Ruth R Montgomery, PhD

2025

• MTHFR allele and one-carbon metabolic profile predict severity of COVID-19

  Petrova B, Syphurs C, Culhane A, Chen J, Chen E, Cotsapas C, Esserman D, Montgomery R, Kleinstein S, Smolen K, Mendez K, Network I, Lasky-Su J, Steen H, Levy O, Diray-Arce J, Kanarek N. MTHFR allele and one-carbon metabolic profile predict severity of COVID-19. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2509118122. PMID: 41410771, DOI: 10.1073/pnas.2509118122.

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• Unravelling the Immunological Enigma of Sickle Cell Disease: Current Understanding and Future Directions

  Jamwal S, Calhoun C, Mohanty S, Montgomery R, Krishnamurti L, Shaw A, Yildirim I. Unravelling the Immunological Enigma of Sickle Cell Disease: Current Understanding and Future Directions. Immunology 2025 PMID: 41387179, DOI: 10.1111/imm.70080.

  Peer-Reviewed Original Research

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• Minimalistic transcriptomic signatures permit accurate early prediction of COVID-19 mortality

  Narendra R, Lydon E, Van Phan H, Spottiswoode N, Neyton L, Diray-Arce J, Network I, Consortium C, Consortium E, Becker P, Kim-Schulze S, Hoch A, Pickering H, van Zalm P, Cairns C, Altman M, Augustine A, Bosinger S, Eckalbar W, Guan L, Jayavelu N, Kleinstein S, Krammer F, Maecker H, Ozonoff A, Peters B, Rouphael N, Montgomery R, Reed E, Schaenman J, Steen H, Levy O, Haller S, Erle D, Hendrickson C, Krummel M, Matthay M, Woodruff P, Haddad E, Calfee C, Langelier C. Minimalistic transcriptomic signatures permit accurate early prediction of COVID-19 mortality. JCI Insight 2025, 10: e195436. PMID: 41212055, PMCID: PMC12643502, DOI: 10.1172/jci.insight.195436.

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• Identifying one-carbon metabolism as a predictor of COVID-19 severity in the IMPACC cohort 3975

  Syphurs C, Petrova B, Diray-Arce J, Culhane A, Chen J, Chen E, Montgomery R, Kleinstein S, Smolen K, Mendez K, Lasky-Su J, Steen H, Levy O, Kanarek N. Identifying one-carbon metabolism as a predictor of COVID-19 severity in the IMPACC cohort 3975. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.1713.

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• Evaluating COVID-19 severity prediction and immune dynamics with NULISAseq: Insights from the IMPACC study

  Abe K, Holmes T, Nguyen T, Abe K, Holmes T, Nguyen T, Kim-Schulze S, Levy O, Baden L, Melamed E, Ehrlich L, McComsey G, Sekaly R, Cairns C, Haddad E, Shaw A, Hafler D, Montgomery R, Corry D, Kheradmand F, Atkinson M, Brakenridge S, Higuita N, Metcalf J, Hough C, Messer W, Pulendran B, Nadeau K, Davis M, Fernandez-Sesma A, Simon V, Kraft M, Bime C, Calfee C, Erle D, Schaenman J, Reed E, Ozonoff A, Peters B, Kleinstein S, Augustine A, Diray-Arce J, Becker P, Rouphael N, Maecker H, Kim-Schulze S, Levy O, Baden L, Melamed E, Ehrlich L, McComsey G, Sekaly R, Cairns C, Haddad E, Shaw A, Hafler D, Montgomery R, Corry D, Kheradmand F, Atkinson M, Brakenridge S, Higuita N, Metcalf J, Hough C, Messer W, Pulendran B, Nadeau K, Davis M, Fernandez-Sesma A, Simon V, Kraft M, Bime C, Calfee C, Erle D, Schaenman J, Reed E, Ozonoff A, Peters B, Kleinstein S, Augustine A, Diray-Arce J, Becker P, Rouphael N, Maecker H. Evaluating COVID-19 severity prediction and immune dynamics with NULISAseq: Insights from the IMPACC study. The Journal Of Immunology 2025, 214: 3310-3320. PMID: 41166719, PMCID: PMC12726064, DOI: 10.1093/jimmun/vkaf263.

