Yun-Hee Youm
Associate Research Scientist in PathologyCards
About
Research
Publications
2026
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging
Mishra M, Kim H, Youm Y, Gonzalez-Hurtado E, Zaitsev K, Dlugos T, Shchukina I, Gliniak C, Ravussin E, Mohanty S, Shaw A, Scherer P, Artyomov M, Dixit V. Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging. Nature Aging 2026, 6: 1064-1078. PMID: 41974968, PMCID: PMC13190345, DOI: 10.1038/s43587-026-01107-0.Peer-Reviewed Original ResearchImmunometabolic resistors of aging in long-lived golden spiny mice
Kim H, Sagiv-Zangi T, Youm Y, Vardi-Naim H, Dlugos T, Strino F, Kazavchinsky-Bar M, Egulsky L, Bodogai M, Biragyn A, Kluger Y, Kronfeld-Schor N, Dixit V. Immunometabolic resistors of aging in long-lived golden spiny mice. Science Advances 2026, 12: eaec9991. PMID: 41739938, PMCID: PMC12935055, DOI: 10.1126/sciadv.aec9991.Peer-Reviewed Original Research
2025
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging.
Mishra M, Kim HH, Youm YH, Gonzalez-Hurtado E, Zaitsev K, Dlugos T, Shchukina I, Gliniak C, Ravussin E, Mohanty S, Shaw AC, Scherer PE, Artyomov MN, Dixit VD. Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging. BioRxiv 2025 PMID: 40799539, DOI: 10.1101/2025.08.04.668533.Publications for non-academic audiencesFGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression
Gliniak C, Gordillo R, Houm Y, Lin Q, Crewe C, Zhang Z, Field B, Fujikawa T, Virostek M, Zhao S, Zhu Y, Rosen C, Horvath T, Dixit V, Scherer P. FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression. Cell Metabolism 2025, 37: 1547-1567.e6. PMID: 40527315, PMCID: PMC12221793, DOI: 10.1016/j.cmet.2025.05.011.Peer-Reviewed Original ResearchCysteine depletion triggers adipose tissue thermogenesis and weight loss
Lee A, Orliaguet L, Youm Y, Maeda R, Dlugos T, Lei Y, Coman D, Shchukina I, Andhey P, Smith S, Ravussin E, Stadler K, Chen B, Artyomov M, Hyder F, Horvath T, Schneeberger M, Sugiura Y, Dixit V. Cysteine depletion triggers adipose tissue thermogenesis and weight loss. Nature Metabolism 2025, 7: 1204-1222. PMID: 40461845, PMCID: PMC12198010, DOI: 10.1038/s42255-025-01297-8.Peer-Reviewed Original ResearchHormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.
Guan C, Ryu S, Dong M, Youm YH, Mohanty S, Maeda R, Orliaguet L, Kim HH, Dlugos T, Smith SR, Ravussin E, Onyuru J, Wang A, Shaw AC, Hoffman HM, Kluger Y, Sugiura Y, Dixit VD. Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome. BioRxiv 2025 PMID: 40501605, DOI: 10.1101/2025.05.27.656381.Publications for non-academic audiencesEnhanced paracrine action of FGF21 in stromal cells delays thymic aging
Youm Y, Gliniak C, Zhang Y, Dlugos T, Scherer P, Dixit V. Enhanced paracrine action of FGF21 in stromal cells delays thymic aging. Nature Aging 2025, 5: 576-587. PMID: 39972172, PMCID: PMC12003152, DOI: 10.1038/s43587-025-00813-5.Peer-Reviewed Original Research
2008
Proteomic analysis of androgen-independent growth in low and high passage human LNCaP prostatic adenocarcinoma cells
Youm YH, Kim S, Bahk YY, Yoo TK. Proteomic analysis of androgen-independent growth in low and high passage human LNCaP prostatic adenocarcinoma cells. BMB Reports 2008, 41: 722-727. PMID: 18959819, DOI: 10.5483/bmbrep.2008.41.10.722.Peer-Reviewed Original Research
2007
Doxazosin-induced clusterin expression and apoptosis in prostate cancer cells
Youm YH, Yang H, Yoon YD, Kim DY, Lee C, Yoo TK. Doxazosin-induced clusterin expression and apoptosis in prostate cancer cells. Urologic Oncology Seminars And Original Investigations 2007, 25: 483-488. PMID: 18047956, DOI: 10.1016/j.urolonc.2007.02.010.Peer-Reviewed Original Research
2006
Apoptosis Induction and Clusterin Expression of NRP-152 Cells by Tamsulosin
Youm Y, Yoon Y, Woo J, Yoo T. Apoptosis Induction and Clusterin Expression of NRP-152 Cells by Tamsulosin. Journal Of The Korean Continence Society 2006, 10: 132. DOI: 10.5213/jkcs.2006.10.2.132.Peer-Reviewed Original Research