2024
Efficacy of Voluntary Medical Male Circumcision to Prevent HIV Infection Among Men Who Have Sex With Men : A Randomized Controlled Trial.
Gao Y, Zhan Y, Sun Y, Zheng W, Zhang W, Fu L, Guo Z, Lin Y, Li Y, Zheng L, Zhan Y, Zhu Z, Duan J, Zhang G, Huang T, Su B, Yu M, Wu G, Ouyang L, Zhao J, Wang G, Zhou Y, Qian H, Fitzpatrick T, Vermund S, Zou H. Efficacy of Voluntary Medical Male Circumcision to Prevent HIV Infection Among Men Who Have Sex With Men : A Randomized Controlled Trial. Annals Of Internal Medicine 2024, 177: 719-728. PMID: 38801778, DOI: 10.7326/m23-3317.Peer-Reviewed Original ResearchVoluntary medical male circumcisionEfficacy of VMMCPreventing incident HIV infectionsRandomized controlled trialsMedical male circumcisionIncident HIV infectionIntervention groupInsertive anal intercoursePractice insertive anal intercourseMale circumcisionAnal intercourseIncidence rate of syphilisHIV infectionRates of syphilisMale sex partnersSexually transmitted infectionsIntention-to-treat analysisPrevent HIV infectionHIV incidenceControl groupHIV riskIncidence rateHerpes simplex virus type 2HIV seroconversionSelf-report
2022
Does Voluntary Medical Male Circumcision Reduce HIV Risk in Men Who Have Sex with Men?
Lin Y, Gao Y, Sun Y, Turner D, Zou H, Vermund S, Qian H. Does Voluntary Medical Male Circumcision Reduce HIV Risk in Men Who Have Sex with Men? Current HIV/AIDS Reports 2022, 19: 522-525. PMID: 36520379, DOI: 10.1007/s11904-022-00637-7.Peer-Reviewed Original ResearchConceptsVoluntary medical male circumcisionRandomized clinical trialsHIV riskMedical male circumcisionPurpose of ReviewToSubgroup of menHIV prevalenceClinical trialsAnal sexMale circumcisionPopulation-level impactAvailable evidenceMSMInsertive roleConflicting resultsMenSexRiskOriginal studyEfficacyInterventionEvidenceReviewToStrong evidencePrevalenceVoluntary Medical Male Circumcision to Reduce HIV Acquisition and Transmission
Vermund S. Voluntary Medical Male Circumcision to Reduce HIV Acquisition and Transmission. Current HIV/AIDS Reports 2022, 19: 471-473. PMID: 36478080, PMCID: PMC10767716, DOI: 10.1007/s11904-022-00631-z.Peer-Reviewed Original ResearchConceptsHIV acquisitionVoluntary medical male circumcisionHIV infection acquisitionVoluntary medical male circumcision (VMMC) programsMinor surgical interventionsMale circumcision programsHIV incidence ratesHigh HIV prevalenceMedical male circumcisionFirst clinical trialUninfected menHIV incidenceHIV prevalenceInfection acquisitionSaharan AfricaSurgical interventionCircumcision programsClinical trialsIncidence ratePreventive benefitsHIV riskCircumcision ratesRecent FindingsSinceMale circumcisionHealth sectionVoluntary Medical Male Circumcision for HIV Prevention: a Global Overview
Zhang C, Vermund S. Voluntary Medical Male Circumcision for HIV Prevention: a Global Overview. Current HIV/AIDS Reports 2022, 19: 474-483. PMID: 36348186, DOI: 10.1007/s11904-022-00632-y.Peer-Reviewed Original ResearchConceptsVoluntary medical male circumcisionMedical male circumcisionHIV preventionMale circumcisionPrevention strategiesEvidence-based HIV prevention strategiesBehavioral prevention strategiesHigher sexual risk behaviorsHIV prevention strategiesSexual risk behaviorsPurpose of ReviewWithDecreased riskClinical trialsCircumcision coverageVMMC coverageProtective effectRecent FindingsThereHealth professionalsSystematic reviewIncidence areaRisk behaviorsSexual partnersHealth authoritiesHealth systemMale partners
2021
Association between medical male circumcision and HIV risk compensation among heterosexual men: a systematic review and meta-analysis