  Peer-Reviewed Original Research

  MeSH Keywords and Concepts

• Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS

  Costa Monteiro A, Pickering H, Sarma A, Taylor C, Jenkins M, Hsu F, Nadel B, Levy O, Baden L, Melamed E, Ehrlich L, McComsey G, Sekaly R, Cairns C, Haddad E, Shaw A, Hafler D, Montgomery R, Corry D, Kheradmand F, Atkinson M, Brakenridge S, Higuita N, Metcalf J, Hough C, Messer W, Pulendran B, Nadeau K, Davis M, Geng L, Fernandez-Sesma A, Simon V, Krammer F, Kraft M, Bime C, Calfee C, Erle D, Bosinger S, Eckalbar W, Maecker H, Rahman A, Guan L, Peters B, Kleinstein S, Augustine A, Diray-Arce J, Becker P, Rouphael N, Agus M, Kulkarni H, Schaenmann J, Salehi-Rad R, Matthay M, Reed E, Sapru A. Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS. Critical Care 2025, 29: 432. PMID: 41088445, PMCID: PMC12522733, DOI: 10.1186/s13054-025-05596-0.

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• A multi-omics recovery factor predicts long COVID in the IMPACC study

  Gabernet G, Maciuch J, Gygi J, Moore J, Hoch A, Syphurs C, Chu T, Jayavelu N, Corry D, Kheradmand F, Baden L, Sekaly R, McComsey G, Haddad E, Cairns C, Rouphael N, Fernandez-Sesma A, Simon V, Metcalf J, Higuita N, Hough C, Messer W, Davis M, Nadeau K, Pulendran B, Kraft M, Bime C, Reed E, Schaenman J, Erle D, Calfee C, Atkinson M, Brakenridge S, Melamed E, Shaw A, Hafler D, Augustine A, Becker P, Ozonoff A, Bosinger S, Eckalbar W, Maecker H, Kim-Schulze S, Steen H, Krammer F, Westendorf K, Network I, Peters B, Fourati S, Altman M, Levy O, Smolen K, Montgomery R, Diray-Arce J, Kleinstein S, Guan L, Ehrlich L. A multi-omics recovery factor predicts long COVID in the IMPACC study. Journal Of Clinical Investigation 2025, 135: e193698. PMID: 40924481, PMCID: PMC12582403, DOI: 10.1172/jci193698.

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• Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study

  Hou J, Haslund-Gourley B, Diray-Arce J, Hoch A, Rouphael N, Becker P, Augustine A, Ozonoff A, Guan L, Kleinstein S, Peters B, Reed E, Altman M, Langelier C, Maecker H, Kim S, Montgomery R, Krammer F, Wilson M, Eckalbar W, Bosinger S, Levy O, Steen H, Rosen L, Baden L, Melamed E, Ehrlich L, McComsey G, Sekaly R, Schaenman J, Shaw A, Hafler D, Corry D, Kheradmand F, Atkinson M, Brakenridge S, Agudelo Higuita N, Metcalf J, Hough C, Messer W, Pulendran B, Nadeau K, Davis M, Fernandez Sesma A, Simon V, Kraft M, Bime C, Calfee C, Erle D, Impacc Network, Robinson L, Cairns C, Haddad E, Comunale M. Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study. Frontiers In Medicine 2025, 12: 1604388. PMID: 40687705, PMCID: PMC12271175, DOI: 10.3389/fmed.2025.1604388.

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• MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury

  Pickering H, Alipanah-Lechner N, Chen E, Duchen D, Maecker H, Kim-Schulze S, Montgomery R, Cotsapas C, Steen H, Krammer F, Langelier C, Levy O, Baden L, Melamed E, Ehrlich L, McComsey G, Sekaly R, Cairns C, Haddad E, Shaw A, Hafler D, Corry D, Kheradmand F, Atkinson M, Brakenridge S, Higuita N, Metcalf J, Hough C, Messer W, Pulendran B, Nadeau K, Davis M, Fernandez-Sesma A, Simon V, Kraft M, Bime C, Erle D, Schaenman J, Ozonoff A, Peters B, Kleinstein S, Augustine A, Diray-Arce J, Becker P, Rouphael N, Altman M, Bosinger S, Eckalbar W, Network I, Calfee C, Aguilar O, Reed E, Greenland J, Calabrese D. MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury. JCI Insight 2025, 10: e191951. PMID: 40608426, PMCID: PMC12333951, DOI: 10.1172/jci.insight.191951.

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• Airway Immune Signatures in Severe and Fatal Infection with COVID-19

  Doni Jayavelu N, Qi J, Fourati S, Kheradmand F, Langelier C, Ehrlich L, Diray-Arce J, Hoch A, Kraft M, Becker P, Altman M, Montgomery R. Airway Immune Signatures in Severe and Fatal Infection with COVID-19. American Journal Of Respiratory Cell And Molecular Biology 2025, 72: 708-712. PMID: 40444914, PMCID: PMC12143404, DOI: 10.1165/rcmb.2024-0462le.

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