2024
Efficacy of Voluntary Medical Male Circumcision to Prevent HIV Infection Among Men Who Have Sex With Men : A Randomized Controlled Trial.
Gao Y, Zhan Y, Sun Y, Zheng W, Zhang W, Fu L, Guo Z, Lin Y, Li Y, Zheng L, Zhan Y, Zhu Z, Duan J, Zhang G, Huang T, Su B, Yu M, Wu G, Ouyang L, Zhao J, Wang G, Zhou Y, Qian H, Fitzpatrick T, Vermund S, Zou H. Efficacy of Voluntary Medical Male Circumcision to Prevent HIV Infection Among Men Who Have Sex With Men : A Randomized Controlled Trial. Annals Of Internal Medicine 2024, 177: 719-728. PMID: 38801778, DOI: 10.7326/m23-3317.Peer-Reviewed Original ResearchVoluntary medical male circumcisionEfficacy of VMMCPreventing incident HIV infectionsRandomized controlled trialsMedical male circumcisionIncident HIV infectionIntervention groupInsertive anal intercoursePractice insertive anal intercourseMale circumcisionAnal intercourseIncidence rate of syphilisHIV infectionRates of syphilisMale sex partnersSexually transmitted infectionsIntention-to-treat analysisPrevent HIV infectionHIV incidenceControl groupHIV riskIncidence rateHerpes simplex virus type 2HIV seroconversionSelf-report
2023
Risk of death and readmission among individuals with heart failure and HIV: A systematic review and meta-analysis
Zhou Y, Zhang X, Gao Y, Alvi R, Erqou S, Chen Y, Wang H, Wang W, Li X, Zanni M, Neilan T, Vermund S, Qian H, Qian F. Risk of death and readmission among individuals with heart failure and HIV: A systematic review and meta-analysis. Journal Of Infection And Public Health 2023, 17: 70-75. PMID: 37992436, DOI: 10.1016/j.jiph.2023.11.004.Peer-Reviewed Original ResearchConceptsHeart failureHF patientsRisk of HFHuman immunodeficiency virus statusPoor HF outcomesRisk of deathWeb of ScienceCause deathCause readmissionHF outcomesAdult patientsCohort studyHIV infectionHIV statusCochrane LibraryIndependent associationVirus statusHigh riskDeath outcomesHIVReadmissionPatientsSystematic reviewSystematic searchRisk
2022
COVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review
Huang D, Zunong J, Li M, Li D, Gong J, Vermund SH, Hu Y. COVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review. Current HIV/AIDS Reports 2022, 19: 167-176. PMID: 35394249, PMCID: PMC8990500, DOI: 10.1007/s11904-022-00606-0.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyCOVID-19 clinical severityCOVID-19 clinical presentationCOVID-19Undetectable viral loadAsymptomatic COVID-19Severe COVID-19Last clinical visitCase series/reportsCase fatality rateCOVID-19 prognosisLate antiretroviral therapyIL-6 resultsSARS-CoV-2COVID-19 diagnosisMedian CD4Gastrointestinal symptomsHIV infectionMedian ageRespiratory distressClinical featuresClinical presentationClinical visitsViral loadClinical details
2021
Hepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in Kazakhstan
Mukhatayeva A, Mustafa A, Dzissyuk N, Issanov A, Bayserkin B, Vermund SH, Ali S. Hepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in Kazakhstan. Scientific Reports 2021, 11: 13542. PMID: 34188081, PMCID: PMC8241865, DOI: 10.1038/s41598-021-92688-w.Peer-Reviewed Original ResearchConceptsStudy participantsHepatitis CHepatitis BRegular screeningHIV-positive study participantsHCV/HBVHIV-positive patientsTB/HIVHIV/HCVDirect acting antiviralsHIV/tuberculosisOpiate substitution therapyInjection drug useHarm reduction effortsAvailability of ARTHCV infectionTB infectionActing antiviralsCertain age groupsPositive patientsHIV infectionHIV prevalenceSubstitution therapyVaccination protocolsQuadruple infectionsHuman Immunodeficiency Virus Infection and Incident Heart Failure: A Meta-Analysis of Prospective Studies
