2013
The role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration.
Friedlaender GE, Lin S, Solchaga LA, Snel LB, Lynch SE. The role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration. Current Pharmaceutical Design 2013, 19: 3384-90. PMID: 23432673, DOI: 10.2174/1381612811319190005.Peer-Reviewed Original ResearchConceptsRecombinant human platelet-derived growth factor-BBClinical studiesMesenchymal stem cellsRecombinant human PDGFStrong mitogenic factorHuman platelet-derived growth factor-BBPlatelet-derived growth factor-BBPivotal clinical studiesImproved safety profileTissue repairGrowth factor-BBMechanism of actionDiabetic patientsChronic footSafety profileAnkle fusionPeriodontal diseaseChronic infectionClinical developmentSoft tissue repairAlveolar boneBone autograftHuman PDGFMitogenic factorFactor-BB
2001
Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions.
Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, Zych GA, Calhoun JH, LaForte AJ, Yin S. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. Journal Of Bone And Joint Surgery 2001, 83-A Suppl 1: s151-8. PMID: 11314793, PMCID: PMC1425155, DOI: 10.2106/00004623-200100002-00010.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone Morphogenetic Protein 7Bone Morphogenetic ProteinsBone TransplantationCollagenDrug CarriersDrug Delivery SystemsFemaleFracture Fixation, IntramedullaryFracture HealingFractures, UnunitedHumansMaleProspective StudiesRadiographyRecombinant ProteinsTibial FracturesTransforming Growth Factor betaConceptsTibial nonunionAdverse eventsRadiographic resultsClinical trialsOsteogenic protein-1Bone autograftAutogenous boneChronic donor site painAutograft-treated patientsFresh autogenous bonePlain radiographic evaluationMulti-center clinical trialPercent of patientsSeverity of painDonor site painGroup of patientsProtein 1Bone morphogenetic proteinNumerous animal modelsInvestigational device exemptionDonor site morbiditySame time pointsType ISite painClinical course