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Ya-Chi Ho

Assistant Professor of Microbial Pathogenesis and Medicine (Infectious Diseases); Investigator, HIV Reservoirs and Viral Eradication Transformative Science Group (Cure TSG); Investigator, BEAT-HIV Martin Delaney Collaboratory



Dr. Ho takes a molecular virology, single-cell and genomics approaches to examine HIV persistence and develop HIV cure strategies. Using clinical samples from HIV-infected individuals, the Ho lab investigates host-HIV interactions with particular interests in HIV-1-host RNA landscape (using single-cell RNAseq), CD4 T cell expansion dynamics, HIV-host genome interactions, and HIV-1-specific silencing, and immune escape mechanisms. Dr. Ho was a board-certified infectious disease attending physician in Taiwan. She received her PhD (2013) and postdoctoral training at Johns Hopkins University School of Medicine in Dr. Robert F. Siliciano's lab. She was a tenure track instructor (2016) and then an assistant professor (2017) at Johns Hopkins School of Medicine before she joined Yale School of Medicine in September 2017. As a investigator of the AIDS Clinical Trial Group (ACTG) and the BEAT HIV Martin Delaney Collaboratory, she actively collaborate with geneticists, bioinformaticians, immunologists and physicians to study HIV-1 persistence. She is currently funded by an NIH R01 grant and an NIH R61/R33 grant as the Principal Investigator.

Education & Training

  • Postdoctoral fellow
    Johns Hopkins School of Medicine (2014)
  • PhD
    Johns Hopkins University School of Medicine, Cellular and Molecular Medicine (2013)
  • MMS
    National Taiwan University, Clinical Medicine (2007)
  • Clinical fellow
    National Taiwan University Hospital (2007)
  • Resident
    National Taiwan University Hospital (2005)
  • MD
    National Cheng Kung University, Medicine (2002)
  • Clinical clerkship
    Duke University Medical Center (2002)
  • Clinical clerkship
    Yale University (2000)


  • National Institutes of Health and Bill & Melinda Gates Foundation Joint Workshop
    Bethesda, United States 2019
  • Invited Speaker, Conferences on Retroviruses and Opportunistic Infections (CROI)
    Seattle, United States 2019
  • IAS 2019, 10th IAS Conference on HIV Science
    Mexico City, Mexico 2019
  • BEAT HIV Delaney Collaboratory Annual Meeting
    Philadelphia, United States 2019
  • Invited Speaker, NIH Strategies for an HIV Cure
    Bethesda, United States 2018

Honors & Recognition

AwardAwarding OrganizationDate
Andy Kaplan PrizeCold Spring Harbor Laboratory Meetings on Retroviruses2018
Gilead Sciences Research Scholar in HIVGilead Sciences2018
Rudolf J. Anderson FellowshipYale University2018
Lois E. and Franklin H. Top, Jr. Yale ScholarYale University School of Medicine2017
Distinguished Alumni AwardNational Cheng Kung University2016
W. W. Smith Charitable Foundation AIDS Research AwardW. W. Smith Charitable Foundation2016
Phi Beta KappaPhi Beta Kappa Honorary Society2014
Michael Shanoff Johns Hopkins Young Investigator AwardJohns Hopkins University School of Medicine2014
Howard Hughes International Student Research FellowshipHoward Hughes Medical Institute2011
Best Teaching Resident AwardNational Taiwan University Hospital2007
Scholarship for PhD Studies AbroadMinistry of Education, Taiwan2007
Best Resident AwardDepartment of Medicine, National Taiwan University Hospital2003, 2004
Phi Tau PhiPhi Tau Phi Honorary Society, Taiwan2002

Professional Service

Cell Reports Medicine, Cell PressBoard Member2020 - Present
Journal of Infectious Diseases, The Infectious Diseases Society of AmericaBoard Member2020 - Present
NIH Special Emphasis Panel Study SectionReviewer2019
PhD Program in Virology, Harvard Medical SchoolPhD Thesis Defense Committee Member for Radwa Sharaf, Po-Ting Liu, Phillip Tomezsko2019
American Foundation for AIDS Research (amfAR)Reviewer2018 - Present
NIH, AIDS Immunology and Pathogenesis Study SectionReviewer2018
Johns Hopkins University School of MedicineAssistant Professor of Medicine2017
DC CFAR Faculty Developmental Grant Study SectionAd hoc reviewer2016
Johns Hopkins University School of MedicineInstructor in Medicine2015 - 2017
Johns Hopkins University School of MedicineResearch Associate2014 - 2015
American Society for MicrobiologyMember2011 - 2017

Departments & Organizations