2023
Progress on the Endometrium
Frankfurter D, Kliman H. Progress on the Endometrium. Obstetrics And Gynecology Clinics Of North America 2023, 50: 677-694. PMID: 37914487, DOI: 10.1016/j.ogc.2023.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEmbryo ImplantationEndometriosisEndometriumFemaleHumansMammalsPregnancyTrophoblastsUterusConceptsAbsence of pregnancyEvidence-based approachEndometrial assessmentStromal maturationEndometrial proliferationEndometrial pathologyInflammatory mediatorsOvarian steroidsImplantation failureBlastocyst implantationEndometrial sloughingDiagnostic measuresEndometriumOffer hopeDynamic tissueDevelopmental markersSingle testTissueInternal reproductionMaturationEndometriosisPregnancyDecidualizationInfertilityUterus
2019
Clinical approach to recurrent implantation failure: evidence-based evaluation of the endometrium
Kliman HJ, Frankfurter D. Clinical approach to recurrent implantation failure: evidence-based evaluation of the endometrium. Fertility And Sterility 2019, 111: 618-628. PMID: 30929719, DOI: 10.1016/j.fertnstert.2019.02.011.Peer-Reviewed Original ResearchConceptsRecurrent implantation failureImplantation failureHigh-quality embryosEvidence-based evaluationInflammatory markersRetained productsInflammatory lesionsHistologic evaluationQuality embryosClinical approachGrowth disordersActionable findingsEndometriumFunctional testsPatientsMolecular eraComplete assessmentTissueCycling tissueEndometrialFailureBest optionLesionsEvaluation
2017
Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss
Stephenson MD, McQueen D, Winter M, Kliman HJ. Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss. Fertility And Sterility 2017, 107: 684-690.e2. PMID: 28081870, DOI: 10.1016/j.fertnstert.2016.11.029.Peer-Reviewed Original ResearchConceptsPregnancy successEndometrial biopsySubsequent pregnancyLH surgePregnancy lossVaginal micronized progesteroneObservational cohort studyUnexplained pregnancy lossRecurrent pregnancy lossCohort of womenCyclin E expressionMicronized progesteronePrior pregnancyCohort studyOngoing pregnancyConcomitant findingsEndometrial glandsOdds ratioInclusion criteriaMAIN OUTCOMEPregnancyE expressionWomenCohortWeeks
2006
Optimization of endometrial preparation results in a normal endometrial function test® (EFT®) and good reproductive outcome in donor ovum recipients
Kliman HJ, Honig S, Walls D, Luna M, McSweet JC, Copperman AB. Optimization of endometrial preparation results in a normal endometrial function test® (EFT®) and good reproductive outcome in donor ovum recipients. Journal Of Assisted Reproduction And Genetics 2006, 23: 299-303. PMID: 16983518, DOI: 10.1007/s10815-006-9061-1.Peer-Reviewed Original ResearchConceptsFunction testsCourse of estrogensOvum donation cyclesUnexplained infertility patientsBetter reproductive outcomesCyclin EOvum recipientsClinical pregnancyEndometrial biopsyInfertility patientsProgesterone supplementationSuch patientsEndometrial receptivityDonation cyclesSuccessful pregnancyPregnancy failureDonor oocytesLeuprolide acetateSole patientUterine preparationsImmunohistochemical stainingReproductive outcomesStimulation protocolTransfer cyclesSuccessful implantationMouse ascites Golgi mucin expression abnormalities in natural cycle endometrial biopsies predict subsequent in vitro fertilization–embryo transfer (IVF-ET) failure in patients with previous IVF-ET failures
Catalanotti JS, Spandorfer SD, Barmat LI, Rosenwaks Z, McSweet JC, Kliman HJ. Mouse ascites Golgi mucin expression abnormalities in natural cycle endometrial biopsies predict subsequent in vitro fertilization–embryo transfer (IVF-ET) failure in patients with previous IVF-ET failures. Fertility And Sterility 2006, 85: 255-258. PMID: 16412771, DOI: 10.1016/j.fertnstert.2005.06.060.Peer-Reviewed Original ResearchConceptsIVF-ET failureFertilization-embryo transfer failureIVF-ET outcomeClinical pregnancy rateRetrospective cohort studyHigh positive predictive valuePositive predictive valueCohort studyEndometrial biopsyIVF-ETEndometrial expressionPregnancy ratePredictive valueExpression abnormalitiesAbnormal miceSignificant decreaseMiceWomenTransfer failureFailureBiopsyPatientsExpressionAbnormalitiesGolgi expression
2003
Improved endometrial assessment using cyclin E and p27
Dubowy RL, Feinberg RF, Keefe DL, Doncel GF, Williams SC, McSweet JC, Kliman HJ. Improved endometrial assessment using cyclin E and p27. Fertility And Sterility 2003, 80: 146-156. PMID: 12849817, DOI: 10.1016/s0015-0282(03)00573-9.Peer-Reviewed Original ResearchConceptsCyclin EDay 20Retrospective clinical studyNormal control biopsiesUniversity Medical CenterEndometrial assessmentMock cycleP27 immunohistochemistryEndometrial biopsyControl biopsiesInfertile womenInfertility patientsEndometrial expressionMenstrual cycleInfertility treatmentClinical studiesMedical CenterMAIN OUTCOMEP27 stainingFertile volunteersP27 expressionDay 17Useful markerProliferative samplesBiopsy
2001
Maternal Hoxa10 is required for pinopod formation in the development of mouse uterine receptivity to embryo implantation
Bagot C, Kliman H, Taylor H. Maternal Hoxa10 is required for pinopod formation in the development of mouse uterine receptivity to embryo implantation. Developmental Dynamics 2001, 222: 538-544. PMID: 11747087, DOI: 10.1002/dvdy.1209.Peer-Reviewed Original ResearchConceptsEndometrial receptivityPinopod formationBlastocyst implantationHOXA10 expressionEndometrial stromal cell proliferationUterine endometrial epithelial cellsAdult female miceState of receptivityExpression of HOXA10Endometrial epithelial cellsStromal cell proliferationTime of implantationHOXA10 antisenseAdult reproductive tractEndometrial developmentGenitourinary tractFemale miceUterine receptivityMouse uterusUterusReproductive tractEpithelial cellsCell proliferationCellular proliferationHOXA10Mouse ascites golgi (MAG) mucin expression and regulation by progesterone in the rat uterus.
