Publications
Showing 1 - 100 results of 5,934 publications
2024
- In silico and in vitro models reveal the molecular mechanisms of hypocontractility caused by TPM1 M8RCreso J, Gokhan I, Rynkiewicz M, Lehman W, Moore J, Campbell S. In silico and in vitro models reveal the molecular mechanisms of hypocontractility caused by TPM1 M8R. Frontiers In Physiology 2024, 15: 1452509. DOI: 10.3389/fphys.2024.1452509.
- miR-33 deletion in hepatocytes attenuates NAFLD-NASH-HCC progressionFernández-Tussy P, Cardelo M, Zhang H, Sun J, Price N, Boutagy N, Goedeke L, Cadena-Sandoval M, Xirouchaki C, Brown W, Yang X, Pastor-Rojo O, Haeusler R, Bennett A, Tiganis T, Suárez Y, Fernández-Hernando C. miR-33 deletion in hepatocytes attenuates NAFLD-NASH-HCC progression. JCI Insight 2024 PMID: 39190492, DOI: 10.1172/jci.insight.168476.
- The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesityLaughlin M, McIndoe R, Adams S, Araiza R, Ayala J, Kennedy L, Lanoue L, Lantier L, Macy J, Malabanan E, McGuinness O, Perry R, Port D, Qi N, Elias C, Shulman G, Wasserman D, Lloyd K. The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity. Mammalian Genome 2024, 1-12. PMID: 39191872, DOI: 10.1007/s00335-024-10067-y.
- Phosphoenolpyruvate carboxykinase-2 (PCK2) is a therapeutic target in triple-negative breast cancerGunasekharan V, Lin H, Marczyk M, Rios-Hoyo A, Campos G, Shan N, Ahmed M, Umlauf S, Gareiss P, Raaisa R, Williams R, Cardone R, Siebel S, Kibbey R, Surovtseva Y, Pusztai L. Phosphoenolpyruvate carboxykinase-2 (PCK2) is a therapeutic target in triple-negative breast cancer. Breast Cancer Research And Treatment 2024, 1-15. PMID: 39177932, DOI: 10.1007/s10549-024-07462-z.
- Small molecule inhibition of glycogen synthase I reduces muscle glycogen content and improves biomarkers in a mouse model of Pompe diseaseGaspar R, Sakuma I, Nasiri A, Hubbard B, LaMoia T, Leitner B, Tep S, Xi Y, Greene E, Ullman J, Petersen K, Shulman G. Small molecule inhibition of glycogen synthase I reduces muscle glycogen content and improves biomarkers in a mouse model of Pompe disease. AJP Endocrinology And Metabolism 2024 PMID: 39171753, DOI: 10.1152/ajpendo.00175.2024.
- Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver diseasePetersen K, Dufour S, Mehal W, Shulman G. Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease. Cell Metabolism 2024 PMID: 39197461, DOI: 10.1016/j.cmet.2024.07.023.
- Reducing filamin A restores cortical synaptic connectivity and early social communication following cellular mosaicism in ASD pathways.Binder M, Escobar I, Xu Y, Sokolov A, Zhang L, Bordey A. Reducing filamin A restores cortical synaptic connectivity and early social communication following cellular mosaicism in ASD pathways. Journal Of Neuroscience 2024 PMID: 39164108, DOI: 10.1523/jneurosci.1245-23.2024.
- Early thrombus formation is required of eccentric and heterogenous neointimal hyperplasia under disturbed flowBai H, Li Z, Zhang W, Thaxton C, Ohashi Y, Gonzalez L, Kano M, Yatsula B, Hwa J, Dardik A. Early thrombus formation is required of eccentric and heterogenous neointimal hyperplasia under disturbed flow. Journal Of Thrombosis And Haemostasis 2024 PMID: 39173878, DOI: 10.1016/j.jtha.2024.07.028.
- Structural bases for Na+-Cl− cotransporter inhibition by thiazide diuretic drugs and activation by kinasesZhao Y, Schubert H, Blakely A, Forbush B, Smith M, Rinehart J, Cao E. Structural bases for Na+-Cl− cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nature Communications 2024, 15: 7006. PMID: 39143061, PMCID: PMC11324901, DOI: 10.1038/s41467-024-51381-y.
- Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activationLaMoia T, Hubbard B, Guerra M, Nasiri A, Sakuma I, Kahn M, Zhang D, Goodman R, Nathanson M, Sancak Y, Perelis M, Mootha V, Shulman G. Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation. Cell Metabolism 2024 PMID: 39153480, DOI: 10.1016/j.cmet.2024.07.016.
- A subdural CMOS optical device for bidirectional neural interfacingPollmann E, Yin H, Uguz I, Dubey A, Wingel K, Choi J, Moazeni S, Gilhotra Y, Andino-Pavlovsky V, Banees A, Parihar A, Boominathan V, Robinson J, Veeraraghavan A, Pieribone V, Pesaran B, Shepard K. A subdural CMOS optical device for bidirectional neural interfacing. Nature Electronics 2024, 1-13. DOI: 10.1038/s41928-024-01209-w.
- VCAM-1 mediates proximal tubule-immune cell crosstalk in failed tubule recovery during AKI-to-CKD transitionMelchinger I, Guo K, Li X, Guo J, Cantley L, Xu L. VCAM-1 mediates proximal tubule-immune cell crosstalk in failed tubule recovery during AKI-to-CKD transition. American Journal Of Physiology. Renal Physiology 2024 PMID: 39116349, DOI: 10.1152/ajprenal.00076.2024.
