2010
Experience‐dependent plasticity in hypocretin/orexin neurones: re‐setting arousal threshold
Gao X, Wang AH. Experience‐dependent plasticity in hypocretin/orexin neurones: re‐setting arousal threshold. Acta Physiologica 2010, 198: 251-262. PMID: 19785627, PMCID: PMC2860674, DOI: 10.1111/j.1748-1716.2009.02047.x.Peer-Reviewed Original ResearchConceptsExperience-dependent plasticityExperience-dependent changesEnvironmental cuesArousal levelMaintenance of arousalBrain areasAddictive drugsBrain functionSynaptic architectureLateral hypothalamusAnimal behaviorExtensive innervationNeuropeptide hypocretinArousal thresholdCore processesSynaptic plasticityHypocretin/orexin neuronesArousalAnimal survivalEnvironmental factorsPlasticityBehavioral factorsNeuronesBehavioral changesOrexin neurones
2007
Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons
Rao Y, Liu ZW, Borok E, Rabenstein RL, Shanabrough M, Lu M, Picciotto MR, Horvath TL, Gao XB. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. Journal Of Clinical Investigation 2007, 117: 4022-4033. PMID: 18060037, PMCID: PMC2104495, DOI: 10.1172/jci32829.Peer-Reviewed Original ResearchConceptsHypocretin/orexin neuronsLong-term potentiationOrexin neuronsGlutamatergic synapsesSynaptic plasticitySleep lossExperience-dependent synaptic plasticityDopamine D1 receptorsChronic sleep lossSleep-wake regulationModafinil treatmentLateral hypothalamusD1 receptorsSimilar potentiationBrain slicesNeuronal activityNeuronal circuitryDopamine systemNervous systemSynaptic strengthNeuronsPathological conditionsGentle handlingMiceWakefulness