityEffects of Cigarette Smoking on Spatial Working Memory and Attentional Deficits in Schizophrenia: Involvement of Nicotinic Receptor Mechanisms
Sacco KA, Termine A, Seyal A, Dudas MM, Vessicchio JC, Krishnan-Sarin S, Jatlow PI, Wexler BE, George TP. Effects of Cigarette Smoking on Spatial Working Memory and Attentional Deficits in Schizophrenia: Involvement of Nicotinic Receptor Mechanisms. JAMA Psychiatry 2005, 62: 649-659. PMID: 15939842, DOI: 10.1001/archpsyc.62.6.649.Peer-Reviewed Original ResearchConceptsVisuospatial working memoryWorking memoryAttentional deficitsCognitive deficitsOvernight abstinenceContinuous Performance Test scoresSpatial working memoryOutpatient mental health centersPerformance test scoresCognitive enhancementCPT performanceNeuropsychological assessmentSmoking reinstatementTobacco cravingControl smokersTest scoresCounterbalanced mannerMental health centersCognitive impairmentReinstatementSubjective effectsNicotine dependenceCigarette smokingDeficitsNicotinic receptor mechanisms
2004
Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits
Bruder GE, Wexler BE, Sage MM, Gil RB, Gorman JM. Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits. Schizophrenia Research 2004, 68: 137-147. PMID: 15099598, DOI: 10.1016/s0920-9964(03)00156-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionAuditory PerceptionCerebral CortexCognition DisordersDichotic Listening TestsDominance, CerebralFemaleFunctional LateralityHumansMaleMemory DisordersMental RecallNeuropsychological TestsPaired-Associate LearningPitch DiscriminationPsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologyVerbal LearningWechsler ScalesConceptsVerbal memory deficitsMemory deficitsVerbal memoryWechsler Memory Scale-RevisedNonverbal cognitive functionsDifferent cognitive deficitsSerial position effectsVerbal materialVisual memoryNonverbal testsAuditory perceptionGeneralized deficitSelective deficitDichotic wordsHemispheric dominanceCognitive deficitsCognitive functionMemoryMedication statusHealthy controlsDeficitsOverall poor performancePosition effectsPoor performancePosition test
2002
Deficits in language-mediated mental operations in patients with schizophrenia
Wexler BE, Donegan N, Stevens AA, Jacob SA. Deficits in language-mediated mental operations in patients with schizophrenia. Schizophrenia Research 2002, 53: 171-179. PMID: 11738530, DOI: 10.1016/s0920-9964(01)00194-3.Peer-Reviewed Original ResearchConceptsMemory taskMemory deficitsMemory testFamiliar soundsNon-verbal memory testsEarly perceptual processingSerial position taskWord memory taskVerbal memory processesVerbal memory taskNon-verbal memoryVerbal memory testsPerceptual processingAttentional competenceVerbal materialVerbal stimuliStimulus itemsMemory processesMental operationsTask difficultyVisual stimuliImpaired performancePosition taskSensory processingAuditory tests
2001
Neurocognitive Enhancement Therapy With Work Therapy: Effects on Neuropsychological Test Performance
Bell M, Bryson G, Greig T, Corcoran C, Wexler BE. Neurocognitive Enhancement Therapy With Work Therapy: Effects on Neuropsychological Test Performance. JAMA Psychiatry 2001, 58: 763-768. PMID: 11483142, DOI: 10.1001/archpsyc.58.8.763.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCognitionCognition DisordersComputer-Assisted InstructionDichotic Listening TestsFeedbackFemaleFrontal LobeHumansMaleMemoryMultivariate AnalysisNeuropsychological TestsOccupational TherapyPsychomotor PerformancePsychotic DisordersSchizophreniaSchizophrenic PsychologyTeachingTreatment OutcomeConceptsNeurocognitive enhancement therapyEnhancement therapyWork therapyMental activityNeuropsychological testingLarge effect size improvementsExecutive function tasksNeuropsychological test performanceEffect size improvementsComputer-based trainingFunction tasksExecutive functionMemory performanceCognitive performanceNeuropsychological testsTraining tasksCognitive deficitsTest performanceComputer trainingCognitive dysfunctionIndependent outcome measureOccupational dysfunctionNatural contextSchizoaffective disorderMemoryEffects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia
