2020
Re-appraising the potential of naringin for natural, novel orthopedic biotherapies
Yu KE, Alder KD, Morris MT, Munger AM, Lee I, Cahill SV, Kwon HK, Back J, Lee FY. Re-appraising the potential of naringin for natural, novel orthopedic biotherapies. Therapeutic Advances In Musculoskeletal Disease 2020, 12: 1759720x20966135. PMID: 33343723, PMCID: PMC7727086, DOI: 10.1177/1759720x20966135.Peer-Reviewed Original ResearchBone morphogenetic proteinExtracellular signal-related kinase (ERK) pathwayRANK/RANKL interactionNumerous molecular pathwaysWnt/β-cateninBone resident cellsStem cell precursorsCellular differentiationKinase pathwayMorphogenetic proteinsPotential of naringinMolecular pathwaysΒ-cateninCellular mechanismsBone-preserving effectCommon musculoskeletal pathologiesEstrogen-sensitive tissuesOsteolytic bone diseaseCommon musculoskeletal conditionsMusculoskeletal developmentSystemic side effectsTreatment of osteoporosisDegenerative joint diseaseCell precursorsBone microenvironment
2011
Actin and ERK1/2-CEBPβ signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cells
Lee HG, Minematsu H, Kim KO, Aydemir A, Shin MJ, Nizami SA, Chung KJ, Hsu AC, Jacobs CR, Lee FY. Actin and ERK1/2-CEBPβ signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cells. Biomaterials 2011, 32: 9197-9206. PMID: 21899882, PMCID: PMC3193180, DOI: 10.1016/j.biomaterials.2011.08.059.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdhesivenessAnimalsBenzimidazolesBone and BonesCCAAT-Enhancer-Binding Protein-betaCyclooxygenase 2Cytochalasin DExtracellular Signal-Regulated MAP KinasesGene Expression RegulationHumansImmunity, InnateInflammationInterleukin-6MAP Kinase Signaling SystemMiceModels, BiologicalOsteogenesisOsteolysisPhagocytosisProtein Kinase InhibitorsSignal TransductionSkullStem CellsTime FactorsTitaniumConceptsInflammatory osteolysisInflammatory responseMacrophage-mediated inflammatory responsesKey inflammatory pathwaysSuitable therapeutic targetInflammatory gene expressionInnate immune responseOsteoprogenitor cellsInflammatory cascadeInflammatory pathwaysImmune responseTherapeutic targetHost bone-implant interfaceAZD6244 treatmentIntracellular mechanismsBone-implant interfaceBone formationCellular mechanismsERK pathwayInflammationΒ pathwayOsteoclastogenesisOsteolysisIntracellular signalingImplant osteointegration