High dietary K+ intake inhibits proximal tubule transport
Wang T, Liu T, Xu S, Frindt G, Weinstein A, Palmer L. High dietary K+ intake inhibits proximal tubule transport. American Journal Of Physiology. Renal Physiology 2023, 325: f224-f234. PMID: 37318989, PMCID: PMC10396284, DOI: 10.1152/ajprenal.00013.2023.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateFree-flow micropunctureFiltration rateUrine volumeFractional NaNephron segmentsOverall kidney functionProximal tubule transportProximal tubule functionNHE3 protein expressionExchanger isoform 3HK animalsKCl dietFraction excretionKidney functionHigh dietaryTubule functionKidney microsomesTubule transportAnesthetized animalsProximal tubulesVolume reabsorptionExcretionWestern blotControl diet