The CTNA has 8 components that function together as an integrated whole. They are organized into 4 Cores (Administrative, Genetics, Clinical, Pilot) and 4 Projects.
- Administrative Core: The Administrative Core, directed by Dr. Kelly DeMartini and Dr. John Krystal, provides an administrative infrastructure for the CTNA, including data management and statistical support, budget functions, and scientific oversight for all projects.
- Clinical Core: The Clinical Core, directed Dr. Stephanie O'Malley, provides for the centralized development and quality control of clinical assessments for all projects.
- Translational Technologies Core: The Translational Technologies Core, directed by Dr. Joel Gelernter and Dr. Alan Anticevic, supports genotyping for each of the projects in order to understand the genetic contributions to drinking behaviors.
- Pilot Core: The Pilot Projects Core, directed by Dr. John Krystal, provides a mechanism to initiate small-scale investigations that implement new technologies or to test important hypotheses associated with the CTNA mission.
- Project 1: The interaction of DA/glutamate signaling in vulnerability to aberant alcohol seeking
- Project 2: Functional Neuroimaging of Alcoholism Vulnerability: Probing Glutamate and Reward, Using the Fyn Kinase Inhibitor Drug, Saracatinib
- Project 3: Fyn Kinase Inhibitors and Alcohol Drinking Behaviors in Heavy Drinkers