Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells
Li Y, Li G, Wang K, Xie Y, Zhou R, Meng Y, Ding R, Ge J, Chen F. Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells. Toxicology And Applied Pharmacology 2017, 319: 1-11. PMID: 28130038, DOI: 10.1016/j.taap.2017.01.016.Peer-Reviewed Original ResearchConceptsAcute promyelocytic leukemiaAPL cellsPhenyl retinateTrans retinoic acid (ATRA) derivativePML-RARα degradationEffects of ATPRHuman acute promyelocytic leukemia NB4 cellsRetinoic acid derivativesΓ-secretase inhibitorAcute promyelocytic leukemia NB4 cellsTrans retinoic acidEssential autophagy genes Atg5Inhibition of autophagyPromyelocytic leukemia NB4 cellsAPL patientsPromyelocytic leukemiaCell differentiationLeukemia NB4 cellsAutophagy gene ATG5Differentiation agentsATPRNB4 cellsRetinoic acidClinical applicationUnderlying mechanism