- Enhanced intratumoral delivery of immunomodulator MPLA via hyperbranched polyglycerol-coated biodegradable nanoparticlesChang J, Shin K, Lewis J, Suh H, Lee J, Damsky W, Xu S, Bosenberg M, Saltzman W, Girardi M. Enhanced intratumoral delivery of immunomodulator MPLA via hyperbranched polyglycerol-coated biodegradable nanoparticles. Journal Of Investigative Dermatology 2024 PMID: 39122142, DOI: 10.1016/j.jid.2024.07.019.
- Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory roleAnastasakis D, Apostolidi M, Garman K, Polash A, Umar M, Meng Q, Scutenaire J, Jarvis J, Wang X, Haase A, Brownell I, Rinehart J, Hafner M. Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role. Molecular Cell 2024 PMID: 39153475, DOI: 10.1016/j.molcel.2024.07.025.
- Next generation triplex-forming PNAs for site-specific genome editing of the F508del CFTR mutationGupta A, Barone C, Quijano E, Piotrowski-Daspit A, Perera J, Riccardi A, Jamali H, Turchick A, Zao W, Saltzman W, Glazer P, Egan M. Next generation triplex-forming PNAs for site-specific genome editing of the F508del CFTR mutation. Journal Of Cystic Fibrosis 2024 PMID: 39107154, DOI: 10.1016/j.jcf.2024.07.009.
- Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculatureDel Gaudio I, Nitzsche A, Boyé K, Bonnin P, Poulet M, Nguyen T, Couty L, Ha H, Nguyen D, Cazenave-Gassiot A, Alaya K, Thérond P, Chun J, Wenk M, Proia R, Henrion D, Nguyen L, Eichmann A, Camerer E. Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature. Cardiovascular Research 2024, cvae168. PMID: 39086170, DOI: 10.1093/cvr/cvae168.
- A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuriaFaniyan T, Zhang X, Morgan D, Robles J, Bathina S, Brookes P, Rahmouni K, Perry R, Chhabra K. A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria. ELife 2024, 12 DOI: 10.7554/elife.91540.4.
- A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuriaFaniyan T, Zhang X, Morgan D, Robles J, Bathina S, Brookes P, Rahmouni K, Perry R, Chhabra K. A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria. ELife 2024, 12: rp91540. PMID: 39082939, PMCID: PMC11290820, DOI: 10.7554/elife.91540.
- The interactions between energy homeostasis and neurovascular plasticityChen B, de Launoit E, Meseguer D, Garcia Caceres C, Eichmann A, Renier N, Schneeberger M. The interactions between energy homeostasis and neurovascular plasticity. Nature Reviews Endocrinology 2024, 1-11. PMID: 39054359, DOI: 10.1038/s41574-024-01021-8.
- Dopamine-mediated interactions between short- and long-term memory dynamicsHuang C, Luo J, Woo S, Roitman L, Li J, Pieribone V, Kannan M, Vasan G, Schnitzer M. Dopamine-mediated interactions between short- and long-term memory dynamics. Nature 2024, 1-3. PMID: 39038490, DOI: 10.1038/s41586-024-07819-w.
- Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunctionRudokas M, McKay M, Toksoy Z, Eisen J, Bögner M, Young L, Akar F. Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction. Cardiovascular Diabetology 2024, 23: 261. PMID: 39026280, PMCID: PMC11264840, DOI: 10.1186/s12933-024-02357-1.
- Wound Healing Society 2023 update on guidelines for arterial ulcersFederman D, Dardik A, Shapshak D, Ueno C, Masterson L, Hopf H, Abdullah N, Junkins S, Mostow E. Wound Healing Society 2023 update on guidelines for arterial ulcers. Wound Repair And Regeneration 2024 PMID: 39021056, DOI: 10.1111/wrr.13204.
- O-GlcNAc modification in endothelial cells modulates adiposity via fat absorption from the intestine in miceOhgaku S, Ida S, Ohashi N, Morino K, Ishikado A, Yanagimachi T, Murata K, Sato D, Ugi S, Nasiri A, Shulman G, Maegawa H, Kume S, Fujita Y. O-GlcNAc modification in endothelial cells modulates adiposity via fat absorption from the intestine in mice. Heliyon 2024, 10: e34490. PMID: 39130439, PMCID: PMC11315187, DOI: 10.1016/j.heliyon.2024.e34490.
- Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernationMohr S, Dai Pra R, Platt M, Feketa V, Shanabrough M, Varela L, Kristant A, Cao H, Merriman D, Horvath T, Bagriantsev S, Gracheva E. Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation. Nature Communications 2024, 15: 5803. PMID: 38987241, PMCID: PMC11236985, DOI: 10.1038/s41467-024-49996-2.
- Downregulation of adipose LPL by PAR2 contributes to the development of hypertriglyceridemiaHuang Y, Chen L, Li L, Qi Y, Tong H, Wu H, Xu J, Leng L, Cheema S, Sun G, Xia Z, McGuire J, Rodrigues B, Young L, Bucala R, Qi D. Downregulation of adipose LPL by PAR2 contributes to the development of hypertriglyceridemia. JCI Insight 2024, 9: e173240. PMID: 38973609, DOI: 10.1172/jci.insight.173240.