Chen Y, Gao Y, Zhou Y, Li X, Wang H, Polonsky TS, Vermund SH, Qian HZ, Qian F. Human Immunodeficiency Virus Infection and Incident Heart Failure: A Meta-Analysis of Prospective Studies. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2021, 87: 741-749. PMID: 33492019, PMCID: PMC10768809, DOI: 10.1097/qai.0000000000002629.Peer-Reviewed Original ResearchConceptsIncident heart failureLow CD4 countHeart failureHIV infectionRandom-effects modelCD4 countSubgroup analysisRisk of HFHuman immunodeficiency virus (HIV) infectionLaird random-effects modelYoung adultsAvailable prospective evidenceImmunodeficiency virus infectionPooled relative riskFull-text assessmentWeb of ScienceFixed-effects modelProspective studyIncident casesProspective evidenceRelative riskVirus infectionFunnel plotMeta-AnalysisSimilar associationAssociation between medical male circumcision and HIV risk compensation among heterosexual men: a systematic review and meta-analysis
Gao Y, Yuan T, Zhan Y, Qian HZ, Sun Y, Zheng W, Fu L, Liang B, Zhu Z, Ouyang L, Liu M, Fitzpatrick T, Wu Z, Meng X, Baeten JM, Zhao J, Vermund SH, Yu M, Wu G, Su B, Zou H. Association between medical male circumcision and HIV risk compensation among heterosexual men: a systematic review and meta-analysis. The Lancet Global Health 2021, 9: e932-e941. PMID: 33939956, PMCID: PMC8690595, DOI: 10.1016/s2214-109x(21)00102-9.Peer-Reviewed Original ResearchConceptsMedical male circumcisionHigh-risk sexual behaviorOdds ratioMultiple sex partnersSex partnersHIV infectionMale circumcisionMantel-Haenszel random-effects modelSystematic reviewCondom useHeterosexual menLow self-perceived riskAdjusted odds ratioSelf-perceived riskPooled odds ratioHIV preventive measuresMultiple sexual partnersSexual behaviorRandom-effects modelSexual health educationOriginal study dataCircumcision prevalenceCochrane LibrarySubgroup analysisEligible studiesAssociation of HIV infection and cognitive impairment in older adults: A meta-analysis
Deng L, Zhang X, Gao Y, Turner D, Qian F, Lu H, Vermund SH, Zhang Y, Qian HZ. Association of HIV infection and cognitive impairment in older adults: A meta-analysis. Ageing Research Reviews 2021, 68: 101310. PMID: 33640473, PMCID: PMC10767715, DOI: 10.1016/j.arr.2021.101310.Peer-Reviewed Original ResearchConceptsHIV infectionCognitive impairmentOlder adultsOdds ratioHuman immunodeficiency virus (HIV) infectionMean differenceMotor/psychomotorImmunodeficiency virus infectionMajor cognitive domainsNewcastle-Ottawa ScaleConfidence intervalsRisk of biasPooled odds ratioCross-sectional studyRandom-effects modelIncome countriesCognitive domainsGlobal cognitive impairmentExecutive functionOlder PLWHVirus infectionHigh-income countriesHIVPLWHUpper middle-income countries
2020
An unrecognized key population? Traditional treatment practices associated with HIV risk among traditional healers in rural South Africa.
Audet CM, Ngobeni S, Mkansi M, Wafawanaka F, Aliyu MH, Vermund SH, Wagner RG. An unrecognized key population? Traditional treatment practices associated with HIV risk among traditional healers in rural South Africa. AIDS 2020, 34: 2313-2317. PMID: 33048882, PMCID: PMC7674239, DOI: 10.1097/qad.0000000000002710.Peer-Reviewed Original ResearchConceptsSkin incisionPatient's bloodHIV testTraditional healersHIV prevalenceKey populationsRapid HIV testsRisk of acquisitionHigh HIV prevalenceBlood-borne pathogensTraditional treatment practicesSouth African traditional healersPositive test resultsCross-sectional surveyPersonal protective equipmentHIV acquisitionHIV infectionPosttest counselingPretest counselingHIV riskOccupational exposureMAIN OUTCOMERural South AfricaHIVAfrican traditional healersHIV Seroconversion and Types of Relationships Among Men Who Have Sex With Men: A Cohort Study in China.
