2011
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons
Klöckener T, Hess S, Belgardt BF, Paeger L, Verhagen LA, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P, Brüning JC. High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nature Neuroscience 2011, 14: 911-918. PMID: 21642975, PMCID: PMC3371271, DOI: 10.1038/nn.2847.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAge FactorsAnimalsAnimals, NewbornBlood GlucoseBody WeightCalorimetryDietary FatsDose-Response Relationship, DrugEatingEnzyme InhibitorsEnzyme-Linked Immunosorbent AssayFemaleGene Expression RegulationGlucose Tolerance TestGreen Fluorescent ProteinsHypoglycemic AgentsIn Vitro TechniquesInjections, IntraventricularInsulinLeptinMaleMiceMice, Inbred C57BLMice, TransgenicNeuronsObesityPatch-Clamp TechniquesPhosphatidylinositol 3-KinasesReceptor, InsulinRNA, MessengerSignal TransductionSteroidogenic Factor 1Time FactorsTolbutamideVentromedial Hypothalamic Nucleus
2006
Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals
Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, Bechmann I, Leranth C, Toran-Allerand D, Priest CA, Roberts JL, Gao XB, Mobbs C, Shulman GI, Diano S, Horvath TL. Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nature Medicine 2006, 13: 89-94. PMID: 17195839, DOI: 10.1038/nm1525.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnorexiaArcuate Nucleus of HypothalamusBody WeightEstradiolEstrogen Receptor alphaExcitatory Postsynaptic PotentialsFemaleInjections, IntraventricularLeptinMaleMelanocortinsMiceMice, Inbred C57BLMice, KnockoutMice, ObeseMicroscopy, ElectronNeuronsObesityOvariectomyPro-OpiomelanocortinRatsRats, Sprague-DawleySignal TransductionSTAT3 Transcription FactorConceptsArcuate nucleusFood intakeLeptin receptor-deficient miceGonadal steroid estradiolRearrangement of synapsesReceptor-deficient miceBody weight regulationBody weight gainWild-type ratsPOMC neuronsLeptin effectsExcitatory inputsMetabolic hormonesLeptin receptorObese animalsSteroids estradiolWeight regulationBody weightSynaptic plasticityWeight gainRobust increaseInput organizationSTAT3 activationEnergy expenditureAdipositygp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor
Janoschek R, Plum L, Koch L, Münzberg H, Diano S, Shanabrough M, Müller W, Horvath TL, Brüning JC. gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 10707-10712. PMID: 16818888, PMCID: PMC1502296, DOI: 10.1073/pnas.0600425103.Peer-Reviewed Original ResearchConceptsCiliary neurotrophic factorAnorectic effectPOMC neuronsNeurotrophic factorCNTF actionAcute anorectic responseNormal energy homeostasisHigh-fat dietStress-induced anorexiaC-fos expressionProopiomelanocortin neuronsAnorectic responseHypothalamic neuronsLeptin resistanceFat dietParaventricular nucleusUnaltered numberKnockout micePOMC cellsCommon cytokinesEnergy homeostasisNeuronsSTAT3 phosphorylationExact siteCre-loxP
2004
Central Administration of Ghrelin and Agouti-Related Protein (83–132) Increases Food Intake and Decreases Spontaneous Locomotor Activity in Rats
Tang-Christensen M, Vrang N, Ortmann S, Bidlingmaier M, Horvath TL, Tschöp M. Central Administration of Ghrelin and Agouti-Related Protein (83–132) Increases Food Intake and Decreases Spontaneous Locomotor Activity in Rats. Endocrinology 2004, 145: 4645-4652. PMID: 15231700, DOI: 10.1210/en.2004-0529.Peer-Reviewed Original ResearchConceptsNeuropeptides neuropeptide YFood intakePhysical activityLocomotor activityOrexigenic neuropeptides neuropeptide YCentral administrationSpontaneous physical activitySingle intracerebroventricular injectionMajor etiological factorGH secretagogue receptorSpontaneous locomotor activityOverall locomotor activityDose-dependent mannerNovel peptide hormoneGhrelin injectionIntracerebroventricular injectionHypothalamic neuronsNeuropeptide YSecretagogue receptorEtiological factorsGhrelinHigh doseEndogenous ligandHunger factorAgRP
2002
Leptin Uptake by Serotonergic Neurones of the Dorsal Raphe
Fernández‐Galaz M, Diano S, Horvath TL, Garcia‐Segura L. Leptin Uptake by Serotonergic Neurones of the Dorsal Raphe. Journal Of Neuroendocrinology 2002, 14: 429-434. PMID: 12047717, DOI: 10.1046/j.1365-2826.2002.00783.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleHumansInjections, IntraventricularLeptinMaleMiceNeuronsRaphe NucleiRatsRats, WistarRecombinant ProteinsSerotoninSex CharacteristicsTime FactorsConceptsEffects of leptinRaphe nucleusDorsal rapheFemale ratsMidbrain serotonergic systemsSerotonergic systemSerotonergic neuronesRaphe neuronesDistribution of neuronesMouse recombinant leptinIntracerebroventricular administrationLeptin administrationLeptin uptakeLeptin treatmentPeriventricular grayMale ratsFood intakeRecombinant leptinLeptinSleep patternsGender differencesBrain functionImportant mediatorLeptin accumulationNeurones
2000
Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats
Dube M, Horvath T, Kalra P, Kalra S. Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats. Peptides 2000, 21: 1557-1560. PMID: 11068104, DOI: 10.1016/s0196-9781(00)00311-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAppetite DepressantsAppetite RegulationCarrier ProteinsEatingFeeding BehaviorInjections, IntraventricularIntracellular Signaling Peptides and ProteinsMaleNaphthalenesNerve Tissue ProteinsNeuronsNeuropeptidesOrexin ReceptorsOrexinsPyrimidinesRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledReceptors, NeuropeptideReceptors, Neuropeptide YSignal TransductionWeight GainConceptsOrexigenic peptideReceptor antagonistSated ratsNPY Y1 receptor antagonistNPY-producing neuronsPotent orexigenic peptideNPY Y5 receptor antagonistsY1 receptor antagonistY5 receptor antagonistsOrexin AIntracerebroventricular injectionY5 receptorsNeuropeptide YReceptor involvementFood intakeStimulate feedingNeuronsAntagonistRatsFeedingOrexinCurrent resultsFunctional linkHypothalamusNPY
1994
Naloxone reduces the feeding evoked by intracerebroventricular galanin injection
Dube M, Horvath T, Leranth C, Kalra P, Kalra S. Naloxone reduces the feeding evoked by intracerebroventricular galanin injection. Physiology & Behavior 1994, 56: 811-813. PMID: 7528433, DOI: 10.1016/0031-9384(94)90247-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainDose-Response Relationship, DrugEatingGalaninHypothalamusInjections, IntraventricularMaleNaloxoneNeuropeptidesPeptidesRatsRats, Sprague-DawleyReceptors, OpioidSatiationConceptsBeta-endorphin releaseFood intakeOpioid receptor antagonist naloxoneHighest naloxone doseDose-related fashionStimulation of feedingImmunopositive cell bodiesGalanin-immunoreactive fibersDose-dependent mannerGalanin injectionICV injectionNaloxone doseAntagonist naloxoneBasal hypothalamusBeta-endorphinCentral injectionMaximal suppressionGalaninMorphological findingsSynaptic connectionsCell bodiesNaloxoneIntakeInjectionStimulation