2022
The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation
Fabrizio V, Lindsay C, Wilcox M, Hong S, Lynn T, Norwitz E, Yonkers K, Abrahams V. The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation. Journal Of Reproductive Immunology 2022, 155: 103786. PMID: 36528909, PMCID: PMC9851981, DOI: 10.1016/j.jri.2022.103786.Peer-Reviewed Original ResearchMeSH KeywordsAntidepressive AgentsExtraembryonic MembranesFemaleFetal Membranes, Premature RuptureFluoxetineHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInfant, NewbornInflammationInterleukin-6P38 Mitogen-Activated Protein KinasesPregnancyPremature BirthSelective Serotonin Reuptake InhibitorsConceptsSerotonin reuptake inhibitorsP38 MAPK activitySerotonin reuptake inhibitor fluoxetineSubsequent preterm birthFirst-line therapyPreterm premature ruptureReuptake inhibitor fluoxetineInflammatory IL-6Normal term deliveryIL-6 productionIL-6 secretionFetal membrane inflammationUnexposed womenAntidepressant treatmentLine therapyPreterm birthAntidepressant useReuptake inhibitorsTerm deliveryMembrane inflammationPremature ruptureIL-6SRI useSterile inflammationP38 MAPK pathway
2014
Single- and double-stranded viral RNA generate distinct cytokine and antiviral responses in human fetal membranes
Bakaysa SL, Potter JA, Hoang M, Han CS, Guller S, Norwitz ER, Abrahams VM. Single- and double-stranded viral RNA generate distinct cytokine and antiviral responses in human fetal membranes. Molecular Human Reproduction 2014, 20: 701-708. PMID: 24723465, PMCID: PMC4072183, DOI: 10.1093/molehr/gau028.Peer-Reviewed Original ResearchConceptsHuman fetal membranesToll-like receptorsMIP-1βMIP-1αFetal membranesAntiviral responseIL-1βIL-6IL-2Viral infectionG-CSFCytokine/chemokine profilesViral ssRNAAdverse pregnancy outcomesMaternal-fetal interfaceInfection-associated inflammationMCP-1 secretionViral dsRNA analogueTNF-α productionMIP-1α secretionTLR adapter proteinsExpression of IFNβPregnancy outcomesCytokine profileChemokine profiles
2011
Nod1 Activation by Bacterial iE-DAP Induces Maternal–Fetal Inflammation and Preterm Labor
Cardenas I, Mulla MJ, Myrtolli K, Sfakianaki AK, Norwitz ER, Tadesse S, Guller S, Abrahams VM. Nod1 Activation by Bacterial iE-DAP Induces Maternal–Fetal Inflammation and Preterm Labor. The Journal Of Immunology 2011, 187: 980-986. PMID: 21677137, DOI: 10.4049/jimmunol.1100578.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell LineDiaminopimelic AcidDisease Models, AnimalFemaleHumansInfant, NewbornInfant, PrematureInflammationMaternal-Fetal ExchangeMiceMice, Inbred C57BLNod1 Signaling Adaptor ProteinObstetric Labor, PrematurePregnancyPregnancy OutcomeTissue Culture TechniquesTrophoblastsConceptsPattern recognition receptorsPreterm laborCytokine profileNOD1 activationRecognition receptorsInfection-associated preterm laborHuman first-trimester trophoblastsIntracellular pattern recognition receptorsProinflammatory cytokine profileHuman term placental tissueActivation of NOD1Maternal-fetal interfaceInfection-associated inflammationFunction of NOD1Term placental tissueFirst trimester trophoblastsThird trimester trophoblastFetal inflammationPreterm deliveryEmbryonic day 14.5Pregnancy outcomesFetal weightIL-6MCP-1NOD2 stimulation