Gao Y, Yuan T, Zhan Y, Qian HZ, Sun Y, Zheng W, Fu L, Liang B, Zhu Z, Ouyang L, Liu M, Fitzpatrick T, Wu Z, Meng X, Baeten JM, Zhao J, Vermund SH, Yu M, Wu G, Su B, Zou H. Association between medical male circumcision and HIV risk compensation among heterosexual men: a systematic review and meta-analysis. The Lancet Global Health 2021, 9: e932-e941. PMID: 33939956, PMCID: PMC8690595, DOI: 10.1016/s2214-109x(21)00102-9.Peer-Reviewed Original ResearchConceptsMedical male circumcisionHigh-risk sexual behaviorOdds ratioMultiple sex partnersSex partnersHIV infectionMale circumcisionMantel-Haenszel random-effects modelSystematic reviewCondom useHeterosexual menLow self-perceived riskAdjusted odds ratioSelf-perceived riskPooled odds ratioHIV preventive measuresMultiple sexual partnersSexual behaviorRandom-effects modelSexual health educationOriginal study dataCircumcision prevalenceCochrane LibrarySubgroup analysisEligible studies
2019
Predicting the long-term impact of voluntary medical male circumcision on HIV incidence among men who have sex with men in Beijing, China
Zhang C, Webb GF, Lou J, Shepherd BE, Qian HZ, Liu Y, Vermund SH. Predicting the long-term impact of voluntary medical male circumcision on HIV incidence among men who have sex with men in Beijing, China. AIDS Care 2019, 32: 343-353. PMID: 31619058, PMCID: PMC6981072, DOI: 10.1080/09540121.2019.1679704.Peer-Reviewed Original ResearchConceptsVoluntary medical male circumcisionNew HIV casesMedical male circumcisionHIV incidenceHIV casesMale circumcisionSignificant public health impactHIV prevention interventionsPublic health impactCoverage ratePrevention interventionsNew infectionsEvidence baseMSMMenHealth impactsIncidenceCircumcisionLong-term impactFirst studyDifferent coverage ratesInfectionPrevalenceBaselineModeling economic and epidemiological impact of voluntary medical male circumcision among men who have sex with men in Beijing, China
Zhang C, Penson DF, Qian HZ, Webb GF, Lou J, Shephard BE, Liu Y, Vermund SH. Modeling economic and epidemiological impact of voluntary medical male circumcision among men who have sex with men in Beijing, China. International Journal Of STD & AIDS 2019, 30: 630-638. PMID: 30890118, PMCID: PMC6666307, DOI: 10.1177/0956462419831859.Peer-Reviewed Original ResearchConceptsVoluntary medical male circumcisionNew HIV casesMedical male circumcisionHIV casesMale circumcisionHIV/AIDS epidemicCoverage rateHIV acquisitionHIV incidenceCumulative numberCircumcision ratesDeterministic compartmental modelEpidemiological impactVMMC implementationAIDS epidemicMenMSMCircumcisionSexYearsCompartmental modelCasesIncidenceVoluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review
Zhang C, Qian HZ, Liu Y, Vermund SH. Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review. SAGE Open Medicine 2019, 7: 2050312119869110. PMID: 31448119, PMCID: PMC6689924, DOI: 10.1177/2050312119869110.Peer-Reviewed Original ResearchVoluntary medical male circumcisionMedical male circumcisionMale circumcisionSystematic reviewHIV infectionProtective effectPotential protective effectArticles/abstractsMeta-Analyses (PRISMA) guidelinesRandomized control trialPreferred Reporting ItemsRandom-effects modelKey study characteristicsComprehensive literature searchSubgroup analysisHIV epidemicHIV preventionHIV riskControl trialReporting ItemsStudy characteristicsLiterature searchCircumcisionSexMen
2016
Lower HIV Risk Among Circumcised Men Who Have Sex With Men in China
