Kaelyn Sumigray, PhD
Assistant Professor of GeneticsDownloadHi-Res Photo
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Appointments
Genetics
Primary
Additional Titles
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
Contact Info
Appointments
Genetics
Primary
Additional Titles
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
Contact Info
Appointments
Genetics
Primary
Additional Titles
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
Contact Info
About
Titles
Assistant Professor of Genetics
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
Biography
Kaelyn Sumigray earned her B.S. from Union College in 2006. She obtained her Ph.D. in 2011 from the Department of Cell Biology at Duke University. She was a postdoctoral fellow first at the University of North Carolina at Chapel Hill, from 2012-2013, where she was awarded an NIH Kirschstein postdoctoral fellowship, followed by a postdoctoral fellow at Duke University with Terry Lechler from 2013-2019, where she was awarded a Dermatology Foundation Research Grant. She joined the Yale faculty in 2019.
Last Updated on April 19, 2025.
Appointments
Genetics
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral associate
- Duke University (2019)
- Postdoctoral Fellow
- University of North Carolina at Chapel Hill (2013)
- PhD
- Duke University, Cell Biology (2011)
- BS
- Union College, Biology (2006)
Research
Overview
Medical Research Interests
Actin Cytoskeleton; Cell Adhesion; Cell Polarity; Cell Shape; Cytoskeleton; Intestinal Polyps; Intestine, Small; Morphogenesis; Organogenesis; Stem Cell Niche; Stem Cells
ORCID
0000-0002-1267-7559- View Lab Website
Sumigray lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Kaelyn Sumigray's published research.
Publications Timeline
A big-picture view of Kaelyn Sumigray's research output by year.
Research Interests
Research topics Kaelyn Sumigray is interested in exploring.
Nadia Ameen, MBBS
Timothy Nottoli, PhD
Andrea Barbieri, MD
Caroline Helen Johnson, PhD
Jing Yan, PhD
Joanna Gibson, MD, PhD
34Publications
1,148Citations
Cell Adhesion
Stem Cells
Intestine, Small
Morphogenesis
Cell Polarity
Cell Shape
Publications
2025
Evidence of secondary Notch signaling within the rat small intestine.
Zagoren E, Dias N, Santos A, Smith Z, Ameen N, Sumigray K. Evidence of secondary Notch signaling within the rat small intestine. Development 2025, 152 PMID: 40371707, PMCID: PMC12188240, DOI: 10.1242/dev.204277.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSecretory lineageRegulate luminal pHSecretory cellsNotch signalingSecretory cell typesSmall intestinal epithelial cellsRNA sequencing dataIntestinal epithelial cellsIntestinal stem cellsSmall intestineFate in vivoFibrosis pathophysiologyRat small intestineCrypt progenitorsTranscription factorsEpithelial cellsRat jejunumStem cellsPseudotime trajectory analysisRare populationLuminal pHRatsHigher expressionIntestinal functionIn vitroSex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase
Aladelokun O, Benitez K, Wang Y, Jain A, Berardi D, Maroun G, Shen X, Roper J, Gibson J, Sumigray K, Khan S, Johnson C. Sex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase. Pharmacological Research 2025, 215: 107736. PMID: 40228761, PMCID: PMC12100670, DOI: 10.1016/j.phrs.2025.107736.Peer-Reviewed Original ResearchConceptsTumor-specific survivalColorectal cancerTumor growthR2G2 miceIncreased serum estradiol levelsSerum estradiol levelsSub-populations of macrophagesAssociated with cancer prognosisSuppressed tumor growthColorectal tumor growthExogenous asparagineColorectal cancer developmentColorectal cancer cellsNegative feed-back effectEstradiol levelsGlutamate levelsSex-related differencesSex-specific effectsMale miceCancer prognosisAsparagine supplementationCancer progressionMiceDecreased numberTumorCFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and Cystic Fibrosis disease
dos Reis D, Jin J, Santos A, Nogueira C, Zagoren E, Donnelley M, Parsons D, Cmielewski P, Reyne N, Mc Carron A, Smith Z, Sumigray K, Ameen N. CFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and Cystic Fibrosis disease. Physiology 2025, 40: 1127. DOI: 10.1152/physiol.2025.40.s1.1127.Peer-Reviewed Original ResearchConceptsCHE cellsGuanylyl cyclase-CNeuropod cellsApical domainRat jejunumHuman intestineSingle-cell RNA sequencingCystic fibrosisLuminal pH regulationSubpopulation of epithelial cellsLong basal processesScRNA-seqRNA sequencingAcid-sensing receptorsWild-type animalsCystic fibrosis diseaseIncreased abundanceHigh-expressing cellsProtein immunolocalizationIntestinal physiologyMorphological coreWild-typeBasal processesHCO3- secretionCFTR
