Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation
Ding J, Chen Y, Zhao Y, Chen F, Dong L, Zhang H, Hu W, Li S, Zhou R, Hu W. Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation. Biochemical Pharmacology 2022, 202: 115107. PMID: 35643339, DOI: 10.1016/j.bcp.2022.115107.Peer-Reviewed Original ResearchConceptsAcid-sensitive ion channel 1aChondrocyte senescenceIon channel 1aChannel 1aBeclin-1Chronic joint diseaseBeclin-1 protein expressionRat OA modelProtein Beclin 1Senescence-related markersJoint diseaseOA modelAging of chondrocytesJoint cavityPsalmotoxin-1Chondrocyte autophagyOsteoarthritisB1 expressionProtein expressionCationic channelsHairpin RNALamin B1Autophagy pathwayArticular cartilageLamin B1 expressionBlockade of ASIC1a inhibits acid-induced rat articular chondrocyte senescence through regulation of autophagy
Yang Y, Ding J, Chen Y, Ma G, Wei X, Zhou R, Hu W. Blockade of ASIC1a inhibits acid-induced rat articular chondrocyte senescence through regulation of autophagy. Human Cell 2022, 35: 665-677. PMID: 35075624, DOI: 10.1007/s13577-022-00676-7.Peer-Reviewed Original ResearchConceptsAcid-sensitive ion channel 1aChondrocyte senescenceRat articular chondrocytesSenescence-related markersExtracellular acidificationSenescence-associated secretory phenotypeTreatment of osteoarthritisPotential therapeutic strategySenescence-associated β-galactosidaseIon channel 1aProtein LC3B-IIArticular chondrocytesC28/I2 chondrocyte cell lineMatrix metalloproteinases genesChondrocyte cell lineTherapeutic strategiesChondrocyte damageControl groupROS expressionPsalmotoxin-1Secretory phenotypeChannel 1aChondrocyte autophagyLC3B-IIMetalloproteinases genes