Qian HZ, Ruan Y, Liu Y, Milam DF, Spiegel HM, Yin L, Li D, Shepherd BE, Shao Y, Vermund SH. Lower HIV Risk Among Circumcised Men Who Have Sex With Men in China. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 71: 444-451. PMID: 26413852, PMCID: PMC4767598, DOI: 10.1097/qai.0000000000000856.Peer-Reviewed Original ResearchConceptsLower oddsHIV infectionGenital examinationMale circumcisionVoluntary medical male circumcisionLifetime male sexual partnersHIV heterosexual transmissionMale sexual transmissionLow HIV riskInsertive anal sexInsertive anal intercourseMedical male circumcisionMale sexual partnersAnal sex rolesUncircumcised menCircumcision statusHeterosexual transmissionSexual transmissionInsertive sexClinical trialsHIV riskCircumcision ratesSyphilis riskAnal intercourseLower risk
2014
A-101 New Evidence that Circumcision Might Protect MSM from HIV
Vermund S, Qian H, Ruan Y, Shao Y, Liu Y, Milam D, Spiegel H, Li D, Yin L. A-101 New Evidence that Circumcision Might Protect MSM from HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: 37. DOI: 10.1097/01.qai.0000456053.93927.60.Peer-Reviewed Original ResearchInsertive anal sexAnal sexUncircumcised menCircumcision statusMale circumcisionMultivariate logistic regression analysisOdds of HIVUnknown HIV statusHIV prevention strategiesCross-sectional studyInsertive anal intercourseLogistic regression analysisAnal sex rolesAdjusted riskHIV clinicSyphilis infectionHIV statusClinical trialsCircumcision ratesGenital examinationAnal intercourseLower oddsGenital examHIVPrevention strategiesStrategic Roles for Health Communication in Combination HIV Prevention and Care Programs
Vermund SH, Van Lith LM, Holtgrave D. Strategic Roles for Health Communication in Combination HIV Prevention and Care Programs. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 66: s237-s240. PMID: 25007259, DOI: 10.1097/qai.0000000000000244.Peer-Reviewed Original ResearchConceptsHIV preventionHealth communicationAcquired Immune Deficiency SyndromeVoluntary medical male circumcisionPrevention of motherOpiate substitution therapyImmune deficiency syndromeCombination HIV preventionMedical male circumcisionRisk of HIVHealth communication expertsEvidence of effectivenessHealth communication strategiesEffective health communicationHealth communication approachChild transmissionPreexposure prophylaxisHIV controlSubstitution therapyDeficiency syndromeCurrent evidenceMale circumcisionCare programNeedle exchangePrevention
2013
Combination Prevention: New Hope for Stopping the Epidemic
Vermund SH, Hayes RJ. Combination Prevention: New Hope for Stopping the Epidemic. Current HIV/AIDS Reports 2013, 10: 169-186. PMID: 23456730, PMCID: PMC3642362, DOI: 10.1007/s11904-013-0155-y.Peer-Reviewed Original ResearchMeSH KeywordsAfrica South of the SaharaAnti-HIV AgentsFemaleHealth Knowledge, Attitudes, PracticeHealth PolicyHealth Services AccessibilityHIV InfectionsHumansInfectious Disease Transmission, VerticalMaleMass ScreeningPatient Acceptance of Health CarePregnancyPregnancy Complications, InfectiousRisk Reduction BehaviorSex WorkersSexual BehaviorSocial StigmaSocioeconomic FactorsWorld Health OrganizationConceptsAntiretroviral therapyVoluntary medical male circumcisionCombination prevention approachesOral antiretroviral drugsPre-exposure prophylaxisMedical male circumcisionSuccessful viral suppressionConsistent condom useEvidence-based modalitiesBoost vaccineViral suppressionHIV testingAntiretroviral coverageHIV transmissionAntiretroviral drugsBlood screeningVaginal microbicidesClean needlesInfection controlAdolescent sexual debutTransmission reductionFemale condomMale circumcisionSingle interventionHIV research
2010
Combination HIV Prevention: Significance, Challenges, and Opportunities
Kurth AE, Celum C, Baeten JM, Vermund SH, Wasserheit JN. Combination HIV Prevention: Significance, Challenges, and Opportunities. Current HIV/AIDS Reports 2010, 8: 62-72. PMID: 20941553, PMCID: PMC3036787, DOI: 10.1007/s11904-010-0063-3.Peer-Reviewed Original ResearchConceptsHIV prevention strategiesHIV transmissionPrevention strategiesPopulation-level HIV transmissionBehavioral risk reductionEvidence-based strategiesNumber of interventionsAntiretroviral medicationsHIV serostatusPrevention packageUninfected personsEpidemiologic profileHIV pandemicMale circumcisionNeedle exchangeEffective interventionsTarget populationInterventionRisk reductionMeasurable reductionPopulation levelDiverse subgroupsMedicationsSerostatusHIV