Sun X, Wang C, Zhao K, Zhang L, Li M, Sun D, Shu W, Ruan Y, Zhang J, Vermund SH, Li D, Hu Y. HIV Seroconversion and Types of Relationships Among Men Who Have Sex With Men: A Cohort Study in China. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2020, 83: 365-372. PMID: 31913999, PMCID: PMC7055498, DOI: 10.1097/qai.0000000000002264.Peer-Reviewed Original ResearchConceptsHIV seroconversionSeroconversion riskHIV seroconversion ratesHIV seroconversion riskMultivariable Cox regressionHIV-negative menIncident HIV infectionRegular sexual partnersRelative excess riskUnprotected anal sexSexual behaviorLast sexual encounterUnsafe sexual behaviorSafer sex educationSeroconversion ratesCohort studyHIV infectionRisky sexual behaviorHIV statusCox regressionExcess riskRisk factorsRegular partnersLow educational attainmentCasual partners
2019
Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART)
Hayes RJ, Donnell D, Floyd S, Mandla N, Bwalya J, Sabapathy K, Yang B, Phiri M, Schaap A, Eshleman SH, Piwowar-Manning E, Kosloff B, James A, Skalland T, Wilson E, Emel L, Macleod D, Dunbar R, Simwinga M, Makola N, Bond V, Hoddinott G, Moore A, Griffith S, Deshmane Sista N, Vermund SH, El-Sadr W, Burns DN, Hargreaves JR, Hauck K, Fraser C, Shanaube K, Bock P, Beyers N, Ayles H, Fidler S. Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART). New England Journal Of Medicine 2019, 381: 207-218. PMID: 31314965, PMCID: PMC6587177, DOI: 10.1056/nejmoa1814556.Peer-Reviewed Original ResearchConceptsHIV-positive participantsViral suppressionHIV infectionGroup BGroup AGroup CMonth 12Universal testingPrevention interventionsPopulation cohortHuman immunodeficiency virus (HIV) infectionHome-based HIV testingBaseline HIV prevalenceCombination prevention interventionsImmunodeficiency virus infectionHIV-positive adultsPopulation-level incidenceNew HIV infectionsAdjusted rate ratiosCommunity-randomized trialLack of effectHIV carePrevious trial resultsStandard careART adherenceVoluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review
Zhang C, Qian HZ, Liu Y, Vermund SH. Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review. SAGE Open Medicine 2019, 7: 2050312119869110. PMID: 31448119, PMCID: PMC6689924, DOI: 10.1177/2050312119869110.Peer-Reviewed Original ResearchVoluntary medical male circumcisionMedical male circumcisionMale circumcisionSystematic reviewHIV infectionProtective effectPotential protective effectArticles/abstractsMeta-Analyses (PRISMA) guidelinesRandomized control trialPreferred Reporting ItemsRandom-effects modelKey study characteristicsComprehensive literature searchSubgroup analysisHIV epidemicHIV preventionHIV riskControl trialReporting ItemsStudy characteristicsLiterature searchCircumcisionSexMen
2018
Risk Prediction Score for HIV Infection: Development and Internal Validation with Cross-Sectional Data from Men Who Have Sex with Men in China
Yin L, Zhao Y, Peratikos MB, Song L, Zhang X, Xin R, Sun Z, Xu Y, Zhang L, Hu Y, Hao C, Ruan Y, Shao Y, Vermund SH, Qian HZ. Risk Prediction Score for HIV Infection: Development and Internal Validation with Cross-Sectional Data from Men Who Have Sex with Men in China. AIDS And Behavior 2018, 22: 2267-2276. PMID: 29786768, PMCID: PMC7024582, DOI: 10.1007/s10461-018-2129-y.