2016
Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling
Jiang M, Qiu Z, Zhang S, Fan X, Cai X, Xu B, Li X, Zhou J, Zhang X, Chu Y, Wang W, Liang J, Horvath T, Yang X, Wu K, Nie Y, Fan D. Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling. Oncotarget 2016, 7: 61390-61402. PMID: 27542217, PMCID: PMC5308659, DOI: 10.18632/oncotarget.11359.Peer-Reviewed Original ResearchMeSH KeywordsAcetylglucosamineAnimalsCell CycleCell Line, TumorCell ProliferationCyclin D1Cyclin-Dependent Kinase 2Down-RegulationFemaleGene Knockdown TechniquesHumansMaleMAP Kinase Signaling SystemMiceMice, Inbred BALB CMice, NudeMiddle AgedMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3N-AcetylglucosaminyltransferasesPhosphorylationProtein Processing, Post-TranslationalRNA InterferenceRNA, Small InterferingSerineStomach NeoplasmsThreonineUp-RegulationXenograft Model Antitumor AssaysConceptsO-GlcNAcylationERK 1/2GlcNAcylation levelsCell cycleInhibition of OGTCell proliferationVivo xenograft assaysGastric cancer cell proliferationGC cell proliferationERK 1/2 pathwayERK-1/2 signalingThreonine residuesGastric cancer cell linesGlcNAc transferaseO-GlcNAcCancer cell proliferationTarget proteinsOGT levelsGastric epithelial cellsOnly enzymeXenograft assayPotential novel therapeutic targetPhosphorylation levelsCDK-2Cancer cell lines
2015
Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis*
Cottrell JR, Li B, Kyung JW, Ashford CJ, Mann JJ, Horvath TL, Ryan TA, Kim SH, Gerber DJ. Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis*. Journal Of Biological Chemistry 2015, 291: 1948-1956. PMID: 26627835, PMCID: PMC4722470, DOI: 10.1074/jbc.m115.705319.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcineurinCells, CulturedEndocytosisHippocampusHumansMaleMiceMice, Inbred BALB CNeuronsRatsSynaptic VesiclesConceptsSynaptic vesicle cyclingVesicle cyclingHippocampal neuronsPsychiatric diseasesSynaptic vesicle endocytosisCultured rat hippocampal neuronsRNAi-mediated knockdownCalcineurin catalytic subunitRat hippocampal neuronsFunctional phosphataseCombination of immunocytochemistryVesicle endocytosisLow expression levelsCatalytic subunitPresynaptic substratePresynaptic terminalsPresynaptic functionΓ isoformsCalcineurin AαCatalytic isoformsImmuno-EMSpecific functionsExpression levelsMost tissuesPPP3CC