2018
4-Amino-2-Trifluoromethyl-Phenyl Retinate induced leukemia cell differentiation by decreasing eIF6
Wang K, Wang C, Zhu C, Li G, Li Y, Feng Y, Ruan J, Zhu F, Meng Y, Zhou R, Chen F. 4-Amino-2-Trifluoromethyl-Phenyl Retinate induced leukemia cell differentiation by decreasing eIF6. Biochemical And Biophysical Research Communications 2018, 503: 2033-2039. PMID: 30078681, DOI: 10.1016/j.bbrc.2018.07.153.Peer-Reviewed Original ResearchConceptsLeukemia cell differentiationTrans retinoic acid (ATRA) derivativeEukaryotic translation initiation factor 6Cell proliferationEffects of ATPRRetinoic acid derivativesCell differentiationSurface antigen CD11bDifferentiation of K562Potential molecular mechanismsProliferation of K562Leukemia cell linesPhenyl retinateATPRInnovative treatmentsLeukemia cellsCell surface antigen CD11bC-MycCell linesFactor 6Induced differentiationK562ProliferationMolecular mechanismsCBF
2017
Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells
Li Y, Li G, Wang K, Xie Y, Zhou R, Meng Y, Ding R, Ge J, Chen F. Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells. Toxicology And Applied Pharmacology 2017, 319: 1-11. PMID: 28130038, DOI: 10.1016/j.taap.2017.01.016.Peer-Reviewed Original ResearchConceptsAcute promyelocytic leukemiaAPL cellsPhenyl retinateTrans retinoic acid (ATRA) derivativePML-RARα degradationEffects of ATPRHuman acute promyelocytic leukemia NB4 cellsRetinoic acid derivativesΓ-secretase inhibitorAcute promyelocytic leukemia NB4 cellsTrans retinoic acidEssential autophagy genes Atg5Inhibition of autophagyPromyelocytic leukemia NB4 cellsAPL patientsPromyelocytic leukemiaCell differentiationLeukemia NB4 cellsAutophagy gene ATG5Differentiation agentsATPRNB4 cellsRetinoic acidClinical applicationUnderlying mechanism