2024
Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia
Berbrier D, Adler T, Leone C, Paidas M, Stachenfeld N, Usselman C. Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia. AJP Heart And Circulatory Physiology 2024, 327: h140-h154. PMID: 38700469, DOI: 10.1152/ajpheart.00020.2024.Peer-Reviewed Original ResearchMuscle sympathetic nerve activitySystolic blood pressureResponse to acute stimuliIsometric handgrip exercise protocolMental stressHandgrip exercise protocolCardiovascular diseaseExercise-induced increaseEffective prevention strategiesAcute stimuliExercise protocolHistory of preeclampsiaBlood pressureIntegrated muscle sympathetic nerve activityElevated long-term riskElevated cardiovascular riskLong-term riskEnd-expiratory apneaSympathetic nerve activityPrevention strategiesHandgrip exerciseBlood pressure responseRisk factorsExaggerated pressorHealthy pregnancy
2023
Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome
Stone T, Yanes Cardozo L, Oluwatade T, Leone C, Burgos M, Okifo F, Pal L, Reckelhoff J, Stachenfeld N. Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome. AJP Heart And Circulatory Physiology 2023, 325: h232-h243. PMID: 37327000, PMCID: PMC10393337, DOI: 10.1152/ajpheart.00164.2023.Peer-Reviewed Original ResearchConceptsSympathetic nervous system activityBlood pressure dysregulationPolycystic ovary syndromeBody mass indexBaroreflex gainOvary syndromeBlood pressureObese insulin-resistant womenPolycystic ovary syndrome phenotypesRenin-angiotensin system activationSerum angiotensin-converting enzymeGonadotropin-releasing hormone antagonistLower sympathetic nervous system activityLower body negative pressureHeightened cardiovascular riskInsulin-resistant womenSystolic blood pressureBody negative pressureNervous system activityAngiotensin-converting enzymeIR womenCardiovascular riskSerum aldosteroneBaroreflex controlDiastolic BPTestosterone effects on autonomic function in women with androgen excess polycystic ovary syndrome
Stone T, Cardozo L, Oluwatade T, Leone C, Okifo F, Reckelhoff J, Pal L, Stachenfeld N. Testosterone effects on autonomic function in women with androgen excess polycystic ovary syndrome. Physiology 2023, 38: 5729543. DOI: 10.1152/physiol.2023.38.s1.5729543.Peer-Reviewed Original ResearchLower body negative pressureBlood pressureHormone interventionSympathetic baroreflexAutonomic functionSimilar systolic blood pressureGonadotropin-releasing hormone antagonistInsulin-resistant womenDiastolic blood pressurePolycystic ovary syndromeSystolic blood pressureCardiovascular autonomic controlBody negative pressureMSNA activitySerum angiotensinOvarian syndromeOvary syndromeResistant womenBaroreflex sensitivityHormone suppressionSerum aldosteroneAutonomic perturbationsT elevationHormone antagonistElevated androgens
2022
Polycystic ovary syndrome and black race are associated with increased blood pressure
Okifo N, Pal L, Mushi M, Stachenfeld N. Polycystic ovary syndrome and black race are associated with increased blood pressure. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r3724.Peer-Reviewed Original ResearchOlder reproductive age womenReproductive-age womenNon-obese groupPolycystic ovary syndromeMultivariable linear regression modelsBlood pressureAge womenObese groupBlack raceBP indicesOvary syndromeRacial breakdownDiagnosis of PCOSNon-obese womenCardiovascular disease riskMultivariable linear regressionType II diabetesLinear regression modelsGreater systolicTubal infertilityIndependent predictorsCommon endocrinopathyRegression modelsBP measurementsPCOSConsequences of hyperandrogenemia during pregnancy in female offspring: attenuated response to angiotensin II
Shawky NM, Dalmasso C, Ojeda NB, Zuchowski Y, Stachenfeld N, Alexander BT, Reckelhoff JF. Consequences of hyperandrogenemia during pregnancy in female offspring: attenuated response to angiotensin II. Journal Of Hypertension 2022, 40: 712-722. PMID: 34980865, PMCID: PMC8897268, DOI: 10.1097/hjh.0000000000003067.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeAttenuated pressor responsesPressor responseBlood pressureAng IIHyperandrogenemic femalesAngiotensin IIFemale offspringModel of PCOSNitrate/nitrite excretionSimilar baseline blood pressureIntrarenal Ang IIBaseline blood pressureElevated blood pressureExaggerated pressor responseHigh-salt dietLow birth weightFemale control offspringDihydrotestosterone pelletsMaternal hyperandrogenemiaMore proteinuriaPCOS womenOvary syndromeRenal injurySalt diet
