2023
Natural Language Processing — A Surveillance Stepping Stone to Identify Child Abuse
Shum M, Hsiao A, Teng W, Asnes A, Amrhein J, Tiyyagura G. Natural Language Processing — A Surveillance Stepping Stone to Identify Child Abuse. Academic Pediatrics 2023, 24: 92-96. PMID: 37652162, PMCID: PMC10840716, DOI: 10.1016/j.acap.2023.08.015.Peer-Reviewed Original ResearchConceptsClinical guidelinesClinical decision support toolSignificant demographic differencesED providersProvider notesInsurance statusGeneral EDsClinical careAbuse evaluationsED typeChild protective servicesChild abuseInjuryAppropriate evaluationChild physical abuseNLP algorithmDemographic differencesPhysical abuseAdherenceDemographic variablesProtective servicesNatural language processing algorithmAbuseUse of an Automated Bilingual Digital Health Tool to Reduce Unhealthy Alcohol Use Among Latino Emergency Department Patients
Vaca F, Dziura J, Abujarad F, Pantalon M, Hsiao A, Reynolds J, Maciejewski K, Field C, D’Onofrio G. Use of an Automated Bilingual Digital Health Tool to Reduce Unhealthy Alcohol Use Among Latino Emergency Department Patients. JAMA Network Open 2023, 6: e2314848. PMID: 37219901, PMCID: PMC10208138, DOI: 10.1001/jamanetworkopen.2023.14848.Peer-Reviewed Original ResearchConceptsStandard care groupNumber of bingesEmergency department patientsStandard careED patientsCare groupBrief interventionDepartment patientsAlcohol screeningDisease burdenUnhealthy drinkingDigital health toolsLevel II trauma centerHealth toolsParticipants 25 yearsAlcohol-related health disparitiesTertiary care centerAdverse health behaviorsUnhealthy alcohol useHigh disease burdenAlcohol use disorderTimeline followback methodEmergency medical careSelf-reported numberHigh-risk drinkingReal-World Observational Evaluation of Common Interventions to Reduce Emergency Department Prescribing of Opioid Medications
Sangal R, Rothenberg C, Hawk K, D'Onofrio G, Hsiao A, Solad Y, Venkatesh A. Real-World Observational Evaluation of Common Interventions to Reduce Emergency Department Prescribing of Opioid Medications. The Joint Commission Journal On Quality And Patient Safety 2023, 49: 239-246. PMID: 36914528, DOI: 10.1016/j.jcjq.2023.01.013.Peer-Reviewed Original ResearchConceptsOpioid prescribingED visitsElectronic health recordsOpioid prescriptionsEmergency department opioid prescriptionsAnalgesia prescriptionOpioid stewardshipOpioid medicationsSecondary outcomesPrimary outcomePreintervention periodInterruptive alertsCommon interventionPrescribingAlert fatigueElectronic prescribingPrevious interventionsHospital systemObservational evaluationHealth recordsVisitsStewardship policiesInterventionOutcomesPrescriptionExploratory Descriptive Analysis of Smart Speaker Utilization in the Emergency Department During the COVID-19 Pandemic
Franco J, Solad Y, Venkatesh A, Van Tonder R, Solod A, Stachowiak T, Hsiao A, Sangal R. Exploratory Descriptive Analysis of Smart Speaker Utilization in the Emergency Department During the COVID-19 Pandemic. Journal Of Emergency Medicine 2023, 64: 506-512. PMID: 36990854, PMCID: PMC9837211, DOI: 10.1016/j.jemermed.2023.01.004.Peer-Reviewed Original ResearchConceptsEmergency departmentRetrospective observational studyNight shift hoursCOVID-19 pandemicHuman Services OfficePatient satisfactionTelehealth deliveryObservational studyCare conversationsPatient communicationHospital roomHealth Insurance PortabilityExploratory descriptive analysisStaff wellbeingFuture studiesInsurance PortabilityDepartmentDescriptive analysisAccountability ActPandemicPatientsHospitalClinicians