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcohol DrinkingChinaCondomsCross-Sectional StudiesHIV InfectionsHomosexuality, MaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisPrevalenceRisk AssessmentRisk FactorsRisk-TakingSafe SexSexual and Gender MinoritiesSexual BehaviorSexual PartnersSurveys and QuestionnairesSyphilisUnsafe SexYoung AdultConceptsHIV infectionRisk scoreHuman immunodeficiency virus (HIV) riskMultivariable logistic regression modelingBootstrap-corrected C-indexMultiple male sexual partnersValid risk scoreVaccine clinical trialsHigh-risk MSMHigh-risk personsRisk prediction scoreReceptive anal intercourseReceptive anal sexInconsistent condom useMale sexual partnersHIV prevention programmingLogistic regression modelingDrug/alcohol addictionHIV acquisitionRisk reduction programsSyphilis infectionHIV prevalenceClinical trialsC-indexIllegal drug useInternet‐based behavioral interventions for preventing HIV infection in men who have sex with men (MSM)
Zhang L, Qian H, Blevins M, Yin L, Ruan Y, Vermund S. Internet‐based behavioral interventions for preventing HIV infection in men who have sex with men (MSM). Cochrane Database Of Systematic Reviews 2018, 2018 PMCID: PMC6491287, DOI: 10.1002/14651858.cd009525.pub2.Peer-Reviewed Original Research
2017
Expanded antiretroviral treatment, sexual networks, and condom use: Treatment as prevention unlikely to succeed without partner reduction among men who have sex with men in China
Lou J, Hu P, Qian HZ, Ruan Y, Jin Z, Xing H, Shao Y, Vermund SH. Expanded antiretroviral treatment, sexual networks, and condom use: Treatment as prevention unlikely to succeed without partner reduction among men who have sex with men in China. PLOS ONE 2017, 12: e0171295. PMID: 28406992, PMCID: PMC5390964, DOI: 10.1371/journal.pone.0171295.Peer-Reviewed Original ResearchConceptsCondom use increasesNew HIV infectionsMale sexual partnersPartner reductionCondom useSexual partnersHIV infectionBeijing MSMHIV new infectionsSexual behavioral changesAntiretroviral treatmentHIV testingHIV incidenceHIV prevalenceCombination interventionsSubstantial additional benefitNew infectionsUse increasesSexual networksInfectionMSMMenRisk reductionBehavioral changesTreatmentImpact of Depression and Anxiety on Initiation of Antiretroviral Therapy Among Men Who Have Sex with Men with Newly Diagnosed HIV Infections in China
Tao J, Vermund SH, Lu H, Ruan Y, Shepherd BE, Kipp AM, Amico KR, Zhang X, Shao Y, Qian HZ. Impact of Depression and Anxiety on Initiation of Antiretroviral Therapy Among Men Who Have Sex with Men with Newly Diagnosed HIV Infections in China. AIDS Patient Care And STDs 2017, 31: 96-104. PMID: 28170305, PMCID: PMC5312604, DOI: 10.1089/apc.2016.0214.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyART initiationHIV diagnosisHIV infectionDepression scoresEarly ART initiationNational ART databaseNew HIV diagnosesImpact of depressionEffect of depressionProspective cohortBorderline depressionCox regressionHADS scoresBaseline prevalenceEligible participantsHospital AnxietyBorderline anxietyDepression ScaleDoctor's adviceChinese MSMChinese menSymptom severityHIVAnxiety scoresEffects of depression and anxiety on antiretroviral therapy adherence among newly diagnosed HIV-infected Chinese MSM
Tao J, Qian HZ, Kipp AM, Ruan Y, Shepherd BE, Amico KR, Shao Y, Lu H, Vermund SH. Effects of depression and anxiety on antiretroviral therapy adherence among newly diagnosed HIV-infected Chinese MSM. AIDS 2017, 31: 401-406. PMID: 27677168, PMCID: PMC5233466, DOI: 10.1097/qad.0000000000001287.Peer-Reviewed Original ResearchConceptsImperfect ART adherenceEffect of depressionART adherenceAntiretroviral therapyHIV infectionChinese MSMHIV treatment outcomesAntiretroviral therapy adherenceEnd of studyMixed-effects logistic regressionHIV diagnosisOne-unit increaseProspective studyTherapy adherenceHospital AnxietyRisk factorsTreatment outcomesDepression ScaleSignificant associationIntensive interventionLogistic regressionMSMAnxiety scoresAdherenceInfection