2020
Pathophysiological effects of androgens on the female vascular system
Stone T, Stachenfeld NS. Pathophysiological effects of androgens on the female vascular system. Biology Of Sex Differences 2020, 11: 45. PMID: 32727622, PMCID: PMC7391603, DOI: 10.1186/s13293-020-00323-6.ChaptersConceptsFemale cardiovascular systemPolycystic ovary syndromeFemale vasculatureHormone therapyOvary syndromePathophysiological effectsCardiovascular systemTransgender menPrimary medical interventionSignificant medical risksHigh blood pressureCardiovascular disease statesEffects of testosteroneEndogenous androgen concentrationsSex differencesPotential causative linkChronic hyperandrogenismTestosterone dosesEndothelial dysfunctionBlood pressurePatient groupVascular functionCardiovascular regulationSex hormonesAndrogen receptorAutonomic Dysfunction in Women with Androgen Excess PCOS
Stone T, Leone C, Ayers T, Stachenfeld N. Autonomic Dysfunction in Women with Androgen Excess PCOS. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.01846.Peer-Reviewed Original ResearchLower body negative pressurePolycystic ovary syndromeForearm vascular resistanceGnRH-antBlood pressureBaroreflex sensitivityEstrogen suppressionBRS slopeHormone suppressionAutonomic functionElevated blood pressureReproductive-age womenBody negative pressureTestosterone-induced changesAutonomic dysfunctionMild hypertensionVascular resistanceObese womenOvary syndromeGnRH antagonistAge womenBP regulationCardiovascular diseaseReproductive endocrinopathyBiochemical manifestationsA recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow
Usselman CW, Adler TE, Coovadia Y, Leone C, Paidas MJ, Stachenfeld NS. A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow. AJP Heart And Circulatory Physiology 2020, 318: h581-h589. PMID: 32004082, DOI: 10.1152/ajpheart.00578.2019.Peer-Reviewed Original ResearchConceptsMuscle sympathetic nerve activitySympathetic nerve activityArterial stiffnessBaroreflex sensitivityPreeclamptic womenUncomplicated pregnanciesNerve activityBlood pressureCardiovascular diseaseCentral pulse wave velocityCardiovagal baroreflex sensitivityElevated arterial stiffnessMuscle sympathetic outflowElevated cardiovascular riskHistory of preeclampsiaNormal blood pressurePeripheral arterial stiffnessSympathetic baroreflex sensitivitySympathetic nervous systemPulse wave velocityHigher MSNACardiovascular dysregulationSympathetic outflowCardiovascular riskNormal pregnancy
2019
Compromised endothelial function in transgender men taking testosterone
Stachenfeld N, Leone C, Gulanski B. Compromised endothelial function in transgender men taking testosterone. The FASEB Journal 2019, 33: 696.4-696.4. DOI: 10.1096/fasebj.2019.33.1_supplement.696.4.Peer-Reviewed Original ResearchEndothelial functionEndothelial dysfunctionBlood pressureTransgender menRisk factorsCisgender femalesCardiovascular risk factorsEarly follicular phaseSystolic blood pressureFull-text articlesTestosterone therapyAndrogen excessCardiovascular riskVasodilatory responseBlood lipidsHDL cholesterolSystolic BPLDL cholesterolCoronary arteryHormonal milieuFollicular phaseAndrogen treatmentMenstrual cycleCardiovascular diseaseAtherosclerotic plaques
2018
Measurement of compensatory reserve predicts racial differences in tolerance to simulated hemorrhage in women
Wenner MM, Hinds KA, Howard JT, Nawn CD, Stachenfeld NS, Convertino VA. Measurement of compensatory reserve predicts racial differences in tolerance to simulated hemorrhage in women. Journal Of Trauma And Acute Care Surgery 2018, 85: s77-s83. PMID: 29443858, PMCID: PMC6023758, DOI: 10.1097/ta.0000000000001837.Peer-Reviewed Original ResearchConceptsLower body negative pressureBeat blood pressureHg lower body negative pressureCentral blood volumeCompensatory reserve measurementHeart rateWhite womenBlood volumeProgressive lower body negative pressureInadequate tissue oxygenationSigns/symptomsBody negative pressureProgressive central hypovolemiaRacial differencesStandard vital signsAfrican American womenBlood pressureHemodynamic decompensationAA womenCentral hypovolemiaRetrospective analysisTissue oxygenationRate of declineHemorrhageNegative pressureBlood pressure predicts endothelial function and the effects of ethinyl estradiol exposure in young women