2024
Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins
Seabrook L, Franco C, Loy C, Osman J, Fredlender C, Zimak J, Campos M, Nguyen S, Watson R, Levine S, Khalil M, Sumigray K, Trader D, Albrecht L. Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. Nature Chemical Biology 2024, 20: 1566-1576. PMID: 39414979, DOI: 10.1038/s41589-024-01741-y.Peer-Reviewed Original ResearchCitationsAltmetricConceptsProtein arginine methyltransferasesTarget proteinsLoss-of-function phenotypesDegradation of intracellular proteinsUbiquitin-proteasome pathwayHistone deacetylase 6Bromodomain-containing protein 4Discovery of small moleculesTargeted protein degradationDegrade target proteinsTargeting chimerasArginine methylationArginine methyltransferasesProtein methylationPathogenic proteinsLysosomal deliveryLysosomal pathwayIntracellular proteinsLysosomal degradationHeterobifunctional small moleculesProtein degradationSmall-molecule degradersLysosomal proteolysisSubstrate degradationSmall molecules313 BEST4+ CFTR high expresser cells in normal rat are neuropods that sense and respond to luminal pH and are altered in dF508 CF intestine
Jin J, dos Reis D, Muiler C, Zagoren E, Donnelley M, Parsons D, Sumigray K, Ameen N. 313 BEST4+ CFTR high expresser cells in normal rat are neuropods that sense and respond to luminal pH and are altered in dF508 CF intestine. Journal Of Cystic Fibrosis 2024, 23: s167. DOI: 10.1016/s1569-1993(24)01153-6.Peer-Reviewed Original ResearchRedefining intestinal stemness: The emergence of a new ISC population
Li M, Sumigray K. Redefining intestinal stemness: The emergence of a new ISC population. Cell 2024, 187: 2900-2902. PMID: 38848673, DOI: 10.1016/j.cell.2024.04.021.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsA Coculture System for Modeling Intestinal Epithelial-Fibroblast Crosstalk
Lee R, Li M, Figetakis M, Sumigray K. A Coculture System for Modeling Intestinal Epithelial-Fibroblast Crosstalk. Methods In Molecular Biology 2024, 1-16. PMID: 38700834, PMCID: PMC11938088, DOI: 10.1007/7651_2024_544.Peer-Reviewed Original ResearchCitationsAltmetric978 CFTR HIGH EXPRESSER CELLS EXPRESS NEUROPOD GENES AND RESPOND TO ENVIRONMENTAL CUES IN THE INTESTINE
Jin J, Reis D, Muiler C, Sumigray K, Ameen N. 978 CFTR HIGH EXPRESSER CELLS EXPRESS NEUROPOD GENES AND RESPOND TO ENVIRONMENTAL CUES IN THE INTESTINE. Gastroenterology 2024, 166: s-236. DOI: 10.1016/s0016-5085(24)01027-8.Peer-Reviewed Original Research
2023
Generation and Manipulation of Rat Intestinal Organoids.
Zagoren E, Santos A, Ameen N, Sumigray K. Generation and Manipulation of Rat Intestinal Organoids. Journal Of Visualized Experiments 2023 PMID: 37427951, DOI: 10.3791/65343.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsAntibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner
Salvi P, Shaughnessy M, Sumigray K, Cowles R. Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner. AJP Gastrointestinal And Liver Physiology 2023, 325: g80-g91. PMID: 37158470, DOI: 10.1152/ajpgi.00113.2022.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSerotonin activitySERT protein expressionSerotonin potentiationEpithelial proliferationSerotonin transporterEndogenous serotoninVillus heightMicrobial depletionIntestinal epithelial growthProtein expressionEpithelial growthSerotonin-dependent mechanismIntestinal villus heightSmall intestine resultsIntestinal surface areaSmall intestinal villiSmall intestinal cryptsIntestinal pathologyPara-chlorophenylalanineISC numbersSerotonin synthesisIntestinal homeostasisEpithelial expressionMouse modelAnimal models
Academic Achievements & Community Involvement
Activities
activity American Heart Association
2022 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity eLife
2022 - PresentJournal ServiceRevieweractivity Science
2023 - PresentJournal ServiceRevieweractivity Nature Cell Biology
2021 - PresentJournal ServiceRevieweractivity Journal of Clinical Investigation
2022 - PresentJournal ServiceReviewer
Honors
honor Chen Innovation Award
03/01/2022Yale School of Medicine AwardYale Stem Cell CenterDetailsUnited Stateshonor Basic Research Award
03/03/2014National AwardDermatology Foundation
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SHM I 336
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Sterling Hall of Medicine, I-Wing
333 Cedar Street
New Haven, CT 06510
389 NSB
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Nathan Smith Building
315 Cedar Street
New Haven, CT 06510
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