2022
COVID-19 surge readiness: use cases demonstrating how hospitals leveraged digital identity access management for infection control and pandemic response
Gellert G, Kelly S, Hsiao A, Herrick B, Weis D, Lutz J, Stanton G, Bonilla S, Borgasano D, Erich M, Reilly C, Johnston D. COVID-19 surge readiness: use cases demonstrating how hospitals leveraged digital identity access management for infection control and pandemic response. BMJ Health & Care Informatics Online 2022, 29: e100680. PMID: 36423933, PMCID: PMC9692137, DOI: 10.1136/bmjhci-2022-100680.Peer-Reviewed Original ResearchConceptsInfection controlCare deliveryCOVID-19SARS-CoV-2Volume of patientsPandemic responseEpidemic infectious diseasesHospitals/health systemsTelehealth consultsClinical careUse casesInfectious diseasesHealth systemPatient safetyContact tracingPatientsVirtual visitsPatient informationHigh infectiousnessIsolation unitHospitalClinical workflowShift startTemperature checksIdentity Access ManagementAlerting Clinicians to 1-Year Mortality Risk in Patients Hospitalized With Heart Failure
Ahmad T, Desai NR, Yamamoto Y, Biswas A, Ghazi L, Martin M, Simonov M, Dhar R, Hsiao A, Kashyap N, Allen L, Velazquez EJ, Wilson FP. Alerting Clinicians to 1-Year Mortality Risk in Patients Hospitalized With Heart Failure. JAMA Cardiology 2022, 7: 905-912. PMID: 35947362, PMCID: PMC9366654, DOI: 10.1001/jamacardio.2022.2496.Peer-Reviewed Original ResearchConceptsUsual care groupElectronic health recordsHeart failureAlert groupMedian agePrimary outcomeFemale patientsTerminal pro-brain natriuretic peptide levelsYale New Haven Health SystemPro-brain natriuretic peptide levelsMedian NT-proBNP levelLeft ventricular ejection fractionLarge tertiary care centerHeart failure hospitalizationHeart failure medicationsNatriuretic peptide levelsNT-proBNP levelsHealth recordsHours of admissionTertiary care centerVentricular ejection fractionRate of hospitalizationIntensive care unitEthnicity groupsSmall community hospital
2021
Development and Validation of a Natural Language Processing Tool to Identify Injuries in Infants Associated With Abuse
Tiyyagura G, Asnes AG, Leventhal JM, Shapiro ED, Auerbach M, Teng W, Powers E, Thomas A, Lindberg DM, McClelland J, Kutryb C, Polzin T, Daughtridge K, Sevin V, Hsiao AL. Development and Validation of a Natural Language Processing Tool to Identify Injuries in Infants Associated With Abuse. Academic Pediatrics 2021, 22: 981-988. PMID: 34780997, PMCID: PMC9095755, DOI: 10.1016/j.acap.2021.11.004.Peer-Reviewed Original ResearchDisparities in Accessing and Reading Open Notes in the Emergency Department Upon Implementation of the 21st Century CURES Act
Sangal RB, Powers E, Rothenberg C, Ndumele C, Ulrich A, Hsiao A, Venkatesh AK. Disparities in Accessing and Reading Open Notes in the Emergency Department Upon Implementation of the 21st Century CURES Act. Annals Of Emergency Medicine 2021, 78: 593-598. PMID: 34353651, DOI: 10.1016/j.annemergmed.2021.06.014.Peer-Reviewed Original ResearchConceptsProportion of patientsPatient portal accessEmergency departmentOpen notesClinical notesPortal accessPublic insuranceUrgent care centersCentury Cures ActDifferent patient demographicsSingle health systemPatient demographicsPrimary outcomeCures ActPatient utilizationPatient visitsCare centerObservational studyPatientsDigital health toolsAge 18Health systemHealth toolsUnique barriersNon-English speakersAn Integrated Approach to Deploy Panel-Based Pharmacogenetic Testing and Clinical Decision Support.