Schwartz LB, Naftolin F, Lyttle CR, Penzias AS, Meaddough EL, Kliman HJ. Mouse ascites golgi (MAG) mucin expression and regulation by progesterone in the rat uterus. Reproductive Sciences 2001, 8: 216-23. PMID: 11525897, DOI: 10.1016/s1071-5576(01)00115-0.Peer-Reviewed Original ResearchConceptsPregnant mare serum gonadotropinSprague-Dawley ratsEndometrial glandsAdult Sprague-Dawley ratsImmature Sprague-Dawley ratsBlood group AGlandular stainingHormonal groupsEndometrial receptivitySerum gonadotropinMucin expressionSprague-DawleyUntreated groupGroup ARat uterusMaximal responseMAG expressionBlood analysisStimulatory effectRU486Glycoprotein epitopesRatsEpitopesGlandProgesterone
2000
Endometrial dating and determination of the window of implantation in healthy fertile women
Acosta A, Elberger L, Borghi M, Calamera J, Chemes H, Doncel G, Kliman H, Lema B, Lustig L, Papier S. Endometrial dating and determination of the window of implantation in healthy fertile women. Fertility And Sterility 2000, 73: 788-798. PMID: 10731542, DOI: 10.1016/s0015-0282(99)00605-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultEmbryo ImplantationEndometriumEstradiolFemaleFollicle Stimulating HormoneGolgi ApparatusGrowth InhibitorsHumansImmunohistochemistryIntegrin alpha4beta1IntegrinsInterleukin-6Leukemia Inhibitory FactorLuteinizing HormoneLymphokinesMenstrual CycleMicroscopy, Electron, ScanningMucinsProspective StudiesReceptors, Interleukin-1Receptors, Interleukin-1 Type IReceptors, Lymphocyte HomingReceptors, ProgesteroneReceptors, VitronectinReference ValuesConceptsWindow of implantationLeukemia inhibitory factorLuteal phaseDay 22Day 20Endometrial datingInterleukin-1 receptor type IAssisted reproductive unitWhole luteal phaseProspective clinical studyHealthy fertile womenIL-1R tIReceptor type IMAG antibodyEndometrial biopsyFertile womenNormal womenImplantation windowP4 receptorReceptor expressionClinical studiesLH peakHealthy volunteersMAIN OUTCOMEImmunohistochemical determination
1995
A mucin-like glycoprotein identified by MAG (mouse ascites Golgi) antibodies. Menstrual cycle-dependent localization in human endometrium.
Kliman HJ, Feinberg RF, Schwartz LB, Feinman MA, Lavi E, Meaddough EL. A mucin-like glycoprotein identified by MAG (mouse ascites Golgi) antibodies. Menstrual cycle-dependent localization in human endometrium. American Journal Of Pathology 1995, 146: 166-81. PMID: 7531946, PMCID: PMC1870765.Peer-Reviewed Original ResearchConceptsMAG antibodyMucin-like glycoproteinHigh molecular weight mucin-like glycoproteinBlood groupCycle days 5Bile duct epitheliumAnti-MAG antibodiesConceptus-endometrial interactionsExpression of mucinsBlood type ABlood group AHuman endometrial glandsEndometrial biopsyPancreatic acinar cellsEndometrial glandsEndometrial surfaceIgG antibodiesImplantation windowHuman endometriumImmunohistochemical stainingGroup AGall bladderLuminal epitheliumDuct epitheliumLacrimal gland
1990
Human trophoblast-endometrial interactions in an in vitro suspension culture system
Kliman H, Feinberg R, Haimowitz J. Human trophoblast-endometrial interactions in an in vitro suspension culture system. Placenta 1990, 11: 349-367. PMID: 2235916, DOI: 10.1016/s0143-4004(05)80226-7.Peer-Reviewed Original Research