2023
Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores
Chen L, Pokhvisneva I, Lahti-Pulkkinen M, Kvist T, Baldwin J, Parent C, Silveira P, Lahti J, Räikkönen K, Glover V, O'Connor T, Meaney M, O'Donnell K. Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 63: 640-651. PMID: 37977417, PMCID: PMC11105503, DOI: 10.1016/j.jaac.2023.08.018.Peer-Reviewed Original ResearchPrenatal maternal depressionMaternal mental healthMaternal depressionAttention-deficit/hyperactivity disorderChild psychiatric symptomsPolygenic risk scoresPsychiatric symptomsRisk scoreMental healthFetal originGenomic riskAvon Longitudinal StudySimilar independent effectsAdolescent psychiatric symptomsHealth hypothesisMaternal symptomsChild CohortIndependent cohortBehavioral symptomsALSPAC cohortMental disordersSymptom dataSymptomsCohortChildren's symptomsEpigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders
Felt J, Yusupov N, Harrington K, Fietz J, Zhang Z, Sliwinski M, Ram N, O'Donnell K, Group B, Meaney M, Putnam F, Noll J, Binder E, Shenk C. Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders. Neurobiology Of Stress 2023, 27: 100577. PMID: 37885906, PMCID: PMC10597797, DOI: 10.1016/j.ynstr.2023.100577.Peer-Reviewed Original ResearchEarly life adversityPsychiatric disordersEpigenetic age accelerationLife adversityAge accelerationProspective cohort studyBiological agingNon-abused controlsCohort studyNeurocognitive screeningPeripheral bloodCommunity cohortNeurocognitive declineIndependent cohortCognitive declineEarly screeningMental disordersCohortGrimAge clockDisordersBiomarkersLower general cognitive abilityEarly declineNeurocognitive abilitiesCognitive abilities
2021
DCC gene network in the prefrontal cortex is associated with total brain volume in childhood
Morgunova A, Pokhvisneva I, Nolvi S, Entringer S, Wadhwa P, Gilmore J, Styner M, Buss C, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP, Flores CA. DCC gene network in the prefrontal cortex is associated with total brain volume in childhood. Journal Of Psychiatry And Neuroscience 2021, 46: e154-e163. PMID: 33206040, PMCID: PMC7955849, DOI: 10.1503/jpn.200081.Peer-Reviewed Original ResearchConceptsTotal brain volumeExpression-based polygenic risk scoreBrain volumePrefrontal cortexSingle nucleotide polymorphismsHigher total brain volumeCommunity-based cohortChildren 1.5Polygenic risk scoresMaternal adversityRisk scoreIndependent cohortReplication cohortCohortCortexBrain developmentChildren 8Donor databaseSmall sample sizeEffect sizeReplication analysis
2019
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Czamara D, Eraslan G, Page CM, Lahti J, Lahti-Pulkkinen M, Hämäläinen E, Kajantie E, Laivuori H, Villa PM, Reynolds RM, Nystad W, Håberg SE, London SJ, O’Donnell K, Garg E, Meaney MJ, Entringer S, Wadhwa PD, Buss C, Jones MJ, Lin DTS, MacIsaac JL, Kobor MS, Koen N, Zar HJ, Koenen KC, Dalvie S, Stein DJ, Kondofersky I, Müller NS, Theis FJ, Räikkönen K, Binder E. Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications 2019, 10: 2548. PMID: 31186427, PMCID: PMC6559955, DOI: 10.1038/s41467-019-10461-0.Peer-Reviewed Original ResearchConceptsDNA methylationEnvironmental factorsCellular functionsEpigenetic processesCord blood DNA methylationBlood DNA methylationMethylationGenetic variantsGenetic contributionIntegrated analysisPrenatal environmental factorsComplex disorderGenetic influencesGxE modelsGenotypesGWASRelative contributionGxEIndependent cohortCpGDisease riskEnrichmentVariants