2006
Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC
Sun P, Lin D, Wang T, Babilonia E, Wang Z, Jin Y, Kemp R, Nasjletti A, Wang W. Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC. American Journal Of Physiology. Renal Physiology 2006, 291: f1192-f1200. PMID: 16849695, DOI: 10.1152/ajprenal.00112.2006.Peer-Reviewed Original ResearchMeSH Keywords8,11,14-Eicosatrienoic AcidAnimalsArachidonic AcidCytochrome P-450 CYP2J2Cytochrome P-450 Enzyme SystemEpithelial Sodium ChannelsFemaleIon Channel GatingKidney Tubules, CollectingMaleMembrane PotentialsPatch-Clamp TechniquesRatsRats, Sprague-DawleySodium, DietarySpecific Pathogen-Free OrganismsConceptsExpression of CYP2C23Thick ascending limbMS-PPOHArachidonic acidEpoxyeicosatrienoic acidsDistal nephronNa absorptionInhibitory effectArachidonic acid-induced inhibitionHigh Na dietNa-deficient dietNa transportMicroM arachidonic acidEpithelial Na channelTamm-Horsfall proteinPatch-clamp studiesCortical CDCYP epoxygenaseAcid-induced inhibitionActivity of ENaCNa dietControl ratsRenal cortexPositive tubulesCYP2C23
1998
Effect of metabolic acidosis on NaCl transport in the proximal tubule
Wang T, Egbert A, Aronson P, Giebisch G. Effect of metabolic acidosis on NaCl transport in the proximal tubule. American Journal Of Physiology 1998, 274: f1015-f1019. PMID: 9841491, DOI: 10.1152/ajprenal.1998.274.6.f1015.Peer-Reviewed Original ResearchConceptsMetabolic acidosisProximal tubulesNaCl reabsorptionRat proximal tubule segmentsAcidotic ratsNaCl transportNaCl absorptionLate proximal tubuleProximal tubule segmentsControl ratsCapillary perfusateBicarbonate absorptionNephron segmentsAcidosisTubule segmentsRatsRecent evidenceJclTubulesFormate exchangeReabsorptionDifferential regulation