Pulk RA, Hsiao AL, Murray MF, Stump L, Schulz WL. An Integrated Approach to Deploy Panel-Based Pharmacogenetic Testing and Clinical Decision Support. The Journal Of Applied Laboratory Medicine 2021, 6: 1094-1096. PMID: 34125206, DOI: 10.1093/jalm/jfab043.Peer-Reviewed Original ResearchREVeAL-HF Design and Rationale of a Pragmatic Randomized Controlled Trial Embedded Within Routine Clinical Practice
Ahmad T, Yamamoto Y, Biswas A, Ghazi L, Martin M, Simonov M, Hsiao A, Kashyap N, Velazquez EJ, Desai NR, Wilson FP. REVeAL-HF Design and Rationale of a Pragmatic Randomized Controlled Trial Embedded Within Routine Clinical Practice. JACC Heart Failure 2021, 9: 409-419. PMID: 33992566, DOI: 10.1016/j.jchf.2021.03.006.Peer-Reviewed Original ResearchConceptsHeart failurePatient outcomesClinical decision makingN-terminal pro-B-type natriuretic peptide levelsPro-B-type natriuretic peptide levelsPragmatic Randomized Controlled TrialIntravenous diuretic agentsNatriuretic peptide levelsRandomized Controlled TrialsRoutine clinical practiceEvidence-based interventionsElectronic health recordsControlled TrialsPatient populationAccurate prognosticationCommon causeDiuretic agentsPeptide levelsClinical practicePg/TrialsHealth recordsSignificant riskMortalityOutcomesClinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionYale New Haven HealthSARS-CoV-2Hospital mortalityRisk of admissionMale sexRisk factorsSARS-CoV-2 testingInvasive mechanical ventilationSevere acute respiratory syndrome virusBurden of diseaseRT-PCR testingAcademic health systemDiverse patient populationsRespiratory syndrome virusEthnic groupsAdult patientsClinical characteristicsDischarge dispositionRespiratory supportPrimary outcomeTreatment guidelinesMechanical ventilationRetrospective studyPatient populationEarly identification of patients with acute gastrointestinal bleeding using natural language processing and decision rules
Shung D, Tsay C, Laine L, Chang D, Li F, Thomas P, Partridge C, Simonov M, Hsiao A, Tay JK, Taylor A. Early identification of patients with acute gastrointestinal bleeding using natural language processing and decision rules. Journal Of Gastroenterology And Hepatology 2021, 36: 1590-1597. PMID: 33105045, DOI: 10.1111/jgh.15313.Peer-Reviewed Original ResearchConceptsNatural language processingElectronic health recordsLanguage processingNLP algorithmSystematized NomenclatureReal timeAcute gastrointestinal bleedingBidirectional Encoder RepresentationsDecision rulesEHR-based phenotyping algorithmsGastrointestinal bleedingRisk stratification scoresEncoder RepresentationsData elementsPhenotyping algorithmStratification scoresHealth recordsAlgorithmPhenotyping of patientsEmergency department patientsTime of presentationRisk stratification modelED reviewDeploymentExternal validation
2020
Inpatient Telehealth Tools to Enhance Communication and Decrease Personal Protective Equipment Consumption during Disaster Situations: A Case Study during the COVID-19 Pandemic
Ong SY, Stump L, Zawalich M, Edwards L, Stanton G, Matthews M, Hsiao AL. Inpatient Telehealth Tools to Enhance Communication and Decrease Personal Protective Equipment Consumption during Disaster Situations: A Case Study during the COVID-19 Pandemic. Applied Clinical Informatics 2020, 11: 733-741. PMID: 33147644, PMCID: PMC7641665, DOI: 10.1055/s-0040-1719180.Peer-Reviewed Original ResearchConceptsUse casesSecurity/privacyHealth care systemPatient care capabilitiesConsumer devicesHealth systemInnovative technology solutionsTechnology solutionsPersonal protective equipment useCare systemLarge health care systemLarge-scale setupsHealth care workersDisaster situationsProtective equipment useHealth care staffUse of PPEDevice usageDevice availabilityPhysical setupInpatient careLarge volumesAmbulatory settingTelehealth toolsCare workersCOVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system
Caraballo C, McCullough M, Fuery MA, Chouairi F, Keating C, Ravindra NG, Miller PE, Malinis M, Kashyap N, Hsiao A, Wilson FP, Curtis JP, Grant M, Velazquez EJ, Desai NR, Ahmad T. COVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system. PLOS ONE 2020, 15: e0238829. PMID: 32997657, PMCID: PMC7526909, DOI: 10.1371/journal.pone.0238829.Peer-Reviewed Original ResearchConceptsHeart failure patientsIntegrated health care systemHeart Failure RegistryHealth care systemFailure patientsCOVID-19 infectionCare systemCOVID-19SARS-CoV-2 infectionReal-time registryRenin-angiotensin blockersRetrospective chart reviewCoronary artery diseaseRisk of deathCOVID-19 testingAngiotensin blockersMultiple comorbiditiesRespiratory failureChart reviewSymptomatic patientsArtery diseaseHeart failureComorbid conditionsPatient mortalityClinical managementTrial study design to test a bilingual digital health tool for alcohol use disorders among Latino emergency department patients