2009
Willingness to Be Circumcised for Preventing HIV among Chinese Men Who Have Sex with Men
Ruan Y, Qian HZ, Li D, Shi W, Li Q, Liang H, Yang Y, Luo F, Vermund SH, Shao Y. Willingness to Be Circumcised for Preventing HIV among Chinese Men Who Have Sex with Men. AIDS Patient Care And STDs 2009, 23: 315-321. PMID: 19335172, PMCID: PMC2743100, DOI: 10.1089/apc.2008.0199.Peer-Reviewed Original ResearchConceptsClinical trialsChinese MSMChinese menMale circumcisionEffectiveness of circumcisionLack of historyUncircumcised MSMHIV acquisitionHIV/Genital hygieneAdult circumcisionFree medical servicesTight foreskinSide effectsSexual partnersInfection riskMSMCircumcisionPreventing HIVMedical servicesTrialsMenHeterosexual menCommunity educationSexPreventing HIV in Developing Countries: Status of Biomedical Interventions
Vermund S. Preventing HIV in Developing Countries: Status of Biomedical Interventions. The FASEB Journal 2009, 23: 199.1-199.1. DOI: 10.1096/fasebj.23.1_supplement.199.1.Peer-Reviewed Original ResearchHIV Prevention Trials NetworkPrevention of motherHIV drug resistanceNeedle exchange programsDNA boostBehavior changeHIV seroconversionHIV seroincidenceEarly therapyPregnant womenHSV-2Clinical trialsHIVMale circumcisionDrug addiction treatmentDrug resistanceTrials NetworkAddiction treatmentBiomedical interventionsSeroincidenceInfantsRisk reductionTherapyPrevention challengesEfficacyChapter 1 Current and futuretrends implicationsfor HIV prevention
Sahasrabuddhe V, Vermund S. Chapter 1 Current and futuretrends implicationsfor HIV prevention. 2009, 9-30. DOI: 10.1016/b978-0-12-374235-3.00001-7.Peer-Reviewed Original ResearchHIV infectionHIV transmissionHIV preventionChronic HIV infectionPre-exposure prophylaxisPartial immune reconstitutionHIV prevention interventionsHIV positive livingNeedle exchange servicesAfrican AIDS epidemicAntiretroviral therapyImmune reconstitutionSecondary preventionPrimary preventionSTI controlSTI ratesDisability levelTertiary preventionPrevention interventionsAIDS deathsMale circumcisionCommunity stigmaEarly preventionMultiple interventionsRisk behaviors
2007
The Future of HIV Prevention: Control of Sexually Transmitted Infections and Circumcision Interventions
Sahasrabuddhe VV, Vermund SH. The Future of HIV Prevention: Control of Sexually Transmitted Infections and Circumcision Interventions. Infectious Disease Clinics Of North America 2007, 21: 241-257. PMID: 17502238, PMCID: PMC2700301, DOI: 10.1016/j.idc.2007.03.005.Peer-Reviewed Original ResearchConceptsHIV infectionGenital tract inflammationMale circumcision programsSTI treatmentCircumcision programsSymptomatic personsHIV preventionCurrent evidenceMale circumcisionCircumcision interventionsInfectionHIVSeparate trialsPreventionTreatmentResearch prioritiesInflammationPersonsControlTrialsCircumcision
2002
Transmission of HIV
Kristensen S, Sinkala M, Vermund S. Transmission of HIV. 2002, 217-230. DOI: 10.1007/0-306-47817-x_13.Peer-Reviewed Original ResearchSafe male circumcisionSustained antiretroviral therapyTransmission of HIVProportion of infectionsSexual partner numberAntiretroviral therapyHIV vaccineSexual exposureHIV preventionSTD treatmentHuman studiesMale circumcisionCondom useMale partnersBehavioral interventionsPartner numbersEmployment-related exposureInterventionHIVAdditional strategiesLower ratesHigh rateLimited valueSaharan AfricaExposure