2018
The role of Ca2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis
Wu X, Ren G, Zhou R, Ge J, Chen F. The role of Ca2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis. Laboratory Investigation 2018, 99: 499-513. PMID: 30487596, DOI: 10.1038/s41374-018-0135-3.Peer-Reviewed Original ResearchConceptsAcid-sensitive ion channelsChondrocyte pyroptosisCaspase-1Rheumatoid arthritisIL-18Role of Ca2Autoimmune diseasesIL-1βAdjuvant arthritis rat modelExpression of ASIC1aMain pathogenic featureRat adjuvant arthritisJoints of ratsArthritis rat modelApoptosis-associated speck-like proteinProinflammatory cytokines interleukinExpression of COL2ASpeck-like proteinASIC-1asAdjuvant arthritisPoor prognosisCytokines interleukinNLRP3 inflammasomeAA ratsRat model
2017
ASIC2a overexpression enhances the protective effect of PcTx1 and APETx2 against acidosis-induced articular chondrocyte apoptosis and cytotoxicity
Zhou R, Ni W, Dai B, Wu X, Wang Z, Xie Y, Wang Z, Yang W, Ge J, Hu W, Chen F. ASIC2a overexpression enhances the protective effect of PcTx1 and APETx2 against acidosis-induced articular chondrocyte apoptosis and cytotoxicity. Gene 2017, 642: 230-240. PMID: 29141196, DOI: 10.1016/j.gene.2017.11.034.Peer-Reviewed Original ResearchMeSH KeywordsAcid Sensing Ion Channel BlockersAcid Sensing Ion ChannelsAcidosisAlkanesulfonic AcidsAnimalsApoptosisCells, CulturedChondrocytesCnidarian VenomsCollagen Type IIDrug SynergismGene Expression RegulationGenetic VectorsMAP Kinase Signaling SystemMorpholinesPeptidesPlasmidsRatsSpider VenomsConceptsAcid-sensing ion channel 1aArticular chondrocyte apoptosisChondrocyte apoptosisChondrocyte cytotoxicityRheumatoid arthritisProtective effectExpression of ASIC1aAcidosis-induced injuryERK1/2 MAPK signaling pathwaysIon channel 1aAlone groupNeuroprotective effectsChondroprotective effectsMAPK signaling pathwaysProtective roleType II collagenChannel 1aNeuronal cellsAPETx2ASIC2aPcTx1Phosphorylated ERK1/2Pathological charactersInduced apoptosisII collagen