Adler TE, Usselman CW, Takamata A, Stachenfeld NS. Blood pressure predicts endothelial function and the effects of ethinyl estradiol exposure in young women. AJP Heart And Circulatory Physiology 2018, 315: h925-h933. PMID: 29906227, DOI: 10.1152/ajpheart.00188.2018.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAdministration, OralAdolescentAdultAntihypertensive AgentsArterial PressureBrachial ArteryDrug Administration ScheduleEndothelium, VascularEthinyl EstradiolExercise TestFemaleHand StrengthHumansHypertensionIschemiaObesityTime FactorsTreatment OutcomeVasodilator AgentsYoung AdultConceptsEthinyl estradiol administrationEndothelial functionBlood pressureEstradiol administrationEthinyl estradiol exposureEndothelial dysfunctionShear stress stimulusEndothelial impairmentEstradiol exposureHBP groupExercise responseNBP groupFlow-mediated dilation responseHigh blood pressure groupYoung womenIschemic handgrip exerciseOral ethinyl estradiolOvert cardiovascular dysfunctionBlood pressure groupFlow-mediated dilationNormal blood pressureHigh blood pressureMild hypertensionFMD responseHandgrip exerciseBlood Pressure Predicts Endothelial Function and Effect of Ethinyl Estradiol in Young Obese and Lean Women
Adler T, Usselman C, Takamata A, Stachenfeld N. Blood Pressure Predicts Endothelial Function and Effect of Ethinyl Estradiol in Young Obese and Lean Women. The FASEB Journal 2018, 32: 713.3-713.3. DOI: 10.1096/fasebj.2018.32.1_supplement.713.3.Peer-Reviewed Original ResearchElevated blood pressureHigh blood pressureBlood pressureEndothelial functionEthinyl estradiol treatmentEndothelial dysfunctionFMD responseHealthy womenEstradiol treatmentAmerican Heart Association guidelinesNew American Heart Association guidelinesIschemic handgrip exerciseHeart Association guidelinesYoung healthy womenFull-text articlesShear stress stimulusRH-FMDMild hypertensionHandgrip exerciseLean womenVasodilatory responseHyperemic responseAssociation guidelinesCardiovascular diseaseEthinyl estradiol
2017
Measurement of the Compensatory Reserve Predicts Racial Differences in Orthostatic Tolerance
Wenner M, Hinds K, Howard J, Nawn C, Stachenfeld N, Convertino V. Measurement of the Compensatory Reserve Predicts Racial Differences in Orthostatic Tolerance. The FASEB Journal 2017, 31: 1087.2-1087.2. DOI: 10.1096/fasebj.31.1_supplement.1087.2.Peer-Reviewed Original ResearchLower body negative pressureBeat blood pressureCompensatory reserve indexMmHg lower body negative pressureCaucasian womenStroke volumeHeart rateOrthostatic toleranceAA womenOrthostatic stressProgressive lower body negative pressureCentral blood volumeBody negative pressureProgressive central hypovolemiaRacial differencesTraditional vital signsUS Army Medical ResearchAfrican American womenBlood pressure waveformBlood pressureHemodynamic decompensationCentral hypovolemiaLBNP stageArmy Medical ResearchBlood volume
2015
Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance
Wenner MM, Taylor HS, Stachenfeld NS. Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance. Microcirculation 2015, 22: 391-399. PMID: 25996650, PMCID: PMC4506724, DOI: 10.1111/micc.12208.Peer-Reviewed Original ResearchConceptsL-NMMAMicrovascular vasodilationHealthy womenVasodilatory responsivenessLocal cutaneous heatingMicrovascular vasodilatory functionMicrovascular vasodilatory responsesBeat blood pressureHealthy young womenLaser Doppler flowmetryHeat-induced vasodilationMicrovascular responsivenessVascular effectsVasodilatory responseBlood pressureMicrovascular functionVasodilatory functionCutaneous heatingInsulin resistanceCutaneous circulationDoppler flowmetryGEN exposureInteraction of E2VasodilationMicrodialysis perfusionEndocrine‐Autonomic Linkages
Sladek CD, Michelini LC, Stachenfeld NS, Stern JE, Urban JH. Endocrine‐Autonomic Linkages. 2015, 5: 1281-1323. PMID: 26140719, DOI: 10.1002/cphy.c140028.Peer-Reviewed Original ResearchConceptsHypothalamic paraventricular nucleusAutonomic nervous systemParasympathetic outflowPeripheral hormonesAutonomic neuronsBlood pressureNeuroendocrine actionsGonadal steroidsParaventricular nucleusMaintenance of homeostasisElectrolyte balanceNeuroendocrine neuronsNervous systemNeuronal populationsAutonomic responsesNeuroendocrine systemAutonomic mechanismsEnergy homeostasisNeuroendocrineBody temperatureNeuronsAutonomic systemPhysiological mechanismsHomeostasisPhysiological parameters
2014
Impact of lower body negative pressure induced hypovolemia on peripheral venous pressure waveform parameters in healthy volunteers