Vaca FE, Dziura J, Abujarad F, Pantalon MV, Hsiao A, Field CA, D'Onofrio G. Trial study design to test a bilingual digital health tool for alcohol use disorders among Latino emergency department patients. Contemporary Clinical Trials 2020, 96: 106104. PMID: 32777381, PMCID: PMC8252296, DOI: 10.1016/j.cct.2020.106104.Peer-Reviewed Original ResearchConceptsAlcohol use disorderBrief interventionSevere alcohol use disorderUse disordersBinge drinking daysSpecialized treatment servicesAlcohol-related health disparitiesAlcohol screeningBrief intervention toolTimeline followback methodHigh-risk drinkingNegative behaviorsTreatment engagementAUD severityImpaired driversStandard careDrinking daysMeaningful contactIntervention toolDigital health toolsUnhealthy drinkingPrimary outcomeLatino patientsHealth toolsWork/schoolAgile Health Care Analytics: Enabling Real-Time Disease Surveillance With a Computational Health Platform
Schulz WL, Durant T, Torre CJ, Hsiao AL, Krumholz HM. Agile Health Care Analytics: Enabling Real-Time Disease Surveillance With a Computational Health Platform. Journal Of Medical Internet Research 2020, 22: e18707. PMID: 32442130, PMCID: PMC7257473, DOI: 10.2196/18707.Peer-Reviewed Original ResearchConceptsReal-time dataHealth information technologyReal-world dataHealth platformInformation technologyCombination of technologiesReal timeSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Timely informationRespiratory syndrome coronavirus 2PlatformRespiratory tract infectionsSyndrome coronavirus 2Health care systemTract infectionsCoronavirus disease (COVID-19) outbreakIncident casesCoronavirus 2Novel applicationTechnologyAnalyticsHealth systemCare systemSpecific pathogens
2019
Evaluating the Impact of a New Smartphone Texting Tool on Patient Care in Obstetrics, an Emergent Healthcare Setting
Feinberg J, Shaw S, Kashyap N, Illuzzi J, Campbell K, Hsiao A, Pettker C. Evaluating the Impact of a New Smartphone Texting Tool on Patient Care in Obstetrics, an Emergent Healthcare Setting. Applied Clinical Informatics 2019, 10: 879-887. PMID: 31747710, PMCID: PMC6867929, DOI: 10.1055/s-0039-1700868.Peer-Reviewed Original ResearchConceptsPatient careText messaging systemEmergent settingSustained improvementYale-New Haven HospitalPoor patient outcomesTimely evaluationNurses' knowledgePatient outcomesTexting systemDecrease riskNew Health Insurance PortabilityHealthcare settingsObstetricsCareHealth Insurance PortabilityWhitney testHospitalClinical workflowMonthsWilcoxon-MannOpen-ended questionsInsurance PortabilityLikert scalePotential benefitsEvaluation of the Patient Request Process for Radiology Imaging in U.S. Hospitals.
Lye CT, Krumholz HM, Eckroate JE, Daniel JG, deBronkart D, Mann MK, Hsiao AL, Forman HP. Evaluation of the Patient Request Process for Radiology Imaging in U.S. Hospitals. Radiology 2019, 292: 409-413. PMID: 31184560, DOI: 10.1148/radiol.2019190473.Peer-Reviewed Original ResearchHealth Care and Precision Medicine Research: Analysis of a Scalable Data Science Platform
McPadden J, Durant TJ, Bunch DR, Coppi A, Price N, Rodgerson K, Torre CJ, Byron W, Hsiao AL, Krumholz HM, Schulz WL. Health Care and Precision Medicine Research: Analysis of a Scalable Data Science Platform. Journal Of Medical Internet Research 2019, 21: e13043. PMID: 30964441, PMCID: PMC6477571, DOI: 10.2196/13043.Peer-Reviewed Original ResearchConceptsData science platformOpen source technologiesHealth care dataSource technologiesModern big data platformScience platformData management approachTraditional computer systemsBig data workloadsBig data platformBig data sourcesReal-time datasetBiomedical research dataHealth care applicationsData-driven researchPatient monitoringScalable analyticsApache StormData lakeData workloadsAnalytics platformData acquisition workflowContinuous patient monitoringUse casesData platformA randomized trial of decision support for tobacco dependence treatment in an inpatient electronic medical record: clinical results
Bernstein SL, Weiss J, DeWitt M, Tetrault JM, Hsiao AL, Dziura J, Sussman S, Miller T, Carpenter K, O’Connor P, Toll B. A randomized trial of decision support for tobacco dependence treatment in an inpatient electronic medical record: clinical results. Implementation Science 2019, 14: 8. PMID: 30670043, PMCID: PMC6343239, DOI: 10.1186/s13012-019-0856-8.Peer-Reviewed Original ResearchConceptsPatient's primary care providerPrimary care providersTobacco treatment medicationsElectronic health recordsTobacco use disorderQuit ratesTreatment medicationsProblem listCare providersUse disordersOne-year quit ratesState tobacco quitlineTobacco quit ratesPrescription of medicationsTobacco dependence treatmentProcess of careSingle hospital systemElectronic medical recordsInpatient electronic medical recordPatient's problem listSustained quittingAdult patientsControl patientsCurrent smokingHospitalized smokers