- Frequency-modulated timer regulates torpor–arousal cycles during hibernation in distinct small mammalian hibernatorsGibo S, Yamaguchi Y, Gracheva E, Bagriantsev S, Tokuda I, Kurosawa G. Frequency-modulated timer regulates torpor–arousal cycles during hibernation in distinct small mammalian hibernators. Npj Biological Timing And Sleep 2024, 1: 3. DOI: 10.1038/s44323-024-00002-4.
- ACVR1/ALK2-p21 signaling axis modulates proliferation of the venous endothelium in the retinal vasculaturePak B, Kim M, Han O, Lee H, Dubrac A, Choi W, Yang J, Boyé K, Cho H, Citrin K, Kim I, Eichmann A, Bautch V, Jin S. ACVR1/ALK2-p21 signaling axis modulates proliferation of the venous endothelium in the retinal vasculature. Angiogenesis 2024, 1-13. PMID: 38955953, DOI: 10.1007/s10456-024-09936-6.
- Preventing MMP23-mediated cleavage of podocyte RARRES1: a novel strategy to halt chronic kidney disease progression?Medina Rangel P, Ishibe S. Preventing MMP23-mediated cleavage of podocyte RARRES1: a novel strategy to halt chronic kidney disease progression? Kidney International 2024, 106: 16-18. PMID: 38906649, DOI: 10.1016/j.kint.2024.05.004.
- Branching in poly(amine-co-ester) polyplexes impacts mRNA transfectionShin K, Suh H, Suberi A, Whang C, Ene M, Grundler J, Grun M, Saltzman W. Branching in poly(amine-co-ester) polyplexes impacts mRNA transfection. Biomaterials 2024, 311: 122692. PMID: 38986360, PMCID: PMC11298310, DOI: 10.1016/j.biomaterials.2024.122692.
- Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitisOgino N, Leite M, Guerra M, Kruglov E, Asashima H, Hafler D, Ito T, Pereira J, Peiffer B, Sun Z, Ehrlich B, Nathanson M. Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis. Journal Of Clinical Investigation 2024, 134: e171691. PMID: 38916955, PMCID: PMC11324315, DOI: 10.1172/jci171691.
- Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocorticoid kinase 1 and TrikaftaDastoor P, Muiler C, Garrison A, Egan M, Carlos Dos Reis D, Santos A, Ameen N. Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocorticoid kinase 1 and Trikafta. European Journal Of Pharmacology 2024, 978: 176771. PMID: 38925289, DOI: 10.1016/j.ejphar.2024.176771.
- Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in miceTsuzuki A, Yamasaki M, Konno K, Miyazaki T, Takei N, Tomita S, Yuzaki M, Watanabe M. Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice. Scientific Reports 2024, 14: 14193. PMID: 38902419, PMCID: PMC11189931, DOI: 10.1038/s41598-024-65076-3.
- 3-Hydroxykynurenine targets kainate receptors to promote defense against infectionParada-Kusz M, Clatworthy A, Goering E, Blackwood S, Shigeta J, Mashin E, Salm E, Choi C, Combs S, Lee J, Rodriguez-Osorio C, Clish C, Tomita S, Hung D. 3-Hydroxykynurenine targets kainate receptors to promote defense against infection. Nature Chemical Biology 2024, 1-11. PMID: 38898166, DOI: 10.1038/s41589-024-01635-z.
- 1571-P: CIDEB and CGI-58 Regulate Liver Lipid Droplet Size with Cholesterol Content, Linking to Inflammation and Fibrosis in Metabolic Dysfunction–Associated SteatohepatitisSAKUMA I, GASPAR R, NASIRI A, KAHN M, ZHENG J, GUERRA M, YIMLAMAI D, MURRAY S, PERELIS M, BARNES W, VATNER D, PETERSEN K, SAMUEL V, SHULMAN G. 1571-P: CIDEB and CGI-58 Regulate Liver Lipid Droplet Size with Cholesterol Content, Linking to Inflammation and Fibrosis in Metabolic Dysfunction–Associated Steatohepatitis. Diabetes 2024, 73 DOI: 10.2337/db24-1571-p.
- 292-OR: Coenzyme A Synthase Knockdown Alleviates Metabolic Dysfunction–Associated Steatohepatitis via Decreasing Cholesterol in Liver Lipid DropletsSAKUMA I, GASPAR R, NASIRI A, KAHN M, GUERRA M, YIMLAMAI D, MURRAY S, PERELIS M, BARNES W, VATNER D, PETERSEN K, SAMUEL V, SHULMAN G. 292-OR: Coenzyme A Synthase Knockdown Alleviates Metabolic Dysfunction–Associated Steatohepatitis via Decreasing Cholesterol in Liver Lipid Droplets. Diabetes 2024, 73 DOI: 10.2337/db24-292-or.
- 1577-P: CIDEB Knockdown Promotes Increased Hepatic Mitochondrial Fat Oxidation and Reverses Hepatic Steatosis and Hepatic Insulin Resistance by the PKCε-Insulin Receptor Kinase PathwayZHENG J, NASIRI A, GASPAR R, HUBBARD B, SAKUMA I, MA X, MURRAY S, PERELIS M, BARNES W, SAMUEL V, PETERSEN K, SHULMAN G. 1577-P: CIDEB Knockdown Promotes Increased Hepatic Mitochondrial Fat Oxidation and Reverses Hepatic Steatosis and Hepatic Insulin Resistance by the PKCε-Insulin Receptor Kinase Pathway. Diabetes 2024, 73 DOI: 10.2337/db24-1577-p.