George TP, Vessicchio JC, Termine A, Sahady DM, Head CA, Pepper WT, Kosten TR, Wexler BE. Effects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia. Neuropsychopharmacology 2001, 26: 75-85. PMID: 11751034, DOI: 10.1016/s0893-133x(01)00296-2.Peer-Reviewed Original ResearchConceptsVisuospatial working memorySmoking abstinenceStroop Color-Word TestAbstinence-induced changesWorking Memory FunctionColor-Word TestPlacebo-controlled smoking cessation trialFunction of genderWorking memoryCigarette smokingWord TestSmoking cessation trialCognitive functionCognitive deficitsMemory functionNicotine-dependent cigarette smokersNon-smoking controlsSignificant impairmentPathophysiology of schizophreniaDopamine functionCortical dopamine functionCessation trialSchizophrenic smokersDepressive symptomsAbstinence
1998
Word and Tone Working Memory Deficits in Schizophrenia
Wexler BE, Stevens AA, Bowers AA, Sernyak MJ, Goldman-Rakic PS. Word and Tone Working Memory Deficits in Schizophrenia. JAMA Psychiatry 1998, 55: 1093-1096. PMID: 9862552, DOI: 10.1001/archpsyc.55.12.1093.Peer-Reviewed Original ResearchConceptsMemory testNonverbal testsVerbal testsMemory deficitsSerial position taskTests of perceptionAuditory memory testVerbal memory deficitsWorking Memory DeficitsImmediate recall taskSignificant performance deficitsRecall taskVerbal memoryPerceptual functionsSustained attentionDiscrimination taskPitch discriminationSelective deficitNormal motivationPerformance deficitsPosition taskMemory testingCognitive functionMedicated outpatientsInformation processing
1995
Abnormal laterality in schizophrenics and their parents
Grosh E, Docherty N, Wexler B. Abnormal laterality in schizophrenics and their parents. Schizophrenia Research 1995, 14: 155-160. PMID: 7710996, DOI: 10.1016/0920-9964(94)00033-5.Peer-Reviewed Original ResearchConceptsRight ear advantageNegative emotional valenceEmotional valenceHemispheric activationLower right-ear advantagesPositive emotional valenceLateralized cerebral functionsLeft-hemispheric activationDichotic word testNeutral wordsPerceptual asymmetryPerceptual advantageWord TestDichotic testsEar advantageValenceWordsParentsAbnormal lateralitySchizophrenic offspringSchizophrenicsSchizophrenic patientsCerebral functionSame subjectsLaterality
1994
Abnormalities in rapid, automatic aspects of attention in schizophrenia: blunted inhibition of return
Huey E, Wexler B. Abnormalities in rapid, automatic aspects of attention in schizophrenia: blunted inhibition of return. Schizophrenia Research 1994, 14: 57-63. PMID: 7893622, DOI: 10.1016/0920-9964(94)90009-4.Peer-Reviewed Original ResearchConceptsHealthy subjectsHealthy control subjectsStable schizophrenic outpatientsInhibition of returnMs intervalsControl subjectsSchizophrenic outpatientsNormal intervalsInhibitory mechanismInhibitionVisual stimuliSchizophrenicsSubjectsStimuliIntervalPresent experimentsOutpatientsAbnormalitiesSchizophreniaDecreased perceptual sensitivity to emotion-evoking stimuli in depression
Wexler B, Levenson L, Warrenburg S, Price L. Decreased perceptual sensitivity to emotion-evoking stimuli in depression. Psychiatry Research 1994, 51: 127-138. PMID: 8022947, DOI: 10.1016/0165-1781(94)90032-9.Peer-Reviewed Original ResearchConceptsFacial displaysOwn faceNegative emotion-related wordsEmotion-evoking stimuliEmotion-related wordsDichotic listening paradigmEmotion-related stimuliNegative facial displaysNormal cognitive processingNeutral wordsAutomatic mimicryCognitive processingPerceptual sensitivityFacial mimicryNegative wordsEmotional responsesDichotic testsSelective perceptionDepressed patientsStimuliWordsHealthy controlsEmotionsFaceSuch measures
1993
Asymmetrical Visual Deprivation: A Technique to Differentially Influence Lateral Hemispheric Function
Levick S, Wexler B, Lorig T, Gur R, Gur R, Schwartz G. Asymmetrical Visual Deprivation: A Technique to Differentially Influence Lateral Hemispheric Function. Perceptual And Motor Skills 1993, 76: 1363-1382. PMID: 8337093, DOI: 10.2466/pms.1993.76.3c.1363.Peer-Reviewed Original ResearchConceptsVisual deprivationHemispheric functionCross-modal influencesSpatial orientation taskPerception of pleasantnessLine bisection testVisual attentionVerbal reasoningContact lens methodIntegrated brainOrientation taskLeft hemisphereMood statesEEG thetaMore thetaLateral asymmetryActivation balanceGeneral hypothesisThetaPleasantnessDeprivationHemisphereInput deprivationPerceptionTask