2016
Sexual Behaviors Linked to Drug and Alcohol Use Among Men Who Have Sex With Men in China
Zhang C, Qian HZ, Yin L, Liu Y, Strauss SM, Ruan Y, Shao Y, Lu H, Vermund SH. Sexual Behaviors Linked to Drug and Alcohol Use Among Men Who Have Sex With Men in China. Substance Use & Misuse 2016, 51: 1821-1830. PMID: 27608264, PMCID: PMC5423713, DOI: 10.1080/10826084.2016.1197264.Peer-Reviewed Original ResearchConceptsAlcohol useHigher oddsAlcohol consumptionSexual behaviorDrug useHigh-risk sexual behaviorFemale partnersHistory of alcoholSexual risk behaviorsHigh-risk behaviorsEffects of drugsSelf-administered questionnaireSyphilis infectionHIV infectionSyphilis prevalenceMean ageSyphilis testingClinical trialsHIV epidemicHIV interventionsBlood samplesHIVHan ethnicityRisk behaviorsMSMThe 2013 HIV Continuum of Care in Tennessee
Wester C, Rebeiro PF, Shavor TJ, Shepherd BE, McGoy SL, Daley B, Morrison M, Vermund SH, Pettit AC. The 2013 HIV Continuum of Care in Tennessee. Public Health Reports 2016, 131: 695-703. PMID: 28123210, PMCID: PMC5230808, DOI: 10.1177/0033354916660082.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAnti-Retroviral AgentsBlack or African AmericanContinuity of Patient CareFemaleHealth Services AccessibilityHealthcare DisparitiesHispanic or LatinoHIV InfectionsHumansMaleMiddle AgedSex FactorsSexual BehaviorSubstance Abuse, IntravenousTennesseeViral LoadYoung AdultConceptsHIV continuumInjection drug usersNon-Hispanic blacksViral suppressionHIV infectionDrug usersHuman immunodeficiency virus (HIV) continuumRyan White ProgramNon-Hispanic black peopleHispanic peopleEnhanced surveillance activitiesPoor outcomeWhite ProgramPatient engagementLaboratory reportingSubgroup disparitiesNashville residentsTennessee residentsCareInfectionSurveillance activitiesVulnerable groupsMenSuppressionResidentsFrequent HIV Testing
Liu Y, Qian HZ, Ruan Y, Wu P, Osborn CY, Jia Y, Yin L, Lu H, He X, Shao Y, Vermund SH. Frequent HIV Testing. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 72: 452-461. PMID: 27003496, PMCID: PMC4925192, DOI: 10.1097/qai.0000000000001001.Peer-Reviewed Original ResearchConceptsMultivariable logistic regression analysisCurrent HIV infectionHIV incidence reductionHIV testing historyPropensity score adjustmentCubic spline modelingBorderline significant trendLogistic regression analysisHigher testing ratesHIV infectionHIV serostatusPrevious HIVHIV epidemicBeijing MSMTesting ratesScore adjustmentIncidence reductionTesting historyHIVInfection statusBehavioral factorsRegression analysisMSMOddsMenRelationship of Stigma and Depression Among Newly HIV-Diagnosed Chinese Men Who Have Sex with Men
Tao J, Wang L, Kipp AM, Qian HZ, Yin L, Ruan Y, Shao Y, Lu H, Vermund SH. Relationship of Stigma and Depression Among Newly HIV-Diagnosed Chinese Men Who Have Sex with Men. AIDS And Behavior 2016, 21: 292-299. PMID: 27376900, PMCID: PMC5322805, DOI: 10.1007/s10461-016-1477-8.Peer-Reviewed Original ResearchConceptsCurrent depressionMultivariable ordinal logistic regressionInternalized stigmaCurrent depression prevalenceRelationship of stigmaTotal stigma scoreLong-term mental healthOne-point increaseNewly HIVHIV diagnosisHIV infectionDepression prevalenceOrdinal logistic regressionHIV stigmaChinese MSMChinese menStigma scoresHIVLogistic regressionMedian scoreEffective interventionsMental healthStrong associationDepressionMen