2013
REGULATION OF GLOMERULOTUBULAR BALANCE IV: IMPLICATION OF AQUAPORIN 1 IN FLOW‐DEPENDENT TRANSPORT AND CELL VOLUME
Du Z, Yan Q, Weinbaum S, Weinstein A, Wang T. REGULATION OF GLOMERULOTUBULAR BALANCE IV: IMPLICATION OF AQUAPORIN 1 IN FLOW‐DEPENDENT TRANSPORT AND CELL VOLUME. The FASEB Journal 2013, 27: 912.27-912.27. DOI: 10.1096/fasebj.27.1_supplement.912.27.Peer-Reviewed Original ResearchKO miceProximal tubulesAQP-1Proximal NaPerfusion rateWT miceFlow-dependent changesCell volumeVolume reabsorptionWater reabsorptionMiceMouse kidneyHCO-3ReabsorptionPeritubular membraneSignificant differencesTubulesAquaporin-1Flow-dependent transportKOH-ATPaseKidneyPrincipal pathwayMicroperfusionPathway
2012
Regulation of glomerulotubular balance. I. Impact of dopamine on flow-dependent transport
Du Z, Yan Q, Wan L, Weinbaum S, Weinstein AM, Wang T. Regulation of glomerulotubular balance. I. Impact of dopamine on flow-dependent transport. American Journal Of Physiology. Renal Physiology 2012, 303: f386-f395. PMID: 22552936, PMCID: PMC3433864, DOI: 10.1152/ajprenal.00531.2011.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAlgorithmsAnimalsBenzazepinesBicarbonatesBiological Transport, ActiveChloridesCyclic AMP-Dependent Protein KinasesDopamineDopamine AntagonistsDopamine D2 Receptor AntagonistsFemaleIsoquinolinesKidney GlomerulusKidney TubulesKidney Tubules, ProximalMacrolidesMiceMicrovilliProton-Translocating ATPasesReceptors, Dopamine D1SodiumSulfonamidesSulpirideConceptsNa/H exchanger 3Impact of dopamineMouse proximal tubulesLuminal flowGlomerulotubular balanceCl reabsorptionProximal tubulesNa-K-ATPase activityProximal tubule reabsorptionPKA-mediated mechanismLuminal flow rateLuminal dopamineDA1 receptorsTubule reabsorptionPKA inhibitor H89Exogenous dopamineH-ATPase activityReabsorptive fluxReabsorptionDopamineNHE3 activityInhibitor H89Perfusion conditionsCoordinated modulationFlow stimulation
2010
ROLE OF DOPAMINE IN MODULATING FLOW‐DEPENDENT SODIUM AND BICARBONATE TRANSPORT IN MOUSE PROXIMAL TUBULE
Du Z, Yan Q, Weinbaum S, Weinstein A, Wang T. ROLE OF DOPAMINE IN MODULATING FLOW‐DEPENDENT SODIUM AND BICARBONATE TRANSPORT IN MOUSE PROXIMAL TUBULE. The FASEB Journal 2010, 24: 1024.2-1024.2. DOI: 10.1096/fasebj.24.1_supplement.1024.2.Peer-Reviewed Original ResearchProximal tubule transportEffects of dopamineMouse proximal tubulesTubule transportProximal tubulesNHE3 endocytosisMin/PKA-mediated mechanismRole of dopamineLuminal flow ratePmoles/min/Luminal dopamineKidney proximal tubulesPerfusion rateSodium reabsorptionNet reabsorptionDopamineReabsorptionCAMP-dependent protein kinase inhibitor H89SCH23390SulpirideInhibitor H89TubulesBicarbonate transportHCO-3
2002
Formate-stimulated NaCl absorption in the proximal tubule is independent of the pendrin protein
Karniski LP, Wang T, Everett LA, Green ED, Giebisch G, Aronson PS. Formate-stimulated NaCl absorption in the proximal tubule is independent of the pendrin protein. American Journal Of Physiology. Renal Physiology 2002, 283: f952-f956. PMID: 12372770, DOI: 10.1152/ajprenal.00182.2002.Peer-Reviewed Original ResearchConceptsProximal tubulesChloride/formate exchangeNaCl reabsorptionChloride reabsorptionElectroneutral NaCl reabsorptionNaCl absorptionRole of pendrinFormate exchangePds-knockout mouseRecycling of formatePendrin proteinReabsorptionMicePendrinBrush border membrane vesiclesTubulesPresent studyChloride transportApical membrane
1998
Effect of metabolic acidosis on NaCl transport in the proximal tubule
Wang T, Egbert A, Aronson P, Giebisch G. Effect of metabolic acidosis on NaCl transport in the proximal tubule. American Journal Of Physiology 1998, 274: f1015-f1019. PMID: 9841491, DOI: 10.1152/ajprenal.1998.274.6.f1015.Peer-Reviewed Original ResearchConceptsMetabolic acidosisProximal tubulesNaCl reabsorptionRat proximal tubule segmentsAcidotic ratsNaCl transportNaCl absorptionLate proximal tubuleProximal tubule segmentsControl ratsCapillary perfusateBicarbonate absorptionNephron segmentsAcidosisTubule segmentsRatsRecent evidenceJclTubulesFormate exchangeReabsorptionDifferential regulation
1995
Effects of a novel KATP channel blocker on renal tubule function and K channel activity.
Wang T, Wang W, Klein-Robbenhaar G, Giebisch G. Effects of a novel KATP channel blocker on renal tubule function and K channel activity. Journal Of Pharmacology And Experimental Therapeutics 1995, 273: 1382-9. PMID: 7791111.Peer-Reviewed Original ResearchConceptsKATP channel blockerLoop of HenleCortical collecting tubuleThick ascending limbPotassium secretionChannel blockersCollecting tubuleAscending limbPotassium recyclingRenal tubule functionK channel activitySodium reabsorptionTubule functionCl reabsorptionK secretionPotassium conductanceApical potassium conductancePrincipal cellsSecretionChannel activityBlockersHenleReabsorptionLimbRecent studies
1989
Neural control of distal tubular bicarbonate and fluid transport
Wang T, Chan Y. Neural control of distal tubular bicarbonate and fluid transport. American Journal Of Physiology 1989, 257: f72-f76. PMID: 2750926, DOI: 10.1152/ajprenal.1989.257.1.f72.Peer-Reviewed Original ResearchConceptsDistal tubulesRenal nerve activityProximal tubular reabsorptionEarly distal tubuleEffects of denervationLate distal tubuleDenervated kidneysReabsorb bicarbonateSham denervationNerve activityElectrolyte excretionTubular reabsorptionNeural regulationDenervationFluid reabsorptionBicarbonate absorptionFluid absorptionFluid samplesNeural controlVolume markerMicroperfusion methodTubulesBicarbonate concentrationJHCO3Reabsorption