2024
Safety, tolerability, pharmacokinetics and pharmacodynamics of a single intravenous dose of SHR-1707 in healthy adult subjects: two randomized, double-blind, single-ascending-dose, phase 1 studies
Yang Y, Qiu H, Fan Y, Zhang Q, Qin H, Wu J, Zhang X, Liu Y, Zhou R, Zhang Q, Ye Z, Ma J, Xu Y, Feng S, Fei Y, Li N, Cui X, Dong F, Wang Q, Shen K, Shakib S, Williams J, Hu W. Safety, tolerability, pharmacokinetics and pharmacodynamics of a single intravenous dose of SHR-1707 in healthy adult subjects: two randomized, double-blind, single-ascending-dose, phase 1 studies. Alzheimer's Research & Therapy 2024, 16: 218. PMID: 39390616, PMCID: PMC11465679, DOI: 10.1186/s13195-024-01584-8.Peer-Reviewed Original ResearchConceptsTreatment-related adverse eventsPhase 1 studySingle-ascending-doseIntravenous doseHealthy adult subjectsDouble-blindElderly subjectsHealthy young adultsAdult subjectsTransient laboratory abnormalitiesPD profilesDose-proportional mannerSingle intravenous dosesYoung adultsDose-dependent increaseIgG1 monoclonal antibodyDose cohortsPlacebo groupLaboratory abnormalitiesPreclinical studiesAdverse eventsClinical developmentDose levelsNo ethnic differencesTransgenic mice
2023
Safety and Tolerability of Tecarfarin (ATI-5923) in Healthy Chinese Volunteers: Multiple Oral Dose-Escalation Phase I Trial
Zhou Q, Wang Z, Wang H, Chen Z, Li X, Dai X, Zhang Y, Yu X, Zhou R, Hu W. Safety and Tolerability of Tecarfarin (ATI-5923) in Healthy Chinese Volunteers: Multiple Oral Dose-Escalation Phase I Trial. American Journal Of Cardiovascular Drugs 2023, 23: 101-112. PMID: 36622539, DOI: 10.1007/s40256-022-00562-5.Peer-Reviewed Original ResearchMeSH KeywordsBenzoatesChinaCoumarinsDose-Response Relationship, DrugDouble-Blind MethodEast Asian PeopleHealthy VolunteersHumansWarfarinConceptsHealthy Chinese volunteersMultiple ascending dosesChinese volunteersDose titrationAdverse eventsPharmacodynamic profileSequential cohortsDose-escalation phase I trialTarget international normalized ratioTreatment-related adverse eventsSerious adverse eventsPhase I trialInternational normalized ratioTarget rangeHealthy Chinese populationAscending dosesI trialNormalized ratioStable anticoagulationTecarfarinCohortChinese populationTolerabilityEarly withdrawalVolunteers
2021
Systemic pharmacological verification of Baixianfeng decoction regulating TNF-PI3K-Akt-NF-κB pathway in treating rheumatoid arthritis
Wei X, Zhou R, Chen Y, Ma G, Yang Y, Lu C, Xu W, Hu W. Systemic pharmacological verification of Baixianfeng decoction regulating TNF-PI3K-Akt-NF-κB pathway in treating rheumatoid arthritis. Bioorganic Chemistry 2021, 119: 105519. PMID: 34864624, DOI: 10.1016/j.bioorg.2021.105519.Peer-Reviewed Original ResearchConceptsAdjuvant arthritis ratsRheumatoid arthritisArthritis ratsIL-1βIL-6Akt-NFSystemic pharmacologyAdjuvant arthritis rat modelAnimal experimentsPathological phenotypesProtein expressionArthritis rat modelP-p65 proteinP-PI3KPathway protein expressionTraditional Chinese medicinePharmacological verificationInflammatory factorsSystemic diseaseRat modelΚB pathwayDegradation of collagenP-AktTNFSerum content
2017
Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells
Li Y, Li G, Wang K, Xie Y, Zhou R, Meng Y, Ding R, Ge J, Chen F. Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells. Toxicology And Applied Pharmacology 2017, 319: 1-11. PMID: 28130038, DOI: 10.1016/j.taap.2017.01.016.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsAutophagyCell DifferentiationCell Line, TumorDose-Response Relationship, DrugHumansLeukemia, Promyelocytic, AcuteRetinoidsConceptsAcute promyelocytic leukemiaAPL cellsPhenyl retinateTrans retinoic acid (ATRA) derivativePML-RARα degradationEffects of ATPRHuman acute promyelocytic leukemia NB4 cellsRetinoic acid derivativesΓ-secretase inhibitorAcute promyelocytic leukemia NB4 cellsTrans retinoic acidEssential autophagy genes Atg5Inhibition of autophagyPromyelocytic leukemia NB4 cellsAPL patientsPromyelocytic leukemiaCell differentiationLeukemia NB4 cellsAutophagy gene ATG5Differentiation agentsATPRNB4 cellsRetinoic acidClinical applicationUnderlying mechanism
2015
Interleukin-6 enhances acid-induced apoptosis via upregulating acid-sensing ion channel 1a expression and function in rat articular chondrocytes
Zhou R, Wu X, Wang Z, Ge J, Chen F. Interleukin-6 enhances acid-induced apoptosis via upregulating acid-sensing ion channel 1a expression and function in rat articular chondrocytes. International Immunopharmacology 2015, 29: 748-760. PMID: 26359543, DOI: 10.1016/j.intimp.2015.08.044.Peer-Reviewed Original ResearchMeSH KeywordsAcid Sensing Ion ChannelsAcidsAnimalsAntibodies, Monoclonal, HumanizedApoptosisApoptosis Regulatory ProteinsArthritis, ExperimentalCartilage, ArticularChondrocytesDose-Response Relationship, DrugEnzyme ActivationInterleukin-6L-Lactate DehydrogenaseMalePeptidesRatsRats, Sprague-DawleySpider VenomsUp-RegulationConceptsInflammatory cytokine interleukin-6Acid-sensing ion channelsArticular chondrocyte apoptosisRat articular chondrocytesChondrocyte apoptosisRheumatoid arthritisAcid-induced cell injuryArticular chondrocytesAdjuvant arthritis ratsPrimary rat articular chondrocytesChronic inflammatory diseaseCytokine interleukin-6IL-6 receptorJAK2/STAT3Dose-dependent mannerArthritis ratsInflammatory diseasesInterleukin-6Specific antagonistCell injuryNF-κBAcid-induced apoptosisLDH releaseArthritic cartilageDownregulated expression