Featured Publications
Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia
Li X, Lozovatsky L, Tommasini S, Fretz J, Finberg K. Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia. Blood Advances 2023, 7: 5156-5171. PMID: 37417950, PMCID: PMC10480544, DOI: 10.1182/bloodadvances.2022009524.Peer-Reviewed Original ResearchConceptsSinusoidal endothelial cellsEndothelial cellsBone marrowBM sectionsFGF23 upregulationFibroblast growth factor 23Iron deficiencyElevated serum erythropoietinFGF23 promoter activityBM endothelial cellsGrowth factor 23Vitamin D metabolismIron deficiency anemiaSystemic iron deficiencyKnockout mice exhibitBone marrow sinusoidal endothelial cellsNormal iron balanceNonanemic controlsChronic anemiaFactor 23D metabolismEndothelial cell populationErythropoietin treatmentDeficiency anemiaMouse model
2021
Bone Marrow Sinusoidal Endothelial Cells Are a Site of Fgf23 Upregulation in Iron Deficiency Anemia
Li X, Lozovatsky L, Fretz J, Finberg K. Bone Marrow Sinusoidal Endothelial Cells Are a Site of Fgf23 Upregulation in Iron Deficiency Anemia. Blood 2021, 138: 759. DOI: 10.1182/blood-2021-153329.Peer-Reviewed Original ResearchIron deficiency anemiaSinusoidal endothelial cellsBone marrow sinusoidal endothelial cellsNon-anemic controlsBone marrowFGF23 upregulationEndothelial cellsHepcidin elevationDeficiency anemiaFGF23 productionSerum erythropoietinChronic iron deficiency anemiaIron deficiencyFGF23 promoter activityTissue iron deficiencyIron-restricted anemiaFemurs of miceSystemic iron deficiencyBone marrow sectionsReporter alleleNormal iron balanceEndothelial cell subtypesTotal FGF23Phosphaturic hormoneBlood loss
2014
Chapter Seven Use of Osmium Tetroxide Staining with Microcomputerized Tomography to Visualize and Quantify Bone Marrow Adipose Tissue In Vivo
Scheller EL, Troiano N, VanHoutan JN, Bouxsein MA, Fretz JA, Xi Y, Nelson T, Katz G, Berry R, Church CD, Doucette CR, Rodeheffer MS, MacDougald OA, Rosen CJ, Horowitz MC. Chapter Seven Use of Osmium Tetroxide Staining with Microcomputerized Tomography to Visualize and Quantify Bone Marrow Adipose Tissue In Vivo. Methods In Enzymology 2014, 537: 123-139. PMID: 24480344, PMCID: PMC4097010, DOI: 10.1016/b978-0-12-411619-1.00007-0.Peer-Reviewed Original ResearchConceptsStromal vascular fractionBone marrowAdipose tissueBone marrow adipose tissueWhite adipose tissue depotsMicrocomputerized tomographyAdipose tissue depotsMarrow recoveryDrug treatmentMedullary canalTissue depotsMetabolic diseasesVascular fractionStromal cellsMarrow fatEndothelial cellsAdipocyte progenitorsMature adipocytesLong bonesMAT volumeAdipocytesStainingOsmium tetroxide stainingHistochemical stainingConventional quantitation