Alian AA, Galante NJ, Stachenfeld NS, Silverman DG, Shelley KH. Impact of lower body negative pressure induced hypovolemia on peripheral venous pressure waveform parameters in healthy volunteers. Physiological Measurement 2014, 35: 1509-1520. PMID: 24901895, DOI: 10.1088/0967-3334/35/7/1509.Peer-Reviewed Original ResearchConceptsLower body negative pressureBlood pressureBody negative pressureCardiac modulationHeart ratePulse pressurePVP waveformsProgressive lower body negative pressureArterial systolic blood pressureFinger arterial blood pressurePeripheral venous pressure waveformsMmHg lower body negative pressureMean blood pressureDiastolic blood pressureSystolic blood pressureArterial blood pressureArterial BP valuesPressure waveformSignificant reductionMild hypovolemiaVenous pressureHemodynamic changesIntravenous siteRespiratory modulationBP values
2013
Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol
Wenner MM, Haddadin A, Taylor HS, Stachenfeld NS. Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol. The Journal Of Physiology 2013, 591: 2345-2355. PMID: 23401618, PMCID: PMC3650699, DOI: 10.1113/jphysiol.2012.247882.Peer-Reviewed Original ResearchConceptsLow orthostatic toleranceE2 administrationOrthostatic toleranceVascular resistanceBlood pressureStroke volumeHeart rateGonadotrophin-releasing hormone antagonistLevels of LBNPLower central volumeReproductive hormone productionAdministration of E2Peripheral vascular resistanceBeat blood pressureAutonomic cardiovascular regulationLower stroke volumeLower body negative pressure testHeart rate responseInfluence of oestradiolBaroreflex controlTolerant womenHormone antagonistCardiovascular regulationPeripheral vasoconstrictionAutonomic control
2012
Autonomic control mechanism of maximal lower body negative pressure application
Selvaraj N, Shelley K, Silverman D, Stachenfeld N, Chon K. Autonomic control mechanism of maximal lower body negative pressure application. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2012, 2012: 3120-3123. PMID: 23366586, DOI: 10.1109/embc.2012.6346625.Peer-Reviewed Original ResearchConceptsLower body negative pressureDiastolic blood pressureHeart rate variabilityBlood pressure variabilityAutonomic control mechanismsPulse pressureSevere hemorrhageTermination of LBNPLower body negative pressure applicationMaximal lower body negative pressureSystolic blood pressure variabilityRoot mean square successive differenceBody negative pressureConscious human subjectsNegative pressure applicationMean square successive differenceSquare successive differenceHigh-frequency powerLBNP applicationSympathetic reflexesAutonomic reflexesSympathetic activityBaroreflex sensitivityBlood pressureLBNP toleranceBlood pressure and water regulation: understanding sex hormone effects within and between men and women
Wenner MM, Stachenfeld NS. Blood pressure and water regulation: understanding sex hormone effects within and between men and women. The Journal Of Physiology 2012, 590: 5949-5961. PMID: 23027816, PMCID: PMC3530109, DOI: 10.1113/jphysiol.2012.236752.Peer-Reviewed Original ResearchConceptsOvarian hormone exposureBlood pressureHormone exposureHormone effectsYoung womenOvarian hormone effectsSuppress reproductive functionBlood pressure controlFirst-line treatmentSex differencesEffects of estrogenPlasma volume expansionCause of deathSex hormone effectsBody fluid regulationGreater morbidityHealthy womenLine treatmentOvarian hormonesMenopausal womenBody water balanceOrthostatic toleranceProgesterone exposureMenstrual cycleHormone administration
2010
Tissue Doppler of Early Mitral Filling Correlates With Simulated Volume Loss in Healthy Subjects
Moore CL, Tham ET, Samuels KJ, McNamara RL, Galante NJ, Stachenfeld N, Shelley K, Dziura J, Silverman DG. Tissue Doppler of Early Mitral Filling Correlates With Simulated Volume Loss in Healthy Subjects. Academic Emergency Medicine 2010, 17: 1162-1168. PMID: 21175513, DOI: 10.1111/j.1553-2712.2010.00906.x.Peer-Reviewed Original ResearchConceptsInferior vena cavaLBNP levelsTissue DopplerHealthy subjectsVital signsPulsed-wave tissue DopplerLower body negative pressureLateral mitral annulusEmergency department patientsTissue Doppler assessmentTissue Doppler velocitiesEarly diastolic fillingAccurate noninvasive assessmentPulsed-wave spectral DopplerLate transmitralNegative pressure levelBlood pressureDepartment patientsDoppler assessmentVena cavaDiastolic fillingVolume lossCardiovascular diseaseMitral annulusFilling wave