- 1583-P: Measuring Mitochondrial Metabolism In Vivo with [1,2-13C2]-L-Glutamine Mass IsotopomersSIEBEL S, CARDONE R, MASON G, KIBBEY R. 1583-P: Measuring Mitochondrial Metabolism In Vivo with [1,2-13C2]-L-Glutamine Mass Isotopomers. Diabetes 2024, 73 DOI: 10.2337/db24-1583-p.
- 899-P: Combinations of the Mitochondrial Protonophore TLC-6740 and/or the ACC2 Inhibitor TLC-3595 Provide Additive Glycemic Benefits to Semaglutide (SEMA) in db/db MiceVIJAYAKUMAR A, SRODA N, MURAKAMI E, WENG S, MYERS R, SUBRAMANIAN M, SHULMAN G. 899-P: Combinations of the Mitochondrial Protonophore TLC-6740 and/or the ACC2 Inhibitor TLC-3595 Provide Additive Glycemic Benefits to Semaglutide (SEMA) in db/db Mice. Diabetes 2024, 73 DOI: 10.2337/db24-899-p.
- 1886-LB: Safety, PK, and Preliminary Efficacy of the Liver-Targeted Mitochondrial Protonophore TLC-6740—A Phase 1 StudyGANE E, HUSS R, SUR J, MURAKAMI E, WENG S, KIRBY B, SHAH A, SHULMAN G, SUBRAMANIAN M, VIJAYAKUMAR A, MYERS R. 1886-LB: Safety, PK, and Preliminary Efficacy of the Liver-Targeted Mitochondrial Protonophore TLC-6740—A Phase 1 Study. Diabetes 2024, 73 DOI: 10.2337/db24-1886-lb.
- 1637-P: TLC-6740, a Liver-Targeted Mitochondrial Protonophore, Increases Energy Expenditure and Lipid Utilization in Obese MiceSRODA N, VIJAYAKUMAR A, MURAKAMI E, WENG S, SHULMAN G, MYERS R, SUBRAMANIAN M. 1637-P: TLC-6740, a Liver-Targeted Mitochondrial Protonophore, Increases Energy Expenditure and Lipid Utilization in Obese Mice. Diabetes 2024, 73 DOI: 10.2337/db24-1637-p.
- 1734-P: ADP Privation of Human Beta-Cell Mitochondria by Pyruvate KinaseRUZ-MALDONADO I, CARDONE R, KIBBEY R. 1734-P: ADP Privation of Human Beta-Cell Mitochondria by Pyruvate Kinase. Diabetes 2024, 73 DOI: 10.2337/db24-1734-p.
- Notch signaling regulates UNC5B to suppress endothelial proliferation, migration, junction activity, and retinal plexus branchingRaza Q, Nadeem T, Youn S, Swaminathan B, Gupta A, Sargis T, Du J, Cuervo H, Eichmann A, Ackerman S, Naiche L, Kitajewski J. Notch signaling regulates UNC5B to suppress endothelial proliferation, migration, junction activity, and retinal plexus branching. Scientific Reports 2024, 14: 13603. PMID: 38866944, PMCID: PMC11169293, DOI: 10.1038/s41598-024-64375-z.
- L-type calcium channel regulation of depression, anxiety and anhedonia-related behavioral phenotypes following chronic stress exposureNunes E, Kebede N, Rajadhyaksha A, Addy N. L-type calcium channel regulation of depression, anxiety and anhedonia-related behavioral phenotypes following chronic stress exposure. Neuropharmacology 2024, 257: 110031. PMID: 38871116, PMCID: PMC11334593, DOI: 10.1016/j.neuropharm.2024.110031.
- Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodelingOhashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.
- Hyperlipidemia and Comprehensive Vascular Events (CVEs) - a Novel Outcome Measure for Peripheral Arterial DiseaseTuttle M, Wells N, Hundito A, Alameddine D, Huttler J, Mena-Hurtado C, Turner J, Inzucchi S, Dardik A, Guzman R, Chaar C. Hyperlipidemia and Comprehensive Vascular Events (CVEs) - a Novel Outcome Measure for Peripheral Arterial Disease. Journal Of Vascular Surgery 2024, 79: e176-e177. DOI: 10.1016/j.jvs.2024.03.220.
- Engineered heart tissue: Design considerations and the state of the artGokhan I, Blum T, Campbell S. Engineered heart tissue: Design considerations and the state of the art. Biophysics Reviews 2024, 5: 021308. PMID: 38912258, PMCID: PMC11192576, DOI: 10.1063/5.0202724.
- ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during agingJiang Q, Song G, He L, Li X, Jiang B, Wang Q, Wang S, Kim C, Barkestani M, Lopez R, Fan M, Wanniarachchi K, Quaranta M, Tian X, Mani A, Gonzalez A, Goodwin J, Sessa W, Ishibe S, Jane-Wit D. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging. Kidney International 2024, 106: 419-432. PMID: 38797325, PMCID: PMC11343665, DOI: 10.1016/j.kint.2024.05.007.
- Molecular and cellular neurocardiology in heart diseaseHabecker B, Bers D, Birren S, Chang R, Herring N, Kay M, Li D, Mendelowitz D, Mongillo M, Montgomery J, Ripplinger C, Tampakakis E, Winbo A, Zaglia T, Zeltner N, Paterson D. Molecular and cellular neurocardiology in heart disease. The Journal Of Physiology 2024 PMID: 38778747, DOI: 10.1113/jp284739.
- A surgeon-scientist's approach to improving arteriovenous fistula patencyDardik A. A surgeon-scientist's approach to improving arteriovenous fistula patency. JVS Vascular Science 2024, 5: 100207. PMID: 38975292, PMCID: PMC11225657, DOI: 10.1016/j.jvssci.2024.100207.
- Deficits in brain glucose transport among younger adults with obesityGunawan F, Matson B, Coppoli A, Jiang L, Ding Y, Perry R, Sanchez‐Rangel E, DeAguiar R, Behar K, Rothman D, Mason G, Hwang J. Deficits in brain glucose transport among younger adults with obesity. Obesity 2024, 32: 1329-1338. PMID: 38764181, DOI: 10.1002/oby.24034.
- Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoysPiotrowski-Daspit A, Bracaglia L, Eaton D, Richfield O, Binns T, Albert C, Gould J, Mortlock R, Egan M, Pober J, Saltzman W. Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys. Nature Communications 2024, 15: 4247. PMID: 38762483, PMCID: PMC11102454, DOI: 10.1038/s41467-024-48442-7.
- Interleukin-16 is increased in dialysis patients but is not a cardiovascular risk factorBrösecke F, Pfau A, Ermer T, Dein Terra Mota Ribeiro A, Rubenbauer L, Rao V, Burlein S, Genser B, Reichel M, Aronson P, Coca S, Knauf F. Interleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor. Scientific Reports 2024, 14: 11323. PMID: 38760468, PMCID: PMC11101424, DOI: 10.1038/s41598-024-61808-7.
- Modifying the Backbone Chemistry of PEG‐based Bottlebrush Block Copolymers for the Formation of Long‐Circulating NanoparticlesGrundler J, Whang C, Shin K, Savan N, Zhong M, Saltzman W. Modifying the Backbone Chemistry of PEG‐based Bottlebrush Block Copolymers for the Formation of Long‐Circulating Nanoparticles. Advanced Healthcare Materials 2024, e2304040. PMID: 38734871, DOI: 10.1002/adhm.202304040.
- Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesityParlakgül G, Pang S, Artico L, Min N, Cagampan E, Villa R, Goncalves R, Lee G, Xu C, Hotamışlıgil G, Arruda A. Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity. Nature Communications 2024, 15: 3982. PMID: 38729945, PMCID: PMC11087507, DOI: 10.1038/s41467-024-48272-7.
- Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluationGrun M, Honhar P, Wang Y, Rossano S, Khang M, Suh H, Fowles K, Kliman H, Cavaliere A, Carson R, Marquez‐Nostra B, Saltzman W. Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation. Bioengineering & Translational Medicine 2024 DOI: 10.1002/btm2.10661.
- A new rat model of aortic sympathetic denervationPavlyha M, Dardik A. A new rat model of aortic sympathetic denervation. JVS Vascular Science 2024, 5: 100205. PMID: 38962560, PMCID: PMC11219950, DOI: 10.1016/j.jvssci.2024.100205.
- Modelling lower-limb peripheral arterial disease using clinically available datasets: impact of inflow boundary conditions on hemodynamic indices for restenosis predictionNinno F, Chiastra C, Colombo M, Dardik A, Strosberg D, Aboian E, Tsui J, Bartlett M, Balabani S, Díaz-Zuccarini V. Modelling lower-limb peripheral arterial disease using clinically available datasets: impact of inflow boundary conditions on hemodynamic indices for restenosis prediction. Computer Methods And Programs In Biomedicine 2024, 251: 108214. PMID: 38759252, DOI: 10.1016/j.cmpb.2024.108214.
- Elastocapillary effects determine early matrix deformation by glioblastoma cell spheroidsAng I, Yousafzai M, Yadav V, Mohler K, Rinehart J, Bouklas N, Murrell M. Elastocapillary effects determine early matrix deformation by glioblastoma cell spheroids. APL Bioengineering 2024, 8: 026109. PMID: 38706957, PMCID: PMC11069407, DOI: 10.1063/5.0191765.
- Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT InhibitorsMurray M, Noronha K, Wang Y, Friedman A, Paradkar S, Suh H, Sundaram R, Brenner C, Saltzman W, Bindra R. Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors. Molecular Cancer Therapeutics 2024, 23: 1176-1187. PMID: 38691846, PMCID: PMC11292319, DOI: 10.1158/1535-7163.mct-24-0012.
- The Biological Psychiatry Cover Art Initiative: Addressing the Underrepresentation of Black People on the Journal Cover Through a Series of Commissioned ArtworksKrystal J, Addy N, Imeh I. The Biological Psychiatry Cover Art Initiative: Addressing the Underrepresentation of Black People on the Journal Cover Through a Series of Commissioned Artworks. Biological Psychiatry 2024, 95: s26. DOI: 10.1016/j.biopsych.2024.02.068.
- Su1930 STRESS-INDUCED SIGNALING AND CFTR IN SGK1 KNOCK OUT MOUSE INTESTINEMuiler C, Santos A, Dastoor P, Jin J, Reis D, Kazi M, Ameen N. Su1930 STRESS-INDUCED SIGNALING AND CFTR IN SGK1 KNOCK OUT MOUSE INTESTINE. Gastroenterology 2024, 166: s-874. DOI: 10.1016/s0016-5085(24)02489-2.
- 978 CFTR HIGH EXPRESSER CELLS EXPRESS NEUROPOD GENES AND RESPOND TO ENVIRONMENTAL CUES IN THE INTESTINEJin J, Reis D, Muiler C, Sumigray K, Ameen N. 978 CFTR HIGH EXPRESSER CELLS EXPRESS NEUROPOD GENES AND RESPOND TO ENVIRONMENTAL CUES IN THE INTESTINE. Gastroenterology 2024, 166: s-236. DOI: 10.1016/s0016-5085(24)01027-8.
- High Resolution Reconstruction of the Proximal Tubule Apical Endocytic PathwayLackner E, Pandya R, Burdyniuk M, Xu C, Pang S, Caplan M, Weisz O. High Resolution Reconstruction of the Proximal Tubule Apical Endocytic Pathway. Physiology 2024, 39: 998. DOI: 10.1152/physiol.2024.39.s1.998.
- Volume microscopic analysis of membrane contact sites in mouse kidney renal proximal tubule epithelial cellsPandya R, Pang S, Lackner E, Reyna-Neyra A, Li W, Sy K, Burdyniuk M, Weisz O, Xu C, Caplan M. Volume microscopic analysis of membrane contact sites in mouse kidney renal proximal tubule epithelial cells. Physiology 2024, 39: 1086. DOI: 10.1152/physiol.2024.39.s1.1086.
- mTOR in Acquired and Genetic Models of EpilepsyWong M, Bordey A, Danzer S. mTOR in Acquired and Genetic Models of Epilepsy. 2024, 45-74. DOI: 10.1093/med/9780197549469.003.0004.
- Abstract 3092: Smooth Muscle Cell Tgf-β Receptor Knockout Improves Arteriovenous Fistula Maturation Via Attenuation Of AutophagyZhang W, Bai H, Gonzalez L, Li Z, Ohashi Y, Thaxton C, aoyagi Y, Yatsula B, Kano M, Xie Y, Cai Y, Chang S, Dardik A. Abstract 3092: Smooth Muscle Cell Tgf-β Receptor Knockout Improves Arteriovenous Fistula Maturation Via Attenuation Of Autophagy. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44 DOI: 10.1161/atvb.44.suppl_1.3092.
- Abstract 1130: Tenascin-C In Arteriovenous Fistula Failure: Unraveling Venous Remodeling DynamicsGonzalez L, Zhang W, Ohashi Y, Vazquez-Padron R, Dardik A. Abstract 1130: Tenascin-C In Arteriovenous Fistula Failure: Unraveling Venous Remodeling Dynamics. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44 DOI: 10.1161/atvb.44.suppl_1.1130.
- Abstract 2011: Development Of Machine Learning Model To Combine Clinical And Imaging Data For Prediction Of Endoleaks: Proof-of-concept StudyKiang S, Roh D, Dardik A, Tomihama R. Abstract 2011: Development Of Machine Learning Model To Combine Clinical And Imaging Data For Prediction Of Endoleaks: Proof-of-concept Study. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44 DOI: 10.1161/atvb.44.suppl_1.2011.
- Abstract 3143: Computational Modeling Of Non-homeostatic Changes Within An Arterial-venous Fistula System Using In Vivo Validation To Understand Mechanical Causes Of Fistula FailureVarsanik M, Thaxton C, Li W, Dardik A, Pocivavsek L. Abstract 3143: Computational Modeling Of Non-homeostatic Changes Within An Arterial-venous Fistula System Using In Vivo Validation To Understand Mechanical Causes Of Fistula Failure. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44 DOI: 10.1161/atvb.44.suppl_1.3143.
- Understanding Impact of CFTR Dysfunction on Airway Immune Cell Composition in Early Lung Disease PathogenesisKockar Kizilirmak T, Yin H, Garrison A, Bruscia E, Egan M, Britto-Leon C. Understanding Impact of CFTR Dysfunction on Airway Immune Cell Composition in Early Lung Disease Pathogenesis. 2024, a6357-a6357. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6357.
- Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach.Regan C, Scierka L, Dardik A, Tonnessen B, Iyad Ochoa Chaar C, Ionescu C, Aboian E, Cardella J, Nassiri N, Guzman R, Attaran R, Nagpal S, Shah S, Smolderen K, Mena-Hurtado C. Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach. Vascular 2024, 17085381241246318. PMID: 38669051, DOI: 10.1177/17085381241246318.
- Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiringSun J, Esplugues E, Bort A, Cardelo M, Ruz-Maldonado I, Fernández-Tussy P, Wong C, Wang H, Ojima I, Kaczocha M, Perry R, Suárez Y, Fernández-Hernando C. Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring. Nature Metabolism 2024, 6: 741-763. PMID: 38664583, DOI: 10.1038/s42255-024-01019-6.
- The Technical and Ethical Framework of Fetal Therapy: Past and Current AdvancesLynn A, Glazer P, Saltzman W, Stitelman D. The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances. Current Stem Cell Reports 2024, 10: 30-36. DOI: 10.1007/s40778-024-00235-w.
- The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3Hanke-Gogokhia C, Zapadka T, Finkelstein S, Klingeborn M, Maugel T, Singer J, Arshavsky V, Demb J. The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3. Journal Of Neuroscience 2024, 44: e1379232024. PMID: 38641407, PMCID: PMC11209669, DOI: 10.1523/jneurosci.1379-23.2024.
- Lost in the dark: Antipatharia-Symbiodiniaceae association in the deep waters of the Red SeaVicario S, Terraneo T, Castano C, Chimienti G, Oury N, Vimercati S, Hume B, Marchese F, Nolan M, Eweida A, Purkis S, Rodrigue M, Pieribone V, Qurban M, Duarte C, Benzoni F. Lost in the dark: Antipatharia-Symbiodiniaceae association in the deep waters of the Red Sea. Frontiers In Marine Science 2024, 11: 1330118. DOI: 10.3389/fmars.2024.1330118.
- Calcium signalling and transport in the kidneyStaruschenko A, Alexander R, Caplan M, Ilatovskaya D. Calcium signalling and transport in the kidney. Nature Reviews Nephrology 2024, 20: 541-555. PMID: 38641658, DOI: 10.1038/s41581-024-00835-z.
- Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model!Merrins M, Kibbey R. Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model! Diabetes 2024, 73: 856-863. PMID: 38768366, PMCID: PMC11109790, DOI: 10.2337/dbi23-0032.
- Presynaptic Proteins and Their Roles in Visual Processing by the Retina.Thoreson W, Zenisek D. Presynaptic Proteins and Their Roles in Visual Processing by the Retina. Annual Review Of Vision Science 2024 PMID: 38621251, DOI: 10.1146/annurev-vision-101322-111204.
- COPII with ALG2 and ESCRTs control lysosome-dependent microautophagy of ER exit sitesLiao Y, Pang S, Li W, Shtengel G, Choi H, Schaefer K, Xu C, Lippincott-Schwartz J. COPII with ALG2 and ESCRTs control lysosome-dependent microautophagy of ER exit sites. Developmental Cell 2024, 59: 1410-1424.e4. PMID: 38593803, DOI: 10.1016/j.devcel.2024.03.027.
- Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasiaBai H, Varsanik M, Thaxton C, Ohashi Y, Gonzalez L, Zhang W, Aoyagi Y, Kano M, Yatsula B, Li Z, Pocivavsek L, Dardik A. Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia. AJP Heart And Circulatory Physiology 2024, 326: h1446-h1461. PMID: 38578237, DOI: 10.1152/ajpheart.00054.2024.
- Leveraging Artificial Intelligence to Optimize the Care of Peripheral Artery Disease PatientsSong J, Tomihama R, Roh D, Cabrera A, Dardik A, Kiang S. Leveraging Artificial Intelligence to Optimize the Care of Peripheral Artery Disease Patients. Annals Of Vascular Surgery 2024, 107: 48-54. PMID: 38582202, DOI: 10.1016/j.avsg.2023.11.057.
- NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cellsSánchez J, Alemán A, Henao J, Olaya J, Ehrlich B. NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells. Journal Of Physiology And Biochemistry 2024, 80: 451-463. PMID: 38564162, PMCID: PMC11074019, DOI: 10.1007/s13105-024-01016-z.
- Reduced Muscle Mass and Muscle Quality in Patients with Intermittent Claudication due to Peripheral Artery DiseaseNishibe T, Dardik A, Akiyama S, Kano M, Fukuda S, Koizumi J, Nishibe M. Reduced Muscle Mass and Muscle Quality in Patients with Intermittent Claudication due to Peripheral Artery Disease. Annals Of Vascular Surgery 2024, 105: 275-281. PMID: 38570014, DOI: 10.1016/j.avsg.2023.12.094.
- Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesityPetersen M, Smith G, Palacios H, Farabi S, Yoshino M, Yoshino J, Cho K, Davila-Roman V, Shankaran M, Barve R, Yu J, Stern J, Patterson B, Hellerstein M, Shulman G, Patti G, Klein S. Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity. Cell Metabolism 2024, 36: 745-761.e5. PMID: 38569471, PMCID: PMC11025492, DOI: 10.1016/j.cmet.2024.03.002.
- Diversity and distribution of coral gall crabs associated with Red Sea mesophotic coralsVimercati S, Terraneo T, Marchese F, Eweida A, Rodrigue M, Pieribone V, Qurban M, Duarte C, Benzoni F. Diversity and distribution of coral gall crabs associated with Red Sea mesophotic corals. Frontiers In Marine Science 2024, 11: 1305396. DOI: 10.3389/fmars.2024.1305396.
- A new metabolic signature to predict melanoma recurrenceVu N, Perry R. A new metabolic signature to predict melanoma recurrence. Clinical And Translational Discovery 2024, 4 DOI: 10.1002/ctd2.288.
- Consistent Symbiodiniaceae community assemblage in a mesophotic-specialist coral along the Saudi Arabian Red SeaVimercati S, Terraneo T, Castano C, Barreca F, Hume B, Marchese F, Ouhssain M, Steckbauer A, Chimienti G, Eweida A, Voolstra C, Rodrigue M, Pieribone V, Purkis S, Qurban M, Jones B, Duarte C, Benzoni F. Consistent Symbiodiniaceae community assemblage in a mesophotic-specialist coral along the Saudi Arabian Red Sea. Frontiers In Marine Science 2024, 11: 1264175. DOI: 10.3389/fmars.2024.1264175.
- Abstract 7117: Convection enhanced delivery of a novel ATR inhibitor synergizes with systemic lomustine for improved treatment of glioblastomaJosowitz A, Lee T, Sundaram R, Pothupitiya J, Brown E, Sule A, Beckta J, Wang Y, Vacca J, Gilad O, Bindra R, Saltzman W. Abstract 7117: Convection enhanced delivery of a novel ATR inhibitor synergizes with systemic lomustine for improved treatment of glioblastoma. Cancer Research 2024, 84: 7117-7117. DOI: 10.1158/1538-7445.am2024-7117.
- Cell Membrane Tension Gradients, Membrane Flows, and Cellular ProcessesYan Q, Gomis Perez C, Karatekin E. Cell Membrane Tension Gradients, Membrane Flows, and Cellular Processes. Physiology 2024, 39: 231-245. PMID: 38501962, DOI: 10.1152/physiol.00007.2024.
- Detection of membrane fission in single Bacillus subtilis cells during endospore formation with high temporal resolutionLandajuela A, Braun M, Rodrigues C, Karatekin E. Detection of membrane fission in single Bacillus subtilis cells during endospore formation with high temporal resolution. STAR Protocols 2024, 5: 102965. PMID: 38502684, PMCID: PMC10963649, DOI: 10.1016/j.xpro.2024.102965.
- Why selective screening for asymptomatic carotid stenosis is currently appropriate: a special reportParaskevas K, Dardik A, Schermerhorn M, Liapis C, Mansilha A, Lal B, Gray W, Brown M, Myrcha P, Lavie C, Zeebregts C, Secemsky E, Saba L, Blecha M, Gurevich V, Silvestrini M, Blinc A, Svetlikov A, Fernandes e Fernandes J, Schneider P, Gloviczki P, White C, AbuRahma A. Why selective screening for asymptomatic carotid stenosis is currently appropriate: a special report. Expert Review Of Cardiovascular Therapy 2024, 22: 159-165. PMID: 38480465, DOI: 10.1080/14779072.2024.2330660.
- Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritisMoledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2024, 134: e180583. PMID: 38488004, PMCID: PMC10940080, DOI: 10.1172/jci180583.
- A new large animal model in venous thromboembolismPavlyha M, Dardik A. A new large animal model in venous thromboembolism. JVS Vascular Science 2024, 5: 100201. PMID: 38681682, PMCID: PMC11047774, DOI: 10.1016/j.jvssci.2024.100201.
- Nav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodyniaNascimento de Lima A, Zhang H, Chen L, Effraim P, Gomis-Perez C, Cheng X, Huang J, Waxman S, Dib-Hajj S. Nav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia. Brain 2024, 147: 3157-3170. PMID: 38447953, DOI: 10.1093/brain/awae071.
- Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neuronsWu J, Quraishi I, Zhang Y, Bromwich M, Kaczmarek L. Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons. Cell Reports 2024, 43: 113904. PMID: 38457342, PMCID: PMC11013952, DOI: 10.1016/j.celrep.2024.113904.
- VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke modelBoisserand L, Geraldo L, Bouchart J, Kamouh M, Lee S, Sanganahalli B, Spajer M, Zhang S, Lee S, Parent M, Xue Y, Skarica M, Yin X, Guegan J, Boyé K, Leser F, Jacob L, Poulet M, Li M, Liu X, Velazquez S, Singhabahu R, Robinson M, Askenase M, Osherov A, Sestan N, Zhou J, Alitalo K, Song E, Eichmann A, Sansing L, Benveniste H, Hyder F, Thomas J. VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model. Journal Of Experimental Medicine 2024, 221: e20221983. PMID: 38442272, PMCID: PMC10913814, DOI: 10.1084/jem.20221983.
- Complementary and Inducible creERT2 Mouse Models for Functional Evaluation of Endothelial Cell Subtypes in the Bone MarrowPoulos M, Ramalingam P, Winiarski A, Gutkin M, Katsnelson L, Carter C, Pibouin-Fragner L, Eichmann A, Thomas J, Miquerol L, Butler J. Complementary and Inducible creERT2 Mouse Models for Functional Evaluation of Endothelial Cell Subtypes in the Bone Marrow. Stem Cell Reviews And Reports 2024, 20: 1135-1149. PMID: 38438768, PMCID: PMC11087254, DOI: 10.1007/s12015-024-10703-9.
- Vascular development, remodeling and maturationFurtado J, Eichmann A. Vascular development, remodeling and maturation. Current Topics In Developmental Biology 2024, 159: 344-370. PMID: 38729681, DOI: 10.1016/bs.ctdb.2024.02.001.
- Compartmentalized ocular lymphatic system mediates eye–brain immunityYin X, Zhang S, Lee J, Dong H, Mourgkos G, Terwilliger G, Kraus A, Geraldo L, Poulet M, Fischer S, Zhou T, Mohammed F, Zhou J, Wang Y, Malloy S, Rohner N, Sharma L, Salinas I, Eichmann A, Thomas J, Saltzman W, Huttner A, Zeiss C, Ring A, Iwasaki A, Song E. Compartmentalized ocular lymphatic system mediates eye–brain immunity. Nature 2024, 628: 204-211. PMID: 38418880, PMCID: PMC10990932, DOI: 10.1038/s41586-024-07130-8.
- The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and functionNguyen L, Xu Y, Nair M, Bordey A. The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function. ELife 2024, 12: rp91010. PMID: 38411613, PMCID: PMC10942629, DOI: 10